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Research Article

Nonproductive Kappa Immunoglobulin Genes: Recombinational Abnormalities and Other Lesions Affecting Transcription, RNA Processing, Turnover, and Translation

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Pages 1660-1675 | Received 12 Feb 1985, Accepted 09 Apr 1985, Published online: 31 Mar 2023

LITERATURE CITED

  • Alt, F., and Baltimore D.. 1982. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc. Natl. Acad. Sci. U.S.A. 79:4118–4122.
  • Alt, F. W., Yancopoulos G. D., Black well T. K., Wood C., Thomas E., Boss M., Coffman R., Rosenberg N., Tonegawa S., and Baltimore D.. 1984. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 3:1209–1219.
  • Altenburger, W., Steinmetz M., and Zachau H. G.. 1980. Functional and nonfunctional joining in immunoglobulin light chain genes of a mouse myeloma. Nature (London) 287:603–607.
  • Bentley, D. L., and Rabbitts T. H.. 1980. Human immunoglobulin variable region genes–DNA sequences of two VKgenes and a pseudogene. Nature (London) 288:730–733.
  • Benton, W. D., and Davis R. W.. 1977. Screening Xgt recombinant clones by hybridization to single plaques in situ. Science 196:180–182.
  • Bergman, Y., Rice D., Grosschedl R., and Baltimore D.. 1984. Two regulatory elements for immunoglobulin k light chain gene expression. Proc. Natl. Acad. Sci. U.S.A. 81:7041–7045.
  • Bernard, O., Gough N. M., and Adams J. M.. 1981. Plasmacytomas with more than one immunoglobulin k mRNA: implications for allelic exclusion. Proc. Natl. Acad. Sci. U.S.A. 78:5812–5816.
  • Breathnach, R., and Chambon P.. 1981. Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50:349–383.
  • Coleclough, C. 1983. Chance, necessity and antibody gene dynamics. Nature (London) 303:23–26.
  • Coleclough, C, Perry R. P., Karjalainen K., and Weigert M.. 1981. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature (London) 290:372–377.
  • Durdik, J., Moore M. W., and Seising E.. 1984. Novel k light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes. Nature (London) 307:749–752.
  • Ephrussi, A., Church G. M., Tonegawa S., and Gilbert W.. 1985. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134–140.
  • Falkner, F. G., and Zachau H. G.. 1984. Correct transcription of an immunoglobulin k gene requires an upstream fragment containing conserved sequence elements. Nature (London) 310: 71–84.
  • Gearhart, P. J., Johnson N. D., Douglas R., and Hood L.. 1981. IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (London) 291:29–34.
  • Gerondakis, S., Boyd A., Bernard O., Webb E., and Adams J. M.. 1984. Activation of immunoglobulin |x gene expression involves stepwise demethylation. EMBO J. 3:3013–3021.
  • Gorski, J., Rollini P., and Mach B.. 1983. Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene. Science 220:1179–1181.
  • Groudine, M., Peretz M., and Weintraub H.. 1981. Transcriptional regulation of hemoglobin switching in chicken embryos. Mol. Cell. Biol. 1:281–288.
  • Harris, L. J., Lang R. B., and Marcu K. B.. 1982. Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas. Proc. Natl. Acad. Sci. U.S.A. 79:4175–4179.
  • Hochtl, J., Muller C. R., and Zachau H. G.. 1982. Recombined flanks of the variable and joining segments of immunoglobulin genes. Proc. Natl. Acad. Sci. U.S.A. 79:1383–1387.
  • Hohn, B. 1979. In vitro packaging of λ and cosmid DNA. Methods Enzymol. 68:299–309.
  • Hozumi, N., Wu G. E., Murialdo H., Roberts L., Vetter D., Fife W. L., Whiteley M., and Sadowski P.. 1981. RNA splicing mutation in an aberrantly rearranged immunoglobulin XI gene. Proc. Natl. Acad. Sci. U.S.A. 78:7019–7023.
  • Huang, H., Crews S., and Hood L.. 1981. An immunoglobulin VH pseudogene. J. Mol. Appl. Genet. 1:93–101.
  • Rabat, E. A., Wu T. T., Bilofsky H., Reid-Miller M., and Perry H.. 1983. Sequences of proteins of immunological interest, p. 45–57. U.S. Department of Health and Human Services, Washington, D.C.
  • Kara, J., Brenner S., Barnett L., and Cesareni G.. 1980. Novel bacteriophage λ cloning vector. Proc. Natl. Acad. Sci. U.S.A. 77:5172–5176.
  • Kelley, D. E., Coleclough C., and Perry R. P.. 1982. Functional significance and evolutionary development of the 5′-terminal regions of immunoglobulin variable-region genes. Cell 29:681–689.
  • Kwan, S.-P., Max E. E., Seidman J. G., Leder P., and Scharff M. D.. 1981. Two kappa immunoglobulin genes are expressed in the myeloma S107. Cell 26:57–66.
  • Leder, P., Tiemeier D., and Enquist L.. 1977. EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the XgtWES system. Science 196:175–177.
  • Lewis, S., Gifford A., and Baltimore D.. 1984. Joining of VK to JKgene segments in a retroviral vector introduced into lymphoid cells. Nature (London) 308:425–428.
  • Lewis, S., Rosenberg N., Alt F., and Baltimore D.. 1982. Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell 30:807–816.
  • Mather, E. L., and Perry R. P.. 1981. Transcriptional regulation of immunoglobulin genes. Nucleic Acids Res. 9:6855–6867.
