Transcriptional Regulation of the Rat Tissue type Plasminogen Activator Gene: Localization of DNA Elements and Nuclear Factors Mediating Constitutive and Cyclic AMP-Induced Expression

REFERENCES

• Altus, Μ. S., D. Pearson, A. Horiuchi, and Y. Nagamine. 1987. Inhibition of protein synthesis in LLC-PK1 cells increases calcitonin-induced plasminogen-activator gene transcription and mRNA stability. Biochem. J. 242:387–392.
   PubMedGoogle Scholar
• Astrup, T., and P. Μ. Permin. 1947. Fibrinolysis in the animal organism. Nature (London) 159:681–682.
   PubMed Web of Science ®Google Scholar
• Beato, Μ. 1991. Transcriptional control by nuclear receptors. FASEB J. 5:2044–2051.
   PubMed Web of Science ®Google Scholar
• Beers, W. H. 1975. Follicular plasminogen and plasminogen activator and the effect of plasmin on ovarian follicle wall. Cell 6:379–386.
   PubMedGoogle Scholar
• Beers, W. H., S. Strickland, and E. Reich. 1975. Ovarian plasminogen activator: relationship to ovulation and hormonal regulation. Cell 6:387–394.
   PubMed Web of Science ®Google Scholar
• Benoist, C., K. O. O’Hare, R. Breathnach, and P. Chambon. 1980. The ovalbumin gene sequence of putative control regions. Nucleic Acids Res. 8:127–142.
   PubMed Web of Science ®Google Scholar
• Cohen, S., H. Ushiro, C. Stoscheck, and Μ. Chinkers. 1982. A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. J. Biol. Chem. 257:1523–1531.
   PubMed Web of Science ®Google Scholar
• Collen, D. 1980. On the regulation and control of fibrinolysis. Thromb. Haemostasis 43:77–89.
   PubMed Web of Science ®Google Scholar
• Comb, M., N. C. Birnbeig, A. Seasholtz, E. Herbert, and H. Μ. Goodman. 1986. A cyclic AMP- and phorbol ester-inducible DNA element. Nature (London) 323:353–356.
   PubMedGoogle Scholar
• Coughlin, S. R., P. J. Barr, L. S. Cousens, L. J. Fretto, and L. T. Williams. 1988. Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vitro. J. Biol. Chem. 263:988–993.
   PubMed Web of Science ®Google Scholar
• Damon, D. H., P. A. D’Amore, and J. A. Wagner. 1990. Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms. J. Cell Biol. 110:1333–1339.
   PubMedGoogle Scholar
• Danö, K., P. A. Andreasen, J. Grondahl-Hansen, P. Kristensen, L. S. Nielsen, and L. Skriver. 1985. Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res. 44:139–266.
   PubMed Web of Science ®Google Scholar
• Darrow, A. L., R. J. Rickles, L. T. Pecorino, and S. Strickland. 1990. Transcription factor SPl is important for retinoic acid- induced expression of the tissue plasminogen activator gene during F, teratocarcinoma cell differentiation. Mol. Cell. Biol. 10:5883–5893.
   PubMedGoogle Scholar
• Davis, J. S., R. V. Farese, and Μ. R. Clark. 1983. Gonadotropinreleasing hormone (GnRH) stimulates phosphatidylinositol metabolism in rat granulosa cells: mechanism of action of GnRH. Proc. Natl. Acad. Sci. USA 80:2049–2053.
   PubMedGoogle Scholar
• de Wet, J. R., K. V. Wood, Μ. de Luca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725–737.
   PubMed Web of Science ®Google Scholar
• Dynan, W. S., S. Sazer, R. Tjian, and R. T. Schimke. 1986. Transcription factor Spl recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature (London) 319:246–248.
   PubMedGoogle Scholar
• Ephrussi, A., G. M∙ Church, S. Tonegawa, and W. Gilbert. 1985. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134–140.
   PubMed Web of Science ®Google Scholar
• Evans, Μ. L, L. J. Hager, and G. S. McKnight. 1981. A somatomedin-like peptide hormone is required during the estro- gen-mediated induction of ovalbumin gene transcription. Cell 25:187–193.
