A Mup Promoter-Thymidine Kinase Reporter Gene Shows Relaxed Tissue-Specific Expression and Confers Male Sterility upon Transgenic Mice

Literature Cited

• Behringer, R. R., R. E. Hammer, R. L. Brinster, R. D. Palmiter, and T. M. Townes. 1987. Two 3′ sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc. Natl. Acad. Sci. USA 84:7056-7060.
   PubMed Web of Science ®Google Scholar
• Behringer, R. R., J. J. Peschon, A. Messing, C. L. Gartside, S. D. Hauschka, R. D. Palmiter, and R. L. Brinster. 1988. Heart and bone tumors in transgenic mice. Proc. Natl. Acad. Sci. USA 85:2648-2652.
   PubMed Web of Science ®Google Scholar
• Bishop, J. O., A. J. Clark, P. M. Clissold, S. Hainey, and U. Francke. 1982. Two main groups of mouse major urinary protein genes, both largely located on chromosome 4. EMBO J. 1:615-620.
   PubMedGoogle Scholar
• Botteri, F. M., H. van der Putten, D. F. Wong, C. A. Sauvage, and R. M. Evans. 1987. Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. Mol. Cell. Biol. 7:3178-3184.
   PubMedGoogle Scholar
• Bradford, M. 1976. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
   PubMed Web of Science ®Google Scholar
• Brinster, R. L., Y. H. Chen, and M. Trumbauer. 1981. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27:223-231.
   PubMed Web of Science ®Google Scholar
• Cato, A. C. B., D. Henderson, and H. Ponta. 1987. The hormone responsive element of the mouse mammary tumor virus DNA mediates the progestin and androgen induction of transcription in the pro viral long terminal region. EMBO J. 6:363-368.
   PubMedGoogle Scholar
• Cheng, Y.-C., and M. Ostrander. 1976. Deoxythymidine kinase induced in HeLa TK" cells by HSV type I and type II. J. Biol. Chem. 251:2605-2610.
   PubMedGoogle Scholar
• Chirgwin, J. M., A. E. Przybyla, R. J. Macdonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
   PubMed Web of Science ®Google Scholar
• Clark, A. J., A. Chave-Cox, X. Ma, and J. O. Bishop. 1985. Analysis of mouse major urinary protein genes: variation between the exonic sequences of Group 1 genes and a comparison with an active gene outwith Group 1 both suggest that gene conversion has occurred between MUP genes. EMBO J. 4:3167-3171.
   PubMedGoogle Scholar
• Clark, A. J., P. M. Clissold, R. Al-Shawi, P. Beattie, and J. O. Bishop. 1984. Structure of mouse major urinary protein genes: different splicing configurations in the 3′-non-coding region. EMBO J. 3:1045-1052.
   PubMedGoogle Scholar
• Clark, A. J., P. M. Clissold, and J. O. Bishop. 1982. Variation between mouse major urinary protein genes isolated from a single inbred line. Gene 18:221-230.
   PubMedGoogle Scholar
• Clark, A. J., P. Ghazal, R. W. Bingham, D. Barrett, and J. O. Bishop. 1985. Sequence structures of a mouse major urinary protein gene and pseudogene compared. EMBO J. 4:3159-3165.
   PubMedGoogle Scholar
• Clissold, P. M., S. Hainey, and J. O. Bishop. 1984. Messenger RNAs coding for mouse major urinary proteins are differentially induced by testosterone. Biochem. Genet. 22:379-387.
   PubMedGoogle Scholar
• Dabre, P., M. Page, and R. J. B. King. 1986. Androgen regulation by the long terminal repeat of mouse mammary tumor virus. Mol. Cell. Biol. 6:2847-2854.
   PubMedGoogle Scholar
• da Costa Soares, V., R. M. Gubits, P. Feigelson, and F. Costantini. 1987. Tissue-specific and hormonally regulated expression of a rat a2u-globulin gene in transgenic mice. Mol. Cell. Biol. 7:3749-3758.
   PubMedGoogle Scholar
• Davis, B. P., and R. J. MacDonald. 1988. Limited transcription of rat elastase I transgene repeats in transgenic mice. Genes Dev. 2:13-22.
   PubMedGoogle Scholar
• Derman, E. 1981. Isolation of a cDNA clone for mouse urinary proteins: age- and sex-related expression of mouse urinary protein genes is transcriptionally controlled. Proc. Natl. Acad. Sci. USA 78:5425-5429.
   PubMedGoogle Scholar
• Goldfarb, M., K. Shimizu, M. Perucho, and M. Wigler. 1982. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature (London) 296:404-409.
   PubMed Web of Science ®Google Scholar
• Gordon, J. W. 1986. A foreign dihydrofolate reductase gene in transgenic mice acts as a dominant mutation. Mol. Cell. Biol. 6:2158-2167.
