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Research Article

Alpha-Cell-Specific Expression of the Glucagon Gene Is Conferred to the Glucagon Promoter Element by the Interactions of DNA-Binding Proteins

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Pages 4877-4888 | Received 16 May 1988, Accepted 23 Aug 1988, Published online: 31 Mar 2023

Literature Cited

  • Alpert, S., D. Hanahan, and G. Teitelman. 1988. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cells 53:295-308.
  • Becker, P. B., S. Ruppert, and G. Schutz. 1987. Genomic footprinting reveals cell-type specific DNA binding of ubiquitous factors. Cell 51:435-443.
  • Cereghini, S., M. Raymondjean, A. G. Carranca, P. Herbomel, and M. Yaniv. 1987. Factors involved in control of tissuespecific expression of the albumin gene. Cell 50:627-638.
  • Choi, O. R., and J. D. Engel. 1986. A 3′ enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult p-globin gene. Nature (London) 323:731-734.
  • DeSimone, V., G. Ciliberto, E. Hardon, G. Paonessa, F. Palla, L. Lundberg, and R. Cortese. 1987. Cis- and trans-acting elements responsible for the cell-specific expression of the human a- antitrypsin gene. EMBO J. 9:2759-2766.
  • Deutsch, P. J., J. L. Jameson, and J. F. Habener. 1987. Cyclic AMP responsiveness of human gonadotropin-a gene transcription is directed by a repeated 18-base pair enhancer. J. Biol. Chem. 262:12169-12174.
  • Drucker, D. J., J. Philippe, L. Jepeal, and J. F. Habener. 1987. Glucagon gene 5′-flanking sequences promote islet cell-specific gene transcription. J. Biol. Chem. 262:15659-15665.
  • Dynan, W. S., and R. Tjian. 1985. Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins. Nature (London) 316:774-778.
  • Edlund, T., M. D. Walker, P. J. Barr, and W. J. Rutter. 1985. Cell-specific expression of the rat insulin gene, evidence for role of two distinct 5′-flanking elements. Science 230:912-916.
  • Galas, D., and A. Schmidt. 1978. DNase footprinting, a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res. 5:3157-3170.
  • Garcia, J. V., L. Bich-Thuy, J. Stafford, and C. Queen. 1986. Synergism between immunoglobulin enhancers and promoters. Nature (London) 322:383-385.
  • Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
  • Graham, F. L., and A. J. Van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
  • Heinrich, G., P. Gros, and J. F. Habener. 1984. Glucagon gene sequence, four of the six exons separate functional domains of rat preproglucagon. J. Biol. Chem. 259:14082-14087.
  • Jameson, J. L., P. J. Deutsch, G. D. Gallagher, R. C. Jaffe, and J. F. Habener. 1987. trans-Acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin a gene. Mol. Cell. Biol. 7:3032-3040.
  • Jantzen, H. M., V. Strahle, B. Glass, F. Stewart, W. Schmid, M. Boshart, R. Miksicer, and G. Schutz. 1987. Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell 48:29-38.
  • Kunkel, G. R., and H. G. Martinson. 1981. Nucleosomes will not form on double-stranded RNA or over poly (dA) - poly (dT) tracts in recombinant DNA. Nucleic Acids Res. 9:6869-6888.
  • Lefebvre, P. J. (ed.). 1983. Glucagon. Handbook of experimental pharmacology, vol. 66. Springer-Verlag, New York.
  • Lichtsteiner, S., J. Wvarin, and U. Schibler. 1987. The interplay of DNA binding proteins on the promoter of the mouse albumin gene. Cell 51:963-973.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Maniatis, T., S. Goodburn, and J. A. Fischer. 1987. Regulation of inducible and tissue-specific gene expression. Science 236:1237-1244.
  • Marini, J. C., S. D. Levene, D. M. Crothers, and P. T. Eglund. 1982. A bent helix in kinetoplast DNA. Cold Spring Harbor Symp. Quant. Biol. 47:279-283.
  • Mojsov, S., G. Heinrich, I. B. Wilson, M. Ravazzola, L. Orci, and J. F. Habener. 1986. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J. Biol. Chem. 261:11880-11889.
  • Musti, A. M., V. M. Ursini, E. V. Awedimento, V. Zimarino, and L. DeLauro. 1987. A cell type specific factor recognizes the rat thyroglobulin promoter. Nucleic Acids Res. 20:8149-8164.
  • Nelson, C., V. R. Albert, H. P. Elsholtz, L. I.-W. Lu, and M. G. Rosenfeld. 1988. Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor. Science 239:1400-1405.
  • Neumann, E., M. Schaefer-Ridder, Y. Wang, and P. H. Hofschneider. 1982. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J. 1:841-845.
  • Ohlsson, H., and T. Edlund. 1986. Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell 45:35-44.
  • Ornitz, D. M., R. E. Hammer, B. L. Davison, R. L. Brinster, and R. D. Palmiter. 1987. Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers. Mol. Cell. Biol. 7:3466-3472.
  • Orskov, C., J. J. Holst, S. Knuhtsen, F. G. A. Baldissera, S. S. Paulsen, and O. V. Nielsen. 1986. Glucagon-like peptides GLP-I and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119:1467-1475.
  • Palmiter, R. D., and R. L. Brinster. 1986. Germline transformation of mice. Annu. Rev. Genet. 20:465-499.
  • Philippe, J., W. L. Chick, and J. F. Habener. 1987. Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines. J. Clin. Invest. 79:351-358.
  • Pictet, R. L., L. B. Rail, P. Phelps, and W. J. Rutter. 1976. The neural crest and the origin of the insulin-producing and other gastro-intestinal hormone-producing cells. Science 191:191-192.
  • Prost, E., and D. D. Moore. 1986. CAT expression vectors for analysis of eukaryotic promoters and enhancers. Gene 45:107-111.
  • Rhodes, D., and A. Klug. 1981. Sequence dependent helical periodicity of DNA. Nature (London) 292:378-380.
  • Sanger, F. L., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
  • Selden, R. F., K. Burke-Howie, M. E. Rowe, H. M. Goodman, and D. D. Moore. 1986. Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol. Cell. Biol. 6:3173-3179.
  • Stuart, G. W., P. F. Searle, and R. D. Palmiter. 1985. Identification of multiple metal regulatory elements in mouse metallo- thionein-I promoter by assaying synthetic sequences. Nature (London) 317:828-831.
  • Takaki, R., J. Ono, M. Nakamura, Y. Yokogawa, S. Kumae, T. Hiraoka, K. Yamaguchi, K. Hamaguchi, and S. Uchida. 1986. Isolation of glucagon-secreting cell lines by cloning insulinoma cells in vitro. In Vitro Cell Dev. Biol. 22:120-126.
  • Unger, R. H., A. Ohneda, I. Valverde, and A. M. Eisentraut. 1967. Mechanisms of response of plasma glucagons to ingested nutrients, evidence for enteric control of islet hormone secretion. J. Clin. Invest. 46:1125-1136.
  • Unger, R. H., and L. Orci. 1981. Glucagon and the A cell. N. Engl. J. Med. 304:1518-1524.
  • Walker, M. D., T. Edlund, A. M. Boulet, and W. J. Rutter. 1983. Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature (London) 306:557-561.
  • White, J. W., and G. F. Saunders. 1986. Structure of the human glucagon gene. Nucleic Acids Res. 14:4719-4730.

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