High-Frequency Homologous Recombination between Duplicate Chromosomal Immunoglobulin μ Heavy-Chain Constant Regions

LITERATURE CITED

• Adams, J. M., D. J. Kemp, O. Bernard, N. Gough, E. Webb, B. Tyler, S. Gerondakis, and S. Cory. 1981. Organization and expression of murine immunoglobulin genes. Immunol. Rev. 59:5–32.
   PubMedGoogle Scholar
• Baker, M. D., N. Pennell, L. Bosnoyan, and M. J. Shulman. 1988. Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line. Proc. Natl. Acad. Sci. USA 85:6432–6436.
   PubMed Web of Science ®Google Scholar
• Baker, M. D., and M. J. Shulman. 1988. Homologous recombination between transferred and chromosomal immunoglobulin κ genes. Mol. Cell. Biol. 8:4041–4047.
   PubMedGoogle Scholar
• Baker, M. D., G. E. Wu, W. M. Toone, H. Murialdo, A. C. Davis, and M. J. Shulman. 1986. A region of the immunoglobulin-μ heavy chain necessary for forming pentameric IgM. J. Immunol. 137:1724–1728.
   PubMedGoogle Scholar
• Baumann, Β., M. J. Potash, and G. Kohler. 1985. Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse. EMBO J. 4:351–359.
   PubMed Web of Science ®Google Scholar
• Blackwell, T. Κ., M. W. Moore, G. D. Yancopoulos, H. Suh, S. Lutzker, E. Seising, and F. W. Alt. 1986. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (London) 324:585–589.
   PubMedGoogle Scholar
• Cunnigham, A. J., and A. Szenberg. 1968. Further improvements in the plaque technique for detecting single antibodyforming cells. Immunology 14:599–600.
   PubMedGoogle Scholar
• Gross-Bellard, M., P. Dudet, and P. Chambon. 1973. Isolation of high-molecular weight DNA from mammalian cells. Eur. J. Biochem. 36:32–38.
   PubMedGoogle Scholar
• Hawley, R. G., M. J. Shulman, H. Murialdo, D. M. Gibson, and N. Hozumi. 1982. Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc. Natl. Acad. Sci. USA 79:7425–7429.
   PubMed Web of Science ®Google Scholar
• Hopjo, T., S. Nakai, Y. Nishida, T. Kataoka, Y. Yamawaki-Kataoka, N. Takahashi, M. Obata, A. Shimizu, Y. Yaoita, T. Nikaido, and N. Ishida. 1981. Rearrangements of immunoglobulin genes during differentiation and evolution. Immunol. Rev. 59:33–67.
   PubMedGoogle Scholar
• Jack, H., and M. Wabl. 1988. Immunoglobulin mRNA stability varies during B lymphocyte differentiation. EMBO J. 7:1041–1046.
   PubMedGoogle Scholar
• Jackson, J. A., and G. R. Fink. 1981. Gene conversion between duplicated genetic elements in yeast. Nature (London) 292:306–311.
   PubMedGoogle Scholar
• Keil, R. L., and G. S. Roeder. 1984. Cis-acting, recombinationstimulating activity in a fragment of the ribosomal DNA of 5. cerevisiae. Cell 39:377–386.
   PubMed Web of Science ®Google Scholar
• Klar, A. J. S., J. N. Strathern, and J. B. Hicks. 1981. A position-effect control for gene transposition: state of expression of yeast mating-type genes affects their ability to switch. Cell 25:517–524.
   PubMed Web of Science ®Google Scholar
• Klein, H. L., and T. D. Petes. 1981. Intrachromosomal gene conversion in yeast. Nature (London) 289:144–148.
   PubMed Web of Science ®Google Scholar
• Kohler, G., M. J. Potash, H. Lehrach, and M. J. Shulman. 1982. Deletions in immunoglobulin mu chains. EMBO J. 1:555–563.
   PubMedGoogle Scholar
• Kohler, G., and M. J. Shulman. 1980. Immunoglobulin M mutants. Eur. J. Immunol. 10:467–476.
   Google Scholar
• Liskay, R. M., A. Letsou, and J. L. Stachelek. 1987. Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells. Genetics 115:161–167.
