3
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Regulation of Adenovirus Gene Expression in Human WI38 Cells by an E1B-Encoded Tumor Antigen

, &
Pages 3763-3773 | Received 29 Apr 1986, Accepted 21 Jul 1986, Published online: 31 Mar 2023

LITERATURE CITED

  • Anderson, C. W., J. B. Lewis, J. F. Atkins, and R. R. Gesteland. 1974. Cell-free synthesis of adenovirus 2 proteins programmed by fractionated messenger RNA: a comparison of polypeptide products and messenger RNA lengths. Proc. Natl. Acad. Sci. USA 71:2756–2760.
  • Aviv, H., and P. Leder. 1972. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc. Natl. Acad. Sci. USA 69:1408–1412.
  • Babiss, L. E., P. B. Fisher, and H. S. Ginsberg. 1984. Effect ontransformation of mutations in the early region 1b-encoded 21- and 55-kilodalton proteins of adenovirus 5. J. Virol. 52:389–395.
  • Babiss, L. E., H. S. Ginsberg, and J. E. Darnell, Jr. 1985. Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol. Cell. Biol. 5:2552–2558.
  • Berk, A. J., F. Lee, T. Harrison, J. Williams, and P. A. Sharp. 1979. Pre-early adenovirus 5 genome product regulates synthesis of early viral messenger RNAs. Cell 17:935–944.
  • Bos, J. L., L. J. Polder, R. Bernards, P. I. Schrier, P. J. van den Elsen, A. J. van der Eb, and H. van Ormondt. 1981. The 2.2 kb Elb mRNA of human Adl2 and Ad5 codes for two tumor antigens starting at different AUG triplets. Cell 27:121–131.
  • Carlock, L. R., and N. C. Jones. 1981. Transformation-defective mutant of adenovirus type 5 containing a single altered Ela mRNA species. J. Virol. 40:657–664.
  • Chinnadurai, G. 1983. Adenovirus 2 locus codes for a 19kd tumor antigen that plays an essential role in cell transformation. Cell 33:759–766.
  • D'Halluin, J. C., C. Allart, C. Cousin, P. A. Boulanger, and G. Martin. 1979. Adenovirus early function required for the protection of viral and cellular DNA. J. Virol. 32:61–71.
  • Dunn, A. R., M. B. Mathews, L. R. Chow, J. Sambrook, and W. Keller. 1978. A supplementary adenoviral leader sequence and its role in messenger translation. Cell 15:511–526.
  • Esche, H., M. B. Mathews, and J. B. Lewis. 1980. Proteins and messenger RNAs of the transforming region of wild-type and mutant adenoviruses. J. Mol. Biol. 142:399–417.
  • Ezoe, H., R. B. Lai Fatt, and S. Mak. 1981. Degradation of intracellular DNA in KB cells infected with cyt mutants of human adenovirus type 12. J. Virol. 40:20–27.
  • Ferguson, B., N. Jones, J. Richler, and M. Rosenberg. 1984. Adenovirus Ela gene product expressed a high level in Escherichia coli is functional. Science 224:1343–1346.
  • Fukui, Y., I. Saito, K. Shiroki, and H. Shimojo. 1984. Isolation of transformation-defective, replication-nondefective early region 1B mutants of adenovirus 12. J. Virol. 49:154–161.
  • Gaynor, R. B., D. Hillman, and A. J. Berk. 1984. Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection. Proc. Natl. Acad. Sci. USA 81:1193–1197.
  • Graham, F. L., J. Smiley, W. C. Russell, and R. Nairu. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59–77.
  • Green, M., K. H. Brackmann, L. A. Lucher, J. S. Symington, and T. A. Kramer. 1983. Human adenovirus 2 Elb-19K and E1B-53K tumor antigens: antipeptide antibodies targeted to the NH2 and COOH termini. J. Virol. 48:604–615.
  • Greenberg, M. E., and E. B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature London) 311:433–438.
