The Adenovirus E1B 19-Kilodalton Protein Stimulates Gene Expression by Increasing DNA Levels

LITERATURE CITED

• Alwine, J. C.. 1985. Transient gene expression control: effects of transfected DNA stability and trans-activation by viral early proteins. Mol. Cell. Biol. 5:1034–1042.
   PubMed Web of Science ®Google Scholar
• Anderson, C. W., R. C. Schmitt, J. E. Smart, and J. B. Lewis. 1984. Early region IB of adenovirus 2 encodes two coterminal proteins of 495 and 155 amino acid residues. J. Virol. 50:387–396.
   PubMedGoogle Scholar
• Babiss, L. E., P. B. Fisher, and H. S. Ginsberg. 1984. Effect on transformation of mutations in the early region 1B-encoded 21-and 55-kilodalton proteins of adenovirus 5. J. Virol. 52:389–395.
   PubMedGoogle Scholar
• Barker, D. B., and A. J. Berk. 1987. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology 156:107–121.
   PubMed Web of Science ®Google Scholar
• Berk, A. J.. 1986. Functions of adenovirus E1A. Cancer Surv. 5:367–387.
   PubMedGoogle Scholar
• Bernards, R., M. G. W. de Leeuw, A. Houweling, and A. J. van der Eb. 1986. Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection. Virology 150:126–139.
   PubMedGoogle Scholar
• Bos, J. L., L. J. Polder, R. Bernards, P. I. Schrier, P. J. van den Eisen, A. J. van der Eb, and H. van Ormondt. 1981. The 2.2 kb E1B mRNA of human adenovirus 12 and adenovirus 5 codes for two tumor antigens starting at different AUG triplets. Cell 27:121–131.
   PubMed Web of Science ®Google Scholar
• Chinnadurai, G.. 1983. Adenovirus 2 lp+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation. Cell 33:759–766.
   PubMedGoogle Scholar
• Chinnadurai, G., S. Chinnadurai, and J. Brusca. 1979. Physical mapping of a large plaque mutation of adenovirus type 2. J. Virol. 32:623–628.
   PubMed Web of Science ®Google Scholar
• D'Halluin, J. C., C. Allart, C. Cousin, P. A. Boulanger, and G. Martin. 1979. Adenovirus early function required for the protection of viral and cellular DNA. J. Virol. 32:61–71.
   PubMedGoogle Scholar
• Imry, C. V., C. H. Herrmann, and M. B. Mathews. 1987. Response of individual adenovirus promoters to the products of the El A gene. Oncogene 2:15–23.
   PubMedGoogle Scholar
• Esche, H., M. B. Mathews, and J. B. Lewis. 1980. Proteins and messenger RNAs of the transforming region of wild-type and mutant adenoviruses. J. Mol. Biol. 142:399–417.
   PubMedGoogle Scholar
• Ezoe, H., R. B. Lai Fatt, and S. Mak. 1981. Degradation of intracellular DNA in KB cells infected with cyt mutants of human adenovirus type 12. J. Virol. 40:20–27.
   PubMedGoogle Scholar
• Gaynor, R. B., L. T. Feldman, and A. J. Berk. 1985. Transcription of class III genes activated by viral immediate early proteins. Science 230:447–450.
   PubMed Web of Science ®Google Scholar
• Gorman, C. M., L. F. Moffat, and Β. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
   PubMed Web of Science ®Google Scholar
• Graham, F. L., J. Smiley, W. C. Russell, and R. Naim. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59–77.
   PubMed Web of Science ®Google Scholar
• Greenberg, M. E., and E. B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (London) 311:433–438.
   PubMed Web of Science ®Google Scholar
• Herr, W., and J. Clarke. 1986. The SV40 enhancer is composed of multiple functional elements that can compensate for one another. Cell 45:461–470.
   PubMed Web of Science ®Google Scholar
• Herrmann, C. H., C. V. Dery, and M. B. Mathews. 1987. Transactivation of host and viral genes by the adenovirus E1B 19K tumor antigen. Oncogene 2:25–35.
   PubMed Web of Science ®Google Scholar
• Hirt, B.. 1967. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:365–369.
