The pathogenesis of Leishmania/HIV co-infection: cellular and immunological mechanisms

References

• Abel, P. M., McSharry, C., Galloway, E., Ross, C., Severn, A., Toner, G., Gruer, L. & Wilkinson, P. C. (1992). Heterogeneity of peripheral blood monocyte populations in human immunodeficiency virus-1 sero-positive patients. FENIS Microbiology and Immunology, 5,317–323.
   PubMedGoogle Scholar
• Alvar, J. (1994). Leishmaniasis and AIDS co-infection: the Spanish example. Parasitology Today, 10, 160–163.
   PubMedGoogle Scholar
• Alvar, J., Verdejo, J., Osuna, A. & Nijera, R. (1987). Visceral leishmaniasis in a patient seropositive for HIV. European Journal of Clinical Microbiology, 6, 604–606.
   PubMedGoogle Scholar
• Aukrust, P., Liabakk, N. B., Muller, F., Lien, E., Espevik, T. & Froland, S. S. (1994). Serum levels of tumor necrosis factor-alpha (TNF-c) and soluble TNF receptors in human immunodeficiency virus type 1 infection - correlations to clinical, immuno-logic, and virologic parameters. Journal of Infectious Diseases, 169, 420–424.
   PubMed Web of Science ®Google Scholar
• Badaró, R. (1997). When Leishmania and HIV interact, a new broad spectrum of leishmaniasis occurs. British Journal of Infectious Diseases, 1, 145–148.
   PubMedGoogle Scholar
• Badaró, R., Carvalho, E. M., Rocha, H., Queiroz, A. C. & Jones, T. C. (1986a). Leishmania donovani: an opportunistic microbe associated with progressive disease in three immunocompromised patients. Lancet, i, 647–649.
   Google Scholar
• Badaró, R., Jones, T. C., Carvalho, E. M., Sampaio, D., Reed, S. G., Barral, A., Teixeira, R. & Johnson Jr, W. D. (1986b). New perspectives on a subclinical form of visceral leishmaniasis. Journal of Infectious Diseases, 154, 1003–1011.
   PubMed Web of Science ®Google Scholar
• Barbeau, B., Bernier, R., Dumais, N., Briand, G., Olivier, M., Faure, R., Posner, B. I. & Tremblay, M. (1997). Activation of HIV-1 LTR transcription and virus replication via NF-KB-dependent and -independent pathways by potent phosphotyrosine phosphatase inhibitors, the peroxovanadium com-pounds. Journal of Biological Chemistry, 272,12,968-12,977.
   Google Scholar
• Barral, A., Barral-Netto, M., Yong, E. C., Brownell, C. E., Twardzik, D. R. & Reed, S. G. (1993). Transforming growth factor p as a virulence mech-anism for Leishmania braziliensis. Proceedings of the National Academy of Sciences of the United States of America, 90, 3442–3446.
   PubMed Web of Science ®Google Scholar
• Barral-Netto, M., Badaró, R., Pedral-Sampaio, D., Carvalho, E. M., Falcoff, E. & Falcoff, R. (1991). Tumor necrosis factor (cachectin) in human visceral leishmaniasis. Journal of Infectious Diseases, 163, 853–857.
   PubMed Web of Science ®Google Scholar
• Barral-Netto, M., Machado, P. & Barral, A. (1995). Human cutaneous leishmaniasis: recent advances in physiopathology and treatment. European Journal of Dermatology, 5,104–113.
   Web of Science ®Google Scholar
• Bernier, R., Turco, S. J., Olivier, M. & Tremblay, M. J. (1995). Activation of human immunodeficiency virus type 1 in monocytoid cells by the protozoan parasite Leishmania donovani. Journal of Virology, 69, 7282–7285.
   PubMed Web of Science ®Google Scholar
• Bernier, R., Barbeau, B., Tremblay, M. J. & Olivier, M. (1998). The lipophosphoglycan of Leish-mania donovani up-regulates HIV-1 transcription in T cells through the nuclear factor-kappa B elements. Journal of Immunology, 160, 2881–2888.
   PubMed Web of Science ®Google Scholar
• Biggar, R. J., Goedert, J. J. & Hoofnagle, J. (1987). Accelerated loss of antibody to hepatitis B surface antigens among immunodeficient homosexual men infected with HIV. New England Journal of Medicine, 316, 630–631.
