Lymphoid and Mesenchymal Tumors in Transgenic Mice Expressing the v-fps Protein-Tyrosine Kinase

LITERATURE CITED

• Adams, J. M., A. W. Harris, C. A. Pinkert, L. M. Corcoran, W. S. Alexander, S. Cory, R. D. Palmiter, and R. L. Brinster. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (London) 318:533–538.
   PubMed Web of Science ®Google Scholar
• Auffray, C., and F. Rougeon. 1980. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur. J. Biochem. 107:303–314.
   PubMedGoogle Scholar
• Bautch, V. L., S. Toda, J. A. Hassell, and D. Hanahan. 1987. Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene. Cell 51:529–538.
   PubMed Web of Science ®Google Scholar
• Behringer, R. R., J. J. Peschon, A. Messing, C. L. Gartside, S. D. Hanschka, R. D. Palmiter, and R. L. Brinster. 1988. Heart and bone tumors in transgenic mice. Proc. Natl. Acad. Sci. USA 85:2648–2652.
   PubMed Web of Science ®Google Scholar
• Bolen, J. B., A. Veillette, A. M. Schwartz, V. Desan, and N. Rosen. 1987. Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells. Oncogene Res. 1:149–168.
   PubMedGoogle Scholar
• Clark, S. S., J. McLaughlin, W. M. Crist, R. Champlin, and O. N. Witte. 1987. Unique forms of the abl tyrosine kinase distinguish PhLpositive ALL. Science 235:85–88.
   PubMed Web of Science ®Google Scholar
• Cook, W. D.. 1982. Rapid thymomas induced by A-MuLV. Proc. Natl. Acad. Sci. USA 79:2917–2921.
   PubMedGoogle Scholar
• Feldman, R. A., J. L. Gabrilove, J. P. Tam, M. A. S. Moore, and H. Hanafusa. 1985. Specific expression of the human cellular fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells. Proc. Natl. Acad. Sci. USA 82:2379–2383.
   PubMed Web of Science ®Google Scholar
• Field, L. J.. 1988. Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice. Science 239:1029–1033.
   PubMed Web of Science ®Google Scholar
• Garnett, D. C., S. E. Tracy, and H. L. Robinson. 1986. Differences in sequences encoding the carboxy-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes. Proc. Natl. Acad. Sci. USA 83:6053–6057.
   PubMedGoogle Scholar
• Groffen, J., N. Heisterkamp, R. Grosveld, W. Van de Ven, and J. R. Stephenson. 1983. Transforming genes of avian (v-fps) and mammahan (v-fes) retroviruses correspond to a common cellular locus. Virology 125:480–486.
   PubMedGoogle Scholar
• Hampe, A., I. Laprevotte, F. Galibert, L. A. Fedele, and C. J. Sherr. 1982. Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes. Cell 30:775–785.
   PubMed Web of Science ®Google Scholar
• Hanafusa, T., L.-H. Wang, S. M. Anderson, R. Karess, W. S. Hayward, and H. Hansfusa. 1980. Characterization of the transforming gene of Fujinami sarcoma virus. Proc. Natl. Acad. Sci. USA 77:3009–3013.
   PubMed Web of Science ®Google Scholar
• Hanahan, D.. 1985. Heritable formation of pancreatic β-cell tumors in transgenic mice expressing recombinant insulin/sim- ian virus 40 oncogenes. Nature (London) 315:115–122.
   PubMed Web of Science ®Google Scholar
• Hogan, B., F. Costantini, and E. Lacy. 1986. Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Hood, L., M. Kronenberg, and T. Hunkapiller. 1985. T cell antigen receptors and the immunoglobulin supergene family. Cell 40:225–229.
   PubMed Web of Science ®Google Scholar
• Kahn, P., B. Adkins, H. Beug, and T. Graf. 1984. src and fps-containing avian sarcoma viruses transform chicken erythroid cells. Proc. Natl. Acad. Sci. USA 81:7122–7126.
   PubMedGoogle Scholar
• Konopka, J. B., S. M. Watanabe, and O. N. Witte. 1984. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell 37:1035–1042.
   PubMed Web of Science ®Google Scholar
• Kurzrock, R., M. Shtalrid, P. Romero, W. S. Kloetzer, M. Talpas, J. M. Trujillo, M. Blick, M. Beran, and J. V. Gutterman. 1987. A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukemia. Nature (London) 325:631–635.
   PubMed Web of Science ®Google Scholar
• Leder, A., P. K. Pattengale, A. Kuo, T. Stewart, and P. Leder. 1986. Consequences of widespread deregulation of c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 45:485–495.
   PubMed Web of Science ®Google Scholar
• Lee, W.-H., K. Bister, T. Pawson, T. Robbins, C. Moscovici, and P. H. Duesberg. 1980. Fujinami sarcoma virus: an avian RNA tumor with a unique transforming gene. Proc. Natl. Acad. Sci. USA 77:2018–2022.
   PubMedGoogle Scholar
• MacDonald, I., J. Levy, and T. Pawson. 1985. Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct /es-related protein. Mol. Cell. Biol. 5:2543–2551.
   PubMedGoogle Scholar
• Malissen, M., K. Minard, S. Mjolness, M. Kronenberg, J. Goverman, T. Hunkapillar, M. B. Prystowsky, Y. Yoshikai, F. Fitch, T. W. Mak, and L. Hood. 1984. Mouse T-cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell 37:1101–1110.