   PubMedGoogle Scholar
• Gordon, K., E. Lee, J. A. Vitale, A. E. Smith, H. Westphal, and L. Hennighausen. 1987. Production of human tissue plasminogen activator in transgenic mouse milk. Bio/Technology 5:1183-1187.
   Google Scholar
• Hanahan, D. 1985. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/ simian virus 40 oncogenes. Nature (London) 315:115-122.
   PubMed Web of Science ®Google Scholar
• Hastie, N. D., W. A. Held, and J. J. Toole. 1979. Multiple genes coding for the androgen-regulated major urinary proteins of the mouse. Cell 17:449-457.
   PubMedGoogle Scholar
• Held, W. A., and J. F. Gallagher. 1985. Rat alpha-2u globulin mRNA expression in the preputial gland. Biochem. Genet. 32:281-290.
   Google Scholar
• Held, W. A., J. F. Gallagher, C. M. Hohman, N. J. Kuhn, B. M. Sampsell, and R. G. Hughes, Jr. 1987. Identification and characterization of functional genes encoding the mouse major urinary proteins. Mol. Cell. Biol. 7:3705-3712.
   PubMedGoogle Scholar
• Hofbauer, R., E. Muellner, C. Seiser, and E. Wintersberger. 1987. Cell cycle regulated synthesis of stable mouse thymidine kinase mRNA is mediated by a sequence within the cDNA. Nucleic Acids Res. 15:741-752.
   PubMedGoogle Scholar
• Hogan, B. L., F. Costantini, and E. Lacy. 1986. Manipulating the mouse embryo. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Jamieson, A. T., G. A. Gentry, and J. A. Subak-Sharpe. 1974. Induction of both thymidine and deoxycytidine kinase activity by herpes virus. J. Gen. Virol. 24:465-480.
   PubMedGoogle Scholar
• Jamieson, A. T., and J. H. Subak-Sharpe. 1974. Biochemical studies on the herpes simplex virus specified deoxypyrimidine kinase activity. J. Gen. Virol. 24:481-492.
   PubMedGoogle Scholar
• Kelley, W. N. 1983. Hereditary orotic aciduria, p. 1202-1226. In J. B. Stanbury, J. B. Wyngarden, D. S. Fredrickson, J. L. Goldstein, and M. S. Brown (ed.), The metabolic basis of inherited disease. McGraw-Hill, New York.
   Google Scholar
• Kieney, M. P., R. Lathe, and J. P. Lecoq. 1983. New versatile cloning and sequencing vectors based on bacteriophage M13. Gene 26:91-99.
   PubMedGoogle Scholar
• Kiessling, U., K. Becker, M. Strauss, J. Schoeneich, and E. Giessler. 1986. Rescue of a tk- plasmid from transgenic mice reveals its episomal transmission. Mol. Gen. Genet. 204:328-333.
   PubMedGoogle Scholar
• Knopf, J. L., J. F. Gallagher, and W. A. Held. 1983. Differential multihormonal regulation of the mouse urinary protein gene family in the liver. Mol. Cell. Biol. 3:2232-2240.
   PubMedGoogle Scholar
• Krumlauf, R., R. E. Hammer, S. M. Tilghman, and R. L. Brinster. 1985. Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol. Cell. Biol. 5:1639-1648.
   PubMedGoogle Scholar
• Kuhn, N. J., M. Woodworth-Gutai, K. W. Gross, and W. A. Held. 1984. Subfamilies of the mouse major urinary protein (MUP) multi-gene family: sequence analysis of cDNA clones and differential regulation. Nucleic Acids Res. 12:6073-6090.
   PubMedGoogle Scholar
• Kurtz, D. T., and P. Feigelson. 1978. Multihormonal control of the messenger RNA for the hepatic protein alpha-2u-globulin, p. 433-455. In G. Litvak (ed.), Biochemical actions of hormones, vol. 5. Academic Press, Inc., New York.
   Google Scholar
• Laperche, Y., K. R. Lynch, K. P. Dolan, and P. Feigelson. 1983. Tissue-specific control of alpha2u-globulin gene expression: constitutive synthesis in the submaxillary gland. Cell 32:453-460.
   PubMedGoogle Scholar
• Low, M. J., R. M. Lechan, R. E. Hammer, R. L. Brinster, J. F. Habener, G. Mandel, and R. H. Goodman. 1986. Gonadotrophspecific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science 231:1002-1004.
   PubMedGoogle Scholar
• Maclnnes, J. L., E. S. Nozik, and D. T. Kurtz. 1986. Tissuespecific expression of the rat alpha2u globulin gene family. Mol. Cell. Biol. 6:3563-3567.
