4
Views
25
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

The Ionizing Radiation-Induced Replication Protein A Phosphorylation Response Differs between Ataxia Telangiectasia and Normal Human Cells

&
Pages 7222-7231 | Received 12 May 1993, Accepted 27 Aug 1993, Published online: 31 Mar 2023

References

  • Biederman, K., J. Sun, A. Giaccia, L. Tosto, and J. Brown. 1991. The scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double strand break repair. Proc. Natl. Acad. Sci. USA 88:1394–1397.
  • Brach, M. A., R. Hass, M. L. Sherman, H. Guqji, R. Weichsel-baum, and D. Kufe. 1991. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.. J. Clin. Invest. 88:691–695.
  • Brill, S. J., and B. Stillman. 1989. Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication. Nature (London) 342:92–95.
  • Brill, S. J., and B. Stillman. 1991. Replication factor-A from Saccharomyces cerevisiae is encoded by three essential genes coordinately expressed at S phase. Genes Dev. 5:1589–1600.
  • Bryant, P. E.%% 1985. Enzymatic restriction of mammalian cell DNA: evidence for double-strand breaks as potentially lethal lesions. Int. J. Radiat. Biol. 48:55–60.
  • Bryant, P. E.%% 1988. The use of restriction endonucleases to study relationships between DNA double-strand breaks, chromosomal aberrations, and other end-points in mammalian cells. Int. J. Radiat. Biol. 49:869–890.
  • Clarke, A. R., C. A. Purdie, D. J. Harrison, R. G. Morris, C. C. Bird, M. L. Hooper, and A. H. Wylie. 1993. Thymocyte apop-tosis induced by p53-dependent and independent pathways. Nature (London) 362:849–852.
  • Cornforth, M. N., and J. S. Bedford. 1985. On the nature of a defect in cells from individuals with ataxia-telangiectasia. Science 227:1589–1591.
  • Coverley, D., M. K. Kenny, M. Munn, W. D. Rupp, D. P. Lane, and R. D. Wood. 1991. Requirement for the replication protein SSB in human DNA excision repair. Nature (London) 349:538–541.
  • Datta, R., R. Hass, H. Guiyi, R. Weichselbaum, and D. Kufe. 1992. Down regulation of cell cycle control genes by ionizing radiation. Cell Growth Differ. 3:637–644.
  • Denekamp, J. 1986. Cell kinetics and radiation biology. Int. J. Radiat. Biol. 49:357–380.
  • Din, S.-U., S. J. Brill, M. P. Fairman, and B. Stillman. 1990. Cell-cycle-regulated phosphoiylation of DNA replication factor A from human and yeast cells. Genes Dev. 4:968–977.
  • Draetta, G., and D. Beach. 1988. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54:17–26.
  • Dutta, A., and B. Stillman. 1992. cdc2 family kinases phospho-iylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J. 11:2189–2199.
  • Elledge, S. J., R. Richman, F. L. Hall, R. T. Williams, N. Lodgson, and J. W. Harper. 1992. CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc. Natl. Acad. Sci. USA 89:2907–2911.
  • Erdille, L. F., W. H. Heyer, R. Kolodner, and T. J. Kelly. 1991. Characterization of a cDNA encoding the 70-kDa singlestranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J. Biol. Chem. 266:12090–12098.
  • Fairman, M. P., and B. Stillman. 1988. Cellular factors required for multiple stages of SV40 DNA replication in vitro. EMBO J. 7:1211–1218.
  • Fotedar, R., and J. M. Roberts. 1992. Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex. EMBO J. 11:2177–2187.
  • Frankenberg, D., M. Frankenberg-Schwager, D. Blocher, and R. Harbich. 1981. Evidence for DNA double-strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions. Radiat. Res. 88:524–532.
  • Fulop, G. M., and R. A. Phillips. 1990. The scid mutation in mice causes a general defect in DNA repair. Nature (London) 347:479–482.
