7
Views
35
CrossRef citations to date
0
Altmetric
Cell Growth and Development

PML, a Growth Suppressor Disrupted in Acute Promyelocytic Leukemia

, , , &
Pages 6858-6867 | Received 20 May 1994, Accepted 27 Jul 1994, Published online: 30 Mar 2023

REFERENCES

  • Alcalay, M. D., D. Zangrilli, P. Paolo, L. Longo, A. Mencarelli, A. Giacomucci, M. Rocchi, A. Biondi, A. Rambaldi, F. LoCoco, D. Diverio, E. Donti, F. Grignani, and P. G. Pelicci. 1991. Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor a locus. Proc. Natl. Acad. Sci. USA 88:1977–1981.
  • Berg, J. M. 1990. Zinc fingers and other metal-binding domains: elements for interactions between macromolecules. J. Biol. Chem. 265:6513–6516.
  • Berger, R., M. Leconiat, J. Derr, D. Vecchione, and P. Jonveaux. 1991. Cytogenetic studies in acute promyelocytic leukemia: a survey of secondary chromosomal abnormalities. Genes Chromosomes Cancer 3:332–337.
  • Borrow, J., A. D. Goddard, D. Sheer, and E. Solomon. 1990. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249:1577–1580.
  • Castaigne, S., C. Chomienne, M. T. Daniel, P. Ballerini, R. Berger, P. Fenaux, and L. Degos. 1990. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76:1704–1709.
  • Chang, K. S., J. Lu, J. M. Trujillo, E. Estey, A. Cork, G. Wang, E. Freireich, and S. A. Stass. 1992. The t(15;17) breakpoint in acute promyelocytic leukemia clusters within two different sites of the myl gene: targets for the detection of minimal residual disease by polymerase chain reaction. Blood 79:554–558.
  • Chang, K. S., S. A. Stass, D. T. Chu, L. L. Deaven, J. M. Trujillo, and E. Freireich. 1992. Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia. Mol. Cell. Biol. 12:800–810.
  • Chang, K. S., J. M. Trujillo, T. Ogura, C. M. Castiglione, K. K. Kidd, S. Zhao, E. Freireich, and S. A. Stass. 1991. Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia. Leukemia 5:200–204.
  • Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745–2752.
  • Chen, S., Y. Zhu, J. Tong, S. Dong, W. Huang, Y. Chen, W. Ziang, L. Zhang, X. Li, G. Qian, Z. Wang, Z. Chen, C. Larsen, and R. Berger. 1991. Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation. Blood 78:2696–2701.
  • Chen, T. M., and V. Defendi. 1992. Functional interaction of p53 with HPV18E6, c-myc and H-ras in 3T3 cells. Oncogene 7:1541–1547.
  • Chin, K. V., K. Ueda, I. Pastan, and M. M. Gottesman. 1991. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 255:459–462.
  • Chomienne, C., P. Ballerini, N. Balitrand, M. T. Daniel, P. Fenaux, S. Castaigne, and L. Degos. 1990. All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship. Blood 76:1710–1717.
  • Chomienne, C., P. Ballerini, N. Balitrand, M. E. Huang, I. Krawice, S. Castaigne, P. Fenaux, P. Tiollais, A. Dejean, L. Degos, and H. de The. 1990. The retinoic acid receptor α gene is rearranged in retinoic acid-sensitive promyelocytic leukemias. Leukemia 4:802–807.
  • Daniel, M. T., M. Koken, O. Romagne, S. Barbey, A. Bazarbachi, M. Stadler, M. C. Guillemin, L. Degos, C. Chomienne, and H. de The. 1993. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood 82:1858–1867.
  • Dermime, S., F. Grignani, M. Clerici, C. Nervi, G. Sozzi, G. P. Talamo, E. Marchesi, F. Formelli, G. Parmiani, P. G. Pelicci, and C. G. Passerini. 1993. Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the PML/RARα protein. Blood 82:1573–1577.
  • de The, H., C. Chomienne, M. Lanotte, L. Degos, and A. Dejean. 1990. The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature (London) 347:558–561.
  • de The, H., C. Lavau, A. Marchio, C. Chomienne, L. Degos, and A. Dejean. 1991. The PML-RARA fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675–684.
  • Doucas, V., J. P. Brockes, M. Yaniv, H. de The, and A. Dejean. 1993. The PML-retinoic acid receptor a translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1. Proc. Natl. Acad. Sci. USA 90:9345–9349.