   PubMed Web of Science ®Google Scholar
• Borthwick, N. J., Bofill, M., Gombert, W. M., Akbar, A. N., Medina, E., Sagawa, K., Lipman, M. C., Johnson, M. A. & Janossy, G. (1994). Lymphocyte activation in HIV-infection. Functional defects of CD 28-T cells. AIDS, 8, 431–441.
   PubMed Web of Science ®Google Scholar
• Cacopardo, B., Nigro, L., Preiser, W., Fama, A., Satariano, M. I., Braner, J., Celesia, B. M., Weber, B., Russo, R. & Doerr, H. W. (1996). Prolonged Th2 cell activation and increased viral replication in HIV -Leishmania co-infected patients despite treatment. Transactions of the Royal Society and Tropical Medicine and Hygiene, 90, 434-435. Carvalho, E. M., Teixeira, R. S. & Johnson Jr, W. D. (1981). Cell mediated immunity in American visceral leishmaniasis: reversible immunosupression during acute infection. Infection and Immunity, 33, 498–502.
   Google Scholar
• Cenini, P., Berhe, N., Hailu, A., McGinnes, K. & Frommel, D. (1993). Mononuclear cell subpopulations and cytokine levels in human visceral leishmaniasis before and after chemotherapy. Journal of Infectious Diseases, 168, 986–993.
   PubMed Web of Science ®Google Scholar
• Cenini, P., Berhe, N., Hailu, A. & Frommel, D. (1994). Mononuclear cell subpopulations in human immunodeficiency virus (HIV)-positive versus HIV-negative patients with visceral leishmaniasis. Journal of Infectious Diseases, 169, 707–708.
   PubMed Web of Science ®Google Scholar
• Chamot, E., Hirschel, B., Wintsch, J., Robert, C. F., Gabriel, V., Deglon, J. J., Yerly, S. & Perrin, L. (1990). Loss of antibodies against hepatitis C virus in HIV-seropositive intravenous drug users. AIDS, 4, 1275–1277.
   PubMed Web of Science ®Google Scholar
• Chehimi, J., Starr, S. E., Frank, I., d'Andrea, A., Ma, X., MacGregor, R. R., Sennelier, J. & Trinchieri, G. (1994). Impaired interleukin 12 pro-duction in human immunodeficiency virus-infected patients. Journal of Experimental Medicine, 179, 1361–1366.
   Google Scholar
• Clerici, M., Stocks, N. I., Zajac, R. A., Boswell, R. D., Lucey, D. R., Via, C. S. & Shearer, G. M. (1989). Detection of three distinct patterns of T helper cell dysfunction in asymptomatic HIV-seropositive patients. Journal of Clinical Investigation, 84, 1892–1899.
   PubMed Web of Science ®Google Scholar
• Clerici, M., Hakim, F. T. D., Venzon, D. J., Blatt, S., Hendrix, C. W., Wynn, T. A. & Shearer, G. M. (1993). Changes in interleukin 2 and interleukin 4 in asymptomatic human immunodeficiency virus-seropositive individuals. Journal of Clinical Investi-gation, 91, 759–765.
   PubMed Web of Science ®Google Scholar
• Coutinho, S. G., Da-Cruz, A. M., Pereira de Oliveira, M., Mendonca, S. C. F., Bertho, A. L. & de Luca, P. M. (1996). CD4 + and CD8 + T cell immune response of immunocompetent and immunocompromised (AIDS) patients with American tegumentary leishmaniasis. Memórias do Institudo Oszvaldo Cruz, 91, 381–384.
   Google Scholar
• Da-Cruz, A. M., Conceicao-Silva, F., Bertho, A. L. & Coutinho, S. G. (1994). Leishmania-reactive CD4 + and CD8 + T cells associated with cure of human cutaneous leishmaniasis. Infection and Immunity, 62, 2614–2618.
   Google Scholar
• Dalgleish, A. G., Beverley, P. C. L., Clapham, P. R., Crawford, D. H., Greaves, M. F. & Weiss, R. A. (1984). The CD4(T4) antigen is an essential com-ponent of the receptor for the AIDS retrovirus. Nature, 312, 763–767.
