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Cell Growth and Development

Dominant-Negative Mutants of Platelet-Derived Growth Factor Revert the Transformed Phenotype of Human Astrocytoma Cells

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Pages 7203-7212 | Received 10 Nov 1992, Accepted 26 Aug 1993, Published online: 31 Mar 2023

References

  • Antoniades, H. N., T. Galanopoulos, J. Neville-Golden, and C. J. O’Hara. 1991. Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNA and their protein products. Proc. Natl. Acad. Sci. USA 89:3942–3946.
  • Armelin, H. A., M. C. S. Armelin, K. Kelly, T. Stewart, P. Leder, B. H. Cochran, and C. D. Stiles. 1984. Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature (London) 310:655–660.
  • Bejcek, B., D. Y. Li, and T. F. Deuel. 1989. Transformation by v-sis occurs by an internal autoactivation mechanism. Science 245:1496–1498.
  • Bejcek, B. E., R. M. Hoffman, D. Lipps, D. Y. Li, C. A. Mitchell, P. W. Msyerus, and T. F. Deuel. 1992. The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF α and β receptors intracellularly and initiate cellular transformation. J. Biol. Chem. 267:3289–3293.
  • Betsholtz, C., A. Johnsson, C.-H. Heldin, and B. Westermark. 1986. Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Proc. Natl. Acad. Sci. USA 83:6440–6444.
  • Bigner, S. H., J. Mark, P. C. Burger, M. S. Mahaley, D. E. Bullard, L. H. Muhlbaier, and D. D. Bigner. 1988. Specific chromosomal abnormalities in malignant human gliomas. Cancer Res. 48:405–411.
  • Blochlinger, K., and H. Digglemann. 1984. Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells. Mol. Cell. Biol. 4:2929–2931.
  • Bowen-Pope, D. F., C. E. Hart, and R. A. Seifert. 1989. Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor. J. Biol. Chem. 264:2502–2508.
  • Ekstrand, A. J., C. D. James, W. K. Cavanee, B. Seliger, R. F. Pettersson, and V. P. Collins. 1991. Genes for epidermal growth factor receptor, transforming growth factor a, and epidermal growth factor and their expression in human gliomas. Cancer Res. 51:2164–2172.
  • Fleming, T., T. Matsui, C. Molloy, K. Robbins, and S. Aaronson. 1989. Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc. Natl. Acad. Sci. USA 86:8063–8067.
  • Fleming, T. P., T. Matsui, M. A. Heidran, C. J. Molloy, J. Artrip, and S. A. Aaronson. 1992. Demonstration of an activated platelet-derived growth factor autocrine pathway and its role in human tumor cell proliferation in vitro. Oncogene 7:1355–1359.
  • Fleming, T. P., A. Saxena, W. C. Clark, J. T. Robertson, E. H. Oldfield, S. A. Aaronson, and I. U. Ali. 1992. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res. 52:4550–4553.
  • Fults, D., D. Brockmeyer, M. W. Tullous, C. A. Pedone, and R. M. Cawthon. 1992. p53 mutations an loss of heterozygosity on chromosome 17 and 10 during astrocytoma progression. Cancer Res. 52:674–679.
  • Guha, A., K. Dashner, P. M. Black, J. Wagner, and C. D. Stiles. Unpublished data.
  • Hammacher, A., U. Heilman, A. Johnsson, A. Ostman, K. Gunnarsson, B. Westermark, and C.-H. Heldin. 1988. A major part of PDGF purified from human platelets is a heterodimer of one A and one B chain. J. Biol. Chem. 263:16493–16498.
  • Hannink, M., and D. J. Donoghue. 1988. Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface. J. Cell Biol. 107:287–298.
  • Harsh, G. R., M. L. Rosenblum, and L. T. Williams. 1989. Oncogene related growth factors and growth factor receptors in human malignant glioma derived cell lines. J. Neuro-Onc. 7:47–56.
  • Hart, C. E., M. Bailey, D. A. Curtis, S. Osbourn, E. Raines, R. Ross, and J. W. Forstrom. 1990. Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets. Biochemistry 29:166–172.
  • Heideran, M. A., J. H. Pierce, J.-C. Yu, D. Lombardi, J. E. Artrip, T. P. Fleming, A. Thomason, and S. A. Aaronson. 1991. Role of αβ receptor heterodimer formation in β platelet-derived growth factor (PDGF) receptor activation by PDGF-AB. J. Biol. Chem. 266:20232–20237.
  • Heldin, C.-H., G. Backstrom, A. Ostman, A. Hammacher, L. Rönnstrand, K. Rubin, M. Nistér, and B. Westermark. 1988. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J. 7:1387–1393.
  • Heldin, C.-H., A. Ernlund, C. Rorsman, and L. Rönnstrand. 1989. Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. J. Biol. Chem. 264:8905–8912.
  • Hermanson, M., K. Funa, M. Hartman, L. Claesson-Welsh, C.-H. Heldin, B. Westermark, and M. Nister. 1992. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 52:3213–3219.
  • Hermanson, M., M. Nistér, C. Betsholotz, C.-H. Heldin, B. Westermark, and K. Funa. 1988. Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc. Natl. Acad. Sci. USA 85:7748–7752.
