A B-Cell-Specific Nuclear Protein That Binds to DNA Sites 5′ to Immunoglobulin Sα Tandem Repeats Is Regulated during Differentiation

LITERATURE CITED

• Alberini, C., R. Biassoni, S. DeAmbrosis, D. Vismara, and R. Sitia. 1987. Differentiation in the murine B cell lymphoma 1.29: individual μ+ clones may be induced by lipopolysaccharide to both IgM secretion and isotype switching. Eur. J. Immunol. 17:555–562.
   PubMedGoogle Scholar
• Alt, F., N. Rosenberg, S. Lewis, E. Thomas, and D. Baltimore. 1981. Organization and reorganization of immunoglobulin genes in an Abelson murine leukemia virus-transformed cells: rearrangement of heavy but not light chain genes. Cell 27:381–390.
   PubMed Web of Science ®Google Scholar
• Boothby, M., H.-C. Lion, and L. H. Glimcher. 1989. Differences in DNA sequence specificity among MHC class II X boxbinding proteins. J. Immunol. 142:1005–1014.
   PubMedGoogle Scholar
• Burrows, P. D., G. B. Beck-Engeder, and M. R. Wabl. 1983. Immunoglobulin heavy chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature (London) 306:243–246.
   PubMedGoogle Scholar
• Davidson, I., J. H. Xiao, R. Rosales, A. Staub, and P. Chambon. 1988. The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence. Cell 54:931–942.
   PubMedGoogle Scholar
• Davis, M. M., K. Calame, P. W. Early, D. L. Livant, R. Joho, I. L. Weissman, and L. Hood. 1980. An immunoglobulin heavychain gene is formed by at least two recombination events. Nature (London) 283:733–739.
   PubMed Web of Science ®Google Scholar
• Davis, M. M., S. K. Kim, and L. Hood. 1980b. DNA sequences mediating class switching in α-immunoglobulins. Science 209:1360–1365.
   PubMed Web of Science ®Google Scholar
• Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from mammalian nuclei. Nucleic Acids Res. 11:1475–1490.
   PubMed Web of Science ®Google Scholar
• Dunnick, M., M. Wilson, and J. Stavnezer. 1989. Mutations, duplications, and deletion of switch regions suggest a role for DNA replication in the immunoglobulin heavy chain switch. Mol. Cell. Biol. 9:1850–1856.
   PubMedGoogle Scholar
• Eckhardt, L. A., and B. Birshtein. 1985. Independent immunoglobulin class-switch events occurring in a single myeloma cell line. Mol. Cell. Biol. 5:856–868.
   PubMedGoogle Scholar
• Fried, M. G., and D. M. Crothers. 1984. Equilibrium studies of the cyclic AMP receptor protein-DNA interaction. J. Mol. Biol. 172:241–262.
   PubMedGoogle Scholar
• Garner, M. M., and A. Rezvin. 1981. A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system. Nucleic Acids Res. 9:3047–3060.
   PubMed Web of Science ®Google Scholar
• Gearhart, P. J., N. H. Sigal, and N. R. Klinman. 1975. Production of antibodies of identical idiotype but diverse immunoglob ulin classes by cells derived from a single stimulated B cell. Proc. Natl. Acad. Sci. USA 72:1707–1711.
   PubMedGoogle Scholar
• Gilman, M. Z., R. N. Wilson, and R. A. Weinberg. 1986. Multiple protein-binding sites in the 5′-flanking region regulate c-fos expression. Mol. Cell. Biol. 6:4305–4316.
   PubMed Web of Science ®Google Scholar
• Greene, L. A., and S. A. Tischler. 1976. Establishment of a noradrenalinergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73:2424–2428.
   PubMed Web of Science ®Google Scholar
• Horibata, K., and A. W. Harris. 1970. Mouse myelomas and lymphomas in culture. Exp. Cell Res. 60:61–77.
   PubMedGoogle Scholar
• Kappler, J. W., B. Skidmore, J. White, and P. Marrack. 1981. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J. Exp. Med. 153:1198–1214.
   PubMed Web of Science ®Google Scholar
• Kataoka, T., T. Miyata, and T. Honjo. 1981. Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Cell 23:357–368.
   PubMedGoogle Scholar
• Klein, S., F. Soblitzky, and A. Radbruch. 1984. Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant. EMBO J. 3:2473–2476.
   PubMed Web of Science ®Google Scholar
• Knapp, M. R., E. Severinson-Gronowicz, J. Shroeder, and S. Strober. 1979. Characterization of the spontaeous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS. J. Immunol. 123:1000–1006.
   PubMedGoogle Scholar
• Lang, R. B., L. W. Stanton, and K. B. Marcu. 1982. On immunoglobulin heavy chain switching: two y2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed. Nucleic Acids Res. 10:611–630.
   PubMedGoogle Scholar
• Lutzker, S., P. Rothman, R. Pollock, R. Coffman, and F. W. Alt. 1988. Mitogen- and IL-4-regulated expression of germ-line Ig y2b transcripts: evidence for directed heavy chain class switching. Cell 53:177–184.
