Transforming Growth Factor β and Cyclosporin A Inhibit the Inducible Activity of the Interleukin-2 Gene in T Cells Through a Noncanonical Octamer-Binding Site

References

• Angel, P., E. A. Allegretto, S. T. Okino, K. Hattori, W. J. Boyle, T. Hunter, and Μ. Karin. 1988. Onoogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (London) 332:166–171.
   PubMed Web of Science ®Google Scholar
• Angel, P., Μ. Imagawa, R. Chiu, P. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and Μ. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729–739.
   PubMed Web of Science ®Google Scholar
• Banerji, J., L. Olson, and W. Schaffner. 1983. A lymphocytespecific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33:729–740.
   PubMed Web of Science ®Google Scholar
• Brabletz, T., I. Pietrowski, and E. Serfling. 1991. The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer. Nucleic Acids Res. 19:61–67.
   PubMedGoogle Scholar
• Briegel, K., B. Hentsch, I. Pfeuffer, and E. Serfling. 1991. One base pair change abolishes the T cell-restricted activity of a κB-like proto-enhancer element from the interleukin 2 promoter. Nucleic Acids Res. 19:5929–5936.
   PubMed Web of Science ®Google Scholar
• Buchkovich, K., L. A. Duffy, and E. Harlow. 1989. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097–1105.
   PubMed Web of Science ®Google Scholar
• Chantry, D., Μ. Turner, E. Abney, and Μ. Feldmann. 1989. Modulation of cytokine production by transforming growth factor-β. J. Immunol. 142:4295–4300.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., J. W. Ludlow, D. Lynch, Y. Furukawa, J. Griffin, H. Piwnica-Worms, C.-M. Huang, and D. Μ. Livingston. 1989. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58:1085–1095.
   PubMed Web of Science ®Google Scholar
• de Wet, J. R., K. V. Wood, Μ. de Luca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725–737.
   PubMed Web of Science ®Google Scholar
• Emmel, E. A., C. L. Verweij, D. B. Durand, K. Μ. Higgins, E. Lacy, and G. Crabtree. 1989. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246:1617–1620.
   PubMed Web of Science ®Google Scholar
• Ephrussi, A., G. Μ. Church, S. Tonegawa, and W. Gilbert. 1985. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134–140.
   PubMed Web of Science ®Google Scholar
• Espevik, T., I. S. Figari, Μ. R. Shalaby, G. A. Lackides, G. D. Lewis, H. Μ. Shepard, and Μ. A. Palladino. 1987. Inhibition of cytokine production by cyclosporin A and transforming growth factor β. J. Exp. Med. 166:571–576.
   PubMed Web of Science ®Google Scholar
• Fletcher, C., N. Heintz, and R. G. Roeder. 1987. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell 51:773–781.
   PubMed Web of Science ®Google Scholar
• Fontana, A., K. Frei, S. Bodmer, E. Hoefer, Μ. H. Schreier, Μ. A. Palladino, and R. Μ. Zinkernagel. 1989. Transforming growth factor-β inhibits the generation of cytotoxic T cells in virus-infected mice. J. Immunol. 143:3230–3234.
   PubMed Web of Science ®Google Scholar
• Gerster, T., P. Matthias, Μ. Thali, J. Jiricny, and W. Schaffner. 1987. Cell-type specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J. 6:1323–1330.
   PubMed Web of Science ®Google Scholar
• Heino, J., and J. Massague. 1990. Cell adhesion to collagen and decreased myogenic gene expression implicated in the control of myogenesis by transforming growth factor B. J. Biol. Chem. 265:10181–10184.
   PubMed Web of Science ®Google Scholar
• Howe, P. H., G. Draetta, and E. B. Leof. 1991. Transforming growth factor β1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol. Cell. Biol. 11:1185–1194.
   PubMed Web of Science ®Google Scholar
• Kamps, Μ. P., L. Corcoran, J. H. LeBowitz, and D. Baltimore. 1990. The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2. Mol. Cell. Biol. 10:5464–5472.
   PubMedGoogle Scholar
• Kehrl, J. H., C. Thevenin, P. Rieckmann, and A. S. Fauci. 1991. Transforming growth factor β suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane to the secreted form of Ig mRNA. J. Immunol. 146:4016–4023.
   PubMedGoogle Scholar
• Kehrl, J. H., L. Μ. Wakefield, A. B. Roberts, S. Jakowlew, Μ. Alvarez-Mon, R. Derynck, Μ. B. Sporn, and A. S. Fauci. 1986. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163:1037–1050.
   PubMed Web of Science ®Google Scholar
• Kerr, L. D., D. B. Miller, and L. Μ. Matrisian. 1990. TGF-βl inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence. Cell 61:267–278.
   PubMed Web of Science ®Google Scholar
• Kim, S. J., P. Angel, R. Lafyatis, K. Hattori, K. Y. Kim, Μ. B. Sporn, Μ. Karin, and A. B. Roberts. 1990. Autoinduction of transforming growth factor β1 is mediated by the AP-I complex. Mol. Cell. Biol. 10:1492–1497.
   PubMed Web of Science ®Google Scholar
• LaBella, F., H. L. Sive, R. G. Roeder, and N. Heintz. 1988. Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus elements. Genes Dev. 2:32–39.