   PubMed Web of Science ®Google Scholar
• De Martini, R. M., Turner, R. R., Formenti, S. C., Boone, D. C., Bishop, P. C., Levine, A. M. & Parker, J. W. (1988). Peripheral blood mono-nuclear cell abnormalities and their relationship to clinical course in homosexual men with HIV infection. Clinical Immunology and Immunopathology, 46, 258–271.
   PubMedGoogle Scholar
• De Souza, E., Souza, I., Naiff, R. D., Guimathes, T. C., Naiff, M. F., Cupolillo, E., Rodrigues, W. A. & Schettini, A. P. (1998). American cutaneous leish-maniasis due to Leishmania (Viannia) guyanensis as an initial clinical presentation of human immuno-deficiency virus infection. Journal of the European Academy of Dermatology and Venereology, 10, 214–217.
   PubMed Web of Science ®Google Scholar
• Desjeux, P. & Alvar, J. (2003). LeishmanialHIV co-infections: epidemiology in Europe. Annals of Tropical Medicine and Parasitology, 97 (Suppl.), 3–15.
   Google Scholar
• Duh, E. J., Maury, W. J., Folks, T. M., Fauci, A. S. & Rabson, A. B. (1989). Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat. Proceeding of the National Academy of Sciences of the United States of America, 86, 5974–5978.
   PubMed Web of Science ®Google Scholar
• Dumais, N., Barbeau, B., Olivier, M. & Tremblay, M. (1998). Prostaglandin E2 upregulates HIV-1 LTR-driven gene activity in T cells via NF-K-dependent and -independent signaling pathways. Journal of Biological Chemistry, 273, 27,306-27,314.
   Google Scholar
• Easterbrook, M. D., Levy, M. H., Gomez, K. M., Turco, S. J., Epand, R. M. & Rosenthal K. L. (1995). Inhibition of HIV-1-induced syncytia formation and infectivity by lipophosphoglycan from Leishmania. Journal of AIDS and Human Retrovirology, 10, 496–505.
   PubMedGoogle Scholar
• Fauci, A. S. (1988a). The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science, 239, 617–622.
   PubMed Web of Science ®Google Scholar
• Fauci, A. S. (1988b). Immunopathogenic mechanisms of human immunodeficiency virus (HIV) infection. In Human Retroviruses, Cancer, and AIDS: Approaches to Prevention and Therapy, ed. Bolegnesi, D. p. 187. New York: Alan R. Liss.
   Google Scholar
• Fauci, A. S. (1996). Host factors and the pathogenesis of HIV-induced disease. Nature, 384, 529–534.
   PubMed Web of Science ®Google Scholar
• Fillola, G., Corberand, J. X., Laharrague, P. F., Levenes, H., Massip, P. & Recco, P. (1992). Peripheral intramonocytic leishmaniasis in an AIDS patient. Journal of Clinical Microbiology, 30, 3284–3285.
   PubMed Web of Science ®Google Scholar
• Foley, P., Kazazi, F., Biti, R., Sorrell, T. C. & Cunningham, A. L. (1992). HIV infection of mono-cytes inhibits the T-lymphocyte proliferative response to recall antigens, via production of eicosanoids. Immunology, 75, 391–397.
   PubMed Web of Science ®Google Scholar
• Folks, T. M., Justement, J., Kinter, A., Dinarello, C. A. & Fauci, A. S. (1987). Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science, 238, 800–802.
   PubMed Web of Science ®Google Scholar
• Frank, Y., Pavlakis, S., Black, K. & Bakshi, S. (1998). Reversible occipital-parietal encephalopathy syndrome in an HIV-infected child. Neurology, 51, 915–916.
   PubMed Web of Science ®Google Scholar
• Frantz, B., Nordby, E., Bren, G., Steffan, N., Paya, C., Kincaid, R., Tocci, M. J., O'Keefe, S. J. & O'Neill, E. A. (1994). Calcineurin acts in synergy with PMA to inactivate IKB/MAD-3 an inhibitor of NF-KB. EMBO Journal, 13, 861–870.
   PubMed Web of Science ®Google Scholar
• Gazzinelli, R. T., Bala, S., Stevens, R., Baseler, M., Wahl, L., Kovacs, J. & Sher, A. (1995). HIV infection supresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines. Journal of Immunology, 155, 1565–1574.
   PubMed Web of Science ®Google Scholar
• Gradoni, L. & Gramiccia, M. (1994). Leishmania infantum tropism: strain genotype or host immune status? Parasitology Today, 10, 264–267.
