The bcl-3 Proto-Oncogene Encodes a Nuclear IκB-like Molecule That Preferentially Interacts with NF-κB p50 and p52 in a Phosphorylation-Dependent Manner

REFERENCES

• Aves, S. J., B. W. Durckacz, A. Carr, and P. Nurse. 1985. Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 “Start” gene. EMBO 4:457–463.
   PubMed Web of Science ®Google Scholar
• Baeuerle, P. A., and D. Baltimore. 1988. IκB: a specific inhibitor of the NF-κB transcription factor. Science 242:540–546.
   PubMed Web of Science ®Google Scholar
• Baeuerle, P. A., and D. Baltimore. 1991. The physiology of the NF-κB transcription factor. Elsevier/North Holland Biochemical Press, Amsterdam.
   Google Scholar
• Beg, A. A., S. M. Ruben, R. I. Scheinman, S. Haskill, C. A. Rosen, and A. S. Baldwin. 1992. IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention. Genes Dev. 6:1899–1913.
   PubMed Web of Science ®Google Scholar
• Blank, V., P. Kourilsky, and A. Israel. 1991. Cytoplasmic retention, DNA binding and processing of the NF-κB p50 precursor is controlled by a small region in its C-terminus. EMBO J. 10:4159–4167.
   PubMed Web of Science ®Google Scholar
• Breeden, L., and K. Nasmyth. 1987. Similarity between cellcycle genes of budding yeast and the notch gene of Drosophila. Nature (London) 329:651–654.
   PubMed Web of Science ®Google Scholar
• Cepko, C. L., B. E. Roberts, and R. C. Mulligan. 1987. Construction and applications of a highly transmissable murine retrovirus shuttle vector. Cell 37:1647–1650.
   Google Scholar
• Coffman, C., W. Harris, and C. Kintner. 1990. Xotch, the xenopus homolog of Drosophila notch. Science 249:1438–1441.
   PubMedGoogle Scholar
• Davis, N., S. Ghosh, D. L. Simmons, P. Tempst, H. Liou, D. Baltimore, and H. R. Bose. 1991. Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science 253:1268–1271.
   PubMedGoogle Scholar
• Ellison, L. W., J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds, S. D. Smith, and J. Sklar. 1991. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649–661.
   PubMedGoogle Scholar
• Franzoso, G., V. Bours, S. Park, M. Tomita-Yamaguchi, K. Kelly, and U. Siebenlist. 1992. The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition. Nature (London) 359:339–342.
   PubMedGoogle Scholar
• Fujita, T., and D. Baltimore. Unpublished data.
   Google Scholar
• Fujita, T., G. P. Nolan, and D. Baltimore. Unpublished data.
   Google Scholar
• Fujita, T., G. P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:775–787.
   PubMed Web of Science ®Google Scholar
• Ghosh, S., and D. Baltimore. 1990. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature (London) 344:678–682.
   PubMed Web of Science ®Google Scholar
• Ghosh, S., A. M. Gifford, L. R. Rivere, P. Tempest, G. P. Nolan, and D. Baltimore. 1990. Cloning of the p50 DNA binding subunit of NF-κB: homology to rel and dorsal. Cell 62:1019–1029.
   PubMed Web of Science ®Google Scholar
• Gilmore, T. D. 1991. Malignant transformation by mutant rel proteins. Trends Genet. 7:318–322.
   PubMed Web of Science ®Google Scholar
• Goebl, M., and M. Yanagida. 1991. The TPR snap helix: a novel protein repeat motif from mitosis to transcription. Trends Biochem. Sci. 185:173–177.
   Google Scholar
• Haskill, S., A. A. Beg, S. M. Tompkins, J. S. Morris, A. D. Yurochko, A. Sampson-Johanne, K. Mondai, P. Ralph, and A. S. Baldwin. 1991. Characterization of an immediate early gene induced in adherant monocytes that encodes IκB-like activity. Cell 65:1281–1289.
   PubMed Web of Science ®Google Scholar
• Henkel, T., U. Zabel, K. van Zee, J. M. Muller, E. Fanning, and P. Baeuerle. 1992. Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit. Cell 68:1121–1133.
   PubMed Web of Science ®Google Scholar
• Inoue, J.-L, L. D. Kerr, A. Kakizuka, and I. M. Verma. 1992. IκB-gamma, A 70 kD protein, identical to the C-terminal half of p105 NF-κB: a new member of the IκB family. Cell 68:1109–1120.
   PubMed Web of Science ®Google Scholar
• Israel, A., A. Kimura, M. Kieran, O. Yano, J. Kanellopoulos, O. Le Bail, and P. Kourilsky. 1987. A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and β2-microglobulin genes. Proc. Natl. Acad. Sci. USA 84:2653–2657.
   PubMedGoogle Scholar
• Kang, S.-M., A.-C. Tran, M. Grilli, and M. J. Lenardo. 1992. NF-κB subunit regulation in nontransformed CD4+ T lymphocytes. Science 256:1452–1456.
   PubMed Web of Science ®Google Scholar
• Kerr, L. D., J.-I. Inoue, N. Davis, E. Link, P. A. Baeuerle, H. R. Bose, and I. M. Verma. 1991. The Rel-associated pp40 protein prevents DNA binding of Rel and NF-κB: relationship with IκB-beta and regulation by phosphorylation. Genes Dev. 5:1464–1476.
   PubMedGoogle Scholar
• Kerr, L. D., C. S. Duckett, P. Wamsley, Q. Zhang, P. Chiao, G. Nabel, T. W. McKeithan, P. A. Baeverle, and I. M. Verma. 1992. The proto-oncogene Bcl-3 encodes an IκB protein. Genes Dev. 6:2352–2363.
