8
Views
16
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Phosphatidylinositol (PI) 3-Kinase and PI 4-Kinase Binding to the CD4-p56lck Complex: the p56lck SH3 Domain Binds to PI 3-Kinase but Not PI 4-Kinase

, , , , , & show all
Pages 7708-7717 | Received 12 May 1993, Accepted 14 Sep 1993, Published online: 31 Mar 2023

References

  • Abraham, N., M. C. Miceli, and J. R. Parnes. 1991. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature (London) 350:63–66.
  • Anderson, P., M. L. Blue, C. Morimoto, and S. F. Schlossman. 1987. Crosslinking of T3 (CD3) and T4 (CD4) enhances the proliferation of resting T lymphocytes. J. Immunol. 139:678–682.
  • Auger, K. R., L. A. Serunian, S. P. Soltoff, P. Libby, and L. C. Cantley. 1989. PDGF dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167–175.
  • Augustine, J. A., S. L. Sutor, and R. T. Abraham. 1991. Interleukin 2- and polyoma virus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes. Mol. Cell. Biol. 11:4431–4440.
  • Barber, E. K., J. D. Dasgupta, S. F. Schlossman, J. M. Trevil-lyan, and C. E. Rudd. 1989. The CD4 and CD8 antigens are coupled to a protein tyrosine kinase (p561ck) that phosphory-lates the CD3 complex. Proc. Natl. Acad. Sci. USA 86:3277–3281.
  • Bedinger, P., A. Moriarty, R. C. von Borstel II, N. Donovan, K. S. Steimer, and D. Littman. 1988. Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4. Nature (London) 334:162–165.
  • Beyers, A. D., L. L. Spruyt, and A. F. Williams. 1992. Molecular associations between the T lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA 89:2945–2949.
  • Burgess, K. E., A. D. Odysseos, C. Zalvan, B. J. Drucker, P. Anderson, S. F. Schlossman, and C. E. Rudd. 1991. Biochemical identification of a direct physical interaction between the CD4: p561ck and Ti(TcR) ζ chain/CD3 complex and protein-tyrosine kinase. Eur. J. Immunol. 21:1663–1668.
  • Burgess, K. E., M. Yamamoto, K. V. S. Prasad, and C. E. Rudd. 1992. CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor ζ chain/CD3 and protein tyrosine kinases p56lck and p59fyn. Proc. Natl. Acad. Sci. USA 89:9311–9315.
  • Cantley, L. C., K. R. Auger, C. Carpenter, B. Duckworth, A. Grazing, R. Kapeller, and S. Soltoff. 1991. Oncogenes and signal transduction. Cell 64:281–302.
  • Caron, L., N. Abraham, T. Pawson, and A. Veillette. 1992. Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine kinase p56lck. Mol. Cell. Biol. 12:2720–2729.
  • Carpenter, C. L., and L. C. Cantley. 1990. Phosphoinositide kinases. Biochemistry 29:11147–11156.
  • Carpenter, C. L., B. C. Duckworth, K. R. Augers, B. Cohen, B. S. Schaffhausen, and L. C. Cantley. 1990. Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biol. Chem. 265:19704–19711.
  • Chan, A. C., B. A. Irving, J. D. Fraser, and A. Weiss. 1991. The ζ chain is associated with a tyrosine kinase and upon T cell antigen receptor stimulation associates with ZAP-70, a 70 kDa tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA 89:9166–9170.
  • Cicchetti, P., B. J. Mayer, G. Thiel, and D. Baltimore. 1992. Identification of a protein that binds to the SH3 region of abl and is similar to Bcr and GAP. Science 257:803–806.
  • Cochet, C., O. Filhol, B. Payrastre, T. Hunter, and G. N. Gill. 1991. Interaction between the epidermal growth factor receptor and phosphoinositide kinases. J. Biol. Chem. 266:637–644.
  • Coughlin, S. R., J. A. Escobedo, and L. T. Williams. 1989. Role of phosphatidyl inositol kinase in PDGF receptor signal transduction. Science 243:1191–1194.
  • Dalgleish, A. G., P. C. Beverly, P. R. Clapham, D. H. Crawford, M. F. Greaves, and R. A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for AIDS retrovirus. Nature (London) 312:736–766.
  • Deans, J. P., S. B. Kanner, R. M. Torres, and J. A. Ledbetter. 1992. Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase. Eur. J. Immunol. 22:661–668.
  • Eichmann, K., J. I. Jonsson, I. Falk, and F. Emmrich. 1987. Effective activation of antigen receptor with either Lyt 2 or L3T4. Eur. J. Immunol. 17:643–650.
  • Emmerich, F., V. Strittmatter, and K. Eichmann. 1986. Synergism in the activation of human CD8 T cells by crosslinking the T cell receptor complex with the CD8. Proc. Natl. Acad. Sci. USA 83:8298–8302.
