Independent Regions of Adenovirus E1A are Required for Binding to and Dissociation of E2F-Protein Complexes

References

• Baeuerle, P. A., and D. Baltimore. 1988. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell 53:211–217.
   PubMed Web of Science ®Google Scholar
• Baker, S. J., S. Markowitz, E. R. Fearon, J. K. V. Willson, and B. Vogelstein. 1990. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249:912–915.
   PubMed Web of Science ®Google Scholar
• Bandara, L. R., J. P. Adamczewski, T. Hunt, and N. La Thangue. 1991. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature (London) 352:249–251.
   PubMed Web of Science ®Google Scholar
• Blake, M. C., and J. C. Azizkhan. 1989. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol. 9:4994–5002.
   PubMed Web of Science ®Google Scholar
• Cao, L., B. Faha, M. Dembski, L.-H. Tsai, E. Harlow, and N. Dyson. 1992. Independent binding of the retinoblastoma protein and pl07 to the transcription factor E2F. Nature (London) 355:176–179.
   PubMedGoogle Scholar
• Chellappan, S., S. Hiebert, M. Mudryj, J. Horowitz, and J. Nevins. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053–1061.
   PubMed Web of Science ®Google Scholar
• Chellappan, S., K. B. Kraus, B. Kroger, K. Munger, P. M. Howley, W. C. Phelps, and J. R. Nevins. 1992. Adenovirus E1A, simian virus 40 tumor antigen, and the human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. USA 89:4549–4553.
   PubMed Web of Science ®Google Scholar
• Cobrinik, D. Personal communication.
   Google Scholar
• Dalton, S.%% 1992. Cell cycle regulation of the human cdc2 gene. EMBO J. 11:1797–1804.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275–283.
   PubMed Web of Science ®Google Scholar
• Devoto, S. H., M. Mudryj, J. Pines, T. Hunter, and J. R. Nevins. 1992. A cyclin A-specific protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell 68:167–176.
   PubMed Web of Science ®Google Scholar
• Dyson, N., R. Bernards, S. H. Friend, L. R. Gooding, J. A. Hassell, E. O. Major, J. M. Pipas, T. Vandyke, and E. Harlow. 1990. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J. Virol. 64:1353–1356.
   PubMed Web of Science ®Google Scholar
• Dyson, N., M. Dembski, A. Fattaey, C. Ngwu, M. Ewen, and K. Helin. 1993. Analysis of pl07-associated proteins: pl07 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol. 67:7641–7647.
   PubMedGoogle Scholar
• Dyson, N., P. Guida, C. McCall, and E. Harlow. 1992. Adenovirus E1A makes two distinct contacts with the retinoblastoma protein. J. Virol. 66:4606–4611.
   PubMedGoogle Scholar
• Dyson, N., P. Guida, K. Munger, and E. Harlow. 1992. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J. Virol. 66:6893–6902.
   PubMed Web of Science ®Google Scholar
• Dyson, N., and E. Harlow. 1992. Adenovirus El A targets key regulators of cell proliferation. Cancer Surv. 12:161–195.
   PubMedGoogle Scholar
• Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934–937.
   PubMed Web of Science ®Google Scholar
• Ewen, M., B. Faha, E. Harlow, and D. Livingston. 1992. Interaction of pl07 with cyclin A independent of complex formation with viral oncoproteins. Science 255:85–87.
   PubMed Web of Science ®Google Scholar
• Ewen, M. E., J. W. Ludlow, E. Marsilio, J. A. DeCaprio, R. C. Millikan, S. H. Cheng, E. Paucha, and D. M. Livingston. 1989. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both pllORb and a second cellular protein, pl20. Cell 58:257–267.
   PubMedGoogle Scholar
• Ewen, M. E., Y. Xing, J. B. Lawrence, and D. M. Livingston. 1991. Molecular cloning, chromosomal mapping, and expression of the cDNA for pl07, a retinoblastoma gene product-related protein. Cell 66:1155–1164.
   PubMed Web of Science ®Google Scholar
• Faha, B., M. Ewen, L.-H. Tsai, D. Livingston, and E. Harlow. 1992. Interaction between human cyclin A and adenovirus ElA-associated pl07 protein. Science 255:87–90.
   PubMed Web of Science ®Google Scholar
• Faha, B., M. Meyerson, and L.-H. Tsai. 1992. Adenovirus El A targets one of two cyclin A-kinase complexes, p. 107-120. In D. Livingston and E. Milich (ed.), Pezcoller Foundation Symposium. John Libbey CIC, Rome.