  • Mather, E. L., and Perry R. P.. 1983. Transcriptional regulation of k immunoglobulin genes. Proc. Natl. Acad. Sci. U.S.A. 80:4689–4693.
  • Max, E. E., Maizel J. V., and Leder P.. 1981. The nucleotide sequence of a 5.5 kb DNA segment encoding the mouse kappa immunoglobulin J and C genes. J. Biol. Chem. 256:5116–5120.
  • Maxam, A. M., and Gilbert W.. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:499–560.
  • McKnight, G. S., and Palmiter R.. 1979. Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J. Biol. Chem. 254:9050–9058.
  • Nelson, K. J., Haimovich J., and Perry R. P.. 1983. Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of |jum and (xsmRNA. Mol. Cell. Biol. 3:1317–1332.
  • Neumaier, P. S., and Zachau H. G.. 1983. Nucleotide sequence of a region downstream of the mouse CK immunoglobulin gene. Nucleic Acids Res. 11:3631–3636.
  • Parslow, T., Blair D. L., Murphy W. J., and Granner D. K.. 1984. Structure of the 5′ ends of immunoglobulin genes: a novel conserved sequence. Proc. Natl. Acad. Sci. U.S.A. 81: 2650–2654.
  • Perry, R. P. 1983. Consequences of myc invasion of immunoglobulin loci: facts and speculation. Cell 33:647–649.
  • Perry, R. P. 1984. What controls the transcription of immunoglobulin genes? Nature (London) 310:14–15.
  • Perry, R. P., Coleclough C., and Weigert M.. 1981. Reorganization and expression of immunoglobulin genes: status of allelic elements. Cold Spring Harbor Symp. Quant. Biol. 45:925–933.
  • Perry, R. P., Kelley D. E., Coleclough C., Seidman J. G., Leder P., Tonegawa S., Matthyssens G., and Weigert M.. 1980. Transcription of mouse k-chain genes: implications for allelic exclusion. Proc. Natl. Acad. Sci. U.S.A. 77:1937–1941.
  • Picard, D., and Schaffner W.. 1984. A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene. Nature (London) 307:80–82.
  • Pollok, B. A., Vakil M., Kearney J. F., and Perry R. P.. 1984. A biological consequence of variation in the site of D-JH gene rearrangement. Nature (London) 311:376–379.
  • Queen, C, and Stafford J.. 1984. Fine mapping of an immunoglobulin gene activator. Mol. Cell. Biol. 4:1042–1049.
  • Rimm, D. L., Horness D., Kucera J., and Blattner F. R.. 1980. Construction of coliphage lambda Charon vectors with Bam HI cloning sites. Gene 12:301–309.
  • Rose, S. M., and Garrard W. T.. 1984. Differentiation-dependent chromatin alterations precede and accompany transcription of immunoglobulin light chain genes. J. Biol. Chem. 259:8534–8544.
  • Schibler, U., Hagenbuchle O., WeUauer P. K., and Pittet A. C.. 1983. Two promoters of different strengths control the transcription of the mouse alpha-amylase gene amy-1a in the parotid gland and the liver. Cell 33:501–508.
  • Seidman, J. G., and Leder P.. 1980. A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events. Nature (London) 286:779–783.
  • Seising, E., and Storb U.. 1981. Somatic mutation of immunoglobulin light-chain variable-region genes. Cell 25:47–58.
  • Seising, E., Voss J., and Storb U.. 1984. Immunoglobulin gene ‘remnant’ DNA–implications for antibody gene recombination. Nucleic Acids Res. 12:4229–4246.
  • Shapiro, M., and Weigert M.. 1984. Aberrant rearrangements at the murine light chain locus in plasmacytomas. Curr. Top. Microbiol. Immunol. 113:190–191.
  • Storb, U., O'Brien R. L., McMulIen M. D., GoUahon K. A., and Brinster R. L.. 1984. High expression of cloned immunoglobulin k gene in transgenic mice is restricted to B lymphocytes. Nature (London) 310:238–241.
  • Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature (London) 302:575–581.
  • Treisman, R., Orkin S. H., and Maniatis T.. 1983. Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes. Nature (London) 302:591–596.
  • Van Ness, B. G., Coleclough C., Perry R. P., and Weigert M.. 1982. DNA between V and J gene segments of immunoglobulin k light chain is frequently retained in cells which rearrange the k locus. Proc. Natl. Acad. Sci. U.S.A. 79:262–266.
  • Van Ness, B. G., Shapiro M., Kelley D. E., Perry R. P., Weigert M., D'Eustachio P., and Ruddle F.. 1983. Aberrant rearrangement of the k light-chain locus involving the heavy-chain locus and chromosome 15 in a mouse plasmacytoma. Nature (London) 301:425–427.
  • Van Ness, B. G., Weigert M., Coleclough C., Mather E. L., Kelley D. E., and Perry R. P.. 1981. Transcription of the unrearranged mouse CK locus: sequence of the initiation region and comparison of activity with a rearranged VK-CK gene. Cell 27:593–602.
  • Walfield, A., Seising E., Arp B., and Storb U.. 1981. Misalignment of U and J gene segments resulting in a nonfunctional immunoglobulin gene. Nucleic Acids Res. 9:1101–1109.
  • Wieringa, B., Meyer F., Reiser J., and Weissmann C.. 1983. Unusual sequence of cryptic splice sites utilized in the β-globin gene following inactivation of an authentic 5′ splice site by site-directed mutagenesis. Nature (London) 301:38–43.

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