Transcriptional Downregulation of the Retina-Specific QR1 Gene by pp60^v-src and Identification of a Novel v-src-Responsive Unit

REFERENCES

• Alema, S., F. Tato, and D. Boettiger. 1985. myc and src oncogenes have complementary effects on cell proliferation and expression of specific extracellular matrix components in definitive chondroblasts. Mol. Cell. Biol. 5:538–544.
   PubMed Web of Science ®Google Scholar
• An, G., K. Hidaka, and L. Siminovitch. 1982. Expression of bacterial β-galactosidase in animal cells. Mol. Cell. Biol. 2:1628–1632.
   PubMed Web of Science ®Google Scholar
• Apel, I., C.-L. Yu, T. Wang, C. Dobry, M. E. Van Antwerp, R. Jove, and E. V. Prochownik. 1992. Regulation of the junB gene by v-src.. Mol. Cell. Biol. 12:3356–3364.
   PubMedGoogle Scholar
• Barnstable, C. J. 1987. A molecular view of vertebrate retinal development. Mol. Neurobiol. 1:9–46.
   PubMed Web of Science ®Google Scholar
• Bedard, P.-A., Y. Yannoni, D. L. Simmons, and R. L. Erikson. 1989. Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src. Mol. Cell. Biol. 9:1371–1375.
   PubMedGoogle Scholar
• Beddington, R. S. P., J. Morgenstern, H. Land, and A. Hogan. 1989. An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis. Development 106:37–46.
   PubMedGoogle Scholar
• Birchenall-Roberts, M. C., F. W. Ruscetti, J. Kasper, H.-D. Lee, R. Friedman, A. Geiser, M. B. Sporn, A. B. Roberts, and S.-J. Kim. 1990. Transcriptional regulation of the transforming growth factor β1 promotor [sic] by v-src gene products is mediated through the AP-1 complex. Mol. Cell. Biol. 10:4978–4983.
   PubMedGoogle Scholar
• Blobel, G. A., and H. Hanafusa. 1991. The v-src inducible gene 9E3/pCEF4 is regulated by both its promoter upstream sequence and its 3′ untranslated region. Proc. Natl. Acad. Sci. USA 88:1162–1166.
   PubMedGoogle Scholar
• Boettiger, D., K. Roby, J. Brumbaugh, J. Biehl, and H. Holtzer. 1977. Transformation of chicken embryo retinal melanoblasts by a temperature-sensitive mutant of Rous sarcoma virus. Cell 11:881–890.
   PubMedGoogle Scholar
• Calothy, G., D. Laugier, F. R. Cross, R. Jove, T. Hanafusa, and H. Hanafusa. 1987. The membrane-binding domain and myristy- lation of pp60v-src are not essential for stimulation of cell proliferation. J. Virol. 61:1678–1681.
   PubMedGoogle Scholar
• Calothy, G., F. Poirier, G. Dambrine, P. Mignatti, P. Combes, and B. Pessac. 1980. Expression of viral oncogenes in differentiating chick embryo neuroretinal cells infected with avian tumor viruses. Cold Spring Harbor Symp.. Quant. Biol. 44:983–990.
   PubMedGoogle Scholar
• Calothy, G., F. Poirier, G. Dambrine, and B. Pessac. 1978. A transformation defective mutant of Rous sarcoma virus inducing chick embryo neuroretinal cell proliferation. Virology 89:75–84.
   PubMedGoogle Scholar
• Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. F. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:52945299.
   Google Scholar
• Crisanti, P., A. M. Lorinet, G. Calothy, and B. Pessac. 1985. Glutamic acid decarboxylase activity is stimulated in quail retina neuronal cells transformed by Rous sarcoma virus and is regulated by pp60v-src. EMBO J. 4:1467–1470.
   PubMedGoogle Scholar
• Dehbi, M., A. Mbiguino, M. Beauchemin, G. Chatelain, and P.-A. Bédard. 1992. Transcriptional activation of the CEF-4/9E3 cytokine gene by pp60v-src Mol. Cell. Biol. 12:1490–1499.
