Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 28, 2006 - Issue 3: Multiple Sclerosis
22
Views
20
CrossRef citations to date
0
Altmetric
Articles

Natalizumab and progressive multifocal leukoencephalopathy: migrating towards safe adhesion molecule therapy in multiple sclerosis

Pages 291-298 | Published online: 02 Dec 2013

REFERENCES

  • Steinman L. Blocking adhesion molecules as therapy for multiple sclerosis: Natal izumab. Nat Rev Drug Discov 2005; 4: 510–518
  • Kleinschmidt-DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-la for multiple sclerosis. N Engl J Med 2005; 353: 369–374
  • Langer-Gould A, Atlas SW, Green AJ, et al. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005; 353: 375–381
  • Van Assche G, Van Ranst M, Sciot R, et al. Progressive multifocal leukoencephalopathy after natal izumab therapy for Crohn's disease. N Engl J Med 2005; 353: 362–368
  • Zurhein G, Chou SM. Particles resembling papova viruses in human cerebral demyelinating disease. Science 1965; 148: 1477–1479
  • Padgett BL, Walker DL, ZuRhein GM, et al. Cultivation of papova-I ike virus from human brain with progressive multifocal leucoen-cephalopathy. Lancet 1971; 1: 1257–1260
  • Weber T, Trebst C, Frye S, et al. Analysis of the systemic and intrathecal humoral immune response in progressive multifocal leukoencephalopathy. I Infect Dis 1997; 176: 250–254
  • Du Pasquier RA, Kuroda MJ, Zheng Y, et al. A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. Brain 2004; 127: 1970–1978
  • Koralnik IJ, Boden D, Mai VX, et al. JC virus DNA load in patients with and without progressive multifocal leukoencephalopathy. Neurology 1999; 52: 253–260
  • Chang H, Wang M, Tsai RT, et al. High incidence of JC viruria in JC-seropositive older individuals. I Neurovirol 2002; 8: 447–451
  • Mori M, Kurata H, Tajima M, et al. JC virus detection by in situ hybridization in brain tissue from elderly patients. Ann Neurol 1991; 29: 428–432
  • White FA 3rd, Ishaq M, Stoner GL, et al. JC virus DNA is present in many human brain samples from patients without progressive multifocal leukoencephalopathy. J Virol 1992; 66: 5726–5734
  • Mori M, Aoki N, Shimada H, et al. Detection of JC virus in the brains of aged patients without progressive multifocal leukoence-phalopathy by the polymerase chain reaction and Southern hybridization analysis. Neurosci Lett 1992; 141: 151–155
  • Heinonen 0, Syrjanen S, Mantyjarvi R, et al JC virus infection and Alzheimer's disease: Reappraisal of an in situ hybridization approach. Ann Neurol 1992; 31: 439–441
  • Telenti A, Aksamit AJ, Jr, Proper J, et al. Detection of JC virus DNA by polymerase chain reaction in patients with progressive multi-focal leukoencephalopathy. J Infect Dis 1990; 162: 858–861
  • Ferrante P, Omodeo-Zorini E, Caldarelli-Stefano R, et al. Detection of JC virus DNA in cerebrospinal fluid from multiple sclerosis patients. Mult Scler 1998; 4: 49–54
  • Tyler KL, Khalili K. Natalizumab and progressive multifocal leukoencephalopathy: Highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PA. Rev Neurol Dis 2005; 2: 144–149
  • Alon R, Kassner PD, Carr MW, et al. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 1995; 128: 1243–1253
  • Berlin C, Bargatze RE, Campbell JJ, et al. Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995; 80: 413–422
  • Chan PY, Aruffo A. VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin. J Biol Chem 1993; 268: 24655–24664
  • Chuluyan HE, Issekutz AC. VLA-4 integrin can mediate CD11/ CD18-independent transendothelial migration of human mono-cytes. J Clin Invest 1993; 92: 2768–2777
  • Yednock TA, Cannon C, Fritz LC, et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992; 356: 63–66
  • Theien BE, Vanderlugt CL, Nickerson-Nutter C, et al. Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE. Blood 2003; 102: 4464–4471
  • Alter A, Duddy M, Hebert S, et al. Determinants of human B cell migration across brain endothelial cells. J Immunol 2003; 170: 4497–4505
  • Biernacki K, Prat A, Blain M, et al. Regulation of Th1 and Th2 lymphocyte migration by human adult brain endothelial cells. J Neuropathol Exp Neurol 2001; 60: 1127–1136
  • Wong D, Prameya R, Dorovini-Zis K. In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: Regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1. J Neuropathol Exp Neurol 1999; 58: 138-152
  • Hall BM, Gibson LF. Regulation of lymphoid and myeloid leukemic cell survival: Role of stromal cell adhesion molecules. Leuk Lymphoma 2004; 45: 35–48
  • Arroyo AG, Yang JT, Rayburn H, et al. Differential requirements for alpha4 integrins during fet al and adult hematopoiesis. Cell 1996; 85: 997–1008
