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Cell Growth and Development

Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F

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Pages 7802-7812 | Received 24 Jun 1993, Accepted 17 Sep 1993, Published online: 31 Mar 2023

References

  • Bagchi, S., P. Raychaudhuri, and J. R. Nevins. 1990. Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell 62:659–669.
  • Bagchi, S., R. Weinmann, and P. Raychaudhuri. 1991. The retinoblastoma protein copurifies with E2F-I, an ElA-regulated inhibitor of the transcription factor E2F. Cell 65:1063–1072.
  • Bandara, L. R., J. P. Adamczewski, T. Hunt, and N. B. LaThangue. 1991. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature (London) 352:249–251.
  • Blake, M. C., and J. C. Azizkhan. 1989. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol. 9:4994–5002.
  • Cao, L., B. Faha, M. Dembski, L. H. Tsai, E. Harlow, and N. Dyson. 1992. Independent binding of the retinoblastoma protein and pl07 to the transcription factor E2F. Nature (London) 355:176–179.
  • Chellappan, S. P., S. Hiebert, M. Mudryj, J. M. Horowitz, and J. R. Nevins. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053–1061.
  • Chittenden, T., D. M. Livingston, and W. J. Kaelin. 1991. The T/ElA-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell 65:1073–1082.
  • Dalton, S.%% 1992. Cell cycle regulation of the human cdc2 gene. EMBO J. 11:1797–1804.
  • Defeo-Jones, D., P. S. Huang, R. E. Jones, K. M. Haskell, G. A. Vuocolo, M. G. Hanobik, H. E. Huber, and A. Oliff. 1991. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. Nature (London) 352:251–254.
  • Defeo-Jones, D., G. A. Vuocolo, K. M. Haskell, M. G. Hanobik, D. M. Kiefer, E. M. McAvoy, M. Ivey-Hoyle, J. L. Brandsma, A. Oliff, and R. E. Jones. 1993. Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts. J. Virol. 67:716–725.
  • Devoto, S. H., M. Mudryj, J. Pines, T. Hunter, and J. R. Nevins. 1992. A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell 68:167–176.
  • Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg. 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73:499–511.
  • Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934–937.
  • Edwards, G. M., H. E. Huber, J. D. DeFeo, G. Vuocolo, P. J. Goodhart, R. Z. Maigetter, G. Sanyal, A. Oliff, and D. C. Heimbrook. 1992. Purification and characterization of a functionally homogeneous 60-kDa species of the retinoblastoma gene product. J. Biol. Chem. 267:7971–7974.
  • Eisenberg, S. P., R. J. Evans, W. P. Arend, E. Verderber, M. T. Brewer, C. H. Hannum, and R. C. Thompson. 1990. Primaiy structure and functional expression from complementary DNA of a human interleukin-1 antagonist. Nature (London) 343:341–346.
  • Ewen, M. E., H. K. Sluss, C. J. Sherr, H. Matsushime, J.-Y. Kato, and D. M. Livingston. 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487–497.
  • Girling, R., J. F. Partridge, L. R. Bandara, N. Burden, N. F. Totty, J. J. Hsuan, and N. B. La Thangue. 1993. A new component of the transcription factor DRTF1/E2F. Nature (London) 362:83–87.
  • Helin, K., J. A. Lees, M. Vidal, N. Dyson, E. Harlow, and A. Fattaey. 1992. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70:337–350.
  • Helin, K., C. Wu, A. R. Fattaey, J. A. Lees, B. D. Dynlacht, C. Ngwu, and E. Harlow. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation. Genes Dev., in press.
  • Hiebert, S. W., M. Blake, J. Azizkhan, and J. R. Nevins. 1991. Role of E2F transcription factor in ElA-mediated trans activation of cellular genes. J. Virol. 65:3547–3552.
  • Hiebert, S. W., S. P. Chellappan, J. M. Horowitz, and J. R. Nevins. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6:177–185.
  • Hiebert, S. W., M. Lipp, and J. R. Nevins. 1989. ElA-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA 86:3594–3598.