   Google Scholar
• Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Dutta, A., M. Hamaguchi, and H. Hanafusa. 1990. Serum independence of transcription from the promoter of an avian retrovirus in v-src-transformed cells is a primary, intracellular effect of increased tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 87:608–612.
   PubMedGoogle Scholar
• Dutta, A., M. Y. Stoeckle, and H. Hanafusa. 1990. Serum and v-src increase the level of a CCAAT-binding factor required for transcription from a retroviral long terminal repeat. Genes Dev. 4:243–254.
   PubMedGoogle Scholar
• Falcone, G., S. Alemà, and F. Tato. 1991. Transcription of muscle-specific genes is repressed by reactivation of pp60v-src in postmitotic quail myotubes. Mol. Cell. Biol. 11:3331–3338.
   PubMedGoogle Scholar
• Falcone, G., F. Tatò, and S. Alemà. 1985. Distinctive effects of the viral oncogenes myc, erb, fps and src on the differentiation of quail myogenic cells. Proc. Natl. Acad. Sci. USA 82:426–430.
   PubMed Web of Science ®Google Scholar
• Fiszman, M. Y., and P. Fuchs. 1975. Temperature-sensitive expression of differentiation in transformed myoblasts. Nature (London) 254:429–431.
   PubMed Web of Science ®Google Scholar
• Fujii, M., D. Shalloway, and I. M. Verma. 1989. Gene regulation by tyrosine kinases: src protein activates various promoters, including c-fos.. Mol. Cell. Biol. 9:2493–2499.
   PubMed Web of Science ®Google Scholar
• Gorman, C. M., G. T. Merlino, M. C. Willingham, I. Pastan, and B. H. Howard. 1982. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc. Natl. Acad. Sci. USA 79:6777–6781.
   PubMed Web of Science ®Google Scholar
• Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyl-transferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
   PubMed Web of Science ®Google Scholar
• Grady, E. F., M. Schwab, and W. Rosenau. 1987. Expression of N-myc and c-src during the development of fetal human brain. Cancer Res. 47:2931–2936.
   PubMed Web of Science ®Google Scholar
• Graham, F. L., and A. J. Van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467.
   PubMed Web of Science ®Google Scholar
• Guermah, M., P. Crisanti, D. Laugier, P. Dezelee, L. Bidou, B. Pessac, and G. Calothy. 1991. Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching. Proc. Natl. Acad. Sci. USA 88:4503–4507.
   PubMed Web of Science ®Google Scholar
• Guermah, M., G. Gillet, D. Michel, D. Laugier, G. Brun, and G. Calothy. 1990. Down regulation by pp60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cells. Mol. Cell. Biol. 10:3584–3590.
   PubMedGoogle Scholar
• Gutman, A., and B. Wasylyk. 1990. The collagenase gene promoter contains a TPA and oncogene-responsive unit encom-passing the PEA3 and AP-1 binding sites. EMBO J. 9:2241–2246.
   PubMed Web of Science ®Google Scholar
• Gutman, A., and B. Wasylyk. 1991. Nuclear targets for transcription regulation by oncogenes. Trends Genet. 7:49–54.
   PubMedGoogle Scholar
• Hendricks, M., and H. Weintraub. 1984. Multiple tropomyosin polypeptides in chicken embryo fibroblasts: differential repression of transcription by Rous sarcoma virus transformation. Mol. Cell. Biol. 4:1823–1833.
   PubMedGoogle Scholar
• Higuchi, R. 1990. Recombinant PCR, p. 177–183. In M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White (ed.), The PCR protocols: a guide to methods and applications. Academic Press, San Diego, Calif.
   Google Scholar
• Holtzer, H., J. Biehl, G. Yeoh, R. Meganathan, and A. Kaji. 1975. Effects of oncogenic virus on muscle differentiation. Proc. Natl. Acad. Sci. USA 72:4051–4055.
