Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH

REFERENCES

• Achan V, Tran C, Arrigoni F, et al. All-trans-retinoic acid increases nitric oxide synthesis by endothelial cells. A role for the induction of dimethylarginine dimethylaminohydrolase. Circ Res 2002; 90: 764–769
   PubMed Web of Science ®Google Scholar
• Afshar J, Pluta RM, Boock RJ, et al. Effect of intracarotid nitric oxide on primate cerebral vasospasm after subarachnoid hemor-rhage. J Neurosurg 1995; 83: 118–122
   PubMed Web of Science ®Google Scholar
• Allen GS. Cerebral arterial spasm. Part 8: The treatment of delayed cerebral arterial spasm in human beings. Surg Neurol 1976; 6: 71–80
   PubMedGoogle Scholar
• Asano T. Oxyhemoglobin as the principal cause of cerebral vasospasm: A holistic view of its actions. Crit Rev Neurosurg 1999; 9: 303–318
   PubMedGoogle Scholar
• Blaumanis OR, Grady PA, Nelson E. Hemodynamic and morphologic aspects of cerebral vasospasm. In: Price TR, Nelson E, eds. Cerebrovascular Diseases, New York: Raven Press, 1979: pp. 283–294
   Google Scholar
• Boger RH, Sydow K, Borlak J, et al. [DL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyl-transferases. Circ Res 2000; 87: 99–105
   PubMed Web of Science ®Google Scholar
• Bredt D, Hwang P, Glatt C, et al. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reduc-tase. Nature 1991; 351: 714–718
   PubMed Web of Science ®Google Scholar
• Brown FD, Hanlon K, Crockard HA, et al. Effect of sodium nitroprusside on cerebral blood flow in conscious human beings. Surg Neurol 1977; 7: 67–70
   PubMedGoogle Scholar
• Brown MM. Brain attack: A new approach to stroke. Clin Med 2002; 2: 60–65
   PubMed Web of Science ®Google Scholar
• Bryan NS, Rassaf T, Maloney RE, et al. Cellular targets and mechanisms of nitros(y1)ation: An insight into their nature and kinetics in vivo. Proc Natl Acad Sci USA 2004; 101: 4308–4313
   PubMed Web of Science ®Google Scholar
• Buchanan JE, Philis JW. The role of nitric oxide in the regulation of cerebral blood flow. Brain Res 1993; 610: 248–255
   PubMed Web of Science ®Google Scholar
• Chen H, Ward MH, Tucker KL, et al. Diet and risk of adult glioma in eastern Nebraska, United States. Cancer Causes Control 2002; 13: 647–655
   PubMed Web of Science ®Google Scholar
• Clark JF, Reilly M, Sharp FR. Oxidation of bilirubin produces compounds that cause prolonged vasospasm of rat cerebral vessels: A contributor to subarachnoid hemorrhage-induced vasospasm. J Cereb Blood Flow Metab 2002; 22: 472–478
   PubMed Web of Science ®Google Scholar
• Cosby K, Partovi KS, Crawford JH, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 2003; 9: 1498–1505
   PubMed Web of Science ®Google Scholar
• Dirnagl U, Lindauer U, Villringer A. Role of nitric oxide coupling of cerebral blood flow to neuronal activation in rats. Neurosci Lett 1992; 149: 43–46
   Web of Science ®Google Scholar
• Dorsch NW. Therapeutic approaches to vasospasm in subar-achnoid hemorrhage. Curr Opin Crit Care 2002; 8: 128–133
   PubMedGoogle Scholar
• Doyle MP, Hoekstra JW. Oxidation of nitrogen oxides by bound dioxygen in hemoproteins. J Inorg Biochem 1981; 14: 351–358
   PubMed Web of Science ®Google Scholar
• Ecker A, Rimenschneider PA. Arteriographic demonstration of spasm of the intracranial arteries with special reference to saccular arterial aneurysms. J Neurosurg 1951; 8: 660–667
   PubMed Web of Science ®Google Scholar
• Egemen N, Turker RK, Sanlidiliek U, et al. The effect of intrathecal sodium nitroprusside on severe chronic vasospasm. Neurol Res 1993; 15: 310–315
   PubMed Web of Science ®Google Scholar
