The int-1 Proto-Oncogene Products Are Glycoproteins That Appear To Enter the Secretory Pathway

LITERATURE CITED

• Bohlen, P., F. Esch, A. Baird, and P. Gospodarowicz. 1985. Acidic fibroblast growth factor (FGF) from bovine brain: aminoterminal sequence and comparison with basic FGF. EMBO J. 8:1951–1956.
   Google Scholar
• Brown, A. M. C., J. Papkoff, Y.-K. T. Fung, G. M. Shackleford, and H. E. Varmus. 1987. Identification of protein products encoded by the proto-oncogene int-1. Mol. Cell. Biol. 7:3971–3977.
   PubMed Web of Science ®Google Scholar
• Brown, A. M. C., R. S. Wildin, T. J. Prendergast, and H. E. Varmus. 1986. A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell 46:1001–1009.
   PubMed Web of Science ®Google Scholar
• Cooper, J. A., and T. Hunter. 1982. Discrete primarylocations of a tyrosine protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts. J. Cell Biol. 94:287–296.
   PubMedGoogle Scholar
• Dickson, C., and G. Peters. 1987. Potential oncogene products related to growth factors. Nature (London) 326:833.
   PubMed Web of Science ®Google Scholar
• Fan, H., and M. Paskind. 1974. Measurement of the sequence complexity of cloned Moloney murine leukemia virus 60 to 70S RNA: evidence for a haploid genome. J. Virol. 14:421–429.
   PubMedGoogle Scholar
• Fung, Y.-K. T., G. M. Shackleford, A. M. C. Brown, G.S. Sanders, and H. E. Varmus. 1985. Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene. Mol. Cell. Biol. 5:3337–3344.
   PubMed Web of Science ®Google Scholar
• Gilmore, R., and G. Blobel. 1985. Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants. Cell 42:497–505.
   PubMedGoogle Scholar
• Gospodarowicz, D., J. Cheng, Q.-M. Lui, A. Baird, and P. Bohlen. 1984. Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor. Proc. Natl. Acad. Sci. USA 81: 6963–6967.
   PubMed Web of Science ®Google Scholar
• Heldin, C.-H., and B. Westermark. 1984. Growth factors: mechanism of action and relation to oncogenes. Cell 37:9–20.
   PubMed Web of Science ®Google Scholar
• Hubbard, S. C., and R. J. Ivatt. 1981. Synthesis and processing of asparagine linked oligosaccharides. Annu. Rev. Biochem. 50:555–583.
   PubMed Web of Science ®Google Scholar
• Jakobovits, A., G. M. Shackleford, H. E. Varmus, and G. R. Martin. 1986. Two proto-oncogenes implicated in mammary tumorigenesis, int-1 and int-2, are independently regulated during mouse development. Proc. Natl. Acad. Sci. USA 83:7806–7810.
   PubMedGoogle Scholar
• Lang, R. A., D. Metcalf, N. M. Gough, A. R. Dunn, and T. J. Gonda. 1985. Expression of a hemopoietic growth factor cDNA in a factor dependent cell line results in autonomous growth and tumorigenicity. Cell 43:531–542.
   PubMed Web of Science ®Google Scholar
• Mester, J., E. Wa,genaar, M. Sluyser, and R. Nusse. 1987. Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and independent mammary tumors of GR mice. J. Virol. 61:1073–1078.
   PubMedGoogle Scholar
• Moore, R., G. Casey, S. Brookes, M. Dixon, G. Peters, and C. Dickson. 1986. Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumor virus. EMBO J. 5:919–924.
   PubMed Web of Science ®Google Scholar
• Morata, G., and P. A. Lawrence. 1977. The development of wingless, a homeotic mutation of Drosophila. Dev. Biol. 56:227–240.
   PubMedGoogle Scholar
• Munro, S., and H. R. B. Pelham. 1987. A C-terminal signal prevents secretion of lumenal FER proteins. Cell 48:899–907.
   PubMed Web of Science ®Google Scholar
• Nusse, R., A. van Ooyen, D. Cox, Y. K. Fung, and H. E. Varmus. 1984. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 5. Nature (London) 307:131–136.
   PubMed Web of Science ®Google Scholar
• Nusse, R., and H. E. Varmus. 1982. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31:99–109.
   PubMed Web of Science ®Google Scholar
• Papkoff, J., E. A. Nigg, and T. Hunter. 1983. The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein. Cell 33:161–172.
