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Transcriptional Regulation

A Negative Regulatory Element in the bcl-2 5'-Untranslated Region Inhibits Expression from an Upstream Promoter

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Pages 3686-3697 | Received 06 Oct 1992, Accepted 12 Mar 1993, Published online: 01 Apr 2023

REFERENCES

  • Adhya, S., and M. Gottesman. 1982. Promoter occlusion: transcription through a promoter may inhibit its activity. Cell 29:939–944.
  • Bakhshi, A., J. P. Jensen, P. Goldman, J. J. Wright, O. W. McBride, A. L. Epstein, and S. J. Korsmeyer. 1985. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41:899–906.
  • Baniahmad, A., C. Steiner, A. C. Kohne, and R. Renkawitz. 1990. Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell 61:505–514.
  • Bender, T. P., C. B. Thompson, and W. M. Kuehl. 1987. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science 237:1473–1476.
  • Bentley, D. L., and M. Groudine. 1986. A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells. Nature (London) 321:702–706.
  • Brand, A. H., L. Breeden, J. Abraham, R. Sternglanz, and K. Nasmyth. 1985. Characterization of a “silencer” in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer. Cell 41:41–48.
  • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate phenol-chloro-form extraction. Anal. Biochem. 162:156–159.
  • Chu, G., H. Hayakawa, and P. Berg. 1987. Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acids Res. 15:1311–1326.
  • Cleary, M. L., N. Galili, and J. Sklar. 1986. Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. J. Exp. Med. 164:315–320.
  • Cleary, M. L., and J. Sklar. 1985. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc. Natl. Acad. Sci. USA 82:7439–7443.
  • Cleary, M. L., S. D. Smith, and J. Sklar. 1986. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/ immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19–28.
  • Connelly, S., and J. L. Manley. 1989. A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signal. Cell 57:561–571.
  • Corbin, V., and T. Maniatis. 1989. Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch. Nature (London) 337:279–282.
  • Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1471–1489.
  • Dynan, W. S., and R. Tjian. 1983. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35:79–87.
  • Falkner, F. G., and H. G. Zachau. 1984. Correct transcription of an immunoglobulin kappa gene requires an upstream fragment containing conserved sequence elements. Nature (London) 310:71–74.
  • Favaloro, J., R. Treisman, and R. Kamen. 1980. Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping. Methods Enzymol. 65:718–749.
  • Felsenfeld, G. 1992. Chromatin as an essential part of the transcriptional mechanism. Nature (London) 355:219–224.
  • Gilmour, D. S., and J. T. Lis. 1986. RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells. Mol. Cell. Biol. 6:3984–3989.
  • Gorman, C., R. Padmanabhan, and B. H. Howard. 1983. High efficiency DNA-mediated transformation of primate cells. Science 221:551–553.
  • Graninger, W. B., M. Seto, B. Boutain, P. Goldman, and S. J. Korsmeyer. 1987. Expression of bcl-2 and bcl-2-Ig fusion transcripts in normal and neoplastic cells. J. Clin. Invest. 80:1512–1515.
  • Gurfinkel, N., T. Unger, D. Givol, and J. F. Mushinski. 1987. Expression of the bcl-2 gene in mouse B lymphocytic cell lines is differentiation stage specific. Eur. J. Immunol. 17:567–570.
  • Herr, W., and J. Clarke. 1986. The SV40 enhancer is composed of multiple functional elements that can compensate for one another. Cell 45:461–470.
  • Hockenbery, D. M., G. Nunez, C. Milliman, R. D. Schreiber, and S. J. Korsmeyer. 1990. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (London) 348:334–336.
  • Hockenbery, D. M., M. Zutter, W. Hickey, M. Nahm, and S. J. Korsmeyer. 1991. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA 88:6961–6965.
  • Kephart, D. D., N. F. Marshall, and D. H. Price. 1992. Stability of Drosophila RNA polymerase II elongation complexes in vitro. Mol. Cell. Biol. 12:2067–2077.
  • Landick, R., and C. Yanofsky. 1987. Transcription attenuation, p. 1276–1301. In F. C. Neidhardt, J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology. American Society for Microbiology, Washington, D.C.