• Findlay JM, Weir BK, Steinke D, et al. Effect of intrathecal thrombolytic therapy on subarachnoid clot and chronic vasos-pasm in primate model of SAH. J Neurosurg 1988; 69: 723–735
   PubMed Web of Science ®Google Scholar
• Frazee JG, Giannotta SL, Stern WE. Intravenous nitroglycerin for the treatment of chronic cerebral vasoconstriction in the primate. J Neurosurg 1981; 55: 865–868
   PubMed Web of Science ®Google Scholar
• Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373–376
   PubMed Web of Science ®Google Scholar
• Gabikian P, Clatterbuck RE, Eberhart CG, et al. Prevention of experimental cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled—release polymer: Toxicity and efficacy studies in rabbits and rats. Stroke 2002; 33: 2681–2686
   PubMed Web of Science ®Google Scholar
• Gallo O, Masino E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst 1998; 90: 587–596
   PubMed Web of Science ®Google Scholar
• Gladwin MT, Crawford JH, Patel RP. The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulation. Free Rad Biol Med 2004; 36: 707–716
   PubMed Web of Science ®Google Scholar
• Gull WM. Cases of aneurism of the cerebral vessels. Guys Hosp Rep 1859; 5: 281–304
   Google Scholar
• Handa Y, Weir BK, Nosko M, et al. The effect of timing of clot removal on chronic vasospasm in a primate model. J Neurosurg 1987; 67: 558–564
   PubMed Web of Science ®Google Scholar
• Hanel RA, Lopes DK, Wehman JC, et al. Endovascular treatment of intracranial aneurysms and vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurg Clin N Am 2005; 16: 317–353
   PubMed Web of Science ®Google Scholar
• Hashi K, Mayer JS, Shinmaru S, et al. Cerebral hemodynamic and metabolic changes after experimental subarachnoid hemorrhage. J Neurol Sci 1972; 17:1–14
   PubMed Web of Science ®Google Scholar
• Hernandez-Perera 0, Perez-Sala D, Navarro-Antol in J, et al. Effects of the 3-hydoxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 1998; 101: 2711–2719
   PubMed Web of Science ®Google Scholar
• Heros RC, Zervas NT, Lavyne MH, et al. Reversal of experimental cerebral vasospasm by intravenous nitroprusside therapy. Surg Neurol 1976; 6: 227–229
   PubMedGoogle Scholar
• Holden DP, Cartwright JE, Nussey SS, et al. Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the meta-bolism of asymmetric dimethylarginine. Circulation 2003; 108: 1575–1580
   PubMed Web of Science ®Google Scholar
• Horky LL, Pluta RM, Boock RJ, et al. Ferrous iron chelator 2,2'-dipyridyl prevents delayed vasospasm in a primate model of subarachnoid hemorrhage.] Neurosurg 1998; 88: 298–303
   PubMed Web of Science ®Google Scholar
• Huncharek M, Kupelnick B. A meta-analysis of maternal cured meat consumption during pregnancy and the risk of childhood brain tumors. Neuroepidemiology 2004; 23: 78–84
   PubMed Web of Science ®Google Scholar
• Ignarro U. Nitric oxide as a unique signaling molecule in the vascular system: A historical overview. J Physiol Pharmacol 2002; 53: 503–514
   PubMed Web of Science ®Google Scholar
• Ito Y, Isotani E, Mizuno Y, et al. Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin. J Cardiovasc Pharmacol 2000; 35: 45–50
   PubMed Web of Science ®Google Scholar
• luliano BA, Pluta RM, Jung C, et al. Endothelial dysfunction in a primate model of cerebral vasospasm. J Neurosurg 2004; 100: 287–294
   Web of Science ®Google Scholar
• Jiang JL, Li Ns NS, Li YJ. Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. Br J Pharmacol 2002; 135: 1175–1182
   PubMed Web of Science ®Google Scholar
• Jung CS, lul iano BA, Harvey-White J, et al. Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage. J Neurosurg 2004; 101: 836–842
   PubMed Web of Science ®Google Scholar