   Google Scholar
• Faha, B. F., E. Harlow, and E. M. Lees. 1993. The adenovirus ElA-associated kinase consists of cyclin E/p33cdk2 and cyclin A/p33cdk2. J. Virol. 67:2456–2465.
   PubMedGoogle Scholar
• Giordano, A., C. McCall, P. Whyte, and B. R. Franza. 1991. Human cyclin A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product. Oncogene 6:481–486.
   PubMed Web of Science ®Google Scholar
• Graham, F. L., A. van der Eb, and H. L. Heyneker. 1974. Size and location of the transforming region in human adenovirus type 5 DNA. Nature (London) 251:687–691.
   PubMed Web of Science ®Google Scholar
• Haley, K. P., J. Overhauser, L. E. Babiss, H. S. Ginsberg, and N. C. Jones. 1984. Transformation properties of type 5 adenovirus mutants that differentially express the El A gene products. Proc. Natl. Acad. Sci. USA 81:5734–5738.
   PubMedGoogle Scholar
• Hamel, P. A., R. M. Gill, R. A. Phillips, and B. L. Gallie. 1992. Transcriptional repression of the E2-containing promoters EIIaE, c-myc and RBI by the product of the RBI gene. Mol. Cell. Biol. 12:3431–3438.
   PubMed Web of Science ®Google Scholar
• Harlow, E., L. V. Crawford, D. C. Pirn, and N. M. Williamson. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39:861–869.
   PubMed Web of Science ®Google Scholar
• Harlow, E., B. J. Franza, and C. Schley. 1985. Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J. Virol. 55:533–546.
   PubMed Web of Science ®Google Scholar
• Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Helin, K., E. Harlow, and A. R. Fattaey. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13:6501–6508.
   PubMed Web of Science ®Google Scholar
• Helin, K., J. A. Lees, M. Vidal, N. Dyson, E. Harlow, and A. Fattaey. 1992. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70:337–350.
   PubMed Web of Science ®Google Scholar
• Hiebert, S. W., M. Blake, J. Azizkhan, and J. R. Nevins. 1991. Role of E2F transcription factor in ElA-mediated frans-activa-tion of cellular genes. J. Virol. 65:3547–3552.
   PubMedGoogle Scholar
• Hiebert, S. W., S. P. Chellappan, J. M. Horowitz, and J. R. Nevins. 1992. The interaction of pRb with E2F inhibits the transcriptional activity of E2F. Genes Dev. 6:177–185.
   PubMed Web of Science ®Google Scholar
• Hiebert, S. W., M. Lipp, and J. R. Nevins. 1989. ElA-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA 86:3594–3598.
   PubMed Web of Science ®Google Scholar
• Houweling, A., P. J. van den Elsen, and A. J. van der Eb. 1980. Partial transformation of primaiy rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. Virology 105:537–550.
   PubMed Web of Science ®Google Scholar
• Hu, Q., C. Bautista, G. Edwards, D. Defeo-Jones, R. Jones, and E. Harlow. 1991. Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol. Cell. Biol. 11:5792–5799.
   PubMed Web of Science ®Google Scholar
• Hu, Q. J., N. Dyson, and E. Harlow. 1990. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9:1147–1155.
   PubMed Web of Science ®Google Scholar
• Huang, P. S., D. R. Patrick, G. Edwards, P. J. Goodhart, H. E. Huber, L. Miles, V. M. Garsky, A. Oliff, and D. C. Heimbrook. 1993. Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein. Mol. Cell. Biol. 13:953–960.
   PubMedGoogle Scholar
• Kaelin, W. G., W. Krek, W. R. Sellers, J. A. DeCaprio, F. Ajchanbaum, C. S. Fuchs, T. Chittenden, Y. Li, P. J. Farnham, M. A. Blanar, D. M. Livingston, and E. K. Flemington. 1992. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:351–364.
   PubMed Web of Science ®Google Scholar
• Kim, Y. K., and A. S. Lee. 1991. Identification of 70-base-pair cell cycle regulatory unit within the promoter of the human thymidine kinase gene and its interaction with cellular factors. Mol. Cell. Biol. 11:2296–2302.
   PubMed Web of Science ®Google Scholar
• Kovesdi, I., R. Reichel, and J. R. Nevins. 1986. Identification of a cellular transcription factor involved in El A trans-activation. Cell 45:219–228.
   PubMed Web of Science ®Google Scholar
• Lees, E., B. Faha, V. Dulic, S. I. Reed, and E. Harlow. 1992. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with pl07 and E2F in a temporally distinct manner. Genes Dev. 61874–1885.