   PubMedGoogle Scholar
• Peters, G., A. E. Lee, and C. Dickson. 1986. Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumor virus. Nature (London) 320:628–630.
   PubMedGoogle Scholar
• Rijsewijk, F., M. Schuermann, E. Wagenaar, P. Parren, D. Weigel, and R. Nusse. 1987. The Drosophila homologue of the mouse mammary oncogene int-1 is identical to the segment polarity gene Wingless. Cell 50:649–657.
   PubMed Web of Science ®Google Scholar
• Robbins, K. C., F. Leal, J. H. Pierce, and S. A. Aaronson. 1985. The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein. EMBO J. 4:1783–1792.
   PubMed Web of Science ®Google Scholar
• Robbins, P. W., S. C. Hubbard, S. J. Turco, and D. F. Wirth. 1977. Proposal for a common oligosaccharide intermediate in the synthesis of membrane glycoproteins. Cell 12:893–900.
   PubMed Web of Science ®Google Scholar
• Roberts, A. B., M. A. Anzano, L. M. Wakefield, N. S. Roche, D. F. Stern, and M. B. Sporn. 1985. Type β transforming growth factor: a bifunctional regulator of cellular growth. Proc. Natl. Acad. Sci. USA 82:119–123.
   PubMed Web of Science ®Google Scholar
• Rosenthal, A., P. B. Lindquist, T. S. Bringman, D. V. Goeddel, and R. Derynick. 1986. Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation. Cell 46:301–309.
   PubMed Web of Science ®Google Scholar
• Sabatini, D. D., G. Kreibich, T. Morimoto, and M. Adesnik. 1982. Mechanisms for the incorporation of proteins in membranes and organelles. J. Cell Biol. 92:1–22.
   PubMed Web of Science ®Google Scholar
• Shackleford, G. M., and H. E. Varmus. 1987. Expression of the proto-oncogene, int-1, is restricted to postmeiotic male germ cells and the neural tube of midgestational embryos. Cell 50:89–95.
   PubMedGoogle Scholar
• Shih, T. Y., M. O. Weeks, P. Gruss, R. Dhar, S. Oroszlan, and E. M. Scolnick. 1982. Identification of a precursor in the biosynthesis of the p21 transforming protein of Harvey murine sarcoma virus. J. Virol. 42:256–261.
   Google Scholar
• Shinnick, T. M., R. A. Lerner, and J. G. Sutcliffe. 1981. Nucleotide sequence of Moloney murine leukemia virus. Nature (London) 293:543–548.
   PubMed Web of Science ®Google Scholar
• Sibley, D. R., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. 1987. Regulation of transmembrane signaling by receptor phosphorylation. Cell 48:913–922.
   PubMed Web of Science ®Google Scholar
• Steck, T. L., and J. Wu. 1973. Selective solubilization of proteins from red blood cell membranes by protein perturbants. J. Supramol. Struct. 1:220–248.
   PubMedGoogle Scholar
• Tarantino, A. L., G. M. Gomez, and T. H. Plummer. 1985. Deglycosylation of asparagine-linked glycans by peptide: N glycosidase F. Biochemistry 24:4665–4671.
   PubMedGoogle Scholar
• van Ooyen, A., and R. Nusse. 1984. Structure and nucleotide sequence of the putative mammary oncogene int-1: proviral insertions leave the protein-encoding domain intact. Cell 39:233–240.
   PubMed Web of Science ®Google Scholar
• Varmus, H. E. 1987. Cellular and viral oncogenes, p. 271–346. In G. Stamatoyannopoulos, A. W. Nienhuis, P. Leder, and P. W. Majerus (ed.). Molecular basis of blood diseases. The W. B. Saunders Co., Philadelphia.
   Google Scholar
• Wickner, W. T., and H. F. Lodish. 1985. Multiple mechanisms of protein insertion into and across membranes. Science 230:400–407.
   PubMed Web of Science ®Google Scholar
• Wilkinson, D. G., J. A. Bailes, and A. P. McMahon. 1987. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50:79–88.
   PubMed Web of Science ®Google Scholar
• Witte, O. N. 1977. Cellular maturation of oncornavirus glycoproteins: topological arrangement of precursor and product forms in cellular membranes. Virology 76:539–553.
   PubMedGoogle Scholar