   PubMedGoogle Scholar
• Magram, J., K. Chada, and F. Costantini. 1985. Developmental regulation of an adult beta-globin gene in transgenic mice. Nature (London) 315:338-340.
   PubMed Web of Science ®Google Scholar
• Merrill, G. F., S. D. Hauschka, and S. L. McKnight. 1984. tk enzyme expression in differentiating muscle cells is regulated through an internal segment of the cellular tk gene. Mol. Cell. Biol. 4:1777-1784.
   PubMedGoogle Scholar
• Messing, A., H. Y. Chen, R. D. Palmiter, and R. L. Brinster. 1983. Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice. Nature (London) 316:461-463.
   Google Scholar
• Mulligan, R. C., and P. Berg. 1980. Expression of a bacterial gene in mammalian cells. Science 209:1422-1427.
   PubMed Web of Science ®Google Scholar
• Overbeek, P. A., S.-P. Lai, K. R. Van Quill, and H. Westphal. 1986. Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences. Science 231:1574-1576.
   PubMed Web of Science ®Google Scholar
• Palmiter, R. D., and R. L. Brinster. 1986. Transgenic mice. Annu. Rev. Genet. 20:465-499.
   PubMed Web of Science ®Google Scholar
• Peschon, J. J., R. R. Behringer, R. L. Brinster, and R. D. Palmiter. 1987. Spermatid-specific expression of protamine 1 in transgenic mice. Proc. Natl. Acad. Sci. USA 84:5316-5319.
   PubMedGoogle Scholar
• Roberts, J. M., and R. Axel. 1982. Gene amplification and gene correction in somatic cells. Cell 29:109-119.
   PubMed Web of Science ®Google Scholar
• Ross, S. R., and D. Solter. 1985. Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice. Proc. Natl. Acad. Sci. USA 82:5880-5884.
   PubMedGoogle Scholar
• Seed, B. 1983. Purification of genomic sequences from bacteriophage libraries by recombination and selection in vivo. Nucleic Acids Res. 11:2427-2445.
   PubMedGoogle Scholar
• Shahan, K., M. Denaro, M. Gilmartin, Y. Shi, and E. Derman. 1987. Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver. Mol. Cell. Biol. 7:1947-1954.
   PubMedGoogle Scholar
• Shahan, K., M. Gilmartin, and E. Derman. 1987. Nucleotide sequences of liver, lachrymal, and submaxillary gland mouse major urinary protein mRNAs: mosaic structure and construction of panels of gene-specific synthetic oligonucleotide probes. Mol. Cell. Biol. 7:1938-1946.
   PubMedGoogle Scholar
• Shaw, P. H., W. A. Held, and N. D. Hastie. 1983. The gene family for major urinary proteins: expression in several secretory tissues of the mouse. Cell 32:755-761.
   PubMed Web of Science ®Google Scholar
• Simons, J. P., I. Wilmut, A. J. Clark, A. L. Archibald, J. O. Bishop, and R. Lathe. 1988. Gene transfer into sheep. Bio/ Technology 6:179-183.
   Google Scholar
• Spiegelberg, T., and J. O. Bishop. 1988. Tissue-specific gene expression in mouse hepatocytes cultured in growth-restricting medium. Mol. Cell. Biol. 8:3338-3344.
   PubMedGoogle Scholar
• Stubblefield, E., and G. C. Mueller. 1965. Thymidine kinase activity in synchronised HeLa cells. Biochem. Biophys. Res. Commun. 20:535-538.
   PubMedGoogle Scholar
• Swanson, L. W., D. M. Simmons, J. Arriza, R. Hammer, R. Brinster, M. G. Rosenfeld, and R. M. Evans. 1985. Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes. Nature (London) 31:363-366.
   Google Scholar
• Swift, G. H., R. E. Hammer, R. J. MacDonald, and R. L. Brinster. 1984. Tissue-specific expression of the rat pancreatic elastase 1 gene in transgenic mice. Cell 38:639-646.
   PubMed Web of Science ®Google Scholar
• Szoka, P., and K. Paigen. 1978. Regulation of mouse major urinary protein production by the Mup-a gene. Genetics 90:597-612.
   PubMedGoogle Scholar
• Wilkie, N. M., J. B. Clements, W. Boll, N. Mantei, D. Lonsdale, and C. Weissmann. 1979. Hybrid plasmids containing an active thymidine kinase gene of herpes simplex virus type I. Nucleic Acids Res. 7:859-877.
   PubMedGoogle Scholar
• Willison, K., and A. Ashworth. 1987. Mammalian spermatogenic gene expression. Trends Genet. 12:351-355.
   Google Scholar
• Yamamoto, K. R. 1985. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:209-252.
   PubMed Web of Science ®Google Scholar