   PubMedGoogle Scholar
• Graziosi, C., Pantaleo, G., Gantt, K. R., Fortin, J. P., Demarest, J. F., Cohen, O. J., Sekaly, R. P. & Fauci, A. S. (1994). Lack of evidence for the dicho-tomy of Thl and Th2 predominance in HIV-infected individuals. Science, 265, 248–252.
   PubMed Web of Science ®Google Scholar
• Haldar, J. P., Ghose, S., Saha, K. C. & Ghose, A. C. (1983). Cell-mediated immune response in Indian kala-azar and post kala-azar dermal leishmaniasis. Infection and Immunity, 42, 702–707.
   PubMed Web of Science ®Google Scholar
• Handman, E., Schnur, L. F., Spithill, T. W. & Mitchell, G. H. (1986). Passive transfer of Leishmania lipopolysaccharide confers parasite survival in macro-phages. Journal of Immunology, 137, 3608–3613.
   PubMed Web of Science ®Google Scholar
• Haug, C. H. J., Aukrust, P., Lien, E., Miller, F., Espevik, T. & Froland, S. S. (1996). Disseminated Mycobacterium avium complex infection in AIDS: immunopathogenic significance of an activated tumor necrosis factor system and depressed serum levels of 1,25 dihydroxyvitamin D. Journal of Infectious Diseases, 173, 259–262.
   PubMed Web of Science ®Google Scholar
• Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M. & Markowitz, M. (1995). Rapid turn-over of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature, 373, 123–126.
   PubMed Web of Science ®Google Scholar
• Janossy, G., Borthwick, N., Lomnitzer, R., Medina, E., Squire, S. B., Phillips, A. N., Lipman, M., Johnson, M. A., Lee, C. & Bofill, M. (1993). Lymphocyte activation in HIV-1 infection. I. Predominant pro-liferative defects among CD45R0 + cells of the CD4 and CD8 lineages. AIDS, 7,613–624.
   PubMed Web of Science ®Google Scholar
• Jeannel, D., Tuppin, P., Bruckler, G., Danis, M. & Gentilini, M. (1989). Leishmaniasis in France. Lancet, II, 804.
   Google Scholar
• Jeronimo, S. M., Oliveira, R. M., Mackay, S., Costa, R. M., Sweet, J., Nacimiento, E. T., Luz, K. G., Fernandez, M. Z., Jernigan, J. & Pearson, R. D. (1994). An urban outbreak of visceral leishmaniasis in Natal, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, 386–388.
   PubMed Web of Science ®Google Scholar
• Jimenez, M. I., Gutierrez-Solar, B., Benito, A., Aguiar, A., Garcia, E., Cercenado, E. & Alvar, J. (1991). Cutaneous Leishmania infantum zymodemes isolated from bone marrow in AIDS patients. Research and Reviews in Parasitology, 51, 95–99.
   Google Scholar
• Jimenez, M. I., LOpez-Velez, R., Molina, R., Cavariate, C. & Alvar, J. (1996). HIV coinfection with a currently non-pathogenic flagellate. Lancet, i, 264–265.
   Web of Science ®Google Scholar
• Kekow, J., Wachsman, W., McCutchan, J. A., Cronin, M., Carson, D. A. & Lotz, M. (1990). Transforming growth factor 13 and noncytopathic mechanisms of immunodeficiency in human immuno-deficiency virus infection. Proceedings of the National Academy of Sciences of the United States of America, 87,8321–8325.
   PubMed Web of Science ®Google Scholar
• Kemp, M., Kurtzhals, J. A. L., Bendtzen, K., Poulsen, L. K., Hansen, M. B., Koech, D. K., Kharazmi, A. & Theander, T. G. (1993). Leishmania donovani-reactive Thl- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis. Infection and Immunity, 61, 1069–1073.
   PubMed Web of Science ®Google Scholar
• Kemp, M., Hey, A. S., Kurtzhals, J. A., Christensen, C. B., Gaafar, A., Mustafa, M.D., Kordonafi, A. A., Ismail, A., Kharazmi, A. & Theander, T. G. (1994). Dichotomy of the human T cell response to Leish-mania antigens. I. Thl -like response to Leishmania major promastigotes antigens in individuals recovered from cutaneous leishmaniasis. Clinical and Experi-mental Immunology, 96, 410–415.
