5
Views
17
CrossRef citations to date
0
Altmetric
Gene Expression

Glucocorticoid Receptor Binding to a Specific DNA Sequence Is Required for Hormone-Dependent Repression of Pro-Opiomelanocortin Gene Transcription

, , , , &
Pages 5305-5314 | Received 07 Jun 1989, Accepted 16 Aug 1989, Published online: 31 Mar 2023

LITERATURE CITED

  • Adler, S., M. L. Waterman, X. He, and M. G. Rosenfeld. 1988. Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell 52:685–695.
  • Affolter, H. U., and T. Reisine. 1985. Corticotropin releasing factor increases pro-opiomelanocortin messenger RNA in mouse anterior pituitary tumor cells. J. Biol. Chem. 260:15477–15481.
  • Akerblom, I. E., E. P. Slater, M. Beato, J. D. Baxter, and P. L. Mellon. 1988. Negative regulation by glucocorticoids through intereference with a cAMP responsive enhancer. Science 241:992–994.
  • Barberis, A., G. Superti-Furga, and M. Busslinger. 1987. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter. Cell 50:347–359.
  • Beato, M.. 1989. Gene regulation by steroid hormones. Cell 56:335–344.
  • Becker, P. B., B. Gloss, W. Schmid, U. Strahle, and G. Schutz. 1986. In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature (London) 324:686–688.
  • Birnberg, N. C., J. C. Lissitzky, M. Hinman, and E. Herbert. 1983. Glucocorticoids regulate pro-opiomelanocortin gene expression in vivo at the levels of transcription and secretion. Proc. Natl. Acad. Sci. USA 80:6982–6986.
  • Brent, R.. 1985. Repression of transcription in yeast. Cell 42:3–4.
  • Buetti, E., and B. Kiihnel. 1986. Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning muta- genesis. J. Mol. Biol. 190:379–389.
  • Busso, N., M. Collart, J.-D. Vassalli, and D. Belin. 1987. Antagonist effect of RU 486 on transcription of glucocorticoid- regulated genes. Exp. Cell Res. 173:425–430.
  • Camper, S. A., Y. A. S. Yao, and F. M. Rottman. 1985. Hormonal regulation of the bovine prolactin promoter in rat pituitary tumor cells. J. Biol. Chem. 260:12246–12251.
  • Chandler, V. L., B. A. Maier, and K. R. Yamamoto. 1983. DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo. Cell 33:489–499.
  • Charron, J., and J. Drouin. 1986. Glucocorticoid inhibition of transcription from episomal pro-opiomelanocortin gene promoter. Proc. Natl. Acad. Sci. USA 83:8903–8907.
  • Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299.
  • Cordingley, M. C., A. T. Reigel, and G. L. Hager. 1987. Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo. Cell 48:261–270.
  • Drouin, J., M. Chamberland, J. Charron, L. Jeannotte, and M. Nemer. 1985. Structure of the rat pro-opiomelanocortin (POMC) gene. FEBS Lett. 193:54–58.
  • Drouin, J., J. Charron, L. Jeannotte, M. Nemer, R. K. Plante, and O. Wrange. 1987. Pro-opiomelanocortin gene: a model for negative regulation of transcription by glucocorticoids. J. Cell Biochem. 35:293–304.
  • Drouin, J., and H. M. Goodman. 1980. Most of the coding region of rat ACTH β-LPH precursor gene lacks intervening sequences. Nature (London) 288:610–613.
  • Drouin, J., and F. Labrie. 1976. Selective effect of androgens on LH and FSH release in anterior pituitary cells in culture. Endocrinology 98:1528–1534.
  • Eberwine, J. H., and J. L. Roberts. 1984. Glucocorticoid regulation of pro-opiomelanocortin gene transcription in the rat pituitary. J. Biol. Chem. 259:2166–2170.
  • Fremeau, R. T., Jr., J. R. Lundblad, D. B. Pritchett, J. N. Wilcox, and J. L. Roberts. 1986. Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei. Science 234:1265–1269.
  • Frisch, S. M., and H. E. Ruley. 1987. Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone. J. Biol. Chem. 262:16300–16304.
  • Gagner, J.-P., and J. Drouin. 1985. Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH. Mol. Cell. Endocrinol. 40:25–32.
