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Cell Growth and Development

The Ras/Raf Signaling Pathway Is Required for Progression of Mouse Embryos Through the Two-Cell Stage

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Pages 6655-6662 | Received 02 May 1994, Accepted 19 Jul 1994, Published online: 30 Mar 2023

REFERENCES

  • Adamson, E. D. 1990. EGF receptor activities in mammalian development. Mol. Reprod. Dev. 27:16–22.
  • Bensaude, O., C. Babinet, M. Morange, and F. Jacob. 1983. Heat shock proteins, first major products of zygotic gene activity. Nature (London) 305:331–333.
  • Bolton, V. N., P. J. Oades, and M. H. Johnson. 1984. The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo. J. Embryol. Exp. Morphol. 79:139–163.
  • Braude, P., H. Pelham, G. Flach, and R. Lobatto. 1979. Posttranscriptional control in the early mouse embryo. Nature (London) 282:102–105.
  • Cai, Η., P. Erhardt, J. Troppmair, M. T. Diaz-Meco, U. R. Rapp, J. Moscat, and G. M. Cooper. 1993. Hydrolysis of phosphatidylcholine couples Ras to activation of the Raf protein kinase during mitogenic signal transduction. Mol. Cell. Biol. 13:7645–7651.
  • Cai, H., J. Szeberenyi, and G. M. Cooper. 1990. Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol. Cell. Biol. 10:5314–5322.
  • Caro, C. M., and A. Trounson. 1984. The effect of protein on preimplantation mouse embryo development in vitro. J. In Vitro Fert. Embryo Transfer 1:183–187.
  • Conover, J. C., G. L. Temeles, J. W. Zimmermann, B. Burke, and R. M. Schultz. 1991. Stage-specific expression of a family of proteins that are major products of zygotic gene activation in the mouse embryo. Dev. Biol. 144:392–404.
  • Cook, S. J., and F. McCormick. 1993. Inhibition by cAMP of Ras-dependent activation of Raf. Science 262:1069–1072.
  • Dent, P., W. Haser, T. A. J. Haystead, L. A. Vincent, T. M. Roberts, and T. W. Sturgill. 1992. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science 257:1404–1407.
  • Feig, L. A., and G. M. Cooper. 1988. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8:3235–3243.
  • Fissore, R., K. V. Jackson, and A. A. Kiessling. 1989. Mouse zygote development in culture medium without protein in the presence of ethylenediaminetetraacetic acid. Biol. Reprod. 41:835–841.
  • Fissore, R., S. O'Keefe, and A. A. Kiessling. 1992. Purine-induced block to mouse embryo cleavage is reversed by compounds that elevate cyclic adenosine monophosphate. Biol. Reprod. 47:1105–1112.
  • Flach, G., M. H. Johnson, P. R. Braude, R. A. S. Taylor, and V. N. Bolton. 1982. The transition from maternal to embryonic control in the 2-cell mouse embryo. EMBO J. 1:681–686.
  • Furth, M. E., L. J. Davis, B. Fleurdelys, and E. M. Scolnick. 1982. Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. J. Virol. 43:294–304.
  • Gille, H., A. D. Sharrocks, and P. Shaw. 1992. Phosphorylation of p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature (London) 358:414–417.
  • Goddard, M. J., and Η. P. M. Pratt. 1983. Control of events during early cleavage of the mouse embryo: an analysis of the 2-cell block. J. Embryol. Exp. Morphol. 73:111–133.
  • Graves, L. M., K. E. Bornfeldt, E. W. Raines, B. C. Potts, S. G. Macdonald, R. Ross, and E. G. Krebs. 1993. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc. Natl. Acad. Sci. USA 90:10300–10304.
  • Hagag, N., S. Halegoua, and M. Viola. 1986. Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21. Nature (London) 319:680–682.
  • Howe, L. R., S. J. Leevers, N. Gomez, S. Nakielny, P. Cohen, and C. J. Marshall. 1992. Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335–342.
  • Kremer, N. E., G. D'Arcangelo, S. M. Thomas, M. DeMarco, J. S. Brugge, and S. Halegoua. 1991. Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of Src and Ras actions. J. Cell. Biol. 115:809–819.
  • Kyriakis, J. M., Η. App, X. Zhang, P. Banerjee, D. L. Brautigan, U. R. Rapp, and J. Avruch. 1992. Raf-1 activates MAP kinase-kinase. Nature (London) 358:417–421.
  • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
  • Latham, K. E., J. I. Garrels, C. Chang, and D. Solter. 1991. Quantitative analysis of protein synthesis in mouse embryos. I. Extensive reprogramming at the one- and two-cell stages. Development 112:921–932.
  • Lowy, D. R., and B. M. Willumsen. 1993. Function and regulation of Ras. Annu. Rev. Biochem. 62:851–891.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Manova, K., K. Nocka, P. Besmer, and R. F. Bachvarova. 1990. Gonadal expression of c-kit encoded at the W locus of the mouse. Development 110:1057–1069.
  • Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381–393.
  • Mehta, T. S., and A. A. Kiessling. 1990. Development potential of mouse embryos conceived in vitro and cultured in ethylenediaminetetraacetic acid with or without amino acids or serum. Biol. Reprod. 43:600–606.