   PubMed Web of Science ®Google Scholar
• Klatzmann, D., Barre-Sinoussi, F., Nugeyre, M. T., Dauguet, C., Vilmer, E., Griscelli, C., Brun-Veziret, F-. Rouzioux, C., Gluckman, J. C., Chermann, J. C. & Montagnier, L. (1984). Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science, 225, 59–63.
   PubMed Web of Science ®Google Scholar
• Klein, S. A., Dobmeyer, J. M., Dobmeyer, T. S., Pape, M., Ottmann, O. G., Helm, E. B., Hoelzer, D. & Rossol, R. (1997). Demonstration of the Thl to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry. AIDS, 11, 1111–1118.
   PubMed Web of Science ®Google Scholar
• Kubar, J., Marty, P., Lelievre, A., Quaranta, J. F., Staccini, P., Caroli-Bosc, C. & Le Fichoux, Y. (1998). Visceral leishmaniosis in HIV-positive patients: primary infection, reactivation and latent infection. Impact of the CD4 + T-lymphocyte counts. AIDS, 12, 2147–2153.
   PubMed Web of Science ®Google Scholar
• Levy, J. A. (1993). Pathogenesis of human immuno-deficiency virus infection. Microbiology Reviews, 57, 183–289.
   PubMedGoogle Scholar
• Lewis, R. S. & Cahalan, M. D. (1995). Potassium and calcium channels in lymphocytes. Annual Review of Immunology, 13, 623–653.
   PubMed Web of Science ®Google Scholar
• Liew, F. Y. & O'Donnell, C. A. (1993). Immunology of leishmaniasis. Advances in Parasitology, 32, 161–259.
   PubMed Web of Science ®Google Scholar
• Maggi, E., Mazzetti, M., Ravina, A., Annunziato, F., de Carli, M., Piccini, M. P., Manetti, R., Carbonari, M., Pesce, A. M., del Prete, G. & Romagnani, S. (1994). Ability of HIV to promote a Thl to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science, 265, 244–248.
   PubMed Web of Science ®Google Scholar
• Mansfield, J. M. & Olivier, M. (2002). Immune evasion by parasites. In Immunology of Infectious Diseases, eds Kaufmann, S. H. E., Sher, A. & Ahmed, R. pp. 379-392. Washington, DC: American Society for Microbiology.
   Google Scholar
• Martinez, P., de la Vega, E., Laguna, F., Soriano, V., Puente, S., Moreno, V., Sentchordi, M. J., Garcia-Aguado, C. & Gonzalez-Lahoz, J. (1993). Diagnosis of visceral leishmaniasis in HIV-infected individuals using peripheral blood smears. AIDS, 7,227–230.
   PubMed Web of Science ®Google Scholar
• Marty, P., Le Fichoux, Y., Pratlong, F. & Gari-Toussaint, M. (1994). Human visceral leishmaniasis in Alpes-Maritimes, France: epidemiological charac-teristics for the period 1985-1992. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, 33–34.
   PubMed Web of Science ®Google Scholar
• Mary, C., Lamouroux, D., Dunan, S. & Quilici, M. (1992). Western blot analysis of antibodies to Leishmania infantum antigens: potential of the 14-kD and 16-kD antigens for diagnosis and epidemiologic purposes. American Journal of Tropical Medicine and Hygiene, 47, 764–771.
   PubMed Web of Science ®Google Scholar
• Matte, C., Maion, G., Mourad, W. & Olivier, M. (2001). Leishmania donovani-induced macrophages cyclooxygenase-2 and prostaglandin E2 synthesis. Parasite Immunology, 23, 177–184.
   PubMed Web of Science ®Google Scholar
• McDougal, J. S., Nicholson, J. K. A., Cross, G. D., Cort, S. P., Kennedy, M. S. & Mawle, A. C. (1986). Binding of the human retrovirus HTLV-III/LAV/ ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry. Journal of Immunology, 137, 2937–2944.
   PubMed Web of Science ®Google Scholar
• Medrano, F. J., Hernandez-Quero, J., Jimenez, E., Pineda, J. A., Rivero, A., Sanchez-Quijano, A., Velez, I. D., Viciana, P., Castillo, R., Reyes, M. J., Carvajal, F., Leal, M. & Lissen, E. (1992). Visceral leishmaniasis in HIV-1-infected individuals: a com-mon opportunistic infection in Spain? AIDS, 6, 1499–1503.