  • Linial, M., N. Gunderson, and M. Groudine. 1985. Enhanced transcription of c-myc in bursal lymphoma cells requires con-tinuous protein synthesis. Science 230:1126–1132.
  • Lowndes, N. F., J. Paul, J. Wu, and M. Allan. 1989. c-Ha-ras gene bidirectional promoter expressed in vitro: location and regulation. Mol. Cell. Biol. 9:3758–3770.
  • Marshall, N. F., and D. H. Price. 1992. Control of formation of two distinct classes of RNA polymerase II elongation com-plexes. Mol. Cell. Biol. 12:2078–2090.
  • McDonnell, T. J., and S. J. Korsmeyer. 1991. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature (London) 349:254–256.
  • Melton, D. A., P. A. Krieg, M. R. Rebagliati, T. Maniatis, K. Zinn, and M. R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035–7056.
  • Negrini, M., E. Sillini, C. Kozak, Y. Tsujimoto, and C. M. Croce. 1987. Molecular analysis of mbcl-2: structure and expres-sion of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 49:455–463.
  • Reed, J. C., Y. Tsujimoto, J. D. Alpers, C. M. Croce, and P. C. Nowell. 1987. Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science 236:1295–1299.
  • Reynolds, G. A., S. K. Basu, T. F. Osborne, D. J. Chin, G. Gil, M. S. Brown, J. L. Goldstein, and K. L. Luskey. 1984. HMG CoA reductase: a negatively regulated gene with unusual promoter and 5′ untranslated regions. Cell 38:275–285.
  • Rosenfeld, C., A. Goutner, C. Choquet, A. M. Venuat, B. Kayibanda, J. L. Pico, and M. F. Greaves. 1977. Phenotype characterization of a unique non-T, non-B, acute lymphoblastic leukaemia cell line. Nature (London) 267:841–843.
  • Rougvie, A. E., and J. T. Lis. 1988. The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged. Cell 54:795–804.
  • Rougvie, A. E., and J. T. Lis. 1990. Postinitiation transcriptional control in Drosophila melanogaster. Mol. Cell. Biol. 10:6041–6045.
  • Selby, M. J., E. S. Bain, P. A. Luciw, and B. M. Peterlin. 1989. Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat. Genes Dev. 3:547–558.
  • Seto, M., U. Jaeger, R. D. Hockett, W. Graninger, S. Bennett, P. Goldman, and S. J. Korsmeyer. 1988. Alternative promoters and exons, somatic mutation and deregulation of the bcl-2-Ig fusion gene in lymphoma. EMBO J. 7:123–131.
  • Silverman, G. A., E. D. Green, R. L. Young, J. I. Jockel, P. H. Domer, and S. J. Korsmeyer. 1990. Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene. Proc. Natl. Acad. Sci. USA 87:9913–9917.
  • Southern, P. J., and P. Berg. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Gen. 1:327–341.
  • Spencer, C. A., and M. Groudine. 1990. Transcription elongation and eukaryotic gene regulation. Oncogene 5:777–785.
  • Stinski, M. F., and T. J. Roehr. 1985. Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virusspecific trans-acting components. J. Virol. 55:431–441.
  • Toohey, M. G., and K. A. Jones. 1989. In vitro formation of short RNA polymerase II transcripts that terminate within the HIV-1 and HIV-2 promoter-proximal downstream regions. Genes Dev. 3:265–282.
  • Tsujimoto, Y., M. Bashir, I. Givol, J. Cossman, E. Jaffe, and C. M. Croce. 1987. DNA rearrangements in human follicular lymphoma can involve the 5′ or 3′ region of the bcl-2 gene. Proc. Natl. Acad. Sci. USA 84:1329–1331.
  • Tsujimoto, Y., L. R. Finger, J. Yunis, P. C. Nowell, and C. M. Croce. 1984. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097–1099.
  • Valerio, D., M. G. C Duyvesteyn, B. M. M Dekker, G. Weeda, T. M. Berkvens, L. van der Voorn, H. van Ormondt, and A. J. van der Eb. 1985. Adenosine deaminase: characterization and expression of a gene with a remarkable promoter. EMBO J. 4:437–443.
  • Vaux, D. L., S. Cory, and J. M. Adams. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (London) 335:440–442.
  • Weintraub, H. 1985. Assembly and propagation of repressed and derepressed chromosomal states. Cell 42:705–711.
  • Winter, J. N., D. Variakojis, and A. L. Epstein. 1984. Phenotypic analysis of established diffuse histiocytic lymphoma cell lines utilizing monoclonal antibodies and cytochemical techniques. Blood 63:140–146.
  • Yunis, J. J. 1983. The chromosomal basis of human neoplasia. Science 221:227–236.

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