• Jung CS, luliano BA, Harvey-White J, et al. CSF levels of ADMA, an endogenous inhibitor of nitric oxide synthase, are associated with cerebral vasospasm after subarachnoid hemorrhage. In: Macdonald R, ed. Cerebral Vasospasm: Proceedings of the 8th International Conference, New York: Thieme, 2004: pp. 92-93
   Google Scholar
• Kassell NF, Helm G, Simmons N, et al. Treatment of cerebral vasospasm with intra-arterial papaverine. J Neurosurg 1992; 77: 848–852
   PubMed Web of Science ®Google Scholar
• Kassell NF, Torner JC. The International Cooperative Study in timing of aneurysm surgery—an update. Stroke 1984; 15: 566–570
   PubMed Web of Science ®Google Scholar
• Kasuya H, Weir BK, Nakane M, et al. Nitric oxide synthase and guanylate cyclase levels in canine basilar artery after subarach-noid hemorrhage. J Neurosurg 1995; 82: 250–255
   PubMed Web of Science ®Google Scholar
• Kiris T, Karasu A, Yavuz C, et al. Reversal of cerebral vasospasm by the nitric oxide donor SNAP in an experimental model of subarachnoid haemorrhage. Acta Neurochir (Wien) 1999; 141: 1323–1328
   PubMed Web of Science ®Google Scholar
• Kistler JP, Lees RS, Candia G, et al. Intravenous nitroglycerin in experimental cerebral vasospasm. A preliminary report. Stroke 1979; 10: 26–29
   PubMed Web of Science ®Google Scholar
• Kleinbongard P, Dejam A, Lauer T, et al. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Rad Biol Med 2003; 35: 790–796
   PubMed Web of Science ®Google Scholar
• Klimo P, Jr, Kestle JR, MacDonald JD, et al. Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage.] Neurosurg 2004; 100:215–224
   PubMed Web of Science ®Google Scholar
• Lau AK, Leichtweis SB, Hume P, et al. Probucol promotes functional reendothelialization in balloon-injured rabbit aortas. Circulation 2003; 107: 2031–2036
   PubMed Web of Science ®Google Scholar
• Lauer T, Preik M, Rassaf T, et al. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci USA 2001; 98: 12814–12819
   PubMed Web of Science ®Google Scholar
• Leiper J, Murray-Rust J, McDonald N, et al. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci USA 2002; 99:13527–13532
   PubMed Web of Science ®Google Scholar
• Little N, Morgan MK, Grinnell V, et al. Intra-arterial papaverine in the management of cerebral vasospasm following subarachnoid hemorrhage. J Clin Neurosci 1994; 1: 42–46
   PubMedGoogle Scholar
• Liu X, Miller MJ, Joshi MS, et al. Diffusion-limited reaction of free nitric oxide with erythrocytes. J Biol Chem 1998; 273: 18709–18713
   PubMed Web of Science ®Google Scholar
• Macdonald R, Weir B, eds. Cerebral Vasospasm, San Diego, CA: Academic Press, 2001: pp. 449–450
   Google Scholar
• Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 1991; 22: 971–982
   PubMed Web of Science ®Google Scholar
• Macdonald RL, Zhang ZD, Curry D, et al. Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates. Neurosurgery 2002; 51: 761–770
   PubMed Web of Science ®Google Scholar
• McGirt MJ, Lynch JR, Parra A, et al. Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke 2002; 33: 2950–2956
   PubMed Web of Science ®Google Scholar
• McKean-Cowdin R, Pogoda JM, Lijinsky W, et al. Maternal prenatal exposure to nitrosatable drugs and childhood brain tumours. Int J Epidemiol 2003; 32: 211–217
   PubMed Web of Science ®Google Scholar
• Moniz E. [Scientific raisins from 125 years SMW (Swiss Medical Weekly). Clinical and physiological results of cerebral angio-graphy. 1935]. Schweiz Med Wochenschr 1995; 125: 1503–1507
   PubMedGoogle Scholar
• Nagababu E, Ramasamy S, Abernethy DR, et al. Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction. J Biol Chem 2003; 278: 46349–46356