   PubMedGoogle Scholar
• Feng, P., Μ. Ohlsson, and T. Ny. 1990. The structure of the TATA-Iess rat tissue-type plasminogen activator gene. J. Biol. Chem. 265:2022–2027.
   PubMed Web of Science ®Google Scholar
• Galas, D., and A. Schmitz. 1978. Dnase footprinting: a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res. 5:3157–3170.
   PubMed Web of Science ®Google Scholar
• Galway, A. B., Μ. Oikawa, T. Ny, and A. J. W. Hsueh. 1989. Epidermal growth factor stimulates tissue plasminogen activator activity and messenger ribonucleic acid levels in cultured rat granulosa cells: mediation by pathways independent of protein kinase-A and -C. Endocrinology 125:126–135.
   PubMedGoogle Scholar
• Gorman, C. Μ., G. T. Merlino, Μ. C. Willingham, I. Pastan, and B. H. Howard. 1982. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA mediated transfection. Proc. Natl. Acad. Sci. USA 79:6777–6781.
   PubMed Web of Science ®Google Scholar
• Gorman, C. Μ., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
   PubMed Web of Science ®Google Scholar
• Heaton, J. H., V. L. Nebes, L. G. O’Dell, S. Μ. Morris, and T. D. Gelehrter. 1989. Glucocorticoid and cyclic nucleotide regulation of plasminogen activator and plasminogen activatorinhibitor gene expression in primary cultures of rat hepatocytes. Mol. Endocrinol. 3:185–192.
   PubMedGoogle Scholar
• Hsueh, A. J. W., C. Wang, and G. F. Erickson. 1980. Direct inhibitory effect of gonadotropin-releasing hormone upon follicle-stimulating hormone induction of luteinizing hormone receptor and aromatase activity in rat granulosa cells. Endocrinology 106:1697–1705.
   PubMed Web of Science ®Google Scholar
• Imagawa, M., R. Chiu, and Μ. Karin. 1987. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51:251–260.
   PubMed Web of Science ®Google Scholar
• Jia, X.-C., T. Ny, and A. J. W. Hsueh. 1990. Synergistic effect of glucocorticoids and androgens on the hormonal induction of tissue plasminogen activator activity and messenger ribonucleic acid levels in granulosa cells. Mol. Cell. Endocrinol. 68:143–151.
   PubMedGoogle Scholar
• Jones, K. A., J. T. Kadonaga, P. J. Rosenfeld, T. J. Kelly, and R. Tjian. 1987. A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell 48:79–89.
   PubMed Web of Science ®Google Scholar
• Kageyama, R., G. T. Merlino, and I. Pastan. 1988. A transcription factor active on the epidermal growth factor receptor gene. Proc. Natl. Acad. Sci. USA 85:5016–5020.
   PubMedGoogle Scholar
• Kageyama, R., G. T. Merlino, and I. Pastan. 1989. Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box. J. Biol. Chem. 264:15508–15514.
   PubMedGoogle Scholar
• Kolena, J., and C. P. Channing. 1972. Stimulatory effects of LH, FSH and prostaglandins upon cyclic 3′,5′-AMP levels in porcine granulosa cells. Endocrinology 90:1543–1550.
   PubMed Web of Science ®Google Scholar
• LaPolt, P. S., Μ. Yamoto, Μ. Veljkovic, C. Sincich, T. Ny, A. Tsafriri, and A. J. W. Hsueh. 1990. Basic fibroblast growth factor induction of granulosa cell tissue-type plasminogen activator expression and oocyte maturation: potential role as a paracrine ovarian hormone. Endocrinology 127:2357–2363.
   PubMed Web of Science ®Google Scholar
• Leegwater, P. A. J., W. van Driel, and P. C. van der Vliet. 1985. Recognition site of nuclear factor I, a sequence-specific DNA- binding protein from HeLa cells that stimulates adenovirus DNA replication. EMBO J. 4:1515–1521.
   PubMedGoogle Scholar
• Lewin, B. 1990. Commitment and activation at pol II promoters: a tail of protein-protein interactions. Cell 61:1161–1164.
