Activated K-ras and N-ras Oncogenes in Primary Renal Mesenchymal Tumors Induced in F344 Rats by Methyl(methoxymethyl)nitrosamine

LITERATURE CITED

• Balmain, A., and I. B. Pragnell. 1983. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature (London) 303:72–74.
   PubMed Web of Science ®Google Scholar
• Balmain, A., M. Ramsden, G. T. Bowden, and J. Smith. 1984. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature (London) 307:658–660.
   PubMed Web of Science ®Google Scholar
• Barbacid, M. 1986. Human oncogenes, p. 3–22. In V. T. de Vita, R. Hellman, and S. Rosenberg (ed.), Important advances in oncology. J. B. Lippincott Co., Philadelphia.
   Google Scholar
• Der, C., T. Krontiris, and G. Cooper. 1982. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc. Natl. Acad. Sci. USA 79:3637–3640.
   PubMed Web of Science ®Google Scholar
• Duesberg, P. H. 1985. Activated proto-onc genes: sufficient or necessary for cancer? Science 228:669–677.
   PubMed Web of Science ®Google Scholar
• Eiter, K., K. F. Hebenbrock, and H. J. Kabbe. 1972. Neve offenkettige and cyclische a -nitrosaminalkylather. Liebigs Ann. Chem. 765:55–77.
   Google Scholar
• Ellis, R. W., D. DeFeo, T. Shih, M. Gonda, H. A. Young, N. Tsuchida, D. Lowy, and E. M. Scolnick. 1981. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature (London) 292:506–511.
   PubMed Web of Science ®Google Scholar
• Fox, T. R., and P. G. Watanabe. 1985. Detection of cellular oncogene in spontaneous liver tumors of B6C3F1 mice. Science 228:596–597.
   PubMed Web of Science ®Google Scholar
• Guerrero, L., P. Calzada, A. Mayer, and A. Pellicer. 1984. A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc. Natl. Acad. Sci. USA 81:202–205.
   PubMed Web of Science ®Google Scholar
• Hard, G. C. 1979. Effect of age at treatment on incidence and type of renal neoplasm induced in the rat by a single dose of dimethyl nitrosamine. Cancer Res. 39:4965–4970.
   PubMedGoogle Scholar
• Kerr, I. B., and D. A. Spandidos. 1984. Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum. Br. J. Cancer 49:681–688.
   PubMedGoogle Scholar
• McGrath, J. P., D. J. Capon, D. H. Smith, E. Y. Chen, P. H. Seeburg, D. V. Goeddel, and A. D. Levinson. 1983. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature (London) 304:501–506.
   PubMed Web of Science ®Google Scholar
• Parada, L. F., C. J. Tabin, C. Shih, and R. A. Weinberg. 1982. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature (London) 297:474–478.
   PubMed Web of Science ®Google Scholar
• Pulciani, S., E. Santos, A. V. Lauver, L. K. Long, S. A. Aaronson, and M. Barbacid. 1982. Oncogenes in solid human tumors. Nature (London) 300:539–542.
   PubMed Web of Science ®Google Scholar
• Pulciani, S., E. Santos, A. V. Lauver, L. K. Long, K. C. Robbins, and M. Barbacid. 1982. Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc. Natl. Acad. Sci. USA 79:2845–2849.
   PubMed Web of Science ®Google Scholar
• Santos, E., S. R. Tronick, S. A. Aaronson, S. Pulciani, and M. Barbacid. 1982. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature (London) 298:343–347.
   PubMed Web of Science ®Google Scholar
• Schwab, M., K. Alitalo, H. E. Varmus, J. M. Bishop, and D. George. 1983. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumor cells. Nature (London) 303:497–501.
   PubMed Web of Science ®Google Scholar
• Shimizu, K., D. Birnbaum, M. A. Ruley, Y. Suard, L. Edlund, E. Taparowsky, M. Goldfarb, and M. Wigler. 1983. Structure of the Ki-ras gene of human lung carcinoma cell line Calu-1. Nature (London) 304:497–500.
   PubMed Web of Science ®Google Scholar
• Shimizu, K., M. Goldfarb, M. Perucho, and M. Wigler. 1983. Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc. Natl. Acad. Sci. USA 80:383–387.
   PubMed Web of Science ®Google Scholar
• Southern, E. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
   PubMed Web of Science ®Google Scholar
• Sukumar, S., V. Notario, D. Martin-Zanca, and M. Barbacid. 1983. Induction of mammary carcinomas in rats by nitrosomethylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature (London) 306:658–661.
   PubMed Web of Science ®Google Scholar
• Taparowsky, E., K. Shimizu, M. Goldfarb, and M. Wigler. 1983. Structure and activation of the human N-ras gene. Cell 34:581–586.
   PubMed Web of Science ®Google Scholar
• Varmus, H. E. 1984. The molecular genetics of cellular oncogenes. Annu. Rev. Genet. 18:553–612.
   PubMed Web of Science ®Google Scholar
• Zarbl, H., S. Sukumar, A. V. Arthur, D. Martin-Zanca, and M. Barbacid. 1985. Direct mutagenesis of H-ras-1 oncogenes by nitro-methyl-urea during initiation of mammary carcinogenesis in rats. Nature (London) 315:382–385.
   PubMed Web of Science ®Google Scholar