7
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Structure and Localization of Genes Encoding Aberrant and Normal Epidermal Growth Factor Receptor RNAs from A431 Human Carcinoma Cells

, , , , , , , , , , , & show all
Pages 1722-1734 | Received 20 Dec 1984, Accepted 15 Apr 1985, Published online: 31 Mar 2023

LITERATURE CITED

  • Adams, J. M., Gerondakis S., Webb E., Corcoran L. M., and Cory S.. 1983. Cellular myc is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas. Proc. Natl. Acad. Sci. U.S.A. 80:1982–1986.
  • Alitalo, K., Schwab M., Lin C. C., Varmus H. E., and Bishop J. M.. 1983. Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc. Natl. Acad. Sci. U.S.A. 80:1707–1711.
  • ar-Rushdi, A., Nishikura K., Erikson J., Watt R., Rovera G., and Croce C. M.. 1983. Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma. Science 222:390–393.
  • Basu, M., Biswas R., and Das M.. 1984. 42,000-molecular weight EGF receptor has protein kinase activity. Nature (London) 311:477–480.
  • Beguinot, L., Lyall R. M., Willingham M. C., and Pas tan I.. 1984. Down-regulation of the EGF receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes. Proc. Natl. Acad. Sci. U.S.A. 81:2384–2388.
  • Caccia, N., Kronenberg M., Saxe D., Haars R., Bruns G. A. P., Goverman J., Malissen M., WiUard H., Yoshikai Y., Simon M., Hood L., and Mak T. W.. 1984. The T cell receptor 0 chain genes are located on chromosome 6 in mice and chromosome 7 in humans. Cell 37:1091–1099.
  • Chirgwin, J. M., Przybyla A. E., MacDonald R. J., and Rutter W. J.. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294–5299.
  • Cohen, S., Ushiro H., Stoscheck C., and Chinkers M.. 1982. A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. J. Biol. Chem. 257:1523–1531.
  • Collins, S., and Groudine M.. 1982. Amplification of endogenous myc-related DNA sequences in a human myeloid leukemia cell line. Nature (London) 298:679–681.
  • Collins, S., and Groudine M.. 1983. Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562. Proc. Natl. Acad. Sci. U.S.A. 80:4813–4817.
  • Covelli, I., Mozzi R., Rossi R., and Frati L.. 1972. The mechanism of action of the epidermal growth factor. III. Stimulation of the uptake of labeled precursors into RNA, DNA, and proteins induced by EGF in isolated tumor cells. Hormones 3:183–191.
  • Dalla-Favera, R., Marinotti S., and Gallo R.. 1983. Translocations and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science 219:963–967.
  • Dalla-Favera, R., Wong-Staal F., and Gallo R. C.. 1982. One gene amplification in promyelocytic leukemia cell line HL-60 and primary leukemic cells of the same patient. Nature (London) 299:61–63.
  • Das, M., Miyakawa T., Fox C. F., Pruss R. M., Aharonov A., and Herschman H. R.. 1977. Specific radiolabeling of a cell surface receptor for epidermal growth factor. Proc. Natl. Acad. Sci. U.S.A. 74:2790–2794.
  • Doolittle, R. F., HunkapiUer M. W., Hood L. E., Devare S. G., Robbins K., Aaronson S. A., and Antoniades H. N.. 1983. Simian sarcoma virus and gene V-sis is derived from the gene (or/genes) encoding a platelet-derived growth factor. Science 221:275–277.
  • Downward, J., Parker P., and Waterfield M. D.. 1984. Autophosphorylation sites on the epidermal growth factor receptor. Nature (London) 311:483–485.
  • Downward, J., Yarden Y., Mayes E., Scarce G., Totty N., Stockwell P., Ullrich A., Schlessinger J., and Waterfield M. D.. 1984. Close similarity of epidermal growth factor receptor and v-erb B oncogene protein sequence. Nature (London) 307: 521–527.
  • Engelbreth-Holm, J., and Rothe-Meyer A.. 1935. On the connection between erythroblastosis (haemocytoblastosis) myelosis and sarcoma in chicken. Acta Pathol. Microbiol. Scand. 12:352–377.
  • Fabricant, R. N., DeLarco J. E., and Todaro G. J.. 1977. Nerve growth factor receptor on human melanoma cells in culture. Proc. Natl. Acad. Sci. U.S.A. 74:565–569.
  • Fung, Y.-K., Lewis W. G., Crittenden L. B., and Rung H.-J.. 1984. Activation of the cellular oncogene c-erb B by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus. Cell 33:357–368.