  • Escobedo, J. A., S. Navankasattusas, W. M. Kavanaugh, D. Milfay, A. V. Fried, and L. T. Williams. 1991. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β receptor. Cell 65:75–82.
  • Ettehadieh, E., J. S. Sanghera, S. L. Pelech, D. Hess-Bienz, J. Watts, N. Shastri, and R. Abersold. 1992. Tyrosyl phosphorylation and activation of MAP kinases by p56lck. Science 239:617–622.
  • Fantl, W. J., J. A. Escobedo, G. A. Martin, C. W. Turck, M. del Rosario, F. McCormic, and L. T. Williams. 1992. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69: 413–423.
  • Fauci, A. S.%% 1988. The human immunodeficiency virus: infectiv-ity and mechanisms of pathogenesis. Science 239:617–622.
  • Fukui, Y., and H. Hanafusa. 1989. Phosphatidylinositol kinase activity associates with viral p60src protein. Mol. Cell. Biol. 9:1651–1658.
  • Glaichenhaus, N., N. Shastri, D. R. Littman, and J. Turner. 1991. Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell 64:511–520.
  • Groux, H., G. Torpier, D. Monte, Y. Mouton, A. Capron, and J. C. Ameisen. 1992. Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus infected asymptomatic individuals. J. Exp. Med. 175:331–340.
  • Haughn, L., S. Gratton, L. Caron, R.-P. Sekaly, A. Veillette, and M. Julius. 1992. Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the αβ T-cell receptor. Nature (London) 358:328–331.
  • Herman, P. K., and S. D. Emr. 1990. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 10: 6742–6754.
  • Hiles, I. D., M. Otsu, S. Volinia, M. J. Fry, I. Gout, R. Dhand, G. Panayatou, F. Ruiz-Larrea, A. Thompson, N. F. Totty, J. J. Hsuan, S. A. Courtneidge, P. J. Parker, and M. J. Waterfield. 1992. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70:419–429.
  • Horak, I. D., M. Popovic, E. M. Horak, P. J. Lucas, R. J. Gress, C. H. June, and J. B. Bolen. 1990. No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gpl20. Nature (London) 348:557–560.
  • Hu, P., B. Margolis, E. Y. Skolinik, R. Lammers, A. Ullrich, and J. Schlessinger. 1992. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol. Cell. Biol. 12:981–990.
  • June, C. H., M. C. Fletcher, J. A. Ledbetter, and L. E. Samelson. 1990. Increases in the tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor activation. J. Immunol. 144:1591–1599.
  • Juszczak, R. J., H. Turchin, A. Truneh, J. Culp, and S. Kassis. 1991. Effect of human immunodeficiency virus gpl20 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes. J. Biol. Chem. 266:11176–11183.
  • Kapeller, R., K. V. S. Prasad, O. Janssen, W. Hou, B. Schaff-hausen, C. E. Rudd, and L. C. Cantley. Identification of two SH3 binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J. Biol. Chem., in press.
  • Kaufmann, R., D. Laroche, K. Buchner, F. Hucho, C. E. Rudd, C. Lindschau, P. Ludwig, A. Hoer, E. Oberdisse, J. Kopp, I.-J. Korner, and H. Repke. 1992. The HIV-1 surface protein gpl20 has no effect on transmembrane signal transduction in T cells. J. Acquired Immune Defic. Syndr. 15:760–770.
  • Kavanaugh, W. M., A. Klippel, J. A. Escobedo, and L. T. Williams. 1992. Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells. Mol. Cell. Biol. 12:3415–3424.
  • Kazlauskas, A., A. Kashishian, J. A. Cooper, and M. Valius. 1992. GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor p subunit. Mol. Cell. Biol. 12:2534–2544.
  • Kelly, K. L., N. B. Ruderman, and K. S. Chen. 1992. Phosphati-dylinositol-3-kinase in isolated rat adipocytes. J. Biol. Chem. 267:3423–3428.
  • Littman, D. R.%% 1987. The structure of the CD4 and CD8 genes. Annu. Rev. Immunol. 5:561–584.
  • Liu, X., L. E. M. Marengere, C. A. Koch, and T. Pawson. 1993. The v-Src SH3 domain binds to phosphatidylinositol 3′-kinase. Mol. Cell. Biol. 13:5225–5232.
  • Luo, K., and B. M. Sefton. 1990. Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol. Cell. Biol. 10:5305–5313.
  • Luo, K., and B. M. Sefton. 1992. Activated lck tyrosine protein kinase stimulates antigen independent interleukin-2 production in T cells. Mol. Cell. Biol. 12:4724–4732.
