18
Views
15
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Identification of Residues in the Human DNA Repair Enzyme HAP1 (Ref-1) That are Essential for Redox Regulation of Jun DNA Binding

, , , &
Pages 5370-5376 | Received 05 May 1993, Accepted 23 Jun 1993, Published online: 31 Mar 2023

REFERENCES

  • Abate, C., D. Luk, and T. Curran. 1990. A ubiquitous nuclear protein stimulates the DNA-binding activity of Fos and Jun indirectly. Cell Growth Differ. 1:455–462.
  • Abate, C., D. Luk, R. Gentz, F. J. Rauscher III, and T. Curran. 1990. Expression and purification of the leu zipper and DNA binding domains of Fos and Jun: both Fos and Jun contact DNA directly. Proc. Natl. Acad. Sci. USA 87:1032–1036.
  • Abate, C., L. Patel, F. J. Rauscher III, and T. Curran. 1990. Redox regulation of Fos and Jun DNA binding activity in vitro. Science 249:1157–1161.
  • Boyle, W. J., T. Smeal, L. H. K Defize, P. Angel, J. R. Woodgett, Μ. Karin, and T. Hunter. 1991. Activation of PKC decreases phosphorylation of c-Jun at sites that only regulate its DNA binding activity. Cell 64:573–584.
  • Bradford, Μ. Μ. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
  • Cunningham, R. P., S. Μ. Saporito, S. G. Spitzer, and B. Weiss. 1986. Endonuclease IV (nfo) mutant of Escherichia coli. J. Bacteriol. 168:1120–1127.
  • Demple, B., T. Herman, and D. S. Chen. 1991. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc. Natl. Acad. Sci. USA 88:11450–11454.
  • Doetsch, P. W., and R. P. Cunningham. 1990. The enzymology of apurinic/apyrimidinic endonucleases. Mutat. Res. 236:173–201.
  • Frame, Μ. C., N. Μ. Wilkie, A. J. Darling, A. Chudleigh, A. Pintzas, J. C. Lang, and D. A. F. Gillespie. 1991. Regulation of AP-1/DNA complex formation in vitro. Oncogene 6:205–209.
  • Guehmann, S., G. Vorbrueggen, F. Kalkbrenner, and K. Moelling. 1992. Reduction of a conserved Cys is essential for Myb DNA-binding. Nucleic Acids Res. 20:2279–2286.
  • Hunter, T., and Μ. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375–387.
  • Kumar, S., A. B. Rabson, and C. Gélinas. 1992. The RXXRXRXXC motif conserved in all Rel/κB proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein. Mol. Cell. Biol. 12:3094–3106.
  • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
  • Landt, O., H. Grunert, and U. Hahn. 1990. A general method for rapid site-directed mutagenesis using the polymerase chain reaction. Gene 96:125–128.
  • Maki, Y., T. J. Bos, C. Davis, Μ. Starbuck, and P. K. Vogt. 1987. Avian sarcoma virus 17 carries the Jun oncogene. Proc. Natl. Acad. Sci. USA 84:2828–2852.
  • Matthews, J. R, N. Wakasugi, J.-L. Virelizier, J. Yodoi, and R. T. Hay. 1992. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 20:3821–3830.
  • McBride, A. A., R. D. Klausner, and P. Μ. Howley. 1992. Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro. Proc. Natl. Acad. Sci. USA 89:7531–7535.
  • Oehler, T., A. Pintzas, S. Stumm, A. Darling, D. Gillespie, and P. Angel. 1993. Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP-l-dependent genes by v-jun. Oncogene 8:1141–1147.
  • Okuno, H., A. Akahori, H. Sato, S. Xanthoudakis, T. Curran, and H. Iba. 1993. Escape from redox regulation enhances the transforming activity of Fos. Oncogene 8:695–701.
  • Reddy, E. P., A. Μ. Skalka, and T. Curran. 1988. The oncogene handbook. Elsevier Press, Amsterdam.
  • Robson, C. N., and I. D. Hickson. 1991. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nucleic Acids Res. 19:5519–5523.
  • Robson, C. N., A. Μ. Milne, D. J. C Pappin, and I. D. Hickson. 1991. Isolation of cDNA clones enooding an enzyme from bovine cells that repairs oxidative DNA damage in vitro: homology with bacterial repair enzymes. Nucleic Acids Res. 19:1087–1092.
  • Sander, M., K. Lowenhaupt, and A. Rich. 1991. Drosophila Rrpl protein: an apurinic endonuclease with homologous recombination activities. Proc. Natl. Acad. Sci. USA 88:6780–6784.
  • Saporito, S. Μ., B. J. Smith-White, and R. P. Cunningham. 1988. Nucleotide sequence of the xth gene of Escherichia coli K-12. J. Bacteriol. 170:4542–4547.
  • Seki, S., K. Akiyama, S. Watanabe, Μ. Hatsushika, S. Ikeda, and K. Tsutsui. 1991. cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J. Biol. Chem. 266:20797–20802.
  • Seki, S., Μ. Hatsushika, S. Watanabe, K. Akiyama, K. Nagao, and K. Tsutsui. 1992. cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III. Biochim. Biophys. Acta 1131:287–299.
  • Studier, F. W., and B. A. Moffatt. 1986. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189:113–130.
  • Tabor, S. 1990. Expression using the T7 RNA polymerase/promoter system, p. 16.2.1–16.2.11. In F. A. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. Wiley Interscience, New York.
  • Winters, T. A., Μ. Weinfeld, and T. J. Jorgensen. 1992. Human HeLa cell enzymes that remove phosphoglycolate 3’-end groups from DNA. Nucleic Acids Res. 20:2573–2580.
  • Xanthoudakis, S., and T. Curran. 1992. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-I DNA-binding activity. EMBO J. 11:653–665.
  • Xanthoudakis, S., G. Miao, F. Wang, Y.-C. E. Pan, and T. Curran. 1992. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 11:3323–3335.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.