   PubMed Web of Science ®Google Scholar
• Nakao K, Murata H, Kanamaru K, et al. Effects of nitroglycerin on vasospasm and cyclic nucleotides in a primate model of subarachnoid hemorrhage. Stroke 1996; 27: 1882–1887
   PubMed Web of Science ®Google Scholar
• Neuwelt EA, Hill SA, Frenkel EP. Osmotic blood—brain barrier modification and combination chemotherapy: Concurrent tumor regression in areas of barrier opening and progression in brain regions distant to barrier opening. Neurosurgery 1984; 15: 362–366
   PubMed Web of Science ®Google Scholar
• Newberne PM. Nitrite promotes lymphoma incidence in rats. Science 1979; 204: 1079–1081
   PubMed Web of Science ®Google Scholar
• Newell DW, Eskridge J, Mayberg M, et al. Endovascular treatment of intracranial aneurysms and cerebral vasospasm. Clin Neurosurg 1992; 39: 348–360
   PubMedGoogle Scholar
• Ng WH, Moochhala S, Yeo TT, et al. Nitric oxide and subarachnoid hemorrhage: Elevated levels in cerebrospinal fluid and their implications. Neurosurgery 2001; 49: 622–627
   PubMed Web of Science ®Google Scholar
• Nishizawa S, Yamamoto S, Yokoyama T, et al. Dysfunction of nitric oxide synthase induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage. Neurol Res 1997; 19: 558–562
   PubMed Web of Science ®Google Scholar
• Ohkita M, Takaoka M, Shiota Y, et al. Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor kappa B. Clin Sci (London) 2002; 103 (Suppl. 48): S68—S71
   Google Scholar
• Oka M. Phosphodiesterase 5 inhibition restores impaired ACh relaxation in hypertensive conduit pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2001; 280: L4324435
   Google Scholar
• Paulson OB. Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery. Neurology 1970; 20: 63–77
   PubMed Web of Science ®Google Scholar
• Pipili-Synetos E, Papageorgious A, Sakkoula E, et al, Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br] Pharmacol 1995; 116: 1829–1834
   PubMed Web of Science ®Google Scholar
• Pluta RM. Delayed cerebral vasospasm and nitric oxide: Review, new hypothesis, and proposed treatment. Pharmacol Ther 2005; 105: 23–56
   PubMed Web of Science ®Google Scholar
• Pluta RM, Afshar JK, Boock RJ, et al. Temporal changes in perivascular concentrations of oxyhemoglobin, deoxyhemoglo-bin and, methemoglobin after subarachnoid hemorrhage. J Neurosurg 1998; 88: 557–561
   PubMed Web of Science ®Google Scholar
• Pluta RM, Boock RJ, Oldfield E. Intracarotid chronic infusion of nitric oxide donors prevents cerebral vasospasm in a primate model of subarachnoid hemorrhage. Present at American Association of Neurological Surgeons Annual Meeting, 1997, Denver, CO, USA
   Google Scholar
• Pluta RM, Jung CS, Shilad S, et al. Probucol does not inhibit production of ADMA or prevent vasospasm in randomized, double-blind placebo-controlled trial in a primate model of vasospasm. J Neurosurg 2005; 103: 731–738
   PubMed Web of Science ®Google Scholar
• Pluta RM, Oldfield EH, Boock RJ. Reversal and prevention of cerebral vasospasm by intracarotid infusions of nitric oxide donors in a primate model of subarachnoid hemorrhage. J Neurosurg 1997; 87: 746–751
   PubMed Web of Science ®Google Scholar
• Pluta RM, Thompson BG, Dawson TM, et al. Loss of nitric oxide synthase immunoreactivity in cerebral vasospasm. J Neurosurg 1996; 84: 648–654
   PubMed Web of Science ®Google Scholar
• Pluta RM, Dejam A, Grimes G, et al. Nitrite infusions to prevent delayed cerebral artery vasospasm in a primate model of subarachnoid aneurismal hemorrhage. JAMA 2005; 293: 1477–1484
   PubMed Web of Science ®Google Scholar
• Pradilla G, Thai QA, Legnani FG, et al. Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits. Neurosurgery 2004; 55: 1393–1399