   PubMed Web of Science ®Google Scholar
• Liu, Y.-X., S. B. Cajander, T. Ny, P. Kristensen, and A. J. W. Hsueh. 1987. Gonadotropin regulation of tissue-type plasminogen activators and urokinase-type plasminogen activators in rat granulosa and theca-interstitial cells during the periovulatory period. Mol. Cell. Endocrinol. 54:221–229.
   PubMedGoogle Scholar
• Maxwell, I. H., and F. Maxwell. 1989. Transient expression of firefly luciferase in electroporated cells. Bulletin 1351. Bio-Rad Laboratories, Richmond, Calif.
   Google Scholar
• Mitehell, P. J., C. Wang, and R. Tjian. 1987. Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell 50:847–861.
   PubMedGoogle Scholar
• Montminy, Μ. R., and L. Μ. Bilezikjian. 1987. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature (London) 328:175–178.
   PubMed Web of Science ®Google Scholar
• Montminy, Μ. R., K. A. Sevarino, J. A. Wagner, G. Mandel, and R. H. Goodman. 1986. Identification of a cyclic-AMP- responsive element within the rat somatostatin gene. Proc. Natl. Acad. Sci. USA 83:6682–6686.
   PubMed Web of Science ®Google Scholar
• Moss, L. G., J. Barnett Moss, and W. J. Rutter. 1988. Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators. Mol. Cell. Biol. 8:2620–2627.
   PubMedGoogle Scholar
• Nagata, K., R. A. Guggenheimer, and J. Hurwitz. 1983. Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA. Proc. Natl. Acad. Sci. USA 80:6177–6181.
   PubMed Web of Science ®Google Scholar
• Ny, T., L. Bjersing, A. J. W Hsueh, and D. J. Loskutoff. 1985. Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropins. Endocrinology 116:1666–1668.
   PubMedGoogle Scholar
• Ny, T., Y.-X. Liu, Μ. Ohlsson, P. B. C Jones, and A. J. W. Hsueh. 1987. Regulation of tissue-type plasminogen activator activity and messenger RNA levels by gonadotropin-releasing hormone in cultured rat granulosa cells and cumulus-oocyte complexes. J. Biol. Chem. 262:11790–11793.
   PubMedGoogle Scholar
• O’Connell, Μ. L., R. Canipari, and S. Strickland. 1987. Hormonal regulation of tissue plasminogen activator secretion and mRNA levels in rat granulosa cells. J. Biol. Chem. 262:2339–2344.
   PubMedGoogle Scholar
• Ohlsson, H., and T. Edlund. 1986. Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell 45:35–44.
   PubMedGoogle Scholar
• Ohlsson, Μ., A. J. W Hsueh, and T. Ny. 1988. Hormonal regulation of tissue-type plasminogen activator messenger ribonucleic acid levels in rat granulosa cells: mechanisms of induction by follicle-stimulating hormone and gonadotropin releasing hormone. Mol. Endocrinol. 2:854–861.
   PubMedGoogle Scholar
• Opdenakker, G., H. Ashino-Fuse, J. van Damme, A. Billau, and P. De Somer. 1983. Effects of 12-O-tetradecanoylphorbol 13-acetate on the production of mRNAs for human tissue-type plasminogen activator. Eur. J. Biochem. 131:481–487.
   PubMedGoogle Scholar
• Pascal, E., and R. Tjian. 1991. Different activation domains of Spl govern formation of multimers and mediate transcriptional synergism. Genes Dev. 5:1646–1656.
   PubMed Web of Science ®Google Scholar
• Pecorino, L. T., A. L. Darrow, and S. Strickland. 1991. In vitro analysis of the tissue plasminogen activator promoter reveals a GC box-binding activity present in murine brain but undetectable in kidney and liver. Mol. Cell. Biol. 11:3139–3147.
   PubMedGoogle Scholar
• Pugh, B. F., and R. Tjian. 1990. Mechanism of transcriptional activation by Spi: evidence for coactivators. Cell 61:1187–1197.