   PubMed Web of Science ®Google Scholar
• Medrano, F. J., Leal, M., Arienti, D., Rey, C., Zagliani, A., Torres, Y., Sanchez-Quijano, Lissen, E. & Clerici, M. (1998a). Tumor necrosis factor p and soluble APO-1/Fas independently predict pro-gression to AIDS in HIV-seropositive patients. AIDS Research and Human Retrovirology, 14, 833–844.
   Web of Science ®Google Scholar
• Medrano, F. J., Rey, C., Leal, M., Cariavate, C., Rubio, A., Sanchez-Quijano, A., Alvar, J. & Lissen, E. (1998b). Dynamics of serum cytokines in patients with visceral leishmaniasis and HIV-1 co-infection. Clinical and Experimental Immunology, 114, 733–737.
   Web of Science ®Google Scholar
• Melbye, M., Biggar, R. J., Ebbesen, P., Nealand, C., Goedert, J. J., Faber, V., Lorenzen, I., Skinhoj, P., Gallo, R. C. & Blattner, W. A. (1986). Long-term seropositivity for HTLV-III in homosexual men without the acquired immunodeficiency syn-drome: development of immunological and clinical abnormalities: a longitudinal study. Annals of Internal Medicine, 104, 496–500.
   PubMed Web of Science ®Google Scholar
• Mellors, J. W., Griffith, B. P., Ortiz, M. A., Landry, M. L. & Ryan, J. L. (1991). Tumor necrosis factor alpha/cachectin enhances human immunodeficiency virus type 1 replication in primary macrophages. Journal of Infectious Diseases, 163, 78–82.
   PubMed Web of Science ®Google Scholar
• Mellors, J. W., Rinaldo, C., Gupta, P., White, R. M., Todd, J. A. & Kingsley, L. A. (1996). Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science, 272, 1167–1170.
   PubMed Web of Science ®Google Scholar
• Mellors, J. W., Murioz, A., Giorgi, J. V., Margolick, J. B., Tassoni, C. J., Gupta, P., Detels, R., Phair, J. P. & Rinaldo Jr, C. R. (1997). Plasma viral load and CD4 + lymphocytes as prognostic morkers of HIV-1 infection. Annals of Internal Medicine, 126, 946–954.
   PubMed Web of Science ®Google Scholar
• Meltzer, M. S., Skillman, D. R., Gomatos, P. J., Kalter, D. C. & Gendelman, H. E. (1990). Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. Annual Review of Immunology, 8, 169–194.
   PubMed Web of Science ®Google Scholar
• Miralles, G. D., Stoeckle, M. Y., McDermott, D. F., Finkelman, F. D. & Murray, H. W. (1994). Thl and Th2 cell-associated cytokines in experimental visceral leishmaniasis. Infection and Immunity, 62, 1058–1063
   PubMed Web of Science ®Google Scholar
• Moreno-Camacho, A., Lopez-Velez, R., Murioz Sanz, A. & Labarga-Echevarria, P. (1998). Intestinal parasitic infections and leishmaniasis in patients with HIV infection. Enfernzedades Infecciosas y Microbiologia Clinica, 16 (Suppl. 1), 52–60.
   Google Scholar
• Morrow, R. H., Colebunders, R. L. & Chin, J. (1989). Interactions of HIV infection with endemic tropical diseases. AIDS, 3 (Suppl. 1), S79—S87.
   Google Scholar
• Murioz-Rodriguez, F. J., Padro, S., Pastor, P., Rosa-Re, D., Valls, M. E., Miro, J. M. & Gatell, M. (1997). Pleural and peritoneal leishmaniasis in an AIDS patient. European Journal of Clinical Micro-biology and Infectious Diseases, 16, 246–248.
   PubMed Web of Science ®Google Scholar
• Murray, H. W., Oca, M. J., Granger, A. M. & Schreiber, R. D. (1989). Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasis. Journal of Clinical Investigation, 83, 1253–1257.
   PubMed Web of Science ®Google Scholar
• Murray, H. W., Squires, K. E., Miralles, C. D., Stoeckle, M. Y., Granger, A. M., Granelli-Piperno, A., Bogdan, C. (1992). Acquired resistance and granuloma formation in experimental visceral leishmaniasis. Differential T cell and lymphokine roles in initial versus established immunity. Journal of Immunology, 148, 1858–1863.