   PubMed Web of Science ®Google Scholar
• Pyne-Geithman GJ, Morgan CJ, Wagner K, et al. Bilirubin production and oxidation in CSF of patients with cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab 2005; 25: 1070–1077
   PubMed Web of Science ®Google Scholar
• Raabe A, Zimmermann M, Setzer M, et al. Effect of intraven-tricular sodium nitroprusside on cerebral hemodynamics and oxygenation in poor-grade aneurysm patients with severe, medically refractory vasospasm. Neurosurgery 2002; 50: 1006–1013
   PubMed Web of Science ®Google Scholar
• Ram Z, Spiegelman R, Findler G, et al. Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration. Case report. Neurosurg 1989; 71: 605–607
   Web of Science ®Google Scholar
• Reid, Johnson, Ollenshow, 1950, 6th International Congress of Radiology, London, Cited after White, R Experimental findings in intracranial aneurysm Vasospasm, Vol I, pp 218-249, ed. Fox, JL, New York: Springer—Verlag
   Google Scholar
• Saavedra JE, Southan GJ, Davies KM, et al. Localizing anti-thrombotic and vasoclilatory activity with a novel, ultrafast nitric oxide donor. Med Chem 1996; 39: 4361–4365
   Google Scholar
• Sambrook MA, Hutchinson EC, Aber GM. Metabolic studies in subarachnoid haemorrhage and strokes. I. Serial changes in acid-base values in blood and cerebrospinal fluid. Brain 1973; 96: 171 —190
   Google Scholar
• Saver JL. Intra-arterial thrombolysis. Neurology 2001; 57 (Suppl. 2): 558—S60
   Google Scholar
• Sawayama Y, Shimizu C, Maeda N, et al. Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST). J Am Coll Cardiol 2002; 39: 610–616
   PubMed Web of Science ®Google Scholar
• Schievink WI. Intracranial aneurysms. N Engl I Med 1997; 336: 28–40
   PubMed Web of Science ®Google Scholar
• Sehba FA, Chereshnev I, Maayani S, et al. Nitric oxide synthase in acute alteration of nitric oxide levels after subarachnoid hemorrhage. Neurosurgery 2004; 55: 671–677
   PubMed Web of Science ®Google Scholar
• Serbinenko FA. Six hundred endovascular neurosurgical proce-dures in vascular pathology. A ten-year experience. Acta Neurochir Suppl (Wien) 1979; 28: 310–311
   PubMedGoogle Scholar
• Smith RJ. Nitrites: FDA beats a surprising retreat. Science 1980; 209: 1100–1101
   PubMed Web of Science ®Google Scholar
• Sobey CG. Cerebrovascular dysfunction after subarachnoid haemorrhage: Novel mechanisms and directions for therapy. Clin Exp Pharmacol Physiol 2001; 28: 926–929
   PubMed Web of Science ®Google Scholar
• Soderberg LS. Increased tumor growth in mice exposed to inhaled isobutyl nitrite. Toxicol Lett 1999; 104: 35–41
   PubMed Web of Science ®Google Scholar
• Stapf C, Mohr JP. Aneurysms and subarachnoid hemorrhage-epidemiology. In: LeRoux PD, Winn HR, Newell DW, eds. Management of Cerebral Aneurysms, Philadelphia, PA: WB Saunders, 2004: pp. 183–187
   Google Scholar
• Steinmeier R, Laumer R, Bondar I, et al. Cerebral hemodynamics in subarachnoid hemorrhage evaluated by Transcranial Doppler sonography. Part 2. Pulsatility Indices: Normal reference values and characteristics in subarachnoid hemorrhage. Neurosurgery 1993; 33: 10–19
   PubMed Web of Science ®Google Scholar
• Stoodley M, Macdonald RL, Weir B, et al. Subarachnoid hemorrhage as a cause of an adaptive response in cerebral vessels. I Neurosurg 2000; 93: 463–470
   PubMed Web of Science ®Google Scholar
• Stoodley M, Weihl CC, Zhang ZD, et al. Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Neurosurgery 2000; 46: 1193–1202
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Osuka K, Noda A, et al. Nitric oxide metabolites in the cisternal cerebral spinal fluid of patients with subarachnoid hemorrhage. Neurosurgery 1997; 41: 807–812