   PubMed Web of Science ®Google Scholar
• Pugh, B. F., and R. Tjian. 1991. Transcription from a TATA- Iess promoter requires a multisubunit TFIID complex. Genes Dev. 5:1935–1945.
   PubMedGoogle Scholar
• Reich, R., R. Miskin, and A. Tsafriri. 1985. Follicular plasminogen activator: involvement in ovulation. Endocrinology 116:516–521.
   PubMed Web of Science ®Google Scholar
• Reich, R., R. Miskin, and A. Tsafriri. 1986. Intrafollicular distribution of plasminogen activators and their hormonal regulation in vitro. Endocrinology 119:1588–1593.
   PubMedGoogle Scholar
• Rickles, R. J., and S. Strickland. 1988. Tissue plasminogen activator mRNA in murine tissues. FEBS Lett. 229:100–106.
   PubMedGoogle Scholar
• Saiki, R. K., D. H. Geltand, S. Stoffel, S. J. Scharf, R. Higuchi, C. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491.
   PubMed Web of Science ®Google Scholar
• Saksela, O., and D. B. Rifkin. 1988. Cell-associated plasminogen activation: regulation and physiological functions. Annu. Rev. Cell Biol. 4:93–126.
   PubMedGoogle Scholar
• Schneider, R., I. Gander, U. Muller, R. Mertz, and E. L. Winnacker. 1986. A sensitive and rapid gel retention assay for nuclear factor I and other DNA-binding proteins in crude nuclear extracts. Nucleic Acids Res. 14:1303–1317.
   PubMedGoogle Scholar
• Schubert, D., S. Heinemann, W. Carlisle, H. Tarikas, B. Kimes, J. Patrick, J. H. Steinbach, W. Culp, and B. L. Brandt. 1974. Clonal cell lines from the rat central nervous system. Nature (London) 249:224–227.
   PubMedGoogle Scholar
• Short, J. Μ., A. Wynshaw-Boris, H. P. Short, and R. W. Hanson. 1986. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. J. Biol. Chem. 261:9721–9726.
   PubMedGoogle Scholar
• Strickland, S., and W. H. Beers. 1976. Studies on the role of plasminogen activator in ovulation: in vitro response of granulosa cells to gonadotropins, cyclic nucleotides, and prostaglandins. J. Biol. Chem. 251:5694–5702.
   PubMed Web of Science ®Google Scholar
• Tsafriri, A., T. A. Bicsak, S. B. Cajander, T. Ny, and A. J. W. Hsueh. 1989. Suppression of ovulation rate by antibodies to tissue-type plasminogen activator and α-2-antiplasmin. Endocrinology 124:415–421.
   PubMedGoogle Scholar
• van Zonneveld, A.-J., S. A. Curriden, and D. J. Loskutoff. 1988. Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter. Proc. Natl. Acad. Sci. USA 85:5525–5529.
   PubMedGoogle Scholar
• Waller, E. K., and W.-D. Schleuning. 1985. Induction of fibrinolytic activity in HeLa cells by phorbol myristate acetate. Tissue type plasminogen activator antigen and mRNA augmentation require intermediate protein synthesis. J. Biol. Chem. 260:6354–6360.
   PubMedGoogle Scholar
• Wasylyk, B., R. Derbyshire, A. Guy, D. Molko, A. Roget, R. Teoule, and P. Chambon. 1980. Specific in vitro transcription of Conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence. Proc. Natl. Acad. Sci. USA 77:7024–7028.
   PubMed Web of Science ®Google Scholar
• Williams, J. R. B. 1951. The fibrinolytic activity of urine. J. Exp. Pathol. 32:530–537.
   Google Scholar
• Yamamoto, K. K., G. A. Gonzalez, W. H. Biggs III, and Μ. R. Montminy. 1988. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature (London) 334:494–498.
   PubMedGoogle Scholar
• Yamamoto, K. K., G. A. Gonzalez, P. Menzel, J. Rivier, and Μ. R. Montminy. 1990. Characterization of a bipartite activator domain in transcription factor CREB. Cell 60:611–617.
   PubMed Web of Science ®Google Scholar