  • Groudine, M., M. Peretz, and H. Weintraub. 1981. Transcriptional regulation of hemoglobin switching in chicken embryos. Mol. Cell. Biol. 1:281–288.
  • Hancock, R. 1982. Topological organization of interphase DNA: the nuclear matrix and other skeletal structures. Biol. Cell. 46:105–122.
  • Hayflick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:614–636.
  • Hayflick, L., and P. S. Moorhead. 1961. The serial cultivation of human diploid cells strains. Exp. Cell Res. 25:585–621.
  • Hearing, P., and T. Shenk. 1985. Sequence-independent autoregulation of the adenovirus type 5 E1A transcription unit. Mol. Cell. Biol. 5:3214–3221.
  • Hirt, B. 1967. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:365–369.
  • Houweling, A., P. J. van den Elsen, and A. J. van der Eb. 1980. Partial transformation of primary rat cells by the left-most 4.5% fragment of adenovirus 5 DNA. Virology 105:537–550.
  • Imperiale, M. J., H. Kao, L. T. Feldman, J. R. Nevins, and S. Strickland. 1984. Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol. Cell. Biol. 4:867–874.
  • Jackson, D. A., and S. B. Patel. 1982. Nuclear organization— does the sub-structure play a crucial role? Trends Biochem. Sci. 7:272–274.
  • Jones, N., and T. Shenk. 1979. An adenovirus type 5 early gene function regulates expression of other early viral genes. Proc. Natl. Acad. Sci. USA 76:3665–3669.
  • Kao, H., and J. R. Nevins. 1983. Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection. Mol. Cell. Biol. 3:2058–2065.
  • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–686.
  • Lai Fatt, R. B., and S. Mak. 1982. Mapping of an adenovirus function involved in the inhibition of DNA degradation. J. Virol. 42:969–977.
  • Leff, T., R. Elkaim, C. R. Goding, P. Jalinot, P. Sassone-Corsi, M. Perricaudet, C. Kedinger, and P. Chambon. 1984. Individual products of the adenovirus 12S and 13S E1A mRNAs stimulate viral EII and EIII expression at the transcriptional level. Proc. Natl. Acad. Sci. USA 81:4381–4385.
  • Logan, J., S. Pilder, and T. Shenk. 1984. Functional analysis of adenovirus type-5 early region 1B. Cancer Cells 2:527–532.
  • Lupkes, J. H., A. Dasis, H. Jochemsen, and A. J. van der Eb. 1981. In vitro synthesis of adenovirus type 5 antigens. I. Translation of early region 1-specific RNA from lytically infected cells. J. Virol. 37:524–529.
  • Montell, C., E. F. Fisher, M. H. Caruthers, and A. J. Berk. 1982. Resolving the functions of overlapping viral genes by site specific mutagenesis at a mRNA splice site. Nature (London) 295:380–384.
  • Montell, C., E. F. Fisher, M. H. Caruthers, and A. J. Berk. 1984. Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites. Mol. Cell. Biol. 4:966–972.
  • Nevins, J. R. 1981. Mechanism of activation of early viral transcription by the adenovirus E1A gene product. Cell 26:213–220.
  • Osborne, T. F., D. N. Arvidson, E. S. Tyau, M. Dunsworth-Brone, and A. J. Berk. 1984. Transcriptional control region within the protein-coding portion of adenovirus E1A genes. Mol. Cell. Biol. 4:1293–1305.
  • Osborne, T. F., R. G. Gaynor, and A. J. Berk. 1982. The TATA homology and the mRNA 5′ untranslated sequence are not required for expression of essential adenovirus E1A functions. Cell 29:139–148.
  • Pelham, H. R. B., and R. J. Jackson. 1976. An efficient mRNA- dependent translation system from reticulocyte lysates. Eur. J. Biochem. 67:247–256.
