7
Views
6
CrossRef citations to date
0
Altmetric
Cell Growth and Development

A Nuclear Tyrosine Phosphatase Downregulates Interferon-Induced Gene Expression

, , &
Pages 7515-7521 | Received 19 Jul 1993, Accepted 03 Sep 1993, Published online: 31 Mar 2023

References

  • Benech, P. D., K. Sastiy, R. R. Iyer, Q. G. Eichbaum, D. P. Raveh, and R. A. B. Ezekowitz. 1992. Definition of Interferon-γ-response elements in a novel human FCγ receptor gene (FeγRIb) and characterization of the gene structure. J. Exp. Med. 176:1115–1123.
  • Cheng, Y. E., C. E. Patterson, and P. Staeheli. 1991. Interferon-induced guanylate-binding proteins lack an N(T)KXD concensus motif and bind GMP in addition to GDP and GTP. Mol. Cell. Biol. 11:4717–4725.
  • Dale, T. C., A. M. Ali Imam, I. M. Kerr, and G. R. Stark. 1989. Rapid activation by interferon α of a latent DNA-binding protein present in the cytoplasm of untreated cells. Proc. Natl. Acad. Sci. USA 86:1203–1207.
  • David, M., and A. C. Larner. 1992. Activation of transcription factors by interferon alpha in a cell free system. Science 257:813–815.
  • David, M., G. Romero, Z. Zhang, J. E. Dixon, and A. C. Larner. 1993. In vitro activation of the transcription factor ISGF3 by IFNα involves a membrane associated tyrosine phosphatase and kinase. J. Biol. Chem. 268:6593–6599.
  • Decker, T., D. J. Lew, Y.-S. E. Cheng, D. E. Levy, and J. E. Darnell. 1989. Interactions of α- and β-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. EMBO J. 8:2009–2014.
  • Decker, T., D. J. Lew, J. Mirkovitch, and J. E. Darnell. 1991. Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor. EMBO J. 10:927–932.
  • Dunphy, W. G., and A. Kumagai. 1991. The cdc25 protein contains an intrinsic phosphatase activity. Cell 67:189–196.
  • Friedman, R. L., S. P. Manley, M. McMahon, I. M. Kerr, and G. R. Stark. 1984. Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell 38:745–755.
  • Fu, X.-Y. 1992. A transcription factor with SH2 and SH3 domains is directly activated by an interferon-α induced cytoplasmic protein tyrosine kinase(s). Cell 70:323–335.
  • Fu, X.-Y., D. S. Kessler, S. A. Veals, D. E. Levy, and J. E. Darnell, Jr. 1990. ISGF-3, the transcriptional activator induced by IFN-α, consists of multiple interacting polypeptide chains. Proc. Natl. Acad. Sci. USA 87:8555–8559.
  • Gutch, M. G., C. Daly, and N. C. Reich. 1992. Tyrosine phosphorylation is required for activation of an α interferon-stimulated transcription factor. Proc. Natl. Acad. Sci. USA 89:11411–11415.
  • Hagiwara, M., A. Alberts, P. Brindle, J. Meinkoth, J. Feramisco, T. Deng, M. Karin, S. Shenolikar, and M. Montminy. 1992. Transcriptional attenuation following cAMP induction requires PP-1 mediated dephosphorylation of CREB. Cell 70:105–113.
  • Igarashi, K., M. David, D. S. Finbloom, and A. C. Larner. 1993. In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade. Mol. Cell. Biol. 13:1634–1640.
  • Igarashi, K., M. David, A. C. Larner, and D. S. Finbloom. 1993. In vitro activation of a transcription factor by IFNγ requires a membrane associated tyrosine kinase and is mimicked by van-date. Mol. Cell. Biol. 13:3984–3989.
  • Larner, A. C., A. Chaudhuri, and J. E. Darnell. 1986. Transcriptional induction by interferon: new protein(s) determine the extent and length of the induction. J. Biol. Chem. 261:453–459.
  • Larner, A. C., G. Jonak, Y.-S. E. Cheng, B. Korant Knight, and J. E. Darnell. 1984. Transcriptional induction of two genes in human cells by β interferon. Proc. Natl. Acad. Sci. USA 81:6733–6737.
  • Levy, D. E., D. S. Kessler, R. Pine, and J. E. Darnell, Jr. 1989. Cytoplasmic activation of ISGF3, the positive regulator of interferon-α-stimulated transcription, reconstituted in vitro. Genes Dev. 3:1362–1371.
  • Levy, D., A. Larner, A. Chauduri, L. E. Babiss, and J. E. Darnell, Jr. 1986. Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proc. Natl. Acad. Sci. USA 83:8929–8933.
  • McLaughlin, S., and J. E. Dixon. 1993. Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila. J. Biol. Chem. 268:6839–6842.
  • Nakagawa, Y., V. Rivera, and A. C. Larner. 1992. A role for the Na/K-ATPase in the control of human c-fos and c-jun transcription. J. Biol. Chem. 267:8785–8788.
  • Pearse, R. N., R. Feinman, K. Shuai, J. E. Darnell, Jr., and J. V. Ravetch. 1993. Interferon γ-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proc. Natl. Acad. Sci. USA 90:4314–4318.
  • Perez, C., J. Wietzerbin, and P. D. Benech. 1993. Two cw-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-γ) activation of the human high-affinity Fey receptor gene: a novel IFN regulatory mechanism. Mol. Cell. Biol. 13:2182–2192.
  • Petricoin, E. F., R. H. Hackett, H. Akai, K. Igarashi, D. S. Finbloom, and A. C. Larner. 1992. Modulation of interferon signaling in human fibroblasts by phorbol esters. Mol. Cell. Biol. 12:4486–4495.
  • Reich, N., B. Evans, D. E. Levy, D. Fahey, E. Knight, and J. E. Darnell, Jr. 1987. Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc. Natl. Acad. Sci. USA 84:6394–6398.
  • Rohan, P. J., P. Davis, A. Moskaluk, M. Kearns, H. Krutzsch, U. Siebenlist, and K. Kelly. 1993. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science 259:1763–1766.
  • Schindler, C., X.-Y. Fu, T. Improta, R. Aebersold, and J. E. Darnell, Jr. 1992. Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon a. Proc. Natl. Acad. Sci. USA 89:7836–7839.
  • Schindler, C., K. Shuai, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Interferon-dependent tyrosine phosphorylation of a latent transcription factor. Science 257:809–813.
  • Shuai, K., C. Schindler, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258:1808–1812.
  • Veals, S. A., C. Schindler, D. Leonard, X. Fu, R. Aebersold, J. E. Darnell, and D. E. Levy. 1992. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol. Cell. Biol. 12:3315–3324.
  • Wadzinski, B. E., W. H. Wheat, S. Jaspers, L. F. Peruski, R. L. Lickteig, G. L. Johnson, and D. J. Klemm. 1993. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphory-lated CREB and regulates CREB transcriptional stimulation. Mol. Cell. Biol. 13:2822–2834.
  • Wilson, K. C., and D. S. Finbloom. 1992. Interferon γ rapidly induces in human monocytes a DNA-binding factor that recognizes the γ response region within the promoter of the gene for the high-affinity Feγ receptor. Proc. Natl. Acad. Sci. USA 89:11964–11968.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.