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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 28, 2006 - Issue 6: Impact of Heart Disease and Stroke on Alzheimer’s Disease
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Articles

Is the ischemic blood–brain barrier insufficiency responsible for full-blown Alzheimer's disease?

Pages 665-671 | Published online: 19 Jul 2013

REFERENCES

  • Bauer HC, Bauer H, Lametschwandtner A, et al. Neovascularization and the appearance of morphological char-acteristics of the blood-brain barrier in the embryonic mouse central nervous system. Brain Res Dey Brain Res 1993; 75: 269–278
  • Zhang Y, Pardridge, WM. Rapid transferrin efflux from brain to blood across the blood-brain barrier. J Neurochem 2001; 76: 1597-1600
  • Leybaert L. Neurobarrier coupling in the brain: A partner of neurovascular and neurometabolic coupling? J Cereb Blood Flow Metab 2005; 25: 2–16
  • Saito K, Suyama K, Nishida K, et al. Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischemia in gerbil brain. Neurosci Lett 1996; 206: 149–152
  • Boutin H, LeFeuvre RA, Horai R, et al. Role of IL-1alpha and IL-1 beta in ischemic brain damage.] Neurosci 2001; 21: 5528–5534
  • Pluta R, Salinska E, Puka M, et al. Early changes in extracellular amino acids and calcium concentrations in rabbit hippocampus following complete 15-min cerebral ischemia. Resuscitation 1988; 16: 193–210
  • Kustova Y, Grinberg A, Basile AS. Increased blood-brain barrier permeability in LP-BM5 infected mice is mediated by neuroexci-tatory mechanisms. Brain Res 1999; 839: 153–163
  • Magistretti PJ, Pellerin L, Rothman DL, et al. Energy on demand. Science 1999; 283: 496–497
  • Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol 2000; 20: 131–147
  • Abbott NJ. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat 2002; 200: 629–638
  • Chen Y, McCarron RM, Azzam N, et al. Endothelin-1 and nitric oxide affect human cerebromicrovascular endothelial responses and signal transduction. Acta Neurochir Suppl 2000; 76: 131–135
  • Wallin A, Blennow K, Fredman P, et al. Blood-brain barrier function in vascular dementia. Acta Neurol Scand 1990; 81: 318–322
  • Tomimoto H, Akiguchi I, Suenaga T, et al. Alterations of the blood-brain barrier and glial cells in white matter lesions in cerebrovascular and Alzheimer's disease patients. Stroke 1996; 27: 2069–2074
  • Blennow K, Wallin A, Fredman P, et al. Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors. Acta Neurol Scand 1990; 81: 323–326
  • Claudio L. Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients. Acta Neuropathol (Berl) 1996; 91: 6–14
  • Petito CK, Pulsinelli WA, Jacobson G, et al. Edema and vascular permeability in cerebral ischemia: Comparison between ischemic neuronal damage and infarction. ] Neuropathol Exp Neurol 1982; 41: 423–436
  • Pluta R, Lossinsky AS, Wisniewski HM, et al. Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest. Brain Res 1994; 633: 41–52
  • Wisniewski HM, Pluta R, Lossinsky AS, et al. Ultrastructural studies of cerebral vascular spasm after cardiac arrest-related global cerebral ischemia in rats. Acta Neuropathol (Berl) 1995; 90: 432-440
  • Pluta R, Barcikowska M, Januszewski S, et al. Evidence of blood-brain barrier permeability/leakage for circulating human Alzheimer's beta-amyloid-(1-42)-peptide. NeuroReport 1996; 7: 1261–1265
  • Shinnou M, Ueno M, Sakamoto H, et al. Blood-brain barrier damage in reperfusion following ischemia in the hippocampus of the Mongolian gerbil brain. Acta Neurol Scand 1998; 98: 406–411
  • Pluta R, Barcikowska M, Misicka A, et al. Ischemic rats as a model in the study of the neurobiological role of human beta-amyloid peptide. Time-dependent disappearing diffuse amyloid plaques in brain. NeuroReport 1999; 10: 3615–3619
  • Lippoldt A, Kniesel U, Liebner S, et al. Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res 2000; 885: 251–261
  • Ueno M, Tomimoto H, Akiguchi I, et al. Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion. J Cereb Blood Flow Metab 2002; 22: 97–104
  • Pluta R, Ulamek M, Luczyk W, et al. Chronic blood-brain barrier opening following ischemia-reperfusion brain injury with 1-year survival. J Cereb Blood Flow Metab 2003; 23 (Suppl.1): 165
  • Pluta R. Blood-brain barrier dysfunction and amyloid precursor protein accumulation in microvascular compartment following ischemia-reperfusion brain injury with 1-year survival. Acta Neurochir Suppl 2003; 86: 117–122