  • Holmgren, L., L. Claesson-Welsh, C.-H. Heldin, and R. Ohlsson. 1992. The expression of PDGF α- and β-receptors in subpopulations of PDGF-producing cells implicates autocrine stimulatory loops in the control of proliferation in cytotrophoblasts that have invaded the maternal endometrium. Growth Factors 6:219–231.
  • James, C. D., E. Carlbom, J. P. Dumanski, M. Hansen, M. Norderskjold, V. P. Collins, and W. K. Cavanee. 1988. Clonal genomic alterations in glioma malignancy stages. Cancer Res. 48:5546–5551.
  • Kanakaraj, P., S. Raj, S. Khan, and S. Bishayee. 1991. Ligand-induced interaction between α- and β-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation. Biochemistry 30:1761–1767.
  • Kaufman, R. J., M. V. Davies, V. K. Pathak, and J. W. B. Hershey. 1989. The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol. Cell. Biol. 9:946–958.
  • Keating, M. T., and L. T. Williams. 1988. Autocrine stimulation of intracellular PDGF receptors in v-sis transformed cells. Science 239:914–916.
  • Key, G. O., W. D. Coffman, and M. T. Kubicek. 1952. Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer Res. 12:264–265.
  • Kumabe, T., Y. Sohma, T. Kayama, T. Yoshimoto, and T. Yamamoto. 1992. Amplification of a platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin. Oncogene 7:627–633.
  • LaRochelle, W. J., M. May-Siroff, K. C. Robbins, and S. A. Aaronson. 1991. A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain. Genes Dev. 5:1191–1199.
  • Lee, B. A., and D. J. Donoghue. 1992. Intracellular retention of membrane-anchored v-sis protein abrogates autocrine signal transduction. J. Cell Biol. 118:1057–1070.
  • Lokeshwar, V. B., S. S. Huang, and J. S. Huang. 1990. Intracellular turnover, novel secretion, and mitogenically active intracellular forms of v-sis gene product in simian sarcoma virus-transformed cells. Implications for intracellular loop autocrine transformation. J. Biol. Chem. 265:1665–1675.
  • Mahaley, M. S., C. Mettlin, N. Natarajan, E. R. Laws, and B. B. Peace. 1989. National survey of patterns of care for brain tumor patients. J. Neurosurg. 71:826–836.
  • Matsui, T., J. H. Pierce, T. P. Fleming, J. S. Greenberger, W. J. LaRochelle, M. Ruggiero, and S. A. Aaronson. 1989. Independent expression of human α or β platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signalling pathways. Proc. Natl. Acad. Sci. USA 86:8314–8318.
  • Mercola, M., P. L. Deininger, S. M. Shamah, J. Porter, C. Wang, and C. D. Stiles. 1990. Dominant-negative mutants of a platelet-derived growth factor gene. Genes Dev. 4:2333–2341.
  • Mercola, M., C. Wang, J. Kelly, C. Brownlee, J. Jackson-Grusby, C. D. Stiles, and D. Bowen-Pope. 1990. Selective expression of PDGF-A and its receptor during early mouse embryogenesis. Dev. Biol. 138:114–122.
  • Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980–990.
  • Nistér, M., L. Claesson-Welsh, A. Eriksson, C.-H. Heldin, and B. Westermark. 1991. Differential expression of platelet derived growth factor receptors in human malignant glioma cell lines. J. Biol. Chem. 266:16755–16763.
  • Risser, R., and R. Pollack. 1974. A non-selective analysis of SV40 transformation of mouse 3T3 cells. Virology 59:471–489.
  • Rönnstrand, L., M. P. Beckmann, B. Faulders, A. Ostman, B. Ek, and C.-H. Heldin. 1987. Purification of the receptor for platelet-derived growth factor from porcine uterus. J. Biol. Chem. 262:2929–2932.
  • Seifert, R. A., C. E. Harts, P. E. Phillips, J. W. Forstrom, R. Ross, M. J. Murrays, and D. F. Bowen-Pope. 1989. Two different subunits associate to create isoform-specific PDGF receptors. J. Biol. Chem. 264:8771–8778.
  • Sidransky, D., T. Mikkelsen, K. Schwechheimer, M. L. Rosenblum, W. Cavanee, and B. Vogelstein. 1992. Clonal expansion of p53 mutant cells is associated with brain tumor progression. Nature (London) 355:846–847.
  • Singh, J. P., M. A. Chaikin, and C. D. Stiles. 1982. Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. J. Cell Biol. 95:667–671.
  • Smits, A., K. Funa, F. S. Vassbotn, M. Beausang-Linder, F. af Ekenstam, C.-H. Heldin, B. Westermark, and M. Nister. 1992. Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin. Am. J. Pathol. 140:639–648.
  • Takahashi, J. A., H. Mori, M. Fukumoto, K. Igarashi, M. Jaye, Y. Oda, H. Kikuchi, and M. Hatanaka. 1990. Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues. Proc. Natl. Acad. Sci. USA 87:5710–5714.
  • Wong, A. J., S. H. Bigner, D. D. Bigner, K. W. Kinzler, S. R. Hamilton, and B. Vogelstein. 1987. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl. Acad. Sci. USA 84:6889–6903.
  • Zhan, X. I., and M. Goldfarb. 1986. Growth factor requirement of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media. Mol. Cell. Biol. 6:3541–3544.

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