A Second c-myb Protein Is Translated from an Alternatively Spliced mRNA Expressed from Normal and 5′-Disrupted myb Loci

LITERATURE CITED

• Bender, T. P., and W. M. Kuehl. 1986. Murine myb protooncogene mRNA: cDNA sequence and evidence for 5′ heterogeneity. Proc. Natl. Acad. Sci. USA 83:3204–3208.
   PubMed Web of Science ®Google Scholar
• Biedenkapp, H., U. Borgmeyer, A. E. Sippel, and K.-H. Klempnauer. 1988. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature (London) 335:835–837.
   PubMed Web of Science ®Google Scholar
• Bister, K., M. Nunn, C. Moscovici, B. Perbal, M. A. Baluda, and P. H. Duesberg. 1982. Acute leukemia viruses E26 and avian myeloblastosis virus have related transformation-specific RNA sequences but different genetic structures, gene products, and oncogenic properties. Proc. Natl. Acad. Sci. USA 79:3677–3681.
   PubMed Web of Science ®Google Scholar
• Boyle, W. J., M. A. Lampert, J. S. Lipsick, and M. A. Baluda. 1984. Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins. Proc. Natl. Acad. Sci. USA 81:4265–4269.
   PubMed Web of Science ®Google Scholar
• Boyle, W. J., J. S. Lipsick, and M. A. Baluda. 1986. Antibodies to the evolutionarily conserved amino-terminal region of the N-myb encoded protein detect the c-myb protein in widely divergent metazoan species. Proc. Natl. Acad. Sci. USA 83:4685–4689.
   PubMedGoogle Scholar
• Cleveland, D. W., S. G. Fischer, M. W. Kirschner, and U. K. Laemmli. 1977. Peptide mapping by limited proteolysis in SDS and analysis by gel electrophoresis. J. Biol. Chem. 252:1102–1106.
   PubMed Web of Science ®Google Scholar
• Coll, J., S. Saule, P. Martin, M. B. Raes, C. Lagrou, T. Graf, H. Beug, I. E. Simon, and D. Stehelin. 1983. The cellular oncogenes c-myc, c-myb and c-erb are transcribed in defined types of avian hematopoietic cells. Exp. Cell Res. 149:151–162.
   PubMed Web of Science ®Google Scholar
• Gerondakis, S., and J. M. Bishop. 1986. Structure of the protein encoded by the chicken proto-oncogene c-myb. Mol. Cell. Biol. 6:3677–3684.
   PubMed Web of Science ®Google Scholar
• Gonda, T. J., S. Cory, P. Sobieszczuk, D. Holtzman, and J. Adams. 1987. Generation of altered transcripts by retroviral insertion within the c-myb gene in two murine monocytic leukemias. J. Virol. 61:2754–2763.
   PubMedGoogle Scholar
• Gonda, T. J., N. M. Gough, A. R. Dunn, and J. de Blaquiere. 1985. Nucleotide sequence of cDNA clones of the murine myb proto-oncogene. EMBO J. 4:2003–2008.
   PubMed Web of Science ®Google Scholar
• Gonda, T. J., D. K. Sheiness, and J. M. Bishop. 1982. Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues. Mol. Cell. Biol. 2:617–624.
   PubMed Web of Science ®Google Scholar
• Hann, S. R., H. D. Abrams, L. R. Rohrschneider, and R. N. Eisenman. 1983. Proteins encoded by the v-myc and c-myc oncogenes: identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell 34:789–798.
   PubMed Web of Science ®Google Scholar
• Hann, S. R., C. B. Thompson, and R. N. Eisenman. 1985. c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature (London) 314:366–369.
   PubMed Web of Science ®Google Scholar
• Ibanez, C. E., and J. S. Lipsick. 1988. Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation and colony formation. J. Virol. 62:1981–1988.
   PubMedGoogle Scholar
• Klempnauer, Κ.-H., C. Bonifer, and A. E. Sippel. 1986. Identification and characterization of the protein encoded by the human c-myb proto-oncogene. EMBO J. 5:1903–1911.
   PubMedGoogle Scholar
• Klempnauer, Κ.-H., G. Ramsay, J. M. Bishop, M. Giovanella Moscovici, C. Moscovici, J. McGrath, and A. D. Levinson. 1983. The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb. Cell 33:345–355.