   PubMed Web of Science ®Google Scholar
• Jones, N., and T. Shenk. 1979. An adenovirus type 5 early gene function regulates expression of other early viral genes. Proc. Natl. Acad. Sci. USA 76:3665–3669.
   PubMed Web of Science ®Google Scholar
• Laemmli, U. K.. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
   PubMed Web of Science ®Google Scholar
• Lai Fatt, R. B., and S. Mak. 1982. Mapping of an adenovirus function involved in the inhibition of DNA degradation. J. Virol. 42:969–977.
   PubMedGoogle Scholar
• Lewis, J. B., and C. W. Anderson. 1987. Identification of adenovirus type 2 early region IB proteins that share the same amino terminus as do the 495R and 155R proteins. J. Virol. 61:3879–3888.
   PubMedGoogle Scholar
• Lucher, L. A., K. H. Brackmann, J. S. Symington, and M. Green. 1984. Antibody directed to a synthetic peptide encoding the NH2-terminal 16 amino acids of the adenovirus type 2 E1B-53K tumor antigen recognizes the E1B-20K tumor antigen. Virology 132:217–221.
   PubMedGoogle Scholar
• Matsuo, T., W. S. M. Wold, S. Hashimoto, A. Rankin, J. Symington, and M. Green. 1982. Polypeptides encoded by transforming region E1B of human adenovirus 2: immunoprecipitation from transformed and infected cells and cell-free translation of ElB-specific mRNA. Virology 118:456–465.
   PubMedGoogle Scholar
• McGlade, C. J., M. L. Tremblay, S.-P. Yee, R. Ross, and P. E. Branton. 1987. Acylation of the 176R (19-kilodalton) early region IB protein of human adenovirus type 5. J. Virol. 61:3227–3234.
   PubMedGoogle Scholar
• Mellits, K. H., and M. B. Mathews. 1988. Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNAI. EMBO J. 7:2849–2859.
   PubMedGoogle Scholar
• Montell, C., E. F. Fisher, M. H. Caruthers, and A. J. Berk. 1984. Control of adenovirus E1B mRNA synthesis by a shift in the activation of RNA splice sites. Mol. Cell. Biol. 4:966–972.
   PubMedGoogle Scholar
• Moran, E., T. Grodzicker, R. J. Roberts, M. B. Mathews, and B. Zerler. 1986. Lytic and transforming functions of individual products of the adenovirus El A gene. J. Virol. 57:765–775.
   PubMedGoogle Scholar
• Natarajan, V.. 1986. Adenovirus-2 E1A and E1B gene products regulate enhancer mediated transcription. Nucleic Acids Res. 14:9445–9456.
   PubMedGoogle Scholar
• Nevins, J. R.. 1982. Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product. Cell 29:913–919.
   PubMed Web of Science ®Google Scholar
• Pater, A., and M. M. Pater. 1988. Expression of the control elements of BK and SV40 viruses in human cells exhibiting different transformed phenotypes. Virology 163:625–628.
   PubMedGoogle Scholar
• Pilder, S., J. Logan, and T. Shenk. 1984. Deletion of the gene encoding the adenovirus 5 early region IB 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA. J. Virol. 52:664–671.
   PubMedGoogle Scholar
• Riabowol, K. T., L. A. Mizzen, and W. J. Welch. 1988. Heat shock is lethal to fibroblasts microinjected with antibodies against hsp70. Science 242:433–436.
   PubMed Web of Science ®Google Scholar
• Rosen, C. A., J. G. Sodroski, and W. A. Haseltine. 1985. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell 41:813–823.
   PubMedGoogle Scholar
• Ruley, H. E.. 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (London) 304:602–606.
   PubMed Web of Science ®Google Scholar
• Senear, A. W., and J. B. Lewis. 1986. Morphological transformation of established rodent cell lines by high-level expression of adenovirus type 2 E1A gene. Mol. Cell. Biol. 6:1253–1260.
   PubMedGoogle Scholar
• Spector, D. J., M. McGrogan, and H. J. Raskas. 1978. Regulation of the appearance of cytoplasmic RNAs from region 1 of the adenovirus 2 genome. J. Mol. Biol. 126:395–414.