  • Mohagheghpour, N., R. Chakrabarti, B. S. Stein, S. Gowda, and E. G. Engelman. 1991. Early activation events render T cells susceptible to HIV-1 induced syncytia formation. J. Biol. Chem. 266:7233–7238.
  • Molina, T. J., K. Kishihara, D. P. Siderovski, W. Van Ewyk, A. Narendran, E. Timms, A. Wakeham, C. J. Paige, K.-U. Hartman, A. Veillette, D. Davidson, and T. W. Mak. 1992. Profound block in thymocyte development in mice lacking p56lck. Nature (London) 357:161–164.
  • Morimoto, C., N. Letvin, A. W. Boyd, M. Hagan, H. M. Brown, M. M. Kornacki, and S. F. Schlossman. 1985. The isolation and characterisation of the human inducer T cell subset. J. Immunol. 134:3762–3769.
  • Morimoto, C., Y. Torimoto, G. Levinson, C. E. Rudd, M. Schreiber, N. H. Dang, N. L. Letvin, and S. F. Schlossman. 1989. 1F7, a novel cell surface molecule involved in helper function of CD4 cells. J. Immunol. 143:3430–3439.
  • Mussachio, A., M. Noble, R. Pauptit, R. Wierenga, and M. Saraste. 1992. Crystal structure of a Src-homology3 (SH3) domain. Nature (London) 359:851–855.
  • Olivier, J. P., T. Raabe, M. Henkemeyer, B. Dickson, G. Mbamalu, B. Margolis, J. Schlessinger, E. Hafen, and T. Pawson. 1993. A drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73:179–191.
  • Otsu, M., I. Hiles, I. Gout, M. J. Fry, F. Ruiz-Larrea, G. Panayotou, A. Thompson, R. Dhand, J. Hsuan, N. Totty, A. Smith, S. J. Morgan, S. A. Courtneidge, P. Parker, and M. D. Waterfield. 1991. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell 65:91–104.
  • Pawson, T., and G. Gish. 1992. SH2 and SH3 domains: from structure to function. Cell 71:359–362.
  • Pleiman, C. M., M. R. Clark, L. K. Timson Gauen, S. Winitz, K. M. Coggeshall, G. L. Johnson, A. S. Shaw, and J. C. Cambier. 1993. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-γ2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. Mol. Cell. Biol. 13:5877–5887.
  • Prasad, K. V. S., O. Janssen, R. Kapeller, M. Raab, L. C. Cantley, and C. E. Rudd. 1993. Src-homology 3 domain of protein kinase p59 fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc. Natl. Acad. Sci. USA 90:7366–7370.
  • Prasad, K. V. S., and C. E. Rudd. 1992. A Raf-l-related pllO polypeptide associates with the CD4-p56lck complex in T cells. Mol. Cell. Biol. 12:5260–5267.
  • Reinherz, E. L., S. C. Meuer, and S. F. Schlossman. 1983. The human T cell receptor analysis with cytotoxic T cell clones. Immunol. Rev. 74:83–112.
  • Reinherz, E. L., S. C. Meuer, and S. F. Schlossman. 1983. The delineation of antigen receptors on human T lymphocytes. Immunol. Today 4:5–8.
  • Ren, R., B. J. Mayer, P. Cicchetti, and D. Baltimore. 1993. Identification of a ten aminoacid proline-rich SH3 binding site. Science 259:1157–1161.
  • Robinson, J. S., D. J. Klionsky, L. M. Banta, and S. M. Emr. 1988. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol. Cell. Biol. 8:4936–4948.
  • Rothstein, D. M., A. da Silva, K. Sugita, M. Yamamoto, K. V. S. Prasad, C. Morimoto, S. Schlossman, and C. E. Rudd. 1993. Human CD4/CD45RA+ and CD4/CD45RA- T cell subsets express CD4-p561ck complexes, CD4-associated lipid kinases, TcR/CD3-p59fyn complexes and share similar tyrosine kinase substrates. Int. Immunol. 5:409–418.
  • Rudd, C. E., O. Janssen, K. V. S. Prasad, M. Raab, A. da Silva, J. C. Telfer, and M. Yamamoto. 1993. Src-related protein tyrosine kinases and their surface receptors. Biochim. Biophys. Acta 1155:239–266.
  • Rudd, C. E., P. Anderson, C. Morimoto, M. Streuli, and S. F. Schlossman. 1989. Molecular interactions, T cell subsets and role of the CD4/CD8-p56lck complex in human T cell activation. Immunol. Rev. 111:223–266.
  • Rudd, C. E., C. Morimoto, L. L. Wong, and S. F. Schlossman. 1987. The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens. J. Exp. Med. 166:1758–1773.