   PubMed Web of Science ®Google Scholar
• Kidd, S. 1992. Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell 71:623–635.
   PubMed Web of Science ®Google Scholar
• Kieran, M., V. Blank, F. Logeat, J. Vandekerckhove, F. Lottspeich, O. Le Bail, M. B. Urban, P. Kourilsky, P. A. Baeuerle, and A. Israel. 1990. The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product. Cell 62:1007–1018.
   PubMed Web of Science ®Google Scholar
• Lenardo, M. J., C. M. Fan, T. Maniatis, and D. Baltimore. 1989. The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell 57:287–294.
   PubMed Web of Science ®Google Scholar
• Lieberman, T. A., and D. Baltimore. 1990. Activation of interleukin-6 gene expression through the NF-κB transcription fac-tor. Mol. Cell. Biol. 10:2327–2334.
   PubMedGoogle Scholar
• Liou, H.-C., and D. Baltimore. Unpublished data.
   Google Scholar
• Liou, H.-C., G. P. Nolan, S. Ghosh, T. Fujita, and D. Baltimore. 1992. The NF-kappa B p50 precursor, pl05, contains an internal I kappa B-like inhibitor that preferentially inhibits p50. EMBO J. 11:3003–3009.
   PubMedGoogle Scholar
• Lux, S. E·, K. M. John, and V. Bennett. 1990. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Nature (London) 344:36–41.
   PubMed Web of Science ®Google Scholar
• Nabel, G., and D. Baltimore. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T-cells. Nature (London) 326:711–713.
   PubMed Web of Science ®Google Scholar
• Neri, A., L. Lombardi, C.-C. Chang, M. Salina, P. Corredini, A. T. Maiolo, R. S. K Chaganti, and R. Dalla-Favera. 1991. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50. Cell 67:1075–1087.
   PubMed Web of Science ®Google Scholar
• Nolan, G. P., and D. Baltimore. 1992. The inhibitory ankyrin and activator Rel proteins. Curr. Opin. Genet. Dev. 2:211–220.
   PubMed Web of Science ®Google Scholar
• Nolan, G. P·, and D. Baltimore. Unpublished data.
   Google Scholar
• Nolan, G. P·, S· Ghosh, H.-C. Liou, P. Tempst, and D. Baltimore. 1991. DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide. Cell 64:961–969.
   PubMed Web of Science ®Google Scholar
• Ohno, H., G. Takimoto, and T. W. McKeithan. 1990. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 60:991–997.
   PubMed Web of Science ®Google Scholar
• Pear, W., G. Nolan, M. Scott, and D. Baltimore. Unpublished data.
   Google Scholar
• Schmid, R., N. D. Perkins, C. S. Duckett, P. C. Andrews, and G. J. Nabel. 1991. Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65. Nature (London) 352:733–736.
   PubMed Web of Science ®Google Scholar
• Scott, M. L., T. Fujita, H.-C. Liou, G. P. Nolan, and D. Baltimore. The p65 subunit of NF-κB regulates IκB by two distinct mechanisms. Genes Dev., in press.
   Google Scholar
• Sen, R., and D. Baltimore. 1986. Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism. Cell 47:921–928.
   PubMed Web of Science ®Google Scholar
• Shinnick, T., R. Lerner, and J. G. Sutcliffe. 1981. Nucleotide sequence of Moloney leukemia virus. Nature (London) 293:543–548.
   PubMed Web of Science ®Google Scholar
• Stall, A. M., M. Carmen Farinas, D. M. Tarlinton, P. A. Lalor, L. A. Herzenberg, S. Straber, and L. A. Herzenberg. 1988. Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and yound autimmune (New Zealand Black-related) animals. Proc. Natl. Acad. Sci. USA 85:7312–7316.
   PubMed Web of Science ®Google Scholar
• Ten, R. M., C. V. Paya, N. Israel, O. Le Bail, M.-G. Mattei, J.-L. Virelizier, P. Kourilsky, and A. Israel. 1992. The charac-terization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation. EMBO J. 11:195–203.
   PubMed Web of Science ®Google Scholar
• Tewari, M., P. Dobrzanski, K. L. Mohn, D. E. Cressman, J.-C. Hsu, R. Bravo, and R. Taub. 1992. Rapid induction in regenerating liver of RL/IF-1 (an IκB B that inhibits NF-κB, RelB-p50, and c-Rel-p50) and PHF, a novel κB site-binding complex. Mol. Cell. Biol. 12:2898–2908.
   PubMed Web of Science ®Google Scholar
• Urban, M. B., and P. A. Baeuerle. 1990. The 65-kD subunit of NF-κB is a receptor for IκB and a modulator of DNA-binding specificity. Genes Dev. 4:1975–1984.
   PubMedGoogle Scholar
• Van Etten, R. A., P. Jackson, and D. Baltimore. 1989. The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization. Cell 58:669–678.
   PubMed Web of Science ®Google Scholar
• Weinmaster, G., V. J. Roberts, and G. Lemke. 1992. A homolog of Drosophila notch expressed during mammalian development. Development 113:199–205.
   Google Scholar
• Wharton, K. A., K. M. Johansen, T. Xu, and S. Artavanis-Tsakonis. 1985. Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43:567–581.
   PubMed Web of Science ®Google Scholar
• Wulczyn, F. G., M. Naumann, and C. Scheidereit. 1992. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature (London) 358:597–599.
   PubMedGoogle Scholar
• Yochem, J., and I. Greenwald. 1989. glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins. Cell 58:553–563.
   PubMedGoogle Scholar
• Zabel, U., and P. A. Baeuerle. 1990. Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA. Cell 65:255–265.
   Google Scholar