   PubMedGoogle Scholar
• Hunter, D. D., M. D. Murphy, C. V. Olsson, and W. J. Brunken. 1992. S-laminin expression in adult and developing retinae: a potential cue for photoreceptor morphogenesis. Neuron 8:399413.
   Google Scholar
• Jähner, D., and T. Hunter. 1991. The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. Mol. Cell. Biol. 11:3682–3690.
   PubMed Web of Science ®Google Scholar
• Jähner, D., and T. Hunter. 1991. The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes. Oncogene 6:1259–1268.
   PubMed Web of Science ®Google Scholar
• Johnston, I. G., T. Paladino, J. W. Gurd, and I. R. Brown. 1990. Molecular cloning of SC1: a putative brain extracellular matrix glycoprotein showing partial similarity to osteonectin/BM40/ SPARC. Neuron 2:165–176.
   Web of Science ®Google Scholar
• Joseph, C. K., S. A. Qureshi, D. J. Wallace, and D. A. Foster. 1992. MARCKS protein is transcriptionally down-regulated in v-src-transformed BALB/c 3T3 cells. J. Biol. Chem. 267:1327–1330.
   PubMedGoogle Scholar
• Jove, R·, E. A. Garber, H. Iba, and H. Hanafusa. 1986. Biochemical properties of p60v-src mutants that induce different cell transformation parameters. J. Virol. 60:849–857.
   PubMedGoogle Scholar
• Kahn, P., B. Adkins, H. Beug, and T. Graf. 1984. src- and fps-containing avian sarcoma viruses transform chicken erythroid cells. Proc. Natl. Acad. Sci. USA 81:7122–7126.
   PubMedGoogle Scholar
• Kawai, S., and H. Hanafusa. 1971. The effects of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant. Virology 46:470–479.
   PubMed Web of Science ®Google Scholar
• Lankat-Buttgereit, B., K. Mann, R. Deutzmann, R. Timpl, and T. Krieg. 1988. Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). FEBS Lett. 236:352–356.
   PubMedGoogle Scholar
• Lynch, S. A., J. S. Brugge, and J. M. Levine. 1986. Induction of altered c-src product during neural differentiation of embryonal carcinoma cells. Science 234:873–876.
   PubMed Web of Science ®Google Scholar
• Martinez, R., B. Mathey-Prevot, A. Bernards, and D. Baltimore. 1987. Neuronal pp60v-src contains a six-amino acid insertion relative to its non-neuronal counterpart. Science 237:411–415.
   PubMedGoogle Scholar
• Marx, M., P. Cerotti, M. Hill, G. Cartoni, A. Sergeant, and M. Kaczorek. 1981. Continuous production of Rous sarcoma virus free of transformation defective virus in clones of established RSV-transformed quail cells. Virology 115:10–19.
   PubMedGoogle Scholar
• Mayer, B. J., R. Jove, J. F. Krane, F. Poirier, G. Calothy, and H. Hanafusa. 1986. Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants. J. Virol. 60:858–867.
   PubMedGoogle Scholar
• Pacifici, M., D. Boettiger, K. Roby, and H. Holtzer. 1977. Transformation of chondroblasts by Rous sarcoma virus and the synthesis of sulfated proteoglycan matrix. Cell 11:891–899.
   PubMed Web of Science ®Google Scholar
• Pessac, B., and G. Calothy. 1974. Transformation of chick embryo neuroretinal cells by Rous sarcoma virus in vitro: induction of proliferation. Science 185:709–710.
   PubMedGoogle Scholar
• Pessac, B., A. Girard, G. Romey, P. Crisanti, A. M. Lorinet, and G. Calothy. 1983. A neuronal clone derived from a Rous sarcoma virus-transformed quail embryo neuroretina established culture. Nature (London) 302:616–618.
   PubMed Web of Science ®Google Scholar
• Pierani, A., A. Heguy, H. Fujii, and R. G. Roeder. 1990. Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters. Mol. Cell. Biol. 10:6204–6215.