   PubMed Web of Science ®Google Scholar
• Marth, J. D., R. Peet, E. G. Krebs, and R. M. Perlmutter. 1985. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and over-expressed in the murine T cell lymphoma LSTRA. Cell 43:393–404.
   PubMed Web of Science ®Google Scholar
• Mathey-Prevot, Β., H. Hanafusa, and S. Kawai. 1982. A cellular protein is immunologically cross-reactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. Cell 28:897–906.
   PubMed Web of Science ®Google Scholar
• Melton, D. A., P. A. Krieg, M. R. Rebagfiati, T. Maniatis, K. Zinn, and M. R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacterial phage SP6 promoter. Nucleic Acids Res. 12:7035–7056.
   PubMed Web of Science ®Google Scholar
• Mucenski, M. L., B. A. Taylor, N. A. Jenkins, and N. G. Copeland. 1986. AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. Mol. Cell. Biol. 6:4236–4243.
   PubMedGoogle Scholar
• Muller, W. J., E. Sinn, P. K. Pattengale, R. Wallace, and P. Leder. 1988. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54:105–115.
   PubMed Web of Science ®Google Scholar
• Pawson, T., J. Guyden, T. H. Kung, K. Radke, T. Gilmore, and G. S. Martin. 1980. A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation. Cell 22:767–775.
   PubMed Web of Science ®Google Scholar
• Quaife, C. J., C. A. Pinkert, D. M. Omitz, R. D. Palmiter, and R. L. Brinster. 1987. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell 48:1023–1034.
   PubMed Web of Science ®Google Scholar
• Reynolds, K., G. S. Hoekzema, J. Vogel, S. H. Hinrichs, and G. Jay. 1988. Multiple endocrine neoplasia induced by the promiscuous expression of a viral oncogene. Proc. Natl. Acad. Sci. USA 85:3135–3139.
   PubMed Web of Science ®Google Scholar
• Rigby, P. W. J., M. Dieckmann, C. Rhodes, and P. Berg. 1977. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol. 113:237–251.
   PubMed Web of Science ®Google Scholar
• Ruther, V., C. Garber, D. Komitowski, R. Muller, and E. F. Wagner. 1987. Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature (London) 325:412–416.
   PubMed Web of Science ®Google Scholar
• Sadowski, I., J. C. Stone, and T. Pawson. 1986. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming action of Fujinami sarcoma virus P130gag-fps. Mol. Cell. Biol. 6:4396–4408.
   PubMed Web of Science ®Google Scholar
• Samelson, L. E., W. F. Davidson, H. C. Morse III, and R. D. Klausner. 1986. Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders. Nature (London) 324:674–676.
   PubMed Web of Science ®Google Scholar
• Samelson, L. E., M. D. Patel, A. M. Weissman, J. B. Harford, and R. D. Klausner. 1986. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46:1083–1090.
   PubMed Web of Science ®Google Scholar
• Shibuya, M., and H. Hanafusa. 1982. Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses. Cell 47:277–284.
   Google Scholar
• Shtivelman, E., B. Lifshitz, R. P. Gale, B. A. Roe, and E. Canaani. 1986. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. Cell 47:277–284.
   PubMed Web of Science ®Google Scholar
• Sinn, E., W. Muller, P. Pattengale, I. Tepler, R. Wallace, and P. Leder. 1987. Coexpression of MMTV/v-Ha-ras and MMTV/ c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49:465–475.
   PubMed Web of Science ®Google Scholar
• Slamon, D. J., J. R. de Kemion, I. M. Verma, and M. J. Cline. 1984. Expression of cellular oncogenes in human malignancies. Science 224:256–262.
   PubMed Web of Science ®Google Scholar
• Southern, E.. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
   PubMed Web of Science ®Google Scholar
• Stewart, T. A., D. K. Pattengale, and P. Leder. 1984. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV Imyc fusion genes. Cell 38:627–637.
   PubMed Web of Science ®Google Scholar
• Suda, Y., S. Aizawa, S. Hirai, T. Inoue, Y. Furuta, M. Suzuki, S. Hirohashi, and Y. Ikawa. 1987. Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B lymphomas and SV40 large T gene a variety of tumors in transgenic mice. EMBO J. 6:4055–4065.
   PubMed Web of Science ®Google Scholar
• Tracy, S. E., B. A. Woda, and H. L. Robinson. 1985. Induction of angiosarcoma by a c-erbB transducing virus. J. Virol. 54:304–310.
   PubMedGoogle Scholar
• Veillette, A., M. A. Bookman, E. M. Horak, and J. B. Bolen. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55:301–308.
   PubMed Web of Science ®Google Scholar
• Voronova, A. F., and Β. M. Sefton. 1986. Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature (London) 319:682–685.
   PubMed Web of Science ®Google Scholar
• Whitlock, C. A., S. F. Ziegler, and O. N. Witte. 1983. Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes. Mol. Cell. Biol. 3:596–604.
   PubMedGoogle Scholar
• Williams, R. L., S. A. Courtneidge, and E. F. Wagner. 1988. Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene. Cell 52:121–131.
   PubMed Web of Science ®Google Scholar
• Yee, S.-P., D. Mock, V. Maltby, M. Silver, J. Rossant, A. Bernstein, and T. Pawson. 1989. Cardiac and neurological abnormalities in v-fps transgenic mice. Proc. Natl. Acad. Sci. USA 86:5873–5877.
   PubMedGoogle Scholar