   PubMed Web of Science ®Google Scholar
• Thomas JE, Nemirovsky A, Zelman V, et al. Rapid reversal of endothel in-1-induced cerebral vasoconstriction by intrathecal administration of nitric oxide donors. Neurosurgery 1997; 40: 1245–1249
   PubMed Web of Science ®Google Scholar
• Thomas JE, Rosenwasser RH. Reversal of severe cerebral vasospasm in three patients after aneurysmal subarachnoid hemorrhage: Initial observations regarding the use of intraven-tricular sodium nitroprusside in humans. Neurosurgery 1999; 44: 48–57
   PubMed Web of Science ®Google Scholar
• Thompson BG, Pluta RM, Girton ME, et al. Nitric oxide mediation of chemoregulation but not autoregulation of cerebral blood flow in primates. I Neurosurg 1996; 84: 71–78
   PubMed Web of Science ®Google Scholar
• Thompson WJ, Piazza GA, Li H, et al. Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phos-phodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res 2000; 60: 3338–3342
   PubMed Web of Science ®Google Scholar
• Toda N, Tanaka T, Ayajiki K, et al. Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys. Neuroscience 2000; 96: 393–398
   PubMed Web of Science ®Google Scholar
• Tran DC, Yeh KC, Brazeau DA, et al. Inhalant nitrite exposure alters mouse hepatic angiogenic gene expression. Biochem Biophys Res Commun 2003; 310: 439–445
   PubMed Web of Science ®Google Scholar
• Treggiari-Venzi MM, Suter PM, Romand JA. Review of medical prevention of vasospasm after aneurysmal subarachnoid hemor-rhage: A problem of neurointensive care. Neurosurgery 2001; 48: 249-261
   Google Scholar
• Vallance P, Chan N. Endothelial function and nitric oxide: Clinical relevance. Heart 2001; 85: 342–350
   PubMed Web of Science ®Google Scholar
• Vemulapalli S, Watkins RW, Chintala M, et al. Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. I Cardiovasc Pharmacol 1996; 28: 862–869
   PubMed Web of Science ®Google Scholar
• Watkins LD. Nitric oxide and cerebral blood flow: An update. Cerebrovasc Brain Metab Rev 1995; 7: 324–337
   PubMedGoogle Scholar
• Weir B, Grace M, Hansen J, et al. Time course of vasospasm in man. I Neurosurg 1978; 48: 173–181
   PubMed Web of Science ®Google Scholar
• Weyerbrock A, Walbridge S, Pluta RM, et al. Selective opening of the blood—tumor barrier by a nitric oxide donor and long-term survival in rats with C6 gliomas. I Neurosurg 2003; 99: 728–737
   PubMed Web of Science ®Google Scholar
• Wilkins RH. Attempted prevention or treatment of intracranial arterial spasm: A survey. Neurosurgery 1980; 6: 198–210
   PubMed Web of Science ®Google Scholar
• Wilkins RH. Attempts at prevention or treatment of intracranial arterial spasm: An update. Neurosurgery 1986; 18: 808–825
   PubMed Web of Science ®Google Scholar
• Wink DA, Cook JA, Pacelli R, et al. Effect of various nitric oxide-donor agents on hydrogen peroxide mediated toxicity: A direct correlation between nitric oxide formation and protection. Arch Biochem Biophys 1996; 331: 241–248
   PubMed Web of Science ®Google Scholar
• Wolf EW, Banerjee A, Soble-Smith J, et al. Reversal of cerebral vasospasm using an intrathecally administered nitric oxide donor. I Neurosurg 1998; 89: 279–288
   PubMed Web of Science ®Google Scholar
• Zhang F, White JG, ladecola C. Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: Evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab 1994; 14: 217–226
   PubMed Web of Science ®Google Scholar
• Zweier JL, Wang P, Samouilov A, et al. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1995; 1: 804–809
   PubMed Web of Science ®Google Scholar