   PubMed Web of Science ®Google Scholar
• Marcu, K. B., J. Banerji, N. A. Penncavage, R. Lang, and N. Amheim. 1980. 5′ flanking regions of immunoglobulin heavy chain constant region genes display length heterogeneity in germlines of inbred mouse strains. Cell 22:187–196.
   PubMedGoogle Scholar
• Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:499–580.
   PubMedGoogle Scholar
• Mowatt, R. M., and W. Dunnick. 1986. DNA sequence of the murine yl switch segment reveals novel structural elements. J. Immunol. 136:2674–2683.
   PubMedGoogle Scholar
• Nikaido, T., Y. Y. Kataoka, and T. Honjo. 1982. Nucleotide sequences of switch regions of immunoglobulin Ce and Cy genes and their comparison. J. Biol. Chem. 257:7322–7329.
   PubMed Web of Science ®Google Scholar
• Oi, V. T., S. L. Morrison, L. A. Herzenberg, and P. Berg. 1983. Immunoglobulin expression in transformed lymphoid cells. Proc. Natl. Acad. Sci. USA 80:825–829.
   PubMed Web of Science ®Google Scholar
• Ott, D. E., F. W. Alt, and K. B. Marcu. 1987. Immunoglobulin heavy chain switch recombination within a retroviral vector in murine pre-B cells. EMBO J. 6:577–584.
   PubMed Web of Science ®Google Scholar
• Paige, C. J., P. W. Kincade, and P. Ralph. 1978. Murine B cell leukemia line with inducible surface immunoglobulin expression. J. Immunol. 121:641–647.
   PubMed Web of Science ®Google Scholar
• Pfiefer, K., K. Kwang-Soo, S. Kogan, and L. Guarante. 1989. Functional dissection and sequence of yeast HAP1 activator. Cell 56:291–301.
   PubMedGoogle Scholar
• Severinson-Gronowicz, E., C. A. Doss, F. D. Howard, D. C. Morrison, and S. Strober. 1980. An in vitro cell line of the B cell tumor BCLj can be activated by LPS to secrete IgM. J. Immunol. 125:976–980.
   PubMedGoogle Scholar
• Siden, E. J., D. Baltimore, D. Clark, and N. E. Rosenberg. 1979. Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson leukemia virus. Cell 16:389–396.
   PubMedGoogle Scholar
• Siebenllst, U., and W. Gilbert. 1980. Contacts between Escherichia coli RNA polymerase and an early promoter of the phage T7. Proc. Natl. Acad. Sci. USA 77:122–126.
   PubMedGoogle Scholar
• Singh, H., R. Sen, D. Baltimore, and P. Sharp. 1986. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (London) 319:154–158.
   PubMed Web of Science ®Google Scholar
• Sitia, R., A. Rubartelli, and U. Hammerling. 1981. Expression of two immunoglobulin isotypes, IgM and IgA, with identical idiotype in the B cell lymphoma 1.29. J. Immunol. 127:1388–1394.
   PubMedGoogle Scholar
• Stavnezer, J., Κ. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling. 1982. Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma 1.29. Mol. Cell. Biol. 2:1002–1013.
   PubMedGoogle Scholar
• Stavnezer, J., G. Radcliffe, Y.-C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson. 1988. Immunoglobulin heavy chain switching may be directed by prior induction of transcripts from constant-region genes. Proc. Natl. Acad. Sci. USA 85:7704–7708.
   PubMed Web of Science ®Google Scholar
• Stavnezer, J., S. Sirlin, and J. Abbott. 1985. Induction of immunoglobulin isotype switching in cultured 1.29 B lymphoma cells. J. Exp. Med. 161:577–601.
   PubMed Web of Science ®Google Scholar
• Stavnezer-Nordgren, J., and S. Sirlin. 1986. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J. 5:95–102.
   PubMed Web of Science ®Google Scholar
• Tada, N., and U. Hammerling. 1980. Secretion of either of a pair of immunoglobulins, IgM or IgX, from somatic hybrid cells derived by fusion of a B-cell lymphoma cell line carrying both immunoglobulin isotypes. Immunogenetics 11:7–12.
   PubMedGoogle Scholar
• Treisman, R.. 1986. Identification of a protein binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 46:567–574.
   PubMed Web of Science ®Google Scholar
• Tucker, P. W., C. P. Liu, J. F. Mushinski, and F. R. Blattner. 1980. Mouse immunoglobulin D: messenger RNA and genomic sequences. Science 209:1353–1360.
   PubMedGoogle Scholar
• Yancopoulos, G. D., R. A. DePinho, K. A. Zimmerman, S. G. Lutzker, N. Rosenberg, and F. W. Alt. 1986. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J. 5:3259–3266.
   PubMed Web of Science ®Google Scholar
• Yaoita, Y., and T. Hoiyo. 1980. Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome. Nature (London) 286:850–853.
   PubMed Web of Science ®Google Scholar