Publication Cover
Acta Clinica Belgica
International Journal of Clinical and Laboratory Medicine
Volume 69, 2014 - Issue 1
232
Views
8
CrossRef citations to date
0
Altmetric
Case Reports

Severe symptomatic hypomagnesaemia induced by the chronic use of proton pump inhibitors: A case report of a patient with Zollinger–Ellison syndrome

, , , &

References

  • Herzig SJ, Howell MD, Ngo LH, Marcantonio ER. Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA. 2009;301:2120–8.
  • Ray S, Delaney M, Muller AF. Proton pump inhibitors and acute interstitial nephritis. BMJ. 2010;341:c4412.
  • Leonard J, Marshall JK, Moayyyedi P. Systematic review of the risk of enteric infection in patients taking acid suppression. Am J Gastroenterol. 2007;102:2047–56.
  • Faulhaber GA, Furlanetto TW. Could magnesium depletion play a role on fracture risk in PPI users? Arch Intern Med. 2010;170:1776.
  • Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med. 2006;355:1834–6.
  • Hess MW, Hoenderop JG, Bindels RJ, Drenth JP. Systematic review: hypomagnesaemia induced by proton pump inhibition. Aliment Pharmacol Ther. 2012;36(5):405–13.
  • Sedehizadeh S, Keogh M, Wills AJ. Reversible hypomagnesaemia-induced subacute cerebellar syndrome. Biol Trace Elem Res. 2011;142;127–9.
  • Reffelmann T, Ittermann T, Dörr M, Völzke H, Reinthaler M, Petersmann A, . Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011;219:280–4.
  • Sontia B, Touyz RM. Role of magnesium in hypertension. Arch Biochem Biophys. 2007;458:33–39.
  • Reffelmann T, Dörr M, Ittermann T, Schwahn C, Völzke H, Ruppert J, . Low serum magnesium concentrations predict increase in left ventricular mass over 5 years independently of common cardiovascular risk factors. Atherosclerosis. 2010;213:563–9.
  • Barbagallo M, Dominguez LJ, Galioto A, Pineo A, Belvedere M. Oral magnesium supplementation improves vascular function in elderly diabetic patients. Magnes Res. 2010;23:131–7.
  • Barbagallo M, Dominguez LJ. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys. 2007;458:40–7.
  • Huang CL, Kuo E. Mechanism of hypokalemia in magnesium deficiency. J Am Soc Nephrol. 2007;18:2649–52.
  • Schlingmann KP, Waldegger S, Konrad M, Chubonov V, Gudermann T. TRPM6 and TRPM7 – gatekeepers of human magnesium metabolism. Biochim Biophys Acta. 2007;1772:813–21.
  • Bai JPF, Hausman E, Lionberger R, Zhang X. Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis. 1. Oral absorption of magnesium. Mol Pharm. 2012;9(12):3495–505.
  • Schlingmann KP, Weber S, Peters M, Neimann Nejsum L, Vitzthum H, Klingel K, . Hypomagnesaemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nature Genetics. 2002;31:166–70.
  • Fernandez-Fernandez FJ, Sesma P, Cainzos-Romero T, Ferreira L. Hypomagnesemia related to the use of omeprazole with negative result for mutation in the TRPM6 gene. Med Clin (Barc). 2011;137:188–9.
  • Thongon N, Krishnamra N. Omeprazole decreases magnesium transport across Caco-2 monolayers. World J Gastroenterol. 2011;17:1574–83.
  • Danziger J, William JH, Scott DJ, Lee J, Lehman LW, Mark RG, . Proton pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int. 2013;83:692–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.