  • Pluta R. Pathological opening of the blood-brain barrier to horseradish peroxidase and amyloid precursor protein following ischemia-reperfusion brain injury. Chemotherapy 2005; 51: 223–226
  • Mehta PD, Prittila T. Biological markers of Alzheimer's disease. Drug Dey Res 2002; 56: 74–84
  • Pluta R, Kida E, Lossinsky AS, et al. Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's beta-amyloid protein precursor in the brain. Brain Res 1994; 649: 323–328
  • Pluta R. From brain ischemia-reperfusion injury to possible sporadic Alzheimer's disease. Curr Neurovasc Res 2004; 1: 441–453
  • Pluta R, Misicka A, Januszewski S, et al. Transport of human beta-amyloid peptide through the rat blood-brain barrier after global cerebral ischemia. Acta Neurochir Suppl 1997; 70: 247–249
  • Deane R, Du Yan S, Submamaryan RK, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 2003; 9: 907–913
  • Pluta R, Misicka A, Barcikowska M, et al. Possible reverse transport of beta-amyloid peptide across the blood-brain barrier. Acta Neurochir Suppl 2000; 76: 73–77
  • Thomas T, Thomas G, McLendon C, et al. beta-amyloid-mediated vasoactivity and vascular endothelial damage. Nature 1996; 380: 168–171
  • Fiala M, Zhang L, Gan X, et al. Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model. Mol Med 1998; 4: 480–489
  • Farkas IG, Czigner A, Farkas E, et al. Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cel I entry into the rat brain. Acta Histochem 2003; 105: 115–125
  • Paris D, Patel N, DelleDonne A, et al. Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis. Neurosci Lett 2004; 366: 80–85
  • Paris D, Townsend K, Quadros A, et al. Inhibition of angiogenesis by Abeta peptides. Angiogenesis 2004; 7: 75–85
  • Pluta R, Januszewski S, Ulamek M. Chronic blood-brain barrier insufficiency and cytotoxic fragment of amyloid precursor protein activity in white matter following ischemia-reperfusion brain injury in long-lived animals. J Cereb Blood Flow Metab 2005; 25: S251
  • Irving EA, Yatsushiro K, McCulloch J, et al. Rapid alteration of tau in oligodendrocytes after focal ischemic injury in the rat: Involvement of free radicals. J Cereb Blood Flow Metab 1997; 17: 612–622
  • Pluta R, Lossinsky AS, Walski M, et al. Platelet occlusion phenomenon after short- and long-term survival following complete cerebral ischemia in rats produced by cardiac arrest. J Hirnforsch 1994; 35: 463–471
  • Pluta R, Lossinsky AS, Mossakowski MJ, et al. Reassessment of a new model of complete cerebral ischemia in rats. Method of induction of clinical death, pathophysiology and cerebrovascular pathology. Acta Neuropathol (Berl) 1991; 83: 1–11
  • Nimmo AJ, Cernak I, Heath DL, et al. Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 2004; 38: 40–47
  • Engler RL, Schmid-Schonbein GW, Pavelec RS. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 1983; 111: 98–111
  • Clark WM, Madden KP, Roth lein R, et al. Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment. Stroke 1991; 22: 877–883
  • Zhang RL, Chopp M, Liu Y, et al. Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology 1994; 44: 1747–1751
  • Moore AH, O'Banion MK. Neuroinflammation and anti-inflam-matory therapy for Alzheimer's disease. Adv Drug Deliv Rev 2002; 54: 1627-1656
  • Chen M, Inestrosa NC, Ross GS, et al. Platelets are the primary source of amyloid beta-peptide in human blood. Biochem Biophys Res Commun 1995; 213: 96–103
  • Smith CC. Stimulated release of the beta-amyloid protein of Alzheimer's disease by normal human platelets. Neurosci Lett 1997; 235: 157–159
  • Li QX, Whyte S, Tanner JE, et al. Secretion of Alzheimer's disease Abeta amyloid peptide by activated human platelets. Lab Invest 1998; 78: 461–469
  • van Nostrand WE, Schmaier AH, Farrow JS, et al. Protease nexin-2/ amyloid beta-protein precursor in blood is a platelet-specific protein. Biochem Biophys Res Commun 1991; 175: 15–21
  • Matsubara E, Ghiso J, Frangione B, et al. Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome. Ann Neurol 1999; 45: 537–541
  • Siljander P, Carpen O, Lassila R. Platelet-derived microparticles associate with fibrin during thrombosis. Blood 1996; 87: 4651–4663
  • Matsubara E, Shoji M, Murakami T, et al. Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta). Ann NY Acad Sci 2002; 977: 340–348