   PubMedGoogle Scholar
• Stillman, B.. 1983. The replication of adenovirus DNA with purified proteins. Cell 35:7–9.
   PubMedGoogle Scholar
• Stillman, B.. 1986. Functions of the adenovirus E1B tumor antigens. Cancer Surv. 5:389–404.
   PubMedGoogle Scholar
• Subramanian, T., M. Kuppuswamy, J. Gysbers, S. Mak, and G. Chinnadurai. 1984. 19-kd tumor antigen coded by early region IB of adenovirus 2 is required for efficient synthesis and for protection of viral DNA. J. Biol. Chem. 259:11777–11783.
   PubMedGoogle Scholar
• Subramanian, T., M. Kuppuswamy, S. Mak, and G. Chinnadurai. 1984. Adenovirus cyt+ locus, which controls cell transformation, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen. J. Virol. 52:336–343.
   PubMedGoogle Scholar
• Takemori, N., C. Cladaras, B. Bhat, A. J. Conley, and W. S. M. Wold. 1984. cyt gene of adenovirus 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptide. J. Virol. 52:793–805.
   PubMedGoogle Scholar
• Takemori, N., J. L. Riggs, and C. Aldrich. 1968. Genetic studies with tumorigenic adenoviruses. I. Isolation of cytocidal (cyt) mutants of adenovirus type 12. Virology 36:575–586.
   PubMedGoogle Scholar
• Takemori, N., J. L. Riggs, and C. Aldrich. 1969. Genetic studies with tumorigenic adenoviruses. II. Heterogeneity of cyt mutants of adenovirus type 12. Virology 38:8–15.
   PubMedGoogle Scholar
• Vales, L. D., and J. E. Darnell. 1989. Promoter occlusion prevents transcription of adenovirus polypeptide IX until after DNA replication. Genes Dev. 3:49–59.
   PubMedGoogle Scholar
• van den Eisen, P. J., A. Houweling, A. J. van der Eb. 1983. Morphological transformation of human adenoviruses is determined to a large extent by gene products of region El A. Virology 131:242–246.
   PubMedGoogle Scholar
• Virtanen, A., and U. Pettersson. 1985. Organization of early region 1B of human adenovirus type 2: identification of four differently spliced mRNAs. J. Virol. 54:383–391.
   PubMed Web of Science ®Google Scholar
• White, E., S. H. Blose, and B. W. Stillman. 1984. Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA. Mol. Cell. Biol. 4:2865–2875.
   PubMedGoogle Scholar
• White, E., A. Denton, and B. Stillman. 1988. Role of the adenovirus E1B 19,000-dalton tumor antigen in regulating early gene expression. J. Virol. 62:3445–3454.
   PubMedGoogle Scholar
• White, E., B. Faha, and B. Stillman. 1986. Regulation of adenovirus gene expression in human WI38 cells by an E1B-encoded tumor antigen. Mol. Cell. Biol. 6:3763–3773.
   PubMed Web of Science ®Google Scholar
• White, E., T. Grodzicker, and B. W. Stillman. 1984. Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause degradation of chromosomal DNA. J. Virol. 52:410–419.
   PubMedGoogle Scholar
• White, E., and B. Stillman. 1987. Expression of adenovirus E1B mutant phenotypes is dependent on the host cell and on synthesis of E1A proteins. J. Virol. 61:426–435.
   PubMedGoogle Scholar
• Wilson, M. C., and J. E. Darnell, Jr.. 1981. Control of messenger RNA concentration by differential cytoplasmic half-life. Adenovirus messenger RNAs from transcription units 1A and 1B. J. Mol. Biol. 148:231–251.
   PubMed Web of Science ®Google Scholar
• Wu, B., R. E. Kingston, and R. Morimoto. 1986. Human HSP70 promoter contains at least two distinct regulatory domains. Proc. Natl. Acad. Sci. USA 83:629–633.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., L. Venkatesh, M. Kuppuswamy, and G. Chinnadurai. 1987. Adenovirus transforming 19-kd T antigen has an enhancer-dependent rrans-activation function and relieves enhancer repression mediated by viral and cellular genes. Genes Dev. 1:645–658.
   PubMedGoogle Scholar