   PubMedGoogle Scholar
• Liskay, R. M., and J. L. Stachelek. 1986. Information transfer between duplicated chromosomal sequences in mammalian cells involves contiguous regions of DNA. Proc. Natl. Acad. Sci. USA 83:1802–1806.
   PubMedGoogle Scholar
• Liskay, R. M., J. L. Stachelek, and A. Letsou. 1984. Homologous recombination between repeated chromosomal sequences in mouse cells. Cold Spring Harbor Symp. Quant. Biol. 49:183–189.
   PubMedGoogle Scholar
• Mansour, S. L., K. R. Thomas, and M. R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (London) 336:348–352.
   PubMed Web of Science ®Google Scholar
• Rohdewohld, H., H. Weiher, W. Reik, R. Jaenisch, and M. Breindl. 1987. Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites. J. Virol. 61:336–343.
   PubMed Web of Science ®Google Scholar
• Schulz, M., U. Freisem-Rabien, R. Jessberger, and W. Doerfler. 1987. Transcriptional activities of mammalian genomes at sites of recombination with foreign DNA. J. Virol. 61:344–353.
   PubMedGoogle Scholar
• Shulman, M. J., C. Heusser, C. Filkin, and G. Kohler. 1982. Mutations affecting the structure and function of immunoglobulin M. Mol. Cell. Biol. 2:1033–1043.
   PubMedGoogle Scholar
• Smith, A. J. H., and P. Berg. 1984. Homologous recombination between defective neo genes in mouse 3T6 cells. Cold Spring Harbor Symp. Quant. Biol. 49:171–181.
   PubMedGoogle Scholar
• Southern, E. M.. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
   PubMed Web of Science ®Google Scholar
• Southern, P. J., and P. Berg. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1:327–341.
   PubMedGoogle Scholar
• Strathern, J. N., A. Klar, J. Hicks, J. Abraham, J. Ivy, K. Nasmyth, and C. McGill. 1982. Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus. Cell 31:183–192.
   PubMed Web of Science ®Google Scholar
• Subramani, S., and J. Rubnitz. 1985. Recombination events after transient infection and stable integration of DNA into mouse cells. Mol. Cell. Biol. 5:659–666.
   PubMedGoogle Scholar
• Subramani, S., and B. L. Seaton. 1988. Homologous recombination in mitotically dividing mammalian cells, p. 549–573. In R. Kucherlapati, and G. R. Smith (ed.), Genetic recombination. American Society for Microbiology, Washington, D.C.
   Google Scholar
• Thomas, B. J., and R. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619–630.
   PubMed Web of Science ®Google Scholar
• Thomas, P.. 1980. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77:5201–5205.
   PubMed Web of Science ®Google Scholar
• Tonegawa, S.. 1983. Somatic generation of antibody diversity. Nature (London) 302:575–581.
   PubMed Web of Science ®Google Scholar
• Trimble, W. S., M. D. Baker, G. L. Boulianne, H. Murialdo, N. Hozumi, and M. J. Shulman. 1986. Analysis of hybridoma mutants defective in synthesis of immunoglobulin M. Somatic Cell Mol. Genet. 12:467–477.
   PubMedGoogle Scholar
• Voelkel-Meiman, K., R. L. Keil, and G. S. Roeder. 1987. Recombination-stimulating sequences in yeast ribosomal RNA correspond to sequences regulating transcription by RNA polymerase I. Cell 48:1071–1079.
   PubMed Web of Science ®Google Scholar
• Yancopoulos, G. D., and F. W. Alt. 1985. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40:271–281.
   PubMed Web of Science ®Google Scholar
• Yancopoulos, G. D., and F. W. Alt. 1986. Regulation of the assembly and expression of variable-region genes. Annu. Rev. Immunol. 4:339–368.
   PubMed Web of Science ®Google Scholar
• Yancopoulos, G. D., T. K. Blackwell, H. Suh, L. Hood, and F. W. Alt. 1986. Introduced T cell receptor variable region gene segments in pre-B cells: evidence that B and T cells use a common recombinase. Cell 44:251–259.
   PubMed Web of Science ®Google Scholar