  • Moodie, S. A., B. M. Willumsen, M. J. Weber, and A. Wolfman. 1993. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260:1658–1661.
  • Mulcahy, L. S., M. R. Smith, and D. W. Stacey. 1985. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature (London) 313:241–243.
  • O'Keefe, S. J., H. Wolfes, A. A. Kiessling, and G. M. Cooper. 1989. Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg. Proc. Natl. Acad. Sci. USA 86:7038–7042.
  • Orr-Urtreger, A., A. Avivi, Y. Zimmer, D. Givol, Y. Yarden, and P. Lonai. 1990. Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development 109:911–923.
  • Pal, S. K., R. Crowell, A. A. Kiessling, and G. M. Cooper. 1993. Expression of proto-oncogenes in mouse eggs and preimplantation embryos. Mol. Reprod. Dev. 35:8–15.
  • Pal, S. K., S. S. Zinkel, A. A. Kiessling, and G. M. Cooper. 1991. c-mos expression in mouse oocytes is controlled by initiator-related sequences immediately downstream of the transcription initiation site. Mol. Cell. Biol. 11:5190–5196.
  • Paria, B. C., S. K. Das, G. K. Andrews, and S. K. Dey. 1993. Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc. Natl. Acad. Sci. USA 90:55–59.
  • Paria, B. C., S. K. Dey, and G. K. Andrews. 1992. Antisense c-myc effects on preimplantation mouse embryo development. Proc. Natl. Acad. Sci. USA 89:10051–10055.
  • Poueymirou, W. T., and R. M. Schultz. 1987. Differential effects of activators of cAMP-dependent protein kinase and protein kinase C on cleavage of one-cell mouse embryos and protein synthesis and phosphorylation in one- and two-cell embryos. Dev. Biol. 121:489–498.
  • Poueymirou, W. T., and R. M. Schultz. 1989. Regulation of mouse preimplantation development: inhibition of synthesis of proteins in the two-cell embryo that require transcription by inhibitors of cAMP-dependent protein kinase. Dev. Biol. 133:588–599.
  • Pratt, Η. P. M., V. N. Bolton, and K. A. Gudgeon. 1983. The legacy from the oocyte and its role in controlling early development of the mouse embryo. Ciba Found. Symp. 98:197–227.
  • Pulverer, B. J., J. M. Kyriakis, J. Avruch, E. Nikolakaki, and J. R. Woodgett. 1991. Phosphorylation of c-jun mediated by MAP kinases. Nature (London) 353:670–674.
  • Rappolee, D. A., C. A. Brenner, R. Schultz, D. Mark, and Z. Werb. 1988. Developmental expression of PDGF, TGF-α, and TGF-β genes in preimplantation mouse embryos. Science 241:708–712.
  • Rappolee, D. A., K. S. Sturm, O. Behrendtsen, G. A. Schultz, R. A. Pedersen, and Z. Werb. 1992. Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Genes Dev. 6:939–952.
  • Serta, R. T., M. M. Seibel, and A. A. Kiessling. The developmental potential of mouse oocytes following a single gonadotropin injection. Hum. Reprod., in press.
  • Sevetson, B. R., X. Kong, and J. C. Lawrence, Jr. 1993. Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 90:10305–10309.
  • Smith, M. R., S. J. DeGudicibus, and D. W. Stacey. 1986. Requirement for c-ras proteins during viral oncogene transformation. Nature (London) 320:540–543.
  • Stanton, V. P., Jr., D. W. Nichols, A. P. Laudano, and G. M. Cooper. 1989. Definition of the human raf amino-terminal regulatory region by deletion mutagenesis. Mol. Cell. Biol. 9:639–647.
  • Szeberenyi, J., H. Cai, and G. M. Cooper. 1990. Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10:5324–5332.
  • Szeberenyi, J., P. Erhardt, H. Cai, and G. M. Cooper. 1992. Role of Ras in signal transduction from the nerve growth factor receptor: relationship to protein kinase C, calcium, and cyclic AMP. Oncogene 7:2105–2113.
  • Thomas, S. M., M. DeMarco, G. D'Arcangelo, S. Halegoua, and J. S. Brugge. 1992. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68:1031–1040.
  • Troppmair, J., J. T. Binder, Η. App, H. Cai, L. Liptak, J. Szeberenyi, G. M. Cooper, and U. R. Rapp. 1992. Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Oncogene 7:1867–1873.
  • Van Aelst, L., M. Barr, S. Marcus, A. Polverino, and M. Wigler. 1993. Complex formation between RAS and RAF and other protein kinases. Proc. Natl. Acad. Sci. USA 90:6213–6217.
  • Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205–214.
  • Warne, P. Η., P. R. Viciana, and J. Downward. 1993. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature (London) 364:352–355.
  • Whitman, M., and D. A. Melton. 1992. Involvement of p21ras in Xenopus mesoderm induction. Nature (London) 357:252–254.
  • Wood, K. W., C. Sarnecki, T. M. Roberts, and J. Blenis. 1992. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68:1041–1050.
  • Wu, J., P. Dent, T. Jelinek, A. Wolfman, M. J. Weber, and T. W. Sturgill. 1993. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science 262:1065–1069.
  • Zhang, X., J. Settleman, J. M. Kyriakis, E. Takeuchi-Suzuki, S. J. Elledge, M. S. Marshall, J. T. Bruder, U. R. Rapp, and J. Avruch. 1993. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (London) 364:308–313.

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