  • Hu, Q. J., C. Bautista, G. M. Edwards, J. D. Defeo, R. E. Jones, and E. Harlow. 1991. Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol. Cell. Biol. 11:5792–5799.
  • Huang, P. S., D. R. Patrick, G. Edwards, P. J. Goodhart, H. E. Huber, L. Miles, V. M. Garsky, A. Oliff, and D. C. Heimbrook. 1993. Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein. Mol. Cell. Biol. 13:953–960.
  • Huber, H. E., G. Edwards, P. J. Goodhart, D. R. Patrick, P. S. Huang, M. Ivey-Hoyle, S. F. Barnett, A. Oliff, and D. C. Heimbrook. 1993. Transcription factor E2F binds DNA as a heterodimer. Proc. Natl. Acad. Sci. USA 90:3525–3529.
  • Jones, N.%% 1990. Transcriptional regulation by dimerization: two sides to an incestuous relationship. Cell 61:9–11.
  • Jones, R. E., R. J. Wegrzyn, D. R. Patrick, N. L. Balishin, G. A. Vuocolo, M. W. Riemen, D. Defeo-Jones, V. M. Garsky, D. C. Heimbrook, and A. Oliff. 1990. Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein. J. Biol. Chem. 265:12782–12785.
  • Kaelin, W. J., W. Krek, W. R. Sellers, J. A. DeCaprio, F. Ajchenbaum, C. S. Fuchs, T. Chittenden, Y. Li, P. J. Farnham, M. A. Blanar, D. M. Livingston, and E. K. Flemington. 1992. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:351–364.
  • Kovesdi, I., R. Reichel, and J. R. Nevins. 1986. Identification of a cellular transcription factor involved in El A transactivation. Cell 45:219–228.
  • Kovesdi, I., R. Reichel, and J. R. Nevins. 1987. Role of an adenovirus E2 promoter binding factor in ElA-mediated coordinate gene control. Proc. Natl. Acad. Sci. USA 84:2180–2184.
  • Lees, J. A., M. Saito, M. Vidal, M. Valentine, T. Look, E. Harlow, N. Dyson, and K. Helin. 1993. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 13:7813–7825.
  • Mudryj, M., S. H. Devoto, S. W. Hiebert, T. Hunter, J. Pines, and J. R. Nevins. 1991. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65:1243–1253.
  • Nevins, J. R.%% 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424–429.
  • Phelps, W. C., C. L. Yee, K. Munger, and P. M. Howley. 1988. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A. Cell 53:539–547.
  • Posnett, D. N., H. McGrath, and J. P. Tam. 1988. A novel method for producing anti-peptide antibodies. J. Biol. Chem. 263:1719–1725.
  • Raychaudhuri, P., R. Rooney, and J. R. Nevins. 1987. Identification of an ElA-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter. EMBO J. 6:4073–4081.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed., p. 7.43-7.45. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Schwarz, J. K., S. H. Devoto, E. J. Smith, S. P. Chellappan, L. Jakoi, and J. R. Nevins. 1993. Interactions of the pl07 and Rb proteins with E2F during the cell-proliferation response. EMBO J. 12:1013–1020.
  • Shan, B., X. Zhu, P.-L. Chen, T. Durfee, Y. Yang, D. Sharp, and W.-H. Lee. 1992. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12:5620–5631.
  • Shirodkar, S., M. Ewen, J. A. DeCaprio, J. Morgan, D. M. Livingston, and T. Chittenden. 1992. The transcription factor E2F interacts with the retinoblastoma product and a pl07-cyclin A complex in a cell cycle-regulated manner. Cell 68:157–166.
  • Stammers, D. K., M. Tisdale, S. Court, V. Parmar, C. Bradley, and C. K. Ross. 1991. Rapid purification and characterization of HIV-1 reverse transcriptase and RNase H engineered to incorporate a C-terminal tripeptide alpha-tubulin epitope. FEBS Lett. 283:298–302.
  • Thalmeier, K., H. Synovzik, R. Mertz, E. L. Winnacker, and M. Lipp. 1989. Nuclear factor E2F mediates basic transcription and trans-activation by Ela of the human MYC promoter. Genes Dev. 3:527–536.
  • Weintraub, S. J., C. A. Prater, and D. C. Dean. 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature (London) 358:259–261.

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