CCR4 Is a Glucose-Regulated Transcription Factor Whose Leucine-Rich Repeat Binds Several Proteins Important for Placing CCR4 in Its Proper Promoter Context

Refrences

• Allison, L. A., and C. J. Ingles. 1989. Mutations in RNA polymerase II enhance or suppress mutations in GAL4. Proc. Natl. Acad. Sci. USA 86: 2794–2798.
   PubMedGoogle Scholar
• Bartolomei, M. S., N. F. Halden, C. R. Cullen, and J. L. Corden. 1988. Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of RNA polymerase II. Mol. Cell. Biol. 8: 330–339.
   PubMed Web of Science ®Google Scholar
• Braun, T., P. R. Schofield, and R. Sprengel. 1991. Amino terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity. EMBO J. 10: 1885–1890.
   PubMed Web of Science ®Google Scholar
• Brent, R., and M. Ptashne. 1985. A eukaryotic transcriptional activator bearing the specificity of a prokaryotic repressor. Cell 43: 729–736.
   PubMed Web of Science ®Google Scholar
• Clark-Adams, C. D., D. Norris, M. A. Osley, J. S. Fassler, and F. Winston. 1988. Changes in histone gene dosage alter transcription in yeast. Genes Dev. 2: 150–159.
   PubMed Web of Science ®Google Scholar
• Clark-Adams, C. D., and F. Winston. 1987. The SPT6 gene is essential for growth and is required for δ-mediated transcription in Saccharomyces cerevisiae. Mol. Cell. Biol. 7: 679–686.
   Google Scholar
• Cook, W. J., D. Chase, D. C. Audino, and C. L. Denis. 1994. Dissection of the ADR1 protein reveals multiple functionally redundant activation domains interspersed with inhibitory domains: evidence for a repressor binding to the ADR1c region. Mol. Cell. Biol. 14: 629–640.
   PubMedGoogle Scholar
• Cook, W. J., S. P. Mosley, D. C. Audino, and C. L. Denis. 1994. Mutations in the zinc-finger region of the yeast regulatory protein ADR1 affect both DNA binding and transcriptional activation. J. Biol. Chem. 269: 9374–9379.
   PubMedGoogle Scholar
• Courey, A. J., and R. Tjian. 1988. Analysis of Spl in vivo reveals multiple transcriptional domains, including a novel glutamine rich motif. Cell 55: 887–898.
   PubMed Web of Science ®Google Scholar
• Dekker, K., H. Yamagata, K. Sakaguchi, and S. Udaka. 1991. Xylose (glucose) isomerase gene from the thermophile Thermus thermophilus: cloning, sequencing, and comparison with other thermostable xylose isomerases. J. Bacteriol. 173: 3078–3083.
   PubMed Web of Science ®Google Scholar
• Denis, C. L. 1984. Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II. Genetics 108: 833–834.
   PubMedGoogle Scholar
• Denis, C. L., M. P. Draper, H.-Y. Liu, T. Malvar, R. Vailari, and J. Cook. CCR4, the suppressor of spt6 and spt10 mutations, is neither regulated nor associated with the SPT proteins and appears to form a functionally distinct complex from that of the SNF/SWI general transcription factors. Submitted for publication.
   Google Scholar
• Denis, C. L., J. Ferguson, and E. T. Young. 1983. mRNA levels for the fermentative alcohol dehydrogenase of Saccharomyces cerevisiae decrease upon growth on a nonfermentable carbon source. J. Biol. Chem. 258: 1165–1171.
   PubMed Web of Science ®Google Scholar
• Denis, C. L., and T. Malvar. 1990. The CCR4 gene from Saccharomyces cerevisiae is required for both nonfermentative and spt-mediated gene expression. Genetics 124: 283–291.
   PubMedGoogle Scholar
• Denis, C. L., and E. T. Young. 1983. Isolation and characterization of the positive regulatory gene ADR1 from Saccharomyces cerevisiae. Mol. Cell. Biol. 3: 360–370.
   Google Scholar
• Eisen, A., W. E. Taylor, H. Blumberg, and E. T. Young. 1988. The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activation sequence of ADH2. Mol. Cell. Biol. 8: 4552–4556.
   Google Scholar
• Golemis, E. A., and R. Brent. 1992. Fused protein domains inhibit DNA binding by LexA. Mol. Cell. Biol. 12: 3006–3014.
   PubMedGoogle Scholar
• Gorsburg, S. L., and L. Guarente. 1989. Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes Dev. 3: 1166–1178.
   PubMedGoogle Scholar
• Hirschhorn, J. N., S. A. Brown, C. D. Clark, and F. Winston. 1992. Evidence that SNF2/SW12 and SNF5 activate transcription in yeast by altering chromatin structure. Genes Dev. 6: 2288–2298.
   PubMed Web of Science ®Google Scholar
• Jenkins, J., J. Janin, F. Rey, M. Chiadmi, H. van Tilbeurgh, I. Lasters, M. De Maeyer, D. Van Belle, S. Wodak, M. Lauwereys, P. Stanssens, N. Mrabet, J. Snauwaert, G. Matthyssens, and A. Lambeir. 1992. Protein engineering of xylose (glucose) isomerase from Actinoplanes missouriensis. 1. Crystallography and site-directed mutagenesis of metal binding sites. Biochemistry 31: 5449–5458.