   PubMedGoogle Scholar
• Lewis, J. B., and M. B. Mathews. 1980. Control of adenovirus early gene expression: a class of immediate early products. Cell 21:303–313.
   PubMedGoogle Scholar
• Means, A. L., J. E. Slansky, S. L. McMahon, M. W. Knuth, and P. J. Farnham. 1992. The HIP binding site is required for growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 12:1054–1063.
   PubMedGoogle Scholar
• Montell, C., E. F. Fisher, M. H. Caruthers, and A. J. Berk. 1982. Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature (London) 295:380–384.
   PubMedGoogle Scholar
• Moran, B., and B. Zerler. 1988. Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene. Mol. Cell. Biol. 8:1756–1764.
   PubMedGoogle Scholar
• Moran, E., B. Zerler, T. M. Harrison, and M. B. Mathews. 1986. Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes. Mol. Cell. Biol. 6:3470–3480.
   PubMedGoogle Scholar
• Mudryj, M., S. H. Devoto, S. W. Hiebert, T. Hunter, J. Pines, and J. R. Nevins. 1991. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65:1243–1253.
   PubMed Web of Science ®Google Scholar
• Munger, K., B. A. Werness, N. Dyson, W. C. Phelps, E. Harlow, and P. M. Howley. 1989. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8:4099–4105.
   PubMed Web of Science ®Google Scholar
• Nevins, J. R.%% 1981. Mechanism of activation of early viral transcription by the adenovirus E1A gene product. Cell 26:213–220.
   PubMed Web of Science ®Google Scholar
• Nevins, J. R.%% 1991. Transcriptional activation by viral regulatoiy proteins. Trends Biochem. Sci. 16:435–439.
   PubMedGoogle Scholar
• Nevins, J. R.%% 1992. E2F; a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424–429.
   PubMed Web of Science ®Google Scholar
• Pagano, M., G. Draetta, and P. Jansen-Durr. 1992. Association of cdk2 kinase with the transcription factor E2F during S phase. Science 255:1144–1147.
   PubMedGoogle Scholar
• Pearson, B. E., H. P. Nasheuer, and T. S. Wang. 1991. Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells. Mol. Cell. Biol. 11:2081–2095.
   PubMedGoogle Scholar
• Perricaudet, M., G. Akusjarvi, A. Virtanen, and U. Pettersson. 1979. Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses. Nature (London) 281:694–696.
   PubMed Web of Science ®Google Scholar
• Phelps, W. C., S. Bagchi, J. A. Barnes, P. Raychaudhuri, V. Kraus, K. Munger, P. M. Howley, and J. R. Nevins. 1991. Analysis of transactivation by human papillomavirus type 16 E7 and adenovirus 12S suggests a common mechanism. J. Virol. 65:6922–6930.
   PubMedGoogle Scholar
• Raychaudhuri, P., S. Bagchi, S. H. Devoto, V. B. Kraus, E. Moran, and J. R. Nevins. 1991. Domains of the adenovirus El A protein that are required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev. 5:1200–1211.
   PubMedGoogle Scholar
• Ruley, H. E.%% 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (London) 304:602–606.
   PubMed Web of Science ®Google Scholar
• Schneider, J. F., F. Fisher, C. R. Goding, and N. C. Jones. 1987. Mutational analysis of the adenovirus Ela gene: the role of transcriptional regulation in transformation. EMBO J. 62053–2060.
   PubMedGoogle Scholar
• Schwarz, J. K., S. H. Devoto, E. J. Smith, S. P. Chellappan, L. Jakoi, and J. R. Nevins. 1993. Interactions of the pl07 and Rb proteins with E2F during the cell proliferation response. EMBO J. 12:1013–1020.
   PubMed Web of Science ®Google Scholar
• Shan, B., X. Zhu, P.-L. Chen, T. Durfee, Y. Yang, D. Sharp, and W.-H. Lee. 1992. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12:5620–5631.
   PubMed Web of Science ®Google Scholar
• Shirodkar, S., M. Ewen, J. A. DeCaprio, D. Morgan, D. Livingston, and T. Chittenden. 1992. The transcription factor E2F interacts with the retinoblastoma product and a pl07-cyclin A complex in a cell cycle-regulated manner. Cell 68:157–166.
   PubMed Web of Science ®Google Scholar
• Slansky, J., Y. Li, W. G. Kaelin, and P. J. Farnham. 1993. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13:1610–1618.