  • Dyck, J. A., G. G. Maul, W. H. Miller, Jr., J. D. Chen, A. Kakizuka, and R. M. Evans. 1994. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76:332–343.
  • Eglitis, M. A., and W. F. Anderson. 1988. Retroviral vector for introduction of genes into mammalian cells. BioTechniques 6:608–614.
  • Eglitis, M. A., P. W. Kantoff, E. Gilboa, and W. F. Anderson. 1985. Gene expression in mice after high efficiency retroviral-mediated gene transfer. Science 230:1395–1398.
  • Fagioli, M., M. Alcalay, P. P. Pandolfi, L. Venturini, A. Mencarelli, A. Simeone, D. Acampora, F. Grignani, and P. G. Pelicci. 1992. Alternative splicing of PML transcripts predicts coexpression of several carboxyl-terminally different protein isoforms. Oncogene 7:1083–1091.
  • Finlay, C. A., P. W. Hinds, and A. J. Levine. 1989. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083–1093.
  • Freemont, P. S., I. M. Hanson, and J. Trowsdale. 1991. A novel cysteine-rich sequence motif. Cell 64:483–484.
  • Giguere, V., E. S. Ong, P. Sequi, and R. M. Evan. 1987. Identification of a receptor for the morphogen retinoic acid. Nature (London) 330:624–629.
  • Ginsberg, D., F. Mechta, M. Yaniv, and M. Oren. 1991. Wild-type p53 can down-modulate the activity of various promoters. Proc. Natl. Acad. Sci. USA 88:9979–9983.
  • Goddard, A., J. Borrow, P. S. Freemont, and E. Solomon. 1991. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 254:1371–1374.
  • Gorman, C. M., G. T. Merlino, M. C. Willingham, I. Pastan, and B. H. Howard. 1982. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc. Natl. Acad. Sci. USA 79:6777–6781.
  • Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
  • Green, S., I. Issemann, and E. Sheer. 1988. A versatile in vivo eukaryotic expression vector for protein engineering. Nucleic Acids Res. 16:369.
  • Grignani, F., P. F. Ferrucci, U. Testa, G. Talamo, M. Fagioli, M. Alcalay, A. Mencarelli, C. Peschle, I. Nicoletti, and P. G. Pelicci. 1993. The acute promyelocytic leukemia-specific PML-RARa fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423–431.
  • Hinds, P. W., C. A. Finlay, A. B. Frey, and A. J. Levine. 1987. Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines. Mol. Cell. Biol. 7:2863–2869.
  • Huang, M., Y. C. Ye, B. R. Chen, J. R. Chai, J. X. Lu, L. Zhoa, L. J. Gu, and Z. Y. Wang. 1988. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567–572.
  • Hunter, T. 1991. Cooperation between oncogenes. Cell 64:249–270.
  • Ishii, S., Y.-H. Xu, R. H. Stratton, B. A. Roe, G. T. Merlino, and I. Pastan. 1985. Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene. Proc. Natl. Acad. Sci. USA 82:4920–4924.
  • Kakizuka, A., W. H. Miller, K. Umesono, R. P. Warrell, S. R. Frankel, V. V. V. S. Murty, E. Dmitrovsky, and R. M. Evans. 1991. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARA with a novel putative transcription factor, PML. Cell 66:663–674.
  • Kastner, P., and P. Chambon. Personal communication.
  • Kastner, P., A. Perez, Y. Lutz, C. Rochette-Egly, M. P. Gaub, B. Durand, M. Lanotte, R. Berger, and P. Chambon. 1992. Structure, localization and transcriptional properties of two classes of retinoic acid receptor a fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J. 11:629–642.
  • Kim, S. J., H. D. Lee, P. D. Robbins, K. Busam, M. B. Sporn, and A. B. Roberts. 1991. Regulation of transforming growth factor β1 gene expression by the product of the retinoblastoma-susceptibility gene. Proc. Natl. Acad. Sci. USA 88:3052–3056.
  • Land, H., A. C. Chen, J. P. Morgenstern, L. F. Parada, and R. A. Weinberg. 1986. Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts. Mol. Cell. Biol. 6:1917–1925.
  • Lanotte, M., V. Martin-Thouvenin, S. Najman, P. Ballerini, F. Valensi, and R. Berger. 1991. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77:1080–1086.
  • Larson, R. A., K. Kondo, J. W. Wardiman, A. E. Butler, Η. M. Golom, and J. D. Rowley. 1984. Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia. Am. J. Med. 76:827–841.