  • Graf, T., Royer-Pokora B., Schubert G. E., and Beug H.. 1976. Evidence for the multiple oncogenic potential of cloned leukemia virus: in vitro and in vivo studies with avian erythroblastosis virus. Virology 71:423–433.
  • Harper, M. E., and Saunders G. F.. 1981. Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization. Chromosoma 83:431–439.
  • Hayday, A. C, Gillies S. D., Saito H., Wood C., Wimar K., Hayward W. S., and Tonegawa S.. 1984. Activation of translocated human c-myc gene by an enhancer in the immunoglobulin heavy chain locus. Nature (London) 307:334–340.
  • Hayward, W. S., Neel B. G., and Astrin S. M.. 1981. Activation of a cellular one gene by promoter insertion in ALV-induced lymphoid leukosis. Nature (London) 290:475–480.
  • Heisterkamp, N., Stephenson J. R., Groffen J., Hansen P. F., de Klein A., Bartram C. R., and Grosveld J.. 1983. Localization of the c-abl oncogene adjacent to a translocation breakpoint in chronic myelocytic leukemia. Nature (London) 306:239–242.
  • Houenberg, M. D., and Cuatrecasas P.. 1973. Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proc. Natl. Acad. Sci. U.S.A. 70:2964–2968.
  • Hunter, T. 1984. The epidermal growth factor receptor gene and its product. Nature (London) 311:414–416.
  • Hunter, T., and Cooper J. A.. 1981. Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell 24:741–752.
  • Hunter, T., Ling N., and Cooper J. A.. 1984. Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (London) 311:480–483.
  • Kondo, I., and Shimizu N.. 1983. Mapping of the human epidermal growth factor receptor (EGFR) on the pl3 to q22 region of chromosome 7. Cytogenet. Cell Genet. 35:9–14.
  • LeBeau, M. M., and Rowley J. D.. 1984. Heritable fragile sites in cancer. Nature (London) 308:607–608.
  • Lembach, K. J. 1976. Enhanced synthesis and extracellular accumulation of hyaluronic acid during stimulation of quiescent human fibroblasts by mouse epidermal growth factor. J. Cell. Physiol. 89:277–288.
  • Lin, C. R., Chen W. S., Kruiger W., Stolarsky L. S., Weber W., Evans R. M., Verma I. M., Gill G. N., and Rosenfeld M. G.. 1984. Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. Science 224:843–848.
  • Maniatis, T., Kee S. G., Efstratiadis A., and Kafatos F. C.. 1976. Amplification and characterization of a β-globin gene synthesized in vitro. Cell 8:163–182.
  • Marcu, K. B., Harris L. J., Stanton L. W., Erikson J., Watt R., and Croce C. M.. 1983. Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc. Natl. Acad. Sci. U.S.A. 80:519–523.
  • Mayes, E. L. V., and Waterfield M. D.. 1984. Biosynthesis of the epidermal growth factor receptor in A431 cells. EMBO j. 3:531–537.
  • Merlino, G. T., Xu Y.-h., Ishii S., Clark A. J. L., Semba K., Toyoshima K., Yamamoto T., and Pastan I.. 1984. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224:417–419.
  • Messing, J., and Vieira J.. 1982. A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. Gene 19:269–276.
  • Mushinski, J. F., Bauer S. R., Potter M., and Reddy E. P.. 1983. Increased expression of myc-related oncogene mRNA characterizes most BALB/c plasmocytomas induced by pristane or Abelson murine leukemia virus. Proc. Natl. Acad. Sci. U.S.A. 80:1073–1077.
  • Mushinski, J. F., Potter M., Bauer S. R., and Reddy E. P.. 1983. DNA rearrangement and altered RNA expression of the c-myc oncogene in mouse plasmacytoid lymphosarcomas. Science 220:795–798.
  • Payne, G. S., Bishop J. M., and Varmus H. E.. 1982. Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature (London) 295:209–215.
  • Rowley, J. D. 1984. Consistent chromosomal rearrangements in human malignant disease and oncogene location, p. 221–226. In Vande Woude G. F., Levine A. J., Topp W. C., and Watson J. D. (ed.), Cancer cells, vol. 2. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Sahyoun, N., Hock R. A., and HoUenberg M. D.. 1978. Insulin and epidermal growth factor-urogastrone: affinity crosslinking to specific binding sites in rat liver membranes. Proc. Natl. Acad. Sci. U.S.A. 75:1675–1679.
  • Sanger, F., Coulson A. R., Barrell B. G., Smith A. J. H., and Roe B. A.. 1980. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J. Mol. Biol. 143:161–178.