   Google Scholar
• Kobe, B., and J. Deisenhofer. 1993. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature (London) 366: 751–756.
   PubMed Web of Science ®Google Scholar
• Laurent, B. C., and M. Carlson. 1992. Yeast SNF2/SWI2, SNF5, and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid. Genes Dev. 6: 1707–1715.
   PubMedGoogle Scholar
• Laurent, B. C., M. A. Treitel, and M. Carlson. 1991. Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation. Proc. Natl. Acad. Sci. USA 88: 2687–2691.
   PubMed Web of Science ®Google Scholar
• Lee, F. S., and B. L. Vallee. 1990. Modular mutagenesis of the human placental ribonuclease inhibitor, a protein with leucine-rich repeats. Proc. Natl. Acad. Sci. USA 87: 1879–1883.
   PubMedGoogle Scholar
• Malvar, T., R. W. Biron, D. B. Kaback, and C. L. Denis. 1992. The CCR4 protein from Saccharomyces cerevisiae contains a leucine-rich repeat region which is required for its control of ADH2 gene expression. Genetics 132: 951–962.
   PubMedGoogle Scholar
• Natsoulis, G., C. Dollard, F. Winston, and J. D. Boeke. 1991. The products of SPT10 and SPT21 genes of Saccharomyces cerevisiae increase the amplitude of transcriptional regulation at a large number of unlinked loci. New Biol. 3: 1249–1259.
   PubMedGoogle Scholar
• Natsoulis, G., F. Winston, and J. D. Boeke. 1994. The SPT10 and SPT21 genes of Saccharomyces cerevisiae. Genetics 136: 93–105.
   PubMedGoogle Scholar
• Neigeborn, L., K. Rubin, and M. Carlson. 1986. Suppressors of snf2 mutations restore invertase derepression and cause temperature-sensitive lethality in yeast. Genetics 112: 741–753.
   PubMedGoogle Scholar
• Nonet, M., D. Sweetser, and R. A. Young. 1987. Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II. Cell 50: 909–915.
   PubMedGoogle Scholar
• Nonet, M., and R. A. Young. 1989. Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics 123: 715–724.
   PubMed Web of Science ®Google Scholar
• Olesen, T., and L. Guarente. 1990. The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/ 3/4 complex. Genes Dev. 4: 1714–1729.
   PubMedGoogle Scholar
• Peterson, C. L., and I. Herskowitz. 1992. Characterization of the yeast SWIly SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 68: 573–583.
   PubMed Web of Science ®Google Scholar
• Peterson, C. L., W. Kruger, and I. Herskowitz. 1991. A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1. Cell 64: 1135–1143.
   PubMed Web of Science ®Google Scholar
• Pinto, I., D. E. Ware, and M. Hampsey. 1992. The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo. Cell 68: 977–988.
   PubMedGoogle Scholar
• Pugh, B. F., and R. Tjian. 1990. Mechanism of transcriptional activation by Spl: evidence for coactivators. Cell 61: 1187–1197.
   PubMed Web of Science ®Google Scholar
• Ruden, D. M., J. Ma, Y. Li, K. Wood, and M. Ptashne. 1991. Generating yeast transcriptional activators containing no yeast protein sequences. Nature (London) 350: 250–252.
   PubMedGoogle Scholar
• Scafe, C., D. M. Chao, J. Lopes, J. P. Hirsch, S. Henry, and R. A. Young. 1990. RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals. Nature (London) 347: 491–494.
   PubMedGoogle Scholar
• Suzuki, N., Y. Choe, Y. Nishida Yamawaki-kataoka, S. Ohnishi, T. Tamaoki, and T. Kataoka. 1990. Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins. Proc. Natl. Acad. Sci. USA 87: 8711–8715.
   PubMedGoogle Scholar
• Swanson, M. S., M. Carlson, and F. Winston. 1990. SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus. Mol. Cell. Biol. 10: 4935–4941.
   PubMedGoogle Scholar
• Swanson, M. S., and F. Winston. 1992. SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae. Genetics 132: 325–336.
   PubMed Web of Science ®Google Scholar
• Thompson, C. M., A. J. Koleske, D. M. Chao, and R. A. Young. 1993. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73: 1361–1375.
   PubMed Web of Science ®Google Scholar
• Vailari, R. C., W. J. Cook, D. C. Audino, M. J. Morgan, D. E. Jensen, A. P. Laudano, and C. L. Denis. 1992. Glucose repression of yeast ADH2 occurs through multiple mechanisms, including control of the protein synthesis of its transcriptional activator ADR1. Mol. Cell. Biol. 12: 1663–1673.
   PubMedGoogle Scholar
• Winston, F., and M. Carlson. 1992. Yeast SNF/SWI transcriptional activators and the SPT/SIN connection. Trends Genet. 8: 387–391.
   PubMed Web of Science ®Google Scholar
• Wray, W., T. Boulikas, V. Wray, and R. Hancock. 1981. Silver staining of proteins in polyacrylamide gels. Anal. Biochem. 118: 197–293.
   PubMed Web of Science ®Google Scholar