   PubMed Web of Science ®Google Scholar
• Stephens, C., and E. Harlow. 1987. Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins. EMBO J. 6:2027–2035.
   PubMedGoogle Scholar
• Subramanian, T., M. Kuppuswamy, R. J. Nasr, and G. Chinndurai. 1987. An N-terminal region of adenovirus Ela essenti for cell transformation and induction of an epithelial cell grow factor. Oncogene 2:105–112.
   Google Scholar
• Thalmeier, K., H. Synovzik, R. Mertz, E.-L. Winnacker, and M. Lipp. 1989. Nuclear factor E2F mediates basic transcription ai trans-activation by Ela of the human MYC promoter. Geni Dev. 3:527–536.
   PubMedGoogle Scholar
• Tooze, J. (ed.). 1981. Molecular biology of tumor viruses, 2nd ed., revised. DNA tumor viruses. Cold Spring Harbor Labortory, Cold Spring Harbor, N.Y.
   Google Scholar
• Tsai, L.-H., E. Harlow, and M. Meyerson. 1991. Isolation of t] human cdk2 gene that encodes the cyclin A- and adenovir ElA-associated p33 kinase. Nature (London) 353:174–177.
   PubMed Web of Science ®Google Scholar
• Ulfendahl, P. J., S. Linder, J. P. Kreivi, K. Nordqvist, C. Sevensson, H. Hultberg, and G. Akusjarvi. 1987. A novel ad novirus-2 E1A mRNA encoding a protein with transcriptk activation properties. EMBO J. 6:2037–2044.
   PubMedGoogle Scholar
• van den Elsen, P., A. Houweling, and A. J. van der Eb. 19. Expression of region Elb of human adenoviruses in the absern of region Ela is not sufficient for complete transformation. Virology 128:377–390.
   PubMedGoogle Scholar
• Velcich, A., and E. Ziff. 1988. Adenovirus Ela ras cooperatk activity is separate from its positive and negative transcriptk regulatory functions. Mol. Cell. Biol. 8:2177–2183.
   PubMedGoogle Scholar
• Whyte, P.%% Personal communication.
   Google Scholar
• Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, I. Raybuck, R. A. Weinberg, and E. Harlow. 1988. Associatk between an oncogene and an anti-oncogene: the adenovir E1A proteins bind to the retinoblastoma gene product. Natu (London) 334:124–129.
   PubMed Web of Science ®Google Scholar
• Whyte, P., H. E. Ruley, and E. Harlow. 1988. Two regions of t adenovirus early region 1A proteins are required for transfc mation. J. Virol. 62:257–265.
   PubMed Web of Science ®Google Scholar
• Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellul targets for transformation by the adenovirus El A proteins. Cell 56:67–75.
   PubMed Web of Science ®Google Scholar
• Wu, E. W., K. E. Clemens, D. V. Heck, and K. Münger. 1993. The human papillomavirus E7 oncoprotein and the cellul transcription factor E2F bind to separate sites on the retinobk toma tumor suppressor protein. J. Virol. 67:2402–2407.
   PubMedGoogle Scholar
• Yee, A. S., P. Raychaudhuri, L. Jakoi, and J. R. Nevins. 1989. The adenovirus-inducible factor E2F stimulates transcripts after specific DNA binding. Mol. Cell. Biol. 9:578–585.
   PubMedGoogle Scholar
• Yee, A. S., R. Reichel, I. Kovesdi, and J. R. Nevins. 1987. Promoter interaction of the ElA-inducible factor E2F and potential role in the formation of a multi-component complex. EMBO J. 6:2061–2068.
   PubMed Web of Science ®Google Scholar
• Zamanian, M., and N. B. La Thangue. 1992. Adenovirus El prevents the retinoblastoma gene product from repressing t activity of a cellular transcription factor. EMBO J. 11:2603–2610.
   PubMedGoogle Scholar
• Zerler, B., B. Moran, K. Maruyama, J. Moomaw, T. Grodzic er, and H. E. Ruley. 1986. Adenovirus E1A coding sequenc that enable ras and pmt oncogenes to transform cultured p mary cells. Mol. Cell. Biol. 6:887–899.
   PubMedGoogle Scholar
• Zhu, L., S. van den Heuvel, K. Helin, A. Fattaey, M. Ewen, Livingston, N. Dyson, and E. Harlow. 1993. Inhibition of c proliferation by pl07, a relative of the retinoblastoma protein. Genes Dev. 7:1111–1125.
   PubMed Web of Science ®Google Scholar