Induced Differentiation of Avian Myeloblastosis Virus-Transformed Myeloblasts: Phenotypic Alteration Without Altered Expression of the Viral Oncogene

LITERATURE CITED

• Bishop, J. M. 1982. Functions and origins of retroviral and transforming genes, p. 999–1108. In Weiss, R., Teich, N., Varmus, H. E., and Coffin, J. (ed.). Molecular biology of tumor viruses, part III, RNA tumor viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y..
   Google Scholar
• Beug, H., and Hayman, M. J. 1984. Temperature-sensitive mutants of avian erythroblastosis virus: surface expression of the erb-B product correlates with transformation. Cell 36:963–972.
   PubMedGoogle Scholar
• Beug, H., Palmieri, S., Freudenstein, C., Zentgraf, H., and Graf, T. 1982. Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus. Cell 28:907–919.
   PubMedGoogle Scholar
• Beug, H., von Kirchbach, A., Doderlein, G., Conscience, J.-F., and Graf, T. 1979. Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation. Cell 18:375–390.
   PubMed Web of Science ®Google Scholar
• Boettiger, D., and Durban, E. 1984. Target cells for avian myeloblastosis virus in embryonic yolk sac and relationship of cell differentiation to cell transformation. J. Virol. 49:841–847.
   PubMedGoogle Scholar
• Boyle, W. J., Lipsick, J. S., Reddy, E. P., and Baluda, M. A. 1983. Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue. Proc. Natl. Acad. Sci. U.S.A. 80:2834–2838.
   PubMedGoogle Scholar
• Burgess, A. W., and Metcalf, D. 1980. Characterization of a serum factor stimulating the differentiation of myelomonocytic cells. Int. J. Cancer 26:647–654.
   PubMed Web of Science ®Google Scholar
• Cleveland, D., Fisher, S. J., Rirschner, M. W., and Laemmli, U. R. 1978. Peptide mapping by limited proteolysis in sodium dodecylsulfate and analysis by gel electrophoresis. J. Biol. Chem. 252:1102–1106.
   Google Scholar
• Coffin, J. M., Varmus, H. E., Bishop, J. M., Essex, M., Hardy, W. D., Jr., Martin, G. S., Rosenberg, N. E., Scolnick, E. M., Weinberg, R. A., and Vogt, P. R. 1981. Proposal for naming host cell-derived inserts in retrovirus genomes. J. Virol. 40:953–957.
   PubMed Web of Science ®Google Scholar
• Craig, R. W., and Block, A. 1984. Early decline in c-myb oncogene expression in the differentiation of human myeloblas-tic leukemia (ML-1) cells induced with 12-0-tetradecanoylphor-bol-13-acetate. Cancer Res. 44:442–446.
   PubMed Web of Science ®Google Scholar
• Durban, E. M., and Boettiger, D. 1981. Differential effects of transforming avian RNA tumor viruses on avian macrophages. Proc. Natl. Acad. Sci. U.S.A. 78:3600–3604.
   PubMed Web of Science ®Google Scholar
• Gazzolo, L., Moscovici, C., Moscovici, M. G., and Samarut, J. 1979. Response of hemopoietic cells to avian acute leukemia viruses: effects on the differentiation of the target cells. Cell 16:627–638.
   PubMedGoogle Scholar
• Gonda, T. J., and Metcalf, D. 1984. Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. Nature (London) 310:249–251.
   PubMed Web of Science ®Google Scholar
• Gonda, T. J., Sheiness, R. D., and Bishop, J. M. 1982. Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues. Mol. Cell. Biol. 2:617–624.
   PubMed Web of Science ®Google Scholar
• Graf, T., and Beug, H. 1978. Avian leukemia viruses: interaction with their target cells in vivo and in vitro. Biochim. Biophys. Acta 516:269–299.
   PubMed Web of Science ®Google Scholar
• Hozumi, M. 1983. Fundamentals of chemotherapy of myeloid leukemia by induction of leukemia cell differentiation. Adv. Cancer Res. 38:121–169.
   PubMed Web of Science ®Google Scholar
• Klempnauer, K.-H., Ramsay, G., Bishop, J. M., Moscovici, M. G., Moscovici, C., McGrath, J. P., and Levinson, A. D. 1983. The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb. Cell 33:345–355.
   PubMed Web of Science ®Google Scholar
• Klempnauer, K.-H., Symonds, G., Evan, G. I., and Bishop, J. M. 1984. Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene. Cell 37:537–547.
   PubMed Web of Science ®Google Scholar
• Koeffler, H. P. 1983. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 62:709–721.
   PubMed Web of Science ®Google Scholar
• Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
   PubMed Web of Science ®Google Scholar
• Lotem, J., and Sachs, L. 1979. Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion. Proc. Natl. Acad. Sci. U.S.A. 76:5158–5162.
   PubMed Web of Science ®Google Scholar
• McCulloch, E. A. 1983. Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982). Blood 62:1–13.
   PubMed Web of Science ®Google Scholar
• McKinnell, R. G., DiBerardino, M. A., Blumenfeld, M., and Bergad, R. D. (ed.). 1980. Results and problems in cell differentiation, vol. 11. Springer-Verlag, New York.