  • Sanger, F., Nicklen S., and Coulson A. R.. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. U.S.A. 74:5463–5467.
  • Savage, C. R., and Cohen S. J.. 1972. Epidermal growth factor and a new derivation: rapid isolation procedures and biological and chemical characterization. J. Biol. Chem. 247:7609–7611.
  • Schwab, M., Alitalo K., Klempnauer K. H., Varmus H., Bishop J. M., Gilbert F., Brodeur G., Goldstein M., and Trent J.. 1983. Amplified DNA with limited homology to the myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor. Nature (London) 305:245–248.
  • Schwab, M., Alitalo K., Varmus H. E., Bishop J. M., and George D.. 1983. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumor cells. Nature (London) 303: 497–501.
  • Shimizu, N., Behzadian M. A., and Shimizu Y.. 1980. Genetics of cell surface receptors for bioactive polypeptides: binding of epidermal growth factor is associated with the presence of human chromosome 7 in human-mouse cell hybrids. Proc. Natl. Acad. Sci. U.S.A. 77:3600–3604.
  • Shimizu, N., Kondo I., Gamou S., Behzadian M. A., and Shimuzu Y.. 1984. Genetic analysis of hyperproduction of epidermal growth factor receptors in human epidermoid carcinoma A431 cells. Somatic Cell Mol. Genet. 10:45–53.
  • Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
  • Spurr, N. K., Solomon E., Jansson M., Sheer D., Goodfel-low P. N., Bodmer W. F., and Vennstrdm B.. 1984. Chromosomal localization of the human homologues to the oncogenes erbA and B. EMBO J. 3:159–163.
  • Stanton, L. W., Watt R., and Marcu K. B.. 1983. Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmocytomas. Nature (London) 303:401–406.
  • Taub, R., Kirsch I., Morton C., Lenoir G., Swan D., Tronick S., Aaronson S., and Leder P.. 1982. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma murine plasmacytoma cells. Proc. Natl. Acad. Sci. U.S.A. 79:7837–7841.
  • Thomas, P. S. 1980. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. U.S.A. 77:5201–5205.
  • Tsujimoto, Y., Yunis J., Onarato-Showe L., Erikson J., Nowell P. C., and Croce C. M.. 1984. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(ll;14) chromosome translocation. Science 224:1403–1406.
  • Ullrich, A., Coussens L., Hayflick J. S., DuU T. J., Gray A., Tarn A. W., Lee J., Yarden Y., Libermann T. A., Schles-singer J., Downward J., Mayes E. L. V., Whittle N., Waterfield M. D., and Seeburg P. H.. 1984. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature (London) 309:418–425.
  • Waterfield, M. D., Scrace T., Whittle N., Stroobant P., Johnsson A., Wasteson A., Westermark B., Heldin C. H., Huang J. S., and Deuel T. F.. 1983. Platelet-derived growth factor is structurally related to the putative transforming proteins p28sisof simian sarcoma virus. Nature (London) 304:35–39.
  • Weber, W., Gill G. N., and Spiess J.J., 1984. Production of an epidermal growth factor receptor-related protein. Science 224:294–297.
  • Willingham, M. C, Haigler H. T., FitzGerald D. J. P., Gallo M. G., Rutherford A. V., and Pastan I. H.. 1983. The morphological pathway of binding and internalization of epidermal growth factor in cultured cells: studies on A431, KB, and 3T3 cells, using multiple methods of labeling. Exp. Cell Res. 146:163–175.
  • Xu, Y.-h., Ishii S., Clark A. J. L., Sullivan M., Wilson R. K., Ma D. P., Roe B. A., Merlino G. T., and Pastan I.. 1984. Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature (London) 309:806–810.
  • Xu, Y.-h., Richert N., Ito S., Merlino G. T., and Pastan I.. 1984. Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. Proc. Natl. Acad. Sci. U.S.A. 81:7308–7312.
  • Yamada, Y., Mudryj M., and de Crombrugghe B.. 1983. A uniquely conserved regulatory signal is found around the translation initiation site in three different collagen genes. J. Biol. Chem. 258:14914–14919.
  • Yamamoto, T., Nishida T., Miyajima N., Kawai S., Ooi T., and Toyoshima K.. 1983. The erb B gene of avian erythroblastosis virus is a member of the Src gene family. Cell 35:71–78.
  • Yamamoto, T., Hihara H., Nishida T., Kawai S., and Toyoshima K.. 1983. A new avian erythroblastosis virus, AEV-H, carries erb B gene responsible for the induction of both erythroblastosis and sarcomas. Cell 34:225–232.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.