  • Furukawa, Y., H. Piwnica-Worms, T. J. Ernst, Y. Kanakura, and J. D. Griffin. 1990. cdc2 gene expression at the G1 to S transition in human T lymphocytes. Science 250:805–808.
  • Game, J.%% 1983. Radiation-sensitive mutants and repair in yeast, p. 105-137. In J. Spencer, D. Spencer, and A. Smith (ed.), Yeast genetics; fundamental and applied aspects. Springer-Verlag, New York.
  • Gatti, R., E. Boder, H. V. Vinters, R. S. Sparkes, A. Norman, and K. Lange. 1991. Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis. Medicine 70:99–117.
  • Giordana, A., P. Whyte, E. Harlow, J. B. R. Franza, and D. Beach. 1989. A 60 kd cdc2-associated polypeptide complexes with the El A proteins in adenovirus-infected cells. Cell 58:981–990.
  • Gould, K., and P. Nurse. 1989. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature (London) 342:39–44.
  • Hallahan, D. E., V. P. Sukhatme, M. L. Sherman, S. Virudacha-lam, D. Kufe, and R. R. Weichselbaum. 1991. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN. Proc. Natl. Acad. Sci. USA 88:2156–2160.
  • Hartwell, L. H., and T. A. Weinert. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science 246:629–634.
  • Hendrickson, E., X. Qin, E. Bump, M. Oettinger, D. Schatz, and D. Weaver. 1991. A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc. Natl. Acad. Sci. USA 88:4061–4065.
  • Heyer, W.-D., and R. D. Kolodner. 1989. Purification and characterization of a protein from Saccharomyces cerevisiae that binds tightly to single-stranded DNA and stimulates a cognate strand exchange protein. Biochemistry 28:2856–2862.
  • Heyer, W.-D., M. R. S. Rao, L. F. Erdille, T. J. Kelly, and R. Kolodner. 1990. An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A. EMBO J. 9:2321–2329.
  • Hoffman, B. D., H. M. Hanauske-Abel, A. Flint, and M. La-lande. 1991. A new class of reversible cell cycle inhibitors. Cytometry 12:26–32.
  • Jaspers, N. G. J., R. A. Gatti, C. Baan, P. C. M. Linssen, and D. Bootsma. 1988. Genetic complementation analysis of ataxia-telangiectasia and Nijmegen breakage syndrome: a survey of 50 patients. Cytogenet. Cell. Genet. 49:259–263.
  • Kastan, M. B., O. Onyekwere, D. Sidransky, B. Vogelstein, and R. W. Craig. 1991. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:6304–6311.
  • Kastan, M. B., Q. Zhan, W. S. El-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and J. A. J. Fornace. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71:587–597.
  • Kenny, M. K., U. Schlegel, H. Furneaux, and J. Hurwitz. 1990. The role of human single-stranded DNA-binding protein and its individual subunits in simian virus 40 DNA replication. J. Biol. Chem. 265:7693–7700.
  • Lalande, M.%% 1990. A reversible arrest point in the late Gx phase of the mammalian cell cycle. Exp. Cell Res. 186:332–339.
  • Lane, D. P.%% 1992. p53, guardian of the genome. Nature (London) 358:15–16.
  • Liu, V. F., and D. T. Weaver. Unpublished data.
  • Lock, R. B., and W. E. Ross. 1990. Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Res. 50:3761–3766.
  • Lowe, S., E. Schmitt, S. Smith, B. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (London) 362:847–849.
  • Matsumoto, T., T. Eki, and J. Hurwitz. 1990. Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system. Proc. Natl. Acad. Sci. USA 87:9712–9716.
  • McKinnon, P. J.%% 1987. Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Hum. Genet. 75: 197–208.
  • Melendy, T., and B. Stillman. 1993. An interaction between replication protein A and SV40 T antigen appears essential for primosome assembly during SV40 DNA replication. J. Biol. Chem. 268:3389–3395.