  • Gagner, J.-P., and J. Drouin. 1987. Tissue-specific regulation of pituitary pro-opiomelanocortin gene transcription by corticotropin-releasing hormone, 3′,5′-cyclic adenosine monophosphate, and glucocorticoids. Mol. Endocrinol. 1:677–682.
  • Galas, D. J., and A. Schmitz. 1978. DNase footprinting: a simple method for detection of protein-DNA binding specificity. Nucleic Acids Res. 5:3157–3170.
  • Giguere, V., S. M. Hollenberg, M. G. Rosenfeld, and R. M. Evans. 1986. Functional domains of the human glucocorticoid receptor. Cell 46:645–652.
  • Glass, C. K., J. M. Holloway, O. V. Devary, and M. G. Rosenfeld. 1988. The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Cell 54:313–323.
  • Godowski, P. J., S. Rusconi, R. Miesfeld, and K. R. Yamamoto. 1987. Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature (London) 325:365–368.
  • Goodbourn, S., H. Burstein, and T. Maniatis. 1986. The human β-interferon gene enhancer is under negative control. Cell 45:601–610.
  • Guertin, M., P. Baril, J. Bartkowiak, A. Anderson, and L. Bdanger. 1983. Rapid suppression of α1-fetoprotein gene transcription by dexamethasone in developing rat liver. Biochemis try 22:4296–4302.
  • Guertin, M., H. Larue, D. Bernier, O. Wrange, M. Chevrette, M.-C. Gingras, and L. Belanger. 1988. Enhancer and promoter elements directing activation and glucocorticoid repression of the α1-fetoprotein gene in hepatocytes. Mol. Cell. Biol. 8:1398–1407.
  • Hollenberg, S. M., V. Giguere, P. Segui, and R. M. Evans. 1987. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell 49:39–46.
  • Huang, A. L., M. C. Ostrowski, D. Berard, and G. L. Hager. 1981. Glucocorticoid regulation of the Ha-MuSV p21 gene conferred by sequences from mouse mammary tumor virus. Cell 27:245–255.
  • Hwung, Y. P., L. H. Wang, S. Y. Tsai, and M. J. Tsai. 1988. Differential binding of the chicken ovalbumin upstream promoter (COUP) transcription factor to two different promoters. J. Biol. Chem. 263:13470–13474.
  • Israel, A., and S. N. Cohen. 1985. Hormonally-mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L cells. Mol. Cell. Biol. 5:2443–2453.
  • Jeannotte, L., M. A. Trifiro, R. K. Plante, M. Chamberland, and J. Drouin. 1987. Tissue-specific activity of the pro-opiomelanocortin gene promoter. Mol. Cell. Biol. 7:4058–4064.
  • Keegan, L., G. Gill, and M. Ptashne. 1986. Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science 231:699–704.
  • Lee, F., R. Mulligan, P. Berg, and G. Ringold. 1981. Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumor virus chimaeric plasmids. Nature (London) 294:228–232.
  • Majors, J., and H. E. Varmus. 1983. A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene. Proc. Natl. Acad. Sci. USA 80:5866–5870.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Melton, D. A., P. A. Krieg, M. R. Rebagliati, T. Maniatis, K. Zinn, and M. R. Green. 1984. Efficient in vivo synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035–7056.
  • Miksicek, R., A. Heber, W. Schmid, U. Danesch, G. Posseckert, M. Beato, and G. Schutz. 1986. Glucocorticoid responsiveness of the transcriptional enhancer of Moloney murine sarcoma virus. Cell 46:283–290.
  • Moguilewsky, M., and D. Philibert. 1984. RU-38486: potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation. J. Steroid Biochem. 20:271–276.
  • Nakamaye, K. L., and F. Eckstein. 1986. Inhibition of restriction endonuclease Nci I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis. Nucleic Acids Res. 14:9679–9698.
  • Nakamura, M., S. Nakanishi, S. Sueoka, H. Imura, and S. Numa. 1978. Effects of steroid hormones on the level of corticotropin messenger RNA activity in cultured mouse-pituitary- tumor cells. Eur. J. Biochem. 86:61–66.
  • Ogata, R. T., and W. Gilbert. 1978. An amino-terminal fragment of lac repressor binds specifically to lac operator. Proc. Natl. Acad. Sci. USA 75:5851–5854.