  • Yanai N, Sekine C, Yagita H, et al. Roles for integrin very late activation antigen-4 in stroma-dependent erythropoiesis. Blood 1994; 83: 2844–2850
  • Miyake K, Weissman IL, Greenberger JS, et al. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J Exp Med 1991; 173: 599–607
  • Wang MW, Consoli U, Lane CM, et al. Rescue from apoptosis in early (CD34-selected) versus late (non-CD34-selected) human hematopoietic cells by very late antigen 4- and vascular cell adhesion molecule (VCAM) 1-dependent adhesion to bone marrow stromal cells. Cell Growth Differ 1998; 9: 105–112
  • Dasgupta S, Jana M, Liu X, et al. Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contact-induced expres-sion of proinflammatory cytokines in microglial cells. J Biol Chem 2003; 278: 22424–22431
  • Damle NK, Klussman K, Leytze G, et al. Costimulation with integrin I igands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of anti-gen-specific CD4+ T lymphocytes. J Immunol 1993; 151: 2368–2379
  • Koopman G, Keehnen RM, Lindhout E, et al. Adhesion through the LFA-1 (CD 11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. J Immunol 1994; 152: 3760–3767
  • Mittelbrunn M, Molina A, Escribese MM, et al. VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses. Proc Natl Acad Sci USA 2004; 101:11058–11063
  • Theien BE, Vanderlugt CL, Eagar TN, et al. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experi-mental autoimmune encephalomyelitis. J Clin Invest 2001; 107: 995–1006
  • Leuker CE, Labow M, Muller W, et al. Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response. J Exp Med 2001; 193: 755–768
  • Houff SA, Major E0, Katz DA, et al. Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med 1988; 318: 301–305
  • Major E0, Amemiya K, Elder G, et al. Glial cells of the human developing brain and B cells of the immune system share a common DNA binding factor for recognition of the regulatory sequences of the human polyomavirus, JCV. J Neurosci Res 1990; 27: 461–471
  • Tornatore C, Berger JR, Houff SA, et al. Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Ann Neurol 1992; 31: 454–462
  • Ransohoff RM. Natalizumab and PML. Nat Neurosci 2005; 8: 1275
  • Koni PA, Joshi SK, Temann UA, et al. Conditional vascular cell adhesion molecule 1 deletion in mice: Impaired lymphocyte migration to bone marrow. J Exp Med 2001; 193: 741–754
  • Ulyanova T, Scott LM, Priestley GV, et al. VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. Blood 2005; 106: 86–94
  • Brooks BR, Walker DL. Progressive multifocal leukoencephalo-pathy. Neurol Clin 1984; 2: 299–313
  • Berger JR, Chauhan A, Galey D, et al. Epidemiological evidence and molecular basis of interactions between HIV and JC virus. J Neurovirol 2001; 7: 329–338
  • Vollmer TL, Phillips JT, Goodman AD, et al. An open-label safety and drug interaction study of natalizumab (Antegren) in combina-tion with interferon-beta (Avonex) in patients with multiple sclerosis. Mult Scler 2004; 10: 511–520
  • Dorries K, Sbiera S, Drews K, et al. Association of human polyomavirus JC with peripheral blood of immunoimpaired and healthy individuals. J Neurovirol 2003; 9 Suppl. 1: 81-87
  • Caruso M, Belloni L, Sthandier 0, et al. Alpha4beta1 integrin acts as a cell receptor for murine polyomavirus at the postattachment level. J Virol 2003; 77: 3913–3921
  • Caruso M, Cavaldesi M, Gentile M, et al. Role of sialic acid-contain ing molecules and the alpha4beta1 integrin receptor in the early steps of polyomavirus infection.] Gen Virol 2003; 84: 2927–2936
  • Nandi A, Estess P, Siegelman M. Bimolecular complex between rolling and firm adhesion receptors required for cell arrest; CD44 association with VLA-4 in T cell extravasation. Immunity 2004; 20: 455-465
  • Si Ghaffari S, Dougherty GJ, Lansdorp PM, et al. Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia. Blood 1995; 86: 2976–2985
  • Miyake K, Medina KL, Hayashi S, et al. Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone mar-row cultures. J Exp Med 1990; 171: 477–488
  • Rafi A, Nagarkatti M, Nagarkatti PS. Hyaluronate-CD44 interac-tions can induce murine B-cell activation. Blood 1997; 89: 2901–2908
  • Soilu-Hanninen M, Laaksonen M, Hanninen A. Hyaluronate receptor (CD44) and integrin alpha4 (CD49d) are up-regulated on T cells during MS relapses. J Neuroimmunol 2005; 166: 189–192
  • Brocke S, Piercy C, Steinman L, et al. Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc Natl Acad Sci USA 1999; 96: 6896–6901
  • Oostendorp RA, Spitzer E, Brandi M, et al. Evidence for diffe-rences in the mechanisms by which antibodies against CD44 promote adhesion of erythroid and granulopoietic pro-genitors to marrow stromal cells. Br] Haematol 1998; 101: 436–445

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.