   PubMed Web of Science ®Google Scholar
• Nabors, G. S. & Farrell, J. P. (1996). Successful chemo-therapy in experimental leishmaniasis is influenced by the polarity of the T cell response before treat-ment. Journal of Infectious Diseases, 173, 979–986.
   PubMed Web of Science ®Google Scholar
• Nigro, L., Cacopardo, B., Preiser, W., Braner, J., Cinatl, J., Palermo, F., Russo, R., Doerr, H. W. & Nunnari, A. (1999). In vitro production of type 1 and type 2 cytokines by peripheral blood mononuclear cells from subjects coinfected with human immuno-deficiency virus and Leishmania infantum. American Journal of Tropical Medicine and Hygiene, 60, 142–145.
   PubMed Web of Science ®Google Scholar
• Olivier, M. (1996). Modulation of host cell intracellular Ca2+ . Parasitology Today, 12, 145–150.
   PubMed Web of Science ®Google Scholar
• Olivier, M., Baimbridge, K. G. & Reiner, N. E. (1992a). Inhibition of N-formyl-methionyl-leucyl-phenylalanine-induced stimulus-response coupling in monocytes infected with Leishmania: evidence for a defect in agonist-induced calcium release. Journal of Immunology, 148, 1188–1196.
   PubMed Web of Science ®Google Scholar
• Olivier, M., Brownsey, R. W. & Reiner, N. E. (1992b). Defective stimulus—response coupling in human monocytes infected with Leishmania donovani is associated with altered activation of protein kinase C. Proceedings of the National Academy of Sciences of the United States of America, 89, 7481–7485.
   PubMed Web of Science ®Google Scholar
• Olivier, M., Romero-Gallo, B. J., Matte, C., Blanchette, J., Posner, B. I., Tremblay, M. & Faure, R. (1998). Modulation of interferon-7-induced macrophage activation by phosphotyrosine phosphatases inhibition. Effect on murine leish-maniasis progression. Journal of Biological Chemistry, 273, 13,944-13,949.
   Google Scholar
• Pantaleo, G., Graziosi, C., Demarest, J. F., Butini, L., Montroni, M., Fox, C. H., Orestein, J. M., Kotler, D. P. & Fauci, A. S. (1993). HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature, 362, 355–358.
   PubMed Web of Science ®Google Scholar
• Pantaleo, G., Graziosi, C., Demarest, J. F., Cohen, O. J., Vaccarezza, M., Gantt, K., Muro Cacho, C. & Fauci, A. S. (1994). Role of lymphoid organs in the pathogenesis of human immuno-deficiency virus (HIV) infection. Immunology Reviews, 140, 105–130.
   PubMed Web of Science ®Google Scholar
• Perelson, A. S., Neumann, A. U., Markowitz, M., Leonard, J. M. & Ho, D. D. (1996). HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science, 271, 1582–1586.
   PubMed Web of Science ®Google Scholar
• Pirmez, C., Yamamura, M., Uyemura, K., Paes-Oliveira, M., Conceicao-Silva, F. & Modlin, R. L. (1993). Cytokine patterns in the pathogenesis of human leishmaniasis. Journal of Clinical Investigation, 91, 1390–1395.
   PubMed Web of Science ®Google Scholar
• Poli, G., Kinter, A. L., Justement, J. S., Bressler, P., Kehrl, J. H. & Fauci, A. S. (1991). Transforming growth factor p suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. Journal of Experi-mental Medicine, 173, 589–597.
   PubMed Web of Science ®Google Scholar
• Pomerantz, R. J., Feinberg, M. B., Trono, D. & Baltimore, D. (1990). Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. Journal of Experimental Medicine, 172, 253–261.
   PubMed Web of Science ®Google Scholar
• Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. (1984). Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science, 224, 497–500.
   PubMed Web of Science ®Google Scholar
• Preiser, W., Cacopardo, B., Nigro, L., Braner, J., Nunnard, A., Doerr, H. W. & Weber, B. (1996). Immunological findings in HIV ILeishmania co-infection. Intervirology, 39, 285–288.
   PubMed Web of Science ®Google Scholar
• Reed, S. G. & Scott, P. (1993). T cells and cyto-kine response in Leishmania. Current Opinion in Immunology, 5, 524–531.