  • Longo, L., D. Trecca, A. Biondi, F. LoCoco, F. Grignani, M. A. Maiolo, P. G. Pelicci, and A. Neri. 1993. Frequency of RAS and p53 mutations in acute promyelocytic leukemia. Leuk. Lymphoma 11:405–410.
  • Markovitz, D., S. Goff, and A. Bank. 1988. A safe packaging line for gene transfer separating viral genes on two different plasmids. J. Virol. 62:1120–1124.
  • Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980–990.
  • Moses, H. L., E. Y. Yang, and J. A. Pietenpol. 1990. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 63:245–247.
  • Pandolfi, P. P., M. Alcalay, M. Fagioli, D. Zangrilli, A. Mencarelli, D. Diverio, A. Biondi, F. LoCoco, A. Rambaldi, F. Grignani, C. Rochette-Egly, M. P. Gaube, P. Chambon, and P. G. Pelicci. 1992. Genomic variability and alternative splicing generate multiple PML/RARα transcripts that encode aberrant PML proteins and PML/RARα isoforms in APL. EMBO J. 11:1397–1407.
  • Pandolfi, P. P., M. Alcalay, A. Mencarelli, A. Biondi, F. LoCoco, F. Grignani, and P. G. Pelicci. 1991. Structure and origin of the acute promyelocytic leukemia myl/RARA cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 6:1285–1292.
  • Perez, A., P. Kastner, S. Sethi, Y. Lutz, C. Reibel, and P. Chambon. 1993. PML/RAR homodimers: distinct DNA binding properties and heteromeric interaction with RXR. EMBO J. 12:3171–3182.
  • Quitschke, W. W., Z.-Y. Lin, L. Deponti-Zilli, and B. M. Paterson. 1989. The β actin promoter: high levels of transcription depend upon a CCAAT binding factor. J. Biol. Chem. 264:9539–9546.
  • Raycroft, L., H. Wu, and G. Lozano. 1990. Transcriptional activation by wild-type but not transforming mutants of the p53 antioncogene. Science 249:1049–1051.
  • Reichel, H., and A. W. Norman. 1989. Systemic effects of vitamin D. Annu. Rev. Med. 40:71–78.
  • Reichlin, M. 1980. Use of glutaraldehyde as a coupling agent for proteins and peptides. Methods Enzymol. 70:159–165.
  • Robbins, P. D., J. M. Horowitz, and R. C. Mulligan. 1990. Negative regulation of human c-fos expression by the retinoblastoma gene product. Nature (London) 46:668–671.
  • Robertson, K. A., B. Emami, L. Mueller, and S. J. Collins. 1992. Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells. Mol. Cell. Biol. 12:3743–3749.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Sawyers, C. L., C. T. Denny, and Ο. N. Witte. 1991. Leukemia and the disruption of normal hematopoiesis. Cell 64:337–350.
  • Sleigh, M. J. 1986. A non-chromatographic assay for expression of the chloramphenicol acetyltransferase gene in eukaryotic cells. Anal. Biochem. 156:251–256.
  • Tanaka, Η., E. Abe, C. Miyaura, T. Kuribayashi, K. Konno, Y. Nishii, and T. Suda. 1982. 1-Alpha, 25-dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60). Biochem. J. 204:713–719.
  • Tsai, S., and S. J. Collins. 1993. A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage. Proc. Natl. Acad. Sci. USA 90:7153–7157.
  • Warrell, R. P., S. P. Frankel, W. H. Miller, D. A. Scheiberg, L. M. Itri, W. M. Hittelman, R. Vyas, M. Andreef, A. Tafuri, A. Jakubowski, J. Gabrilove, M. S. Gordon, and E. Dmitrovsky. 1991. Differentiation therapy of acute promyelocytic leukemia with tretinoin (All-Trans-retinoic acid). N. Engl. J. Med. 324:1385–1393.
  • Weinberg, R. A. 1989. Oncogenes and multistep carcinogenesis, p. 307–326. In R. Weinberg (ed.), Oncogenes and the molecular origins of cancer. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Weis, K., S. Rambaud, C. Lavau, J. Jansen, T. Carvalho, M. Carmo-Fonseca, A. Lamond, and A. Dejean. 1994. Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells. Cell 76:345–356.
  • Yamamoto, K., S. Hirosawa, H. Sakamaki, and N. Aoki. 1992. Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia. Am. J. Hematol. 40:252–258.
  • Yu, D., A. Matin, and M. C. Hung. 1992. The retinoblastoma gene product suppresses neu oncogene-induced transformation via transcriptional repression of neu. J. Biol. Chem. 267:10203–10206.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.