   Google Scholar
• Metcalf, D. 1982. Sources and biology of regulatory factors active in mouse myeloid leukemic cells. J. Cell. Physiol. l(Suppl.):175–183.
   Google Scholar
• Mintz, B., and Fleischman, R. A. 1981. Teratocarcinomas and other neoplasms as developmental defects in gene expression. Adv. Cancer Res. 34:211–278.
   PubMedGoogle Scholar
• Moscovici, C. 1975. Leukemic transformation with avian myeloblastosis virus: present status. Curr. Top. Microbiol. Immunol. 71:79–101.
   PubMedGoogle Scholar
• Moscovici, C., and Gazzolo, L. 1982. Transformation of hemopoietic cells with avian leukemia viruses, p. 83–106. In Klein, G. (ed.), Advances in viral oncology, vol. 1. Raven Press, New York.
   Google Scholar
• Moscovici, M. G., Jurdic, P., Samarut, J., Gazzolo, L., Mura, C. V., and Moscovici, C. 1983. Characterization of the hemopoietic target cells for the avian leukemia virus E26. Virology 129:65–78.
   PubMedGoogle Scholar
• Moscovici, M. G., and Moscovici, C. 1980. AMV-induced transformation of hemopoietic cells: growth of producers and non-producers, p. 503–514. In Rossi, G. B. (ed.), In vivo and in vitro erythropoiesis: the friend system. Elsevier, New York.
   Google Scholar
• Moscovici, M. G., and Moscovici, C. 1983. Isolation and characterization of a temperature-sensitive mutant of avian myeloblastosis virus. Proc. Natl. Acad. Sci. U.S.A. 80:1421–1425.
   PubMedGoogle Scholar
• Moscovici, C., Zeller, N., and Moscovici, M. G. 1982. Continuous lines of AMV-transformed non-producer cells: growth and oncogenic potential in the chick embryo, p. 435–449. In Revoltella, R. F., Pontieri, G. M., Basilico, C., Rovera, G., Gallo, R. C., and Subak-Sharpe, J. H. (ed.), Expression of differentiated functions in cancer cells. Raven Press, New York.
   Google Scholar
• Muller, R., Slamon, D. J., Tremblay, J. M., Cline, M. J., and Verma, I. M. 1982. Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature (London) 299:640–644.
   PubMed Web of Science ®Google Scholar
• O'Farrell, P. H. 1975. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 250:4007–4021.
   PubMed Web of Science ®Google Scholar
• Pessano, S., Gazzolo, L., and Moscovici, C. 1979. The effect of a tumor promoter on avian leukemic cells. Microbiologica 2:379–392.
   Google Scholar
• Radke, K., Beug, H., Kornfeld, S., and Graf, T. 1982. Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell 31:643–653.
   PubMedGoogle Scholar
• Sachs, L. 1978. Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia. Nature (London) 274:535–539.
   PubMed Web of Science ®Google Scholar
• Sachs, L. 1982. Normal development programmes in myeloid leukaemia: regulatory proteins in the control of growth and differentiation. Cancer Surv. 1:321–342.
   Google Scholar
• Samarut, J., and Gazzolo, L. 1982. Target cells infected by avian erythroblastosis virus differentiate and become transformed. Cell 28:921–929.
   PubMedGoogle Scholar
• Saunders, G. F. (ed.). 1978. Cell differentiation and neoplasia. Raven Press, New York.
   Google Scholar
• Symonds, G., and Sachs, L. 1982. Modulation of cell competence for induction of differentiation in myeloid leukemic cells. J. Cell. Physiol. 111:9–14.
   PubMedGoogle Scholar
• Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76:4350–4354.
   PubMed Web of Science ®Google Scholar
• Weiss, B., and Sachs, L. 1978. Indirect induction of differentiation in myeloid leukemic cells by lipid A. Proc. Natl. Acad. Sci. U.S.A. 75:1374–1378.
   PubMedGoogle Scholar
• Westin, E. H., Gallo, R. C., Arya, S. K., Eva, A., Souza, L. M., Baluda, M. A., Aaronson, S. A., and Wong-Staal, F. 1982. Differential expression of the amv gene in human hematopoietic cells. Proc. Natl. Acad. Sci. U.S.A. 79:2194–2198.
   PubMed Web of Science ®Google Scholar
• Westin, E. H., Wong-Staal, F., Gelmann, E. P., Dalla Favera, R., Papas, T. S., Lautenberger, J. A., Eva, A., Reddy, E. P., Tronick, S. R., Aaronson, S. A., and Gallo, R. C. 1982. Expression of cellular homologues of retroviral one genes in human hematopoietic cells. Proc. Natl. Acad. Sci. U.S.A. 79:2490–2494.
   PubMed Web of Science ®Google Scholar
• Whitlock, C. A., Ziegler, S. F., Treiman, L. J., Stafford, J. J., and Witte, O. N. 1983. Differentiation of cloned populations of immature B cells after transformation with Abelson murine leukemia virus. Cell 332:903–911.
   Google Scholar
• Williams, W. J., Beutler, E., Erslev, A. J., and Rundles, R. W. (ed.). 1977. Hematology, 2nd ed. McGraw-Hill Book Co., New York.
   Google Scholar