Mating Type-Like Conversion Promoted by the 2μm Circle Site-Specific Recombinase: Implications for the Double-Strand-Gap Repair Model

LITERATURE CITED

• Andrews, B. J., G. A. Protean, L. G. Beatty, and P. D. Sadowski. 1985. The FLP recombinase of the 2 micron circle DNA of yeast: interaction with target sequences. Cell 40:796–803.
   Google Scholar
• Beggs, D. 1978. Transformation of yeast by a replicating hybrid plasmid. Nature (London) 275:104–109.
   PubMed Web of Science ®Google Scholar
• Broach, J. R., V. R. Guarascio, and M. Jayaram. 1982. Recombination within the 2 micron circle is site-specific. Cell 29:227–234.
   PubMed Web of Science ®Google Scholar
• Cryer, D. R., R. Eccleshall, and J. Marmur. 1975. Isolation of yeast DNA. Methods Cell Biol. 12:39–44.
   PubMedGoogle Scholar
• Game, J. C., T. J. Zamb, R. J. Braun, M. Resnick, and R. M. Roth. 1980. The role of radiation (rad) genes in meiotic recombination in yeast. Genetics 106:207–226.
   Google Scholar
• Gronostajski, R. M., and P. D. Sadowski. 1985. Determination of DNA sequences essential for FLP-mediated recombination by a novel method. J. Biol. Chem. 260:12320–12327.
   PubMedGoogle Scholar
• Hartley, J. L., and J. E. Donelson. 1980. Nucleotide sequence of the yeast plasmid. Nature (London) 286:860–864.
   PubMed Web of Science ®Google Scholar
• Hawthorne, D. C. 1963. A deletion in yeast and its bearing on the structure of the mating type locus. Genetics 48:1727–1729.
   PubMedGoogle Scholar
• Holliday, R. 1964. A mechanism of recombination in fungi. Genet. Res. 5:282–304.
   Web of Science ®Google Scholar
• Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163–168.
   PubMed Web of Science ®Google Scholar
• Jackson, J. A., and G. R. Fink. 1981. Gene conversion between duplicated genetic elements in yeast. Nature (London) 292:206–211.
   Google Scholar
• Jayaram, M. 1985. Two micrometer circle site-specific recombination: the minimal substrate and the possible role of flanking sequences. Proc. Natl. Acad. Sci. USA 82:5875–5879.
   PubMedGoogle Scholar
• Jayaram, M., and J. R. Broach. 1983. Yeast plasmid 2 micron circle promotes recombination within bacterial transposon Tn5. Proc. Natl. Acad. Sci. USA 80:7264–7268.
   PubMedGoogle Scholar
• Jayaram, M., Y. Y. Li, and J. R. Broach. 1983. The yeast plasmid 2 micron circle encodes components required for its high copy propagation. Cell 34:95–104.
   PubMed Web of Science ®Google Scholar
• Kikuchi, Y. 1983. Yeast plasmid requires a cis-acting locus and two plasmid proteins for its stable maintenance. Cell 35:487–493.
   PubMed Web of Science ®Google Scholar
• Klar, A. J. S., and J. N. Strathern. 1984. Resolution of recombination intermediates generated during yeast mating type switching. Nature (London) 310:744–748.
   PubMedGoogle Scholar
• Klein, H. L. 1984. Lack of association between intrachromo- somal gene conversion and reciprocal exchange. Nature (London) 310:748–753.
   PubMedGoogle Scholar
• Klein, H. L., and T. D. Petes. 1981. Intrachromosomal gene conversion in yeast. Nature (London) 289:144–148.
   PubMed Web of Science ®Google Scholar
• Kostriken, R., J. N. Strathern, A. J. S. Klar, J. B. Hicks, and F. Heffron. 1983. A site-specific endonuclease essential for mating type switching in Saccharomyces cerevisiae. Cell 35:167–174.
   PubMed Web of Science ®Google Scholar
• Malone, R., and R. E. Esposito. 1980. The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast. Proc. Natl. Acad. Sci. USA 77:503–507.
   PubMed Web of Science ®Google Scholar
• Mandel, M., and A. Higa. 1970. Calcium dependent bacteriophage DNA infection. J. Mol. Biol. 53:159–162.
   PubMed Web of Science ®Google Scholar
• Nasmyth, K. 1983. Molecular analysis of a cell lineage. Nature (London) 302:670–676.
   PubMed Web of Science ®Google Scholar
• Orr-Weaver, T. L., and J. W. Szostak. 1983. Yeast recombination: the association between double-strand gap repair and crossing over. Proc. Natl. Acad. Sci. USA 80:4417–4421.
   PubMed Web of Science ®Google Scholar
• Orr-Weaver, T. L., J. W. Szostak, and R. J. Rothstein. 1981. Yeast transformation: a model system for the study of recombination. Proc. Natl. Acad. Sci. USA 78:6354–6358.
   PubMed Web of Science ®Google Scholar
• Prakash, S., L. Prakash, W. Burke, and B. A. Montelone. 1980. Effects of the RAD52 gene on recombination in Saccharomyces cerevisiae. Genetics 94:31–50.
   PubMed Web of Science ®Google Scholar
• Resnick, M. A., and P. Martin. 1976. The repair of doublestrand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Mol. Gen. Genet. 143:119–129.
   PubMedGoogle Scholar
• Ruvkun, G. B., and F. M. Ausubel. 1981. A general method for site-directed mutagenesis in prokaryotes. Nature (London) 289:85–88.
   PubMed Web of Science ®Google Scholar
• Senecoff, J. F., R. C. Bruckner, and M. M. Cox. 1985. The FLP recombinase of the yeast 2μm plasmid: characterization of its recombination site. Proc. Natl. Acad. Sci. USA 82:7270–7274.
   PubMed Web of Science ®Google Scholar
• Sigurdson, D. C., M. E. Gaarder, and D. M. Livingston. 1981. Characterization of the transmission during cytoductant formation of the 2 micron DNA plasmid from Saccharomyces cerevisiae. Mol. Gen. Genet. 183:59–65.
   PubMedGoogle Scholar
• Southern, E. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
   PubMed Web of Science ®Google Scholar
• Strathern, J. N., A. J. S. Klar, J. B. Hicks, J. A. Abraham, J. M. Ivy, K. A. Nasmyth, and C. McGill. 1982. Homothallic switching of yeast mating type is mediated by a double-stranded cut in the MAT locus. Cell 31:183–192.
   PubMed Web of Science ®Google Scholar
• Strathern, J. N., C. S. Newlon, I. Herskowitz, and J. B. Hicks. 1979. Isolation of a circular chromosome. III. Implications for the mechanism of mating type interconversion. Cell 18:309–320.
   PubMedGoogle Scholar
• Szostak, J. W., T. L. Orr-Weaver, R. J. Rothstein, and F. W. Stahl. 1983. The double-strand-break repair model for recombination. Cell 33:25–35.
   PubMed Web of Science ®Google Scholar
• Weiffenbach, B., and J. Haber. 1981. Homothallic mating type switching generates lethal chromosome breaks in rad52 strains of Saccharomyces cerevisiae. Mol. Cell. Biol. 1:522–534.
   PubMed Web of Science ®Google Scholar