  • Oro, A. E., S. M. Hollenbert, and R. M. Evans. 1988. Transcriptional inhibition by a glucocorticoid receptor-β-galactosidase fusion protein. Cell 55:1109–1114.
  • Payvar, F. P., D. De Franco, G. L. Firestone, B. Edgar, O. Wrange, S. Okret, J.-A. Gustafsson, and K. R. Yamamoto. 1983. Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region. Cell 35:381–392.
  • Perlmann, T., and O. Wrange. 1988. Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome. EMBO J. 7:3073–3079.
  • Pfeifer, K., T. Prezant, and L. Guarente. 1987. Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell 49:19–27.
  • Ponta, H., N. Kennedy, P. Skroch, N. E. Hynes, and B. Groner. 1985. Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties. Proc. Natl. Acad. Sci. USA 82:1020–1024.
  • Potter, H., L. Weir, and P. Leder. 1984. Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc. Natl. Acad. Sci. USA 81:7161–7165.
  • Ptashne, M.. 1986. A genetic switch. Cell Press & Blackwell Scientific Publications, Cambridge, Mass.
  • Renkawitz, R., G. Schutz, D. von der Ahe, and M. Beato. 1984. Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding. Cell 37:503–510.
  • Reznikoff, W. S., D. Siegele, D. W. Cowing, and C. A. Gross. 1985. The regulation of transcription initiation in bacteria. Annu. Rev. Genet. 19:355–387.
  • Richard-Foy, H., and G. L. Hager. 1987. Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter. EMBO J. 6:2321–2328.
  • Roberts, J. L., M. L. Budarf, J. D. Baxter, and E. Herbert. 1979. Selective reduction of pro-adrenocorticotropin/endorphin proteins and messenger ribonucleic acid activity in mouse pituitary tumor cells by glucocorticoids. Biochemistry 18:4907–4915.
  • Sakai, D. D., S. Helms, J. Carlstedt-Duke, J.-A. Gustafsson, F. M. Rottman, and K. R. Yamamoto. 1988. Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev. 2:1144–1154.
  • Scheidereit, C., and M. Beato. 1984. Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory elements by mouse mammary tumor virus. Proc. Natl. Acad. Sci. USA 81:3029–3033.
  • Scheidereit, C., S. Geisse, H. M. Westphal, and M. Beato. 1983. The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumor virus. Nature (London) 304:749–752.
  • Schiile, R., M. Muller, H. Otsuka-Murakami, and R. Renkawitz. 1988. Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature (London) 332:87–92.
  • Strahle, U., G. Klock, and G. Schutz. 1987. A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression. Proc. Natl. Acad. Sci. USA 84:7871–7875.
  • Tremblay, Y., I. Tretjakoff, A. Peterson, T. Antakly, C. X. Zhang, and J. Drouin. 1988. Pituitary-specific expression and glucocorticoid regulation of a pro-opiomelanocortin (POMC) fusion gene in transgenic mice. Proc. Natl. Acad. Sci. USA 85:8890–8894.
  • von der Ahe, D., S. Janich, C. Scheidereit, R. Renkawitz, G. Schutz, and M. Beato. 1985. Glucocorticoid and progesterone receptors bind to the same site in two hormonally regulated promoters. Nature (London) 313:706–709.
  • Webster, N. J. G., S. Green, J. R. Jin, and P. Chambon. 1988. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54:199–207.
  • Weiner, F. R., M. J. Czaja, D. M. Jefferson, M.-A. Giambrone, R. Tur-Kaspa, L. M. Reid, and M. A. Zern. 1987. The effects of dexamethasone on in vitro collagen gene expression. J. Biol. Chem. 252:6955–6958.
  • Wrange, O., J. Carlstedt-Duke, and J. A. Gustafsson. 1986. Stoichiometric analysis of the specific interaction of the glucocorticoid receptor with DNA. J. Biol. Chem. 261:11770–11778.
  • Wrange, O., S. Okret, M. Radojcic, J. Carlstedt-Duke, and J.-A. Gustafsson. 1984. Characterization of the purified glucocorticoid receptor from rat liver cytosol. J. Biol. Chem. 259:4534–4541.
  • Yamamoto, K. R.. 1985. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:209–252.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.