LITERATURE CITED
- Berget, S. M., and B. L. Robberson. 1986. U1, U2 and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation. Cell 46:691–696.
- Bindereif, A., and M. R. Green. 1986. Ribonucleoprotein complex formation during pre-mRNA splicing in vitro. Mol. Cell. Biol. 6:2582–2592.
- Bindereif, A., and M. R. Green. 1987. An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly. EMBO J. 6:2415–2424.
- Black, D. L., B. Chabot, and J. A. Steitz. 1985. U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell 42:737–750.
- Black, D. L., and J. A. Steitz. 1986. Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein. Cell 46:697–704.
- Chabot, B., D. L. Black, D. M. LeMaster, and J. A. Steitz. 1985. The 3′ splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein. Science 230:1344–1349.
- Chabot, B., and J. A. Steitz. 1987. Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol. Cell. Biol. 7:281–293.
- Chabot, B., and J. A. Steitz. 1987. Recognition of mutant and cryptic 5′ splice sites by the U1 small nuclear ribonucleoprotein in vitro. Mol. Cell. Biol. 7:698–707.
- Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated nuclei. Nucleic Acids. Res. 11:1475–1489.
- Fradin, A., R. Jove, C. Hemenway, H. D. Keiser, J. L. Manley, and C. Prives. 1984. Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs. Cell 37:927–936.
- Frendeway, D., and W. Keller. 1985. The stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences. Cell 42:355–367.
- Frendeway, D., A. Kramer, and W. Keller. 1987. Different small nuclear ribonucleoprotein particles are involved in different steps of splicing complex formation. Cold Spring Harbor Symp. Quant. Biol. 52:287–297.
- Fu, X.-Y., J. D. Colgan, and J. L. Manley. 1988. Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small t-antigen pre-mRNA. Mol. Cell. Biol. 8:3582–3590.
- Fu, X.-Y., and J. L. Manley. 1987. Factors influencing alternative splice site utilization in vivo. Mol. Cell. Biol. 7:738–748.
- Gerke, V., and J. A. Steitz. 1986. A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of pre-messenger RNA. Cell 47:973–984.
- Grabowski, P. J., S. R. Seiler, and P. A. Sharp. 1985. A multicomponent complex is involved in the splicing of messenger RNA precursors. Cell 42:345–353.
- Grabowski, P. J., and P. A. Sharp. 1986. Affinity chromatography of splicing complexes: U2, U5 and U4 + U6 small nuclear ribonucleoprotein particles in the spliceosome. Science 223:1294–1299.
- Hornig, H., M. Aebi, and C. Weissman. 1986. Effects of mutations at the lariat branch acceptor site on β-globin pre-mRNA splicing in vitro. Nature (London) 324:589–591.
- Keller, E. B., and W. A. Noon. 1984. Intron splicing: a conserved internal signal in introns of animal pre-mRNAs. Proc. Natl. Acad. Sci. USA 81:7417–7420.
- Keller, E. B., and W. A. Noon. 1985. Intron splicing: a conserved internal signal in introns of Drosophila pre-mRNAs. Nucleic Acids Res. 13:4971–4980.
- Konarska, M. M., and P. A. Sharp. 1986. Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs. Cell 48:845–855.
- Konarska, M. M., and P. A. Sharp. 1987. Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell 49:763–774.
- Krainer, A. R., and T. Maniatis. 1985. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell 42:725–736.
- Krainer, A. R., T. Maniatis, B. Ruskin, and M. R. Green. 1984. Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell 36:993–1005.
- Kramer, A.. 1987. Analysis of RNase A-resistant regions of adenovirus 2 major late precursor-mRNA in splicing extracts reveals an ordered interaction of nuclear components with the substrate RNA. J. Mol. Biol. 196:559–573.
- Kramer, A., W. Keller, B. Appel, and R. Luhrmann. 1984. The 5′ terminus of the RNA moiety of Ul small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors. Cell 38:299–307.
- Lamond, A. I., M. M. Konarska, and P. A. Sharp. 1987. A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation. Genes Dev. 1:532–543.
- Manley, J. L., J. C. S. Noble, X.-Y. Fu, and H. Ge. 1987. Factors that influence alternative splice site selection in vivo, p. 97–112. In M. Inouye, and B. S. Dudock (ed.), Molecular biology of RNA: new perspectives. Academic Press, Inc., New York.
- Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:499–560.
- Mount, S. M., I. Petterson, M. Hinterberger, A. Karmas, and J. A. Steitz. 1983. The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro. Cell 33:509–518.
- Noble, J. C. S., Z.-Q. Pan, C. Prives, and J. L. Manley. 1987. Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites. Cell 50:227–236.
- Noble, J. C. S., C. Prives, and J. L. Manley. 1986. In vitro splicing of simian virus 40 early pre-mRNA. Nucleic Acids Res. 14:1219–1235.
- Noble, J. C. S., C. Prives, and J. L. Manley. 1988. Alternative splicing of SV40 early pre-mRNA is determined by branch site selection. Genes Dev. 2:1460–1475.
- Padgett, R. A., M. M. Konarska, M. Aebi, H. Hornig, C. Weissmann, and P. A. Sharp. 1985. Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit β-globin genes. Proc. Natl. Acad. Sci. USA 82:8349–8353.
- Padgett, R. A., S. M. Mount, J. A. Steitz, and P. A. Sharp. 1983. Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein. Cell 35:101–107.
- Parker, R., P. G. Siliciano, and C. Guthrie. 1987. Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA. Cell 49:229–239.
- Perkins, K. K., H. M. Furneaux, and J. Hurwitz. 1986. RNA splicing products formed with isolated fractions from HeLa cells are associated with fast-sedimenting complexes. Proc. Natl. Acad. Sci. USA 83:887–891.
- Reed, R., and T. Maniatis. 1985. Intron sequences involved in lariat formation during pre-mRNA splicing. Cell 41:95–105.
- Ruskin, B., and M. R. Green. 1985. Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing. Cell 43:131–142.
- Ruskin, B., and M. R. Green. 1985. An RNA processing activity that debranches RNA lariates. Science 229:135–140.
- Ruskin, B., J. M. Greene, and M. R. Green. 1985. Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants. Cell 41:833–834.
- Ruskin, B., P. D. Zamore, and M. R. Green. 1988. A factor, U2AF, is required for U2 snRNP binding and complex assembly. Cell 52:207–219.
- Tazi, J., C. Alibert, J. Temsamani, I. Reveillaud, G. Cathala, C. Burnel, and P. Jeanteur. 1986. A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein. Cell 47:755–766.
- Tooze, J. (ed.). 1981. DNA tumor viruses, 2nd ed., revised. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- van Santen, V. L., and R. A. Spritz. 1986. Alternative splicing of SV40 early pre-mRNA in vitro. Nucleic Acids Res. 14:9911–9926.
- Zeitlin, S., and A. Efstratiadis. 1984. In vivo splicing products of the rabbit β-globin pre-mRNA. Cell 39:589–602.
- Zhuang, Y., H. Leung, and A. M. Weiner. 1987. The natural 5′ splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. Mol. Cell. Biol. 7:3018–3020.
- Zhuang, Y., and A. M. Weiner. 1986. A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation. Cell 46:827–835.
- Zillmann, M., S. D. Rose, and S. M. Berget. 1987. U1 small nuclear ribonucleoproteins are required early during spliceosome assembly. Mol. Cell. Biol. 7:2877–2883.
- Zillmann, M., M. L. Zapp, and S. M. Berget. 1988. Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles. Mol. Cell. Biol. 8:814–821.