   PubMed Web of Science ®Google Scholar
• Klempnauer, Κ.-H., and A. E. Sippel. 1987. The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J. 6:2719–2725.
   PubMed Web of Science ®Google Scholar
• Klempnauer, Κ.-H., G. Symonds, G. I. Evan, and J. M. Bishop. 1984. Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene. Cell 37:537–547.
   PubMed Web of Science ®Google Scholar
• Luscher, B., and R. N. Eisenman. 1988. c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock. Mol. Cell. Biol. 8:2504–2512.
   PubMedGoogle Scholar
• Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Moelling, Κ., E. Pfaff, H. Beug, P. Beimling, T. Bunte, H. E. Schaller, and T. Graf. 1985. DNA-binding activity is associated with purified myb proteins from AMV and E26 virus and is temperature-sensitive for E26 mutants. Cell 40:983–990.
   PubMedGoogle Scholar
• Moscovici, C., L. Gazzolo, and M. G. Moscovici. 1975. Focus assay and defectiveness of avian myeloblastosis virus. Virology 68:173–181.
   PubMedGoogle Scholar
• Paige, C. J., P. W. Kincade, and P. Ralph. 1978. Murine B cell leukemia line with inducible surface immunoglobulin expression. J. Immunol. 121:641–647.
   PubMed Web of Science ®Google Scholar
• Peters, C. W. B., A. E. Sippel, M. Vingron, and K.-H. Klempnauer. 1987. Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain. EMBO J. 6:3085–3090.
   PubMedGoogle Scholar
• Rosson, D., D. Dugan, and E. P. Reddy. 1987. Aberrant splicing events that are induced by proviral integration: implications for myb oncogene activation. Proc. Natl. Acad. Sci. USA 84:3171–3175.
   PubMed Web of Science ®Google Scholar
• Rosson, D., and E. P. Reddy. 1986. Nucleotide sequence of chicken c-myb complementary DNA and implications for myb oncogene activation. Nature (London) 319:604–606.
   PubMed Web of Science ®Google Scholar
• Sheiness, D., and M. Gardinier. 1984. Expression of a protooncogene (proto-myb) in hemopoietic tissues of mice. Mol. Cell. Biol. 4:1206–1212.
   PubMed Web of Science ®Google Scholar
• Shen-Ong, G. L. C.. 1987. Alternative internal splicing in c-myb RNAs occurs commonly in normal and tumor cells. EMBO J. 6:4035–4039.
   PubMedGoogle Scholar
• Shen-Ong, G. L. C., K. Holmes, and H. C. Morse III. 1987. Phorbol ester-induced growth arrest of murine myelomonocytic leukemic cells with virus-disrupted myb locus is not accompanied by decreased myc and myb expression. Proc. Natl. Acad. Sci. USA 84:199–203.
   PubMed Web of Science ®Google Scholar
• Shen-Ong, G. L. C., H. C. Morse III, M. Potter, and J. F. Mushinski. 1986. Two modes of c-myb activation in virus- induced mouse myeloid tumors. Mol. Cell. Biol. 6:380–392.
   PubMed Web of Science ®Google Scholar
• Shen-Ong, G. L. C., M. Potter, J. F. Mushinski, S. Lavu, and E. P. Reddy. 1984. Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas. Science 226:1077–1080.
   PubMed Web of Science ®Google Scholar
• Shen-Ong, G. L. C., and L. Wolff. 1987. Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice: requirement of c-myb activation but lack of v-abl involvement. J. Virol. 61:3721–3725.
   PubMedGoogle Scholar
• Souza, L. M., J. N. Strommer, R. L. Hillyard, M. C. Komaromy, and M. A. Baluda. 1980. Cellular sequences are present in the presumptive avian myeloblastosis virus genome. Proc. Natl. Acad. Sci. USA 77:5177–5181.
   PubMed Web of Science ®Google Scholar
• Thompson, C. Β., P. B. Chailoner, P. E. Neiman, and M. Groudine. 1986. Expression of the c-myb proto-oncogene during cellular proliferation. Nature (London) 319:374–380.
   PubMed Web of Science ®Google Scholar
• Westin, E. H., R. C. Gallo, S. K. Arya, A. Eva, L. M. Souza, M. A. Baluda, S. A. Aaronson, and F. Wong-Staal. 1982. Differential expression of amv gene in human hematopoietic cells. Proc. Natl. Acad. Sci. USA 79:2194–2198.
   PubMed Web of Science ®Google Scholar