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Cell Growth and Development

Characterization of the Schizosaccharomyces pombe ral2 Gene Implicated in Activation of the ras1 Gene Product

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Pages 5617-5622 | Received 30 May 1989, Accepted 11 Sep 1989, Published online: 31 Mar 2023

LITERATURE CITED

  • Adari, H., D. R. Lowy, Β. M. Willumsen, C. J. Der, and F. McCormick. 1988. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science 240:518–521.
  • Beach, D., M. Piper, and P. Nurse. 1982. Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol. Gen. Genet. 187:326–329.
  • Beckner, S. K., S. Hattori, and T. Shih. 1985. The ras oncogene product p21 is not a regulatory component of adenylate cyclase. Nature (London) 317:71–72.
  • Birchmeier, C., D. Broek, and M. Wigler. 1985. RAS proteins can induce meiosis in Xenopus oocytes. Cell 43:615–621.
  • Broek, D., T. Toda, T. Michaelis, L. Levin, C. Birchmeier, M. Zoller, S. Powers, and M. Wigler. 1987. The 5. cerevisiae CDC25 gene product regulates the J?AS/adenylate cyclase pathway. Cell 48:789–799.
  • Cales, C., J. F. Hancock, C. J. Marshall, and A. Hall. 1988. The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product. Nature (London) 332:548–551.
  • Camonis, J. H., M. Kalekine, B. Gongre, H. Garreau, E. Boy-Marcotte, and M. Jacquet. 1986. Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae. EMBO J. 5:375–380.
  • Egel, R., and M. Egel-Mitani. 1974. Premeiotic DNA synthesis in fission yeast. Exp. Cell Res. 88:127–134.
  • Fujiyama, A., K. Matsumoto, and F. Tamanoi. 1987. A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing steps. EMBO J. 6:223–228.
  • Fukui, Y., and Y. Kaziro. 1985. Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe. EMBO J. 4:687–691.
  • Fukui, Y., Y. Kaziro, and M. Yamamoto. 1986. Mating pheromone-like diffusible factor released by Schizosaccharomyces pombe. EMBO J. 5:1991–1993.
  • Fukui, Y., T. Kozasa, Y. Kaziro, T. Takeda, and M. Yamamoto. 1986. Role of a ras homolog in the life cycle of Schizosaccharomyces pombe. Cell 44:329–336.
  • Fukui, Y., and M. Yamamoto. 1988. Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to rasl−. Mol. Gen. Genet. 215:26–31.
  • Gibbs, J., I. Sigal, M. Poe, and E. Scolnick. 1984. Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules. Proc. Natl. Acad. Sci. USA 81:5704–5708.
  • Girgsdies, O.. 1982. Sterile mutants of Schizosaccharomyces pombe: analysis by somatic hybridization. Curr. Genet. 6:223–227.
  • Goodman, L. E., C. M. Perou, A. Fujiyama, and F. Tamanoi. 1988. Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localization of ras proteins. Yeast 4:271–281.
  • Gutz, H., H. Heslot, U. Leupold, and N. Loprieno. 1974. Schizosaccharomyces pombe, p. 395–446. In R. D. King (ed.), Handbook of genetics, vol. 1. Plenum Publishing Corp., New York.
  • Hancock, J. F., A. I. Magee, J. E. Childs, and C. J. Marshall. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57:1167–1177.
  • Kataoka, T., S. Powers, C. McGill, O. Fasano, J. Strathern, J. Broach, and M. Wigler. 1984. Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37:437–455.
  • Leupold, U.. 1950. Die Vererbung von Homothallie und Het- erothallie bei Schizosaccharomyces pombe. C. R. Trav. Lab. Carlsberg Ser. Physiol. 24:381–480.
  • Levitzki, A., J. Rudick, I. Pastan, W. C. Vass, and D. R. Lowy. 1986. Adenylate cyclase activity of NIH3T3 cells morphologically transformed by ras genes. FEBS Lett. 197:134–138.
  • Lund, P. M., Y. Hasegawa, K. Kitamura, C. Shimoda, Y. Fukui, and M. Yamamoto. 1987. Mapping of the rasl gene of Schizosaccharomyces pombe. Mol. Gen. Genet. 209:627–629.
  • Martegani, E., M. D. Baroni, G. Frascotti, and L. Alberghina. 1986. Molecular cloning and transcriptional analysis of the start gene CDC25 of Saccharomyces cerevisiae. EMBO J. 5:2363–2369.
  • McGrath, J., D. Capon, D. Goeddel, and A. Levinson. 1984. Comparative biochemical properties of normal and activated human ras p21 protein. Nature (London) 310:644–655.
  • Messing, J.. 1983. New M13 vectors for cloning. Methods Enzymol. 101:20–78.
  • Nadin-Davis, S. A., and A. Nasim. 1988. A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast. EMBO J. 7:985–993.
  • Nadin-Davis, S. A., A. Nasim, and D. Beach. 1986. Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J. 5:2963–2971.
  • Nadin-Davis, S. A., A. Nasim, Y. Fukui, and M. Yamamoto. 1989. Oncogene homologs, p. 97–126. In A. Nasim, B. Johnson, and P. Young (ed.), The molecular biology of the fission yeast. Academic Press, Inc., New York.
  • Nadin-Davis, S. A., R. C. A. Yang, S. A. Narang, and A. Nasim. 1986. The cloning and characterization of a RAS gene from Schizosaccharomyces pombe. J. Mol. Evol. 23:41–51.
  • Powers, S., S. Michaelis, D. Broek, S. Santa Anna-A, J. Field, I. Herskowitz, and M. Wigler. 1986. RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell 47:413–422.
  • Robinson, L. C., J. B. Gibbs, M. S. Marshall, and K. Tatchell. 1987. CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae. Science 235:1218–1221.
  • Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
  • Shimoda, C., and M. Uehira. 1985. Cloning of the Schizosaccharomyces pombe mei3 gene essential for the initiation of meiosis. Mol. Gen. Genet. 201:353–356.
  • Sipiczki, M., and L. Ferenczy. 1977. Protoplast fusion of Schizosaccharomyces pombe auxotrophic mutants of identical mating-type. Mol. Gen. Genet. 151:77–81.
  • Southern, E.. 1979. Gel electrophoresis of restriction fragments. Methods Enzymol. 68:152–176.
  • Sweet, R., S. Yokoyama, T. Kamata, J. Feramisco, M. Rosenberg, and M. Gross. 1984. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity. Nature (London) 311:273–275.
  • Tamanoi, F., M. Rao, N. Samiy, and M. Walsh. 1985. Enzymatic properties of yeast RAS2 protein, p. 251–256. In J. Feramisco, B. Ozanne, and C. Stiles (ed.), Cancer cells, vol. 3. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Tanaka, K., K. Matsumoto, and A. Toh-e. 1989. IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 9:757–768.
  • Tatchell, K., D. T. Chaleff, D. DeFeo-Jones, and E. M. Scolnick. 1984. Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viability. Nature (London) 309:523–527.
  • Toda, T., I. Uno, T. Ishikawa, S. Powers, T. Kataoka, D. Broek, S. Cameron, J. Broach, K. Matsumoto, and M. Wigler. 1985. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40:27–36.
  • Trahey, M., and F. McCormick. 1987. A cytoplasmic protein stimulates normal N-ras p21 GRPase, but does not affect oncogenic mutants. Science 238:542–545.
  • Vogel, U. S., R. A. F. Dixon, M. D. Schaber, R. E. Diehl, M. S. Marshall, E. M. Scolnick, I. S. Sigal, and J. B. Gibbs. 1988. Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature (London) 335:90–93.

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