LITERATURE CITED
- Berk, A. J., and P. A. Sharp. 1978. Spliced early mRNAs of simian virus 40. Proc. Natl. Acad. Sci. USA 75:1274–1278.
- Bunzli, H. F., B. Glatthaar, P. Kunz, E. Mulhaupt, and R. E. Humbel. 1972. Amino acid sequence of the two insulins from mouse (Mus musculus). Hope-Seyler's Z. Physiol. Chem. 353:451–458.
- Edlund, T., M. D. Walker, P. J. Barr, and W. J. Rutter. 1985. Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′-flanking elements. Science 230:912–916.
- Gidoni, D., J. T. Kadonaga, H. Barrera-Saldana, K. Takahashi, P. Chambon, and R. Tjian. 1985. Bidirectional transcription mediated by tandem Spl binding interactions. Science 230:511–517.
- Hanahan, D. 1985. Heritable formation of pancreatic β-cell tumors in transgenic mice expressing recombinant insulin/sim- ian virus 40 oncogenes. Nature (London) 315:115–122.
- Harlow, E., L. V. Crawford, D. C. Pim, and N. M. Williamson. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39:861–869.
- Johnston, M., and R. W. Davis. 1984. Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cere-visiae. Mol. Cell. Biol. 4:1440–1448.
- Lehrach, H., D. Diamond, J. M. Wozney, and H. Boedtker. 1977. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 16:4743–4751.
- Lomedico, P., N. Rosenthal, A. Efstradiatis, W. Gilbert, R. Kolodner, and R. Tizard. 1979. The structure and evolution of the two nonallelic rat preproinsulin genes. Cell 18:545–558.
- Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning, a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- Ohlsson, H., and T. Edlund. 1986. Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell 45:35–44.
- Osley, M. A., J. Gould, S. Kim, M. Kane, and L. Hereford. 1986. Identification of sequences in a yeast histone promoter involved in periodic transcription. Cell 45:537–544.
- Soares, M. B., E. Schon, A. Henderson, S. K. Karathanasis, R. Cate, S. Zeitlin, J. Chirgwin, and A. Efstradiatis. 1985. RNA- mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol. Cell. Biol. 5:2090–2103.
- Steiner, D. F., S. J. Chan, J. M. Welsh, and S. C. M. Kwok. 1985. Structure and evolution of the insulin gene. Annu. Rev. Genet. 19:463–484.
- Steiner, D. F., J. L. Clark, C. Nolan, A. H. Rubenstein, E. Margoliash, B. Aten, and P. E. Oyer. 1969. Proinsulin and the biosynthesis of insulin. Rec. Prog. Horm. Res. 25:207–268.
- Thomas, P. S. 1980. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77:5201–5205.
- Vigneron, M., H. A. Barrera-Saldana, D. Baty, R. E. Everett, and P. Chambon. 1984. Effect of the 21-bp repeat upstream element on in vitro transcription from the early and late SV40 promoters. EMBO J. 3:2373–2382.
- Walker, M. D., T. Edlund, A. M. Boulet, and W. J. Rutter. 1983. Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature (London) 306:557–561.