   PubMed Web of Science ®Google Scholar
• Laiho, M., J. A. DeCaprio, J. W. Ludlow, D. Μ. Livingston, and J. Massague. 1990. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175–185.
   PubMed Web of Science ®Google Scholar
• Laiho, M., L. Ronnstrand, J. Heino, J. A. DeCaprio, J. W. Ludlow, D. Μ. Uvingston, and J. Massague. 1991. Control of JunB and extracellular matrix protein expression by transforming growth factor βl is independent of simian virus 40 T antigen-sensitive growth-inhibitory events. Mol. Cell. Biol. 11:972–978.
   PubMedGoogle Scholar
• Lee, G., L. R. Ellingsworth, S. GilUs, R. Wall, and P. W. Kinkade. 1987. β transforming growth factors are potential regulators of B lymphopoiesis. J. Exp. Med. 166:1290–1299.
   PubMed Web of Science ®Google Scholar
• Li, L., J.-S. Hu, and E. N. Olson. 1990. Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type β transforming growth factor. J. Biol. Chem. 265:1556–1562.
   PubMed Web of Science ®Google Scholar
• Massague, J. 1990. The transforming growth factor-β family. Annu. Rev. Cell Biol. 6:597–641.
   PubMedGoogle Scholar
• Miller, C. L., A. L. Feldhaus, J. W. Rooney, L. D. Rhodes, C. H. Sibley, and H. Singh. 1991. Regulation and a possible stagespecific function of Oct-2 during pre-B-cell differentiation. Mol. Cell. Biol. 11:4885–4894.
   PubMedGoogle Scholar
• Moses, H. L., E. Y. Yang, and J. A. Pietenpol. 1990. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 63:245–247.
   PubMed Web of Science ®Google Scholar
• Müller, Μ. M., S. Ruppert., W. Schaffner, and P. Matthias. 1988. A cloned octamer transcription factor stimulates transcription from Iymphoid-Specific promoters in non-B cells. Nature (London) 336:544–551.
   PubMedGoogle Scholar
• Müller-Deubert, S., E. Bohn, S. Chuvpilo, B. Hentsch, U. Korthäuer, I. Pfeuffer, C. Schomberg, R. Kroezek, A. Schimpl, and E. Serfling. Submitted for publication.
   Google Scholar
• Pfeuffer, I., T. Brabletz, S. Klein-Heβling, B. Hentsch, P. Matthias, and E. Serfling. Unpublished data.
   Google Scholar
• Pietenpol, J. A., J. T. Holt, R. W. Stein, and H. L. Moses. 1990. Transforming growth factor βl suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc. Natl. Acad. Sci. USA 87:3758–3762.
   PubMed Web of Science ®Google Scholar
• Randak, C., T. Brabletz, Μ. Hergenröther, I. Sobotta, and E. Serfling. 1990. Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocytespecific factors to the IL-2 enhancer. EMBO J. 9:2529–2536.
   PubMed Web of Science ®Google Scholar
• Robbins, P. D., J. Μ. Horowitz, and R. C. Mulligan. 1990. Negative regulation of human c-fos expression by the retinoblastoma gene product. Nature (London) 346:668–671.
   PubMed Web of Science ®Google Scholar
• Roberts, S. B., N. Segil, and N. Heintz. 1991. Differential phosphorylation of the transcription factor Octl during the cell cycle. Science 253:1022–1026.
   PubMedGoogle Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Schluesener, H. J., and O. Lider. 1989. Transforming growth factors β1 and β2: cytokines with identical immunosuppressive effects and a potential role in the regulation of autoimmune T cell function. J. Neuroimmunol. 24:249–258.
   PubMed Web of Science ®Google Scholar
• Schreiber, E., P. Matthias, Μ. Μ. Müller, and W. Schaffner. 1988. Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). EMBO J. 7:4221–4229.
   PubMed Web of Science ®Google Scholar
• Schreiber, E., P. Matthias, M. M. Müller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with “miniextracts”, prepared from a small number of cells. Nucleic Acids Res. 17:6419.
   PubMed Web of Science ®Google Scholar
• Serfling, E., B. Barthelmäs, I. Pfeuffer, B. Schenk, S. Zarius, R. Swoboda, F. Mercurio, and Μ. Karin. 1989. Ubiquitious and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J. 8:465–473.
   PubMed Web of Science ®Google Scholar
• Siepl, C., S. Bodmer, K. Frei, H. R. MacDonald, R. DeMartin, E. Hofer, and A. Fontana. 1988. The glioblastoma-derived T cell supressor factor/transforming growth-factor β2 inhibits T cell growth without affecting the interaction of interleukin 2 with its receptor. Eur. J. Immunol. 18:593–600.
   PubMed Web of Science ®Google Scholar
• Swoboda, R., E. Weeker, and A. Schimpl. 1987. Regulation of 112 expression in mitogen-activated murine T-lymphocytes. Immunobiology 174:300–312.
   PubMedGoogle Scholar
• Ullman, K. S., W. Μ. Flanagan, C. A. Edwards, and G. R. Crabtree. 1991. Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40. Science 254:558–562.
   PubMedGoogle Scholar
• Zentella, A., F. Μ. B Weis, D. A. Ralph, Μ. Laiho, and J. Massague. 1991. Early gene responses to transforming growth factor β in cells lacking growth-suppressive RB function. Mol. Cell. Biol. 11:4952–4958.
   PubMedGoogle Scholar