  • Rudd, C. E., J. M. Trevillyan, J. D. Dasgupta, L. L. Wong, and S. F. Schlossman. 1988. The CD4 receptor is complexed in detergent lysates to a protein tyrosine kinase (pp58) from human T lymphocytes. Proc. Natl. Acad. Sci. USA 85:5190–5194.
  • Simon, M. A., G. S. Dodson, and G. M. Rubin. 1993. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and SOS proteins in vitro. Cell 73:169–177.
  • Skolnik, E. Y., B. Margolis, M. Mohammadi, E. Lowenstein, R. Fischer, A. Drepps, A. Ullrich, and J. Schlessinger. 1991. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83–90.
  • Sleckman, B. P., A. Peterson, J. A. Foran, J. C. Gorga, C. J. Kara, J. L. Strominger, S. J. Burakoff, and J. L. Greenstein. 1988. Functional analysis of a cytoplasmic tail domain deleted mutants of the CD4 molecule. J. Immunol. 141:49–54.
  • Smith, D. B., and K. S. Johnson. 1988. Single step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31–40.
  • Sugimoto, Y., M. Whitman, L. C. Cantley, and R. L. Erikson. 1984. Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidyl inositol and diacylglyc-erol. Proc. Natl. Acad. Sci. USA 81:2117–2121.
  • Talmage, D. A., R. Freund, A. Young, J. Dahl, C. J. Dawe, and T. L. Beqjamin. 1989. Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidyl inositol 3-kinase and optimal tumorogenesis. Cell 59:55–65.
  • Thompson, P. A., J. S. Gutkind, K. C. Robbins, J. A. Ledbetter, and J. B. Bolen. 1992. Identification of distinct populations of PI-3 kinase activity following T-cell activation. Oncogene 7:719–725.
  • Veillette, A., M. A. Bookman, E. M. Horak, and J. B. Bolen. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine kinase p56lck. Cell 55:301–308.
  • Veillette, A., M. A. Bookman, E. M. Horak, L. E. Samelson, and J. B. Bolen. 1989. Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature (London) 338:257–259.
  • Wages, D. S., J. Keefer, T. Rail, and M. J. Weber. 1992. Mutations in the SH3 domain of the src oncogene which decrease the association of phosphatidylinositol 3′-kinase activity with the pp60v-src and alter cellular morphology. J. Virol. 66:1866–1874.
  • Waksman, G., D. Kominos, S. C. Robertson, N. Pant, D. Baltimore, R. Birge, D. Cowbum, H. Hanafusa, B. J. Mayer, M. Overduin, M. R. Resh, C. B. Rios, L. Silverman, and J. Kuriyan. 1992. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine phosphorylated peptides. Nature (London) 358:646–653.
  • Ward, S. G., S. C. Ley, C. MacPhee, and D. Cantrell. 1992. Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens. Eur. J. Immunol. 22:45–49.
  • Weber, J. R., G. M. Bell, M. Y. Han, T. Pawson, and J. B. Imboden. 1992. Association of the tyrosine kinase lck with phospholipase C-yl after stimulation of the T cell antigen receptor. J. Exp. Med. 176:373–379.
  • Weinhold, K. J., H. K. Lyerly, S. D. Stanley, A. Austin, T. J. Mathews, and D. Bolognesi. 1989. HIV-1 gpl20-mediated immune suppression and lymphocyte destruction in the absence of viral infection. J. Immunol. 142:3091–3097.
  • Whitman, M., C. P. Downs, M. Keeler, T. Keller, and L. C. Cantley. 1988. Type I phosphatidyl inositol kinase makes a novel inositol phospholipid, phosphatidylinositol 3-phosphate. Nature 332:644–646.
  • Whitman, M., D. R. Kaplan, B. Schaffhausen, L. C. Cantley, and T. M. Roberts. 1985. Association of phosphatidylinositol kinase activity with polyoma middle T competent for transformation. Nature (London) 315:239–242.
  • Yonezawa, K., H. Ueda, K. Hara, K. Nishida, A. Ando, A. Chavenieu, H. Matsuba, K. Shii, Y. Yokono, Y. Fukui, B. Calas, F. Grigorescu, R. Dhand, I. Gout, M. Otsu, M. Waterfield, and M. Kasuga. 1992. Insulin-dependent formation of a complex containing an 85 kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1. J. Biol. Chem. 267:25958–25966.
  • Yoshida, H., Y. Koga, Y. Moroi, G. Kimura, and K. Nomuto. 1991. The effect of p56lck, a lymphocyte specific protein tyrosine kinase, on the syncytium formation induced by human immunodeficiency virus envelope glycoprotein. Int. Immunol. 4:233–242.
  • Yu, H., M. K. Rosen, T. B. Shin, C. Seidel-Dugan, J. S. Brugge, and S. L. Schreiber. 1992. Solution structure of the SH3 domain of src and identification of its ligand binding site. Science 258:1665–1668.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.