   PubMedGoogle Scholar
• Poirier, F., G. Calothy, R. E. Karess, E. Erikson, and H. Hanafusa. 1982. Role of p60src kinase activity in the induction of neuroretinal cell proliferation by Rous sarcoma virus. J. Virol. 42:780–789.
   PubMedGoogle Scholar
• Pouponnot, C., G. Calothy, and A. Pierani. Unpublished data.
   Google Scholar
• Qureshi, S. A., X. Cao, V. P. Sukhatme, and D. A. Foster. 1991. N-src activates mitogen-responsive transcription factor Egr-1 via serum response elements. J. Biol. Chem. 266:10802–10806.
   PubMedGoogle Scholar
• Qureshi, S. A., C. K. Joseph, M. Rim, A. Maroney, and D. A. Foster. 1991. v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts. Oncogene 6:995–999.
   PubMedGoogle Scholar
• Ryseck, R. P., and R. Bravo. 1991. c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins. Oncogene 6:533–542.
   PubMedGoogle Scholar
• Sage, E. H., and P. Bornstein. 1991. Extracellular proteins that modulate cell-matrix interactions. J. Biol. Chem. 266:14831–14834.
   PubMed Web of Science ®Google Scholar
• Saint, R., and P. L. Wigley. 1992. Developmental regulation of the cell cycle. Curr. Opin. Genet. Dev. 2:614–620.
   PubMedGoogle Scholar
• Schöntal, A., P. Herrlich, H. J. Rahmsdorf, and H. Ponta. 1988. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 54:325–334.
   PubMedGoogle Scholar
• Schwartz, R. I., D. A. Farson, W. J. Soo, and M. J. Bissel. 1978. Primary avian tendon cells in culture. An improved system for understanding malignant transformation. J. Cell Biol. 79:672–679.
   Google Scholar
• Simmons, D. L., D. B. Levy, Y. Yannoni, and R. L. Erikson. 1989. Identification of a phorbol ester-repressible v-src-inducible gene. Proc. Natl. Acad. Sci. USA 86:1178–1182.
   PubMed Web of Science ®Google Scholar
• Simonneau, L., P. Crisanti, A. M. Lorinet, F. Alliot, Y. Courtois, G. Calothy, and B. Pessac. 1986. Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus. Mol. Cell. Biol. 6:3704–3710.
   PubMedGoogle Scholar
• Sorge, L. K., B. T. Levy, and P. F. Maness. 1984. pp60c-src is developmentally regulated in the neural retina. Cell 36:249–257.
   PubMedGoogle Scholar
• Stein, B., H. J. Rahmsdorf, A. Steffen, M. Litfin, and P. Herrlich. 1989. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol. Cell. Biol. 9:5169–5181.
   PubMed Web of Science ®Google Scholar
• Vardimon, L., L. E. Fox, R. Cohen-Kupiec, L. Degenstein, and A. A. Moscona. 1991. Expression of N-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase. Mol. Cell. Biol. 11:5275–5284.
   PubMedGoogle Scholar
• Vardimon, L., L. E. Fox, and A. A. Moscona. 1986. Accumulation of c-src mRNA is developmentally regulated in embryonic neural retina. Mol. Cell. Biol. 6:4109–4111.
   PubMedGoogle Scholar
• Wasylyk, C., P. Flores, A. Gutman, and B. Wasylyk. 1989. PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes. EMBO J. 8:3371–3378.
   PubMedGoogle Scholar
• Wasylyk, C., J. L. Imler, and B. Wasylyk. 1988. Transforming but not immortalizing oncogenes activate the transcription factor PEA1. EMBO J. 7:2475–2483.
   PubMedGoogle Scholar
• Welham, M. J., J. A. Wyke, A. Lang, and A. W. Wyke. 1990. Mitogenesis induced by pp60v-src is not accompanied by increased expression of immediate early response genes. Oncogene 5:161–169.
   PubMedGoogle Scholar