  • Moore, S. P., L. F. Erdile, T. J. Kelly, and R. Fishel. 1991. The human homologous pairing protein HPP-1 is specifically stimulated by the cognate single-stranded binding protein hRP-A. Proc. Natl. Acad. Sci. USA 88:9067–9071.
  • Muschel, R. J., H. B. Zhang, G. Iliakis, and W. G. McKenna. 1991. Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation. Cancer Res. 51:5113–5117.
  • Nurse, P., and Y. Bissett. 1981. Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature (London) 292:558–560.
  • Painter, R. B., and B. R. Young. 1980. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. USA 77:7315–7317.
  • Pandita, T. K., and W. N. Hittleman. 1992. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiat. Res. 130:94–103.
  • Pines, J., and T. Hunter. 1989. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34 cdc2. Cell 58:833–846.
  • Sargentini, N. J., and K. C. Smith. 1986. Quantitation of the involvement of the recA, recB, recC, recF, recJ, recN, lexA, radA, radB, uvrD and umuC genes in the repair of X-ray-induced DNA double-strand breaks in Escherichia coli. Radiat. Res. 107:58–72.
  • Sherman, M. L., R. Datta, D. E. Hallahan, R. R. Weichselbaum, and D. W. Kufe. 1990. Ionizing radiation regulates expression of the c-jun protooncogene. Proc. Natl. Acad. Sci. USA 87:5663–5666.
  • Taccioli, G., G. Rathbun, E. Oltz, T. Stamato, P. Jeggo, and F. Alt. 1993. Impairment of V(D)J recombination in double-strand break repair mutants. Science 260:207–210.
  • Tang, T., and B. Neel. Personal communication.
  • Taylor, Y. C., P. G. Duncan, X. Zhang, and W. D. Wright. 1991. Differences in the DNA supercoiling response of irradiated cell lines from ataxia-telangiectasia versus unaffected individuals. Int. J. Radiat. Biol. 59:359–371.
  • Tolmach, L. J., R. W. Jones, and P. M. Busse. 1977. The action of caffeine on X-irradiated HeLa cells delayed inhibition of DNA synthesis. Radiat. Res. 71:653–665.
  • Tsurimoto, T., and B. Stillman. 1989. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, a and 8. EMBO J. 8:3883–3889.
  • Uckun, F. M., G. L. Schieven, L. M. Tuel-Ahlgren, I. Dibirdik, D. E. Myers, J. A. Ledbetter, and C. W. Song. 1993. Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors. Proc. Natl. Acad. Sci. USA 90:252–256.
  • Uckun, F. M., L. M. Tuel-Ahlgren, C. W. Song, K. Waddick, D. E. Myers, J. Kirihara, J. A. Ledbetter, and G. L. Shieven. 1992. Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death. Proc. Natl. Acad. Sci. USA 89:9005–9009.
  • Weinert, T. A., and L. H. Hartwell. 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241:317–322.
  • Weinert, T. A., and L. H. Hartwell. 1990. Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage. Mol. Cell. Biol. 10:6554–6564.
  • Wobbe, C. R., F. B. Dean, Y. Murakami, L. Weissbach, and J. Hurwitz. 1986. Simian virus 40 DNA replication in vitro: study of events preceding elongation of chains. Proc. Natl. Acad. Sci. USA 83:4612–4616.
  • Wold, M. S., D. H. Weinberg, D. M. Virshup, J. J. Li, and T. J. Kelly. 1989. Identification of cellular proteins required for simian virus 40 DNA replication. J. Biol. Chem. 264:2801–2809.
  • Young, B. R., and R. B. Painter. 1989. Radioresistant DNA synthesis and human genetic diseases. Hum. Genet. 82:113–117.
  • Zampetti-Bosseler, F., and D. Scott. 1981. Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation. Int. J. Radiat. Biol. 39:547–558.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.