   PubMed Web of Science ®Google Scholar
• Reiner, N. E. & Malemud, C. J. (1984). Arachidonic acid metabolism in murine leishmaniasis (donovani): ex-vivo evidence for increased cyclooxygenase and 5-lipoxygenase activity in spleen cells. Cellular Immunology, 88, 501–510.
   PubMed Web of Science ®Google Scholar
• Reiner, S. L. & Locksley, R. M. (1995). The regulation of immunity to Leishmania major. Annual Review of Immunology, 13, 151–177.
   PubMed Web of Science ®Google Scholar
• Russo, R., Nigro, L., Minniti, S., Montinieri, A., Gradoni, L., Caldeira, L. & Davidson, R. N. (1996). Visceral leishmaniasis in HIV infected patients: treat-ment with high dose liposomal amphotericin B (AmBisome). Journal of Infection, 32, 133–137.
   PubMed Web of Science ®Google Scholar
• Scott, P. (1991). IFN-7 modulates the early develop-ment of Thl and Th2 responses in a murine model of cutaneous leishmaniasis. Journal of Immunology, 147, 3149–3155.
   PubMed Web of Science ®Google Scholar
• Scott, P. (1993). IL-12: initiation cytokine for cell mediated immunity. Science, 260, 496–497.
   PubMed Web of Science ®Google Scholar
• Sebastian, J. J., Garcia, S., Soria, M. T., Pac, J., Vicente, J. & Uribarrena, R. (1997). Visceral leishmaniasis diagnosed by colonoscopy. Journal of Clinical Gastroenterology, 25, 691–692.
   PubMed Web of Science ®Google Scholar
• Tremblay, M., Olivier, M. & Bernier, R. (1996). Leishmania and the pathogenesis of HIV infection. Parasitology Today, 12, 257–261.
   PubMedGoogle Scholar
• Turco, S. J. (1999). Adversial relationship between the Leishmania lipophosphoglycan and protein kinase C of host macrophages. Parasite Immunology, 21, 597–600.
   PubMed Web of Science ®Google Scholar
• Vázquez-Pineiro, T., Fernandez Alvarez, J. M., Gonzalo Lafuente, J. C., Cano, J., Gimeno, M. & Berenguer, J. (1998). Visceral leishmaniasis: a lingual presentation in a patient with HIV infection. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 86, 179–182.
   PubMed Web of Science ®Google Scholar
• Weissman, D. & Fauci, A. S. (1997). Role of dendritic cells in immunopathogenesis of human immuno-deficiency virus infection. Clinical Microbiology Reviews, 10, 358–367.
   PubMed Web of Science ®Google Scholar
• Wolday, D., Akuffo, H., Fessahaye, G., Valantine, A. & Britton, S. (1998). Live and killed human immuno-deficiency virus type-1 increases the intracellular growth of Leishmania donovani in monocyte-derived cells. Scandinavian Journal of Infectious Diseases, 39, 29–34.
   Google Scholar
• World Health Organization (1997). LeishmanialHIV co-infection. Epidemiological analysis of 692 retro-spective cases. Weekly Epidemiological Record, 72, 49–54.
   PubMedGoogle Scholar
• Zaitseva, M. B., Lee, S., Rabin, R. L., Tiffany, H. L., Farber, J. M., Peden, K. W., Murphy, P. M. & Golding, H. (1998). CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection. Journal of Immunology, 161, 3103 —3113 .
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Nakata, K., Weiden, M. & Rom, W. N. (1995). Mycobacterium tuberculosis enhances human immunodeficiency virus type-1 replication by tran-scriptional activation at the long terminal repeat. Journal of Clinical Investigation, 95, 2324–2331.
   PubMed Web of Science ®Google Scholar
• Zijlstra, E. E., El-Hassan, A. M., Ismael, A. & Ghalib, H. W. (1994). Endemic kala-azar in eastern Sudan: a longitudinal study on the incidence of clinical and subclinical infection and post-kala-azar dermal leishmaniasis. American Journal of Tropical Medicine and Hygiene, 51, 826–836.
   PubMed Web of Science ®Google Scholar
• Zumla, A. & Croft, S. L. (1992). Chemotherapy and immunity in opportunistic parasitic infections in AIDS. Parasitology, 105, S93–S101.
   PubMed Web of Science ®Google Scholar