  • Persson, H., M. G. Katze, and L. Philipson. 1982. Purification of a native membrane-associated adenovirus tumor antigen. J. Virol. 42:905–917.
  • Pilder, S., J. Logan, and T. Shenk. 1984. Deletion of the gene encoding the adenovirus 5 early region 1B 21,000-molecular- weight polypeptide leads to degradation of viral and cellular DNA. J. Virol. 52:664–671.
  • Pilder, S., M. Moore, J. Logan, and T. Shenk. 1986. The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol. Cell. Biol. 6:470–476.
  • Ricciardi, R. P., R. L. Jones, C. L. Cepko, P. A. Sharp, and B. E. Roberts. 1981. Expression of early adenovirus genes requires a viral encoded acidic polypeptide. Proc. Natl. Acad. Sci. USA 78:6121–6125.
  • Rigby, P. W. J., M. Dieckmann, C. Rhodes, and P. Berg. 1977. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol. 113:237–251.
  • Ruley, H. E. 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (London) 304:602–606.
  • Sharp, P. A. 1984. Adenovirus transcription, p. 173–204. H. S. Ginsberg (ed.), The adenoviruses. Plenum Publishing Corp., New York.
  • Shiroki, K., K. Ohshima, Y. Iukui, and H. Ariga. 1986. The adenovirus type 12 early-region 1B 58,000 Mr gene product is required for viral DNA synthesis and for initiation of cell transformation. J. Virol. 57:792–801.
  • Spector, D. J., M. McGrogan, H. J. Raskas. 1978. Regulation of the appearance of cytoplasmic RNAs from region 1 of the adenovirus 2 genome. J. Mol. Biol. 126:395–414.
  • Spindler, K. R., D. S. E. Rosser, and A. J. Berk. 1984. Analysis of adenovirus transforming proteins from early regions 1A and IB with antisera to inducible fusion antigens produced in Escherichia coli cells. J. Virol. 49:132–141.
  • Stein, R., and E. B. Ziff. 1984. HeLa cell β-tubulin gene transcription is stimulated by adenovirus 5 in parallel with viral early genes by an Ela-dependent mechanism. Mol. Cell. Biol. 4:2792–2801.
  • Stillman, B. W. 1983. The replication of adenovirus DNA. UCLA Symp. Mol. Cell. Biol. 10:381–393.
  • Subramanian, T., M. Kuppuswamy, J. Gysbers, S. Mak, and G. Chinnadurai. 1984. 19-kDa tumor antigen coded by early region Elb of adenovirus 2 is required for efficient synthesis and for protection of viral DNA. J. Biol. Chem. 259:11777–11783.
  • Subramanian, T., M. Kuppuswamy, S. Mak, and G. Chinnadurai. 1984. Adenovirus cyt+ locus, which controls cell transformation and tumorigenicity, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen. J. Virol. 52:336–343.
  • Svensson, C., and G. Akusjarvi. 1984. Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes. EMBO J. 3:789–794.
  • Takemori, N., C. Cladaras, B. Bhat, A. J. Conley, and W. S. M. Wold. 1984. cyt gene of adenovirus 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptide. J. Virol. 52:793–805.
  • Takemori, N., J. L. Riggs, and C. Aldrich. 1968. Genetic studies with tumorigenic adenoviruses. I. Isolation of cytocidal (cyt) mutants of adenovirus type 12. Virology 36:575–586.
  • Takemori, N., J. L. Riggs, and C. D. Aldrich. 1969. Genetic studies with tumorigenic adenoviruses. II. Heterogeneity of cyt mutants of adenovirus type 12. Virology 38:8–15.
  • White, E., S. H. Blose, and B. W. Stillman. 1984. Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA. Mol. Cell. Biol. 4:2865–2875.
  • White, E., T. Grodzicker, and B. W. Stillman. 1984. Mutations in the gene encoding the adenovirus E1B 19K tumor antigen cause degradation of chromosomal DNA. J. Virol. 52:410–419.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.