  • Silberberg DH, Manning MC, Schreiber AD. Tissue culture demyelination by normal human serum. Ann Neurol 1984; 15: 575–580
  • Ikeda K, Tomonaga M. Alzheimer&s disease amyloid precursor protein is present in the myelin sheath of central nervous system in rat. Brain Res 1990; 527: 140–144
  • lwata A, Chen XH, McIntosh TK, et al. Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes. J Neuropathol Exp Neurol 2002; 61: 1056–1068
  • Wagner KR, Dean C, Beiler S, et al. Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: Implications for white matter injury with increased blood-brain barrier permeability. Curr Neurovasc Res 2005; 2: 149–155
  • Hayflick L. The illusion of cell immortality. Br J Cancer 2000; 83: 841–846
  • Minamino T, Miyauchi H, Yoshida T, et al. Vascular cell senescence and vascular aging. J Mol Cell Cardiol 2004; 36: 175–183
  • Carmel iet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653–660
  • Lupo G, Anfuso CD, Assero G, et al. Amyloid beta(1-42) and its beta(25-35) fragment induce in vitro phosphatidylcholine hydro-lysis in bovine retina capillary pericytes. Neurosci Lett 2001; 303: 185–188
  • Anfuso CD, Assero G, Lupo G, et al. Amyloid beta(1-42) and its beta(25-35) fragment induce activation and membrane transloca-tion of cytosolic phospholipase A2 in bovine retina capillary pericytes. Biochim Biophys Acta 2004; 1686: 125–138
  • Hirschi KK, D'Amore PA. Control of angiogenesis by the pericyte: Molecular mechanisms and significance. EXS 1997; 79: 419–428
  • Ramsauer M, Krause D, Dermietzel R. Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytes. FASEBJ 2002; 16: 1274–1276
  • Kokaia Z, Lindvall O. Neurogenesis after ischaemic brain insults. Curr Opin Neurobiol 2003; 13:127–132
  • Lou issaint A, Jr, Rao S, Leventhal C, et al. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 2002; 34: 945–960
  • Atwood CS, Bowen RL, Smith MA, et al. Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for maintenance of vascular integrity and blood supply. Brain Res Brain Res Rev 2003; 43: 164–178
  • Ishimaru H, Ishikawa K, Haga S, et al. Accumulation of apolipoprotein E and beta-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death. NeuroReport 1996; 7: 3063–3067
  • Bailey TL, Rivara CB, Rocher AB, et al. The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease. Neurol Res 2004; 26: 573–578
  • Pluta R, Kida E, Golabek AA, et al. Possible involvement of patomechanism(s) operating in brain ischemia, in Alzheimer's disease pathology. J Cereb Blood Flow Metab 1995; 15: (Suppl. 1): S803
  • Kalaria RN. The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging 2000; 21: 321–330
  • Kudo T, Imaizumi K, Tanimukai H, et al. Are cerebrovascular factors involved in Alzheimer's disease? Neurobiol Aging 2000; 21: 215–224
  • Pluta R. Alzheimer lesions after ischemia-reperfusion brain injury. Folia Neuropathol 2004; 42: 181–186
  • de la Torre JC. Is Alzheimer &s disease preceded by neurodegenera-tion or cerebral hypoperfusion? Ann Neurol 2005; 57: 783–784
  • Humpel C, Marksteiner J. Cerebrovascular damage as a cause for Alzheimer's disease. Curr Neurovasc Res 2005; 2: 341–347
  • Deane R, Wu Z, Sagare A, et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 2004; 43: 333–344
  • Grammas P, Moore P, Weigel PH. Microvessels from Alzheimer's disease brains kill neurons in vitro. Am Pathol 1999; 154: 337–342
  • Pluta R. The role of apolipoprotein E in the deposition of beta-amyloid peptide during ischemia-reperfusion brain injury. A model of early Alzheimer's disease. Ann NY Acad Sci 2000; 903: 324–334
  • Pluta R. Glial expression of the beta-amyloid peptide in cardiac arrest. J Neurol Sci 2002; 203-204: 277-280
  • Pluta R. Astroglial expression of the beta-amyloid in ischemia-reperfusion brain injury. Ann NY Acad Sci 2002; 977: 102–108
  • de la Torre JC. Vascular basis of Alzheimer's pathogenesis. Ann NY Acad Sci 2002; 977: 196–215
  • Alzheimer A. Über eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiatr Psych Gericht Med (Berlin) 1907; 64: 146–148
  • Klegeris A, McGeer PL. beta-amyloid protein enhances macro-phage production of oxygen free radicals and glutamate. J Neurosci Res 1997; 49: 229–235
  • Verbeek MM, de Waal RM, Schipper JJ, et al. Rapid degeneration of cultured human brain pericytes by amyloid beta protein. J Neurochem 1997; 68: 1135–1141

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