Immunomodulatory effectiveness of azithromycin in prevention of postlaminectomy epidural fibrosis

References

• Almeida DB, Prandini MN, Awamura Y, Vitola ML, Simiao MP, Milano JB, et al. Outcome following lumbar disc surgery: the role of fibrosis. Acta Neurochir (Wien) 2008; 150: 1167–76.
   PubMed Web of Science ®Google Scholar
• Anderson SR. A rationale for the treatment algorithm of failed back surgery syndrome. Curr Rev Pain 2000; 4: 395–406.
   PubMedGoogle Scholar
• Barbera J, Gonzalez J, Esquerdo J, Broseta J, Barcia-Salorio JL. Prophylaxis of the laminectomy membrane. An experi-mental study in dogs. J Neurosurg 1978; 49: 419–24.
   Google Scholar
• Bora H, Aykol SV, Akyrirek N, Akmansu M, Ataoglu O. Inhibition of epidural scar tissue formation after spinal surgery: external irradiation vs. spinal membrane application. Int J Radiat Oncol Biol Phys 2001; 51: 507–13.
   PubMed Web of Science ®Google Scholar
• Celik SE, Altan T, Celik S, Göksu K, Ince I, Kapran Z. Mitomycin protection of peridural fibrosis in lumbar disc surgery. J Neurosurg Spine 2008; 9: 243–48.
   PubMed Web of Science ®Google Scholar
• Cook SD, Prewett AB, Dalton JE, Whitecloud TS 3rd. Reduction in perineural scar formation after laminectomy with Polyactive membrane sheets. Spine (Phila Pa 1976) 1994; 19: 1815–25.
   PubMed Web of Science ®Google Scholar
• de Tribolet N, Porchet F, Lutz TW, Gratzl O, Brotchi J, van Alphen HA, et al. Clinical assessment of a novel antiadhesion barrier gel: prospective, randomized, multicenter, clinical trial of ADCON-L to inhibit postoperative peridural fibrosis and related symptoms after lumbar discectomy. Am J Orthop (Belle Mead NJ) 1998; 27: 111–20.
   PubMedGoogle Scholar
• DiFazio FA, Nichols JB, Pope MH, Frymoyer JW. The use of expanded polytetrafluoroethylene as an interpositional mem-brane after lumbar laminectomy. Spine (Phila Pa 1976) 1995; 20: 986–91.
   Google Scholar
• Dogulu F, Kurt G, Emmez H, Erdem O, Memis L, Baykaner K, et al. Topical mitomycin C-induced inhibition of post-laminectomy peridural fibrosis in rabbits. J Neurosurg 2003; 99: 76–79.
   PubMed Web of Science ®Google Scholar
• Ozer AF, Oktenoglu T, Sasani M, Bozkus H, Canbulat N, Karaarslan E, et al. Preserving the ligamentum flavum in lumbar discectomy: a new technique that prevents scar tissue formation in the first 6 months postsurgery. Neurosurgery 2006;59(1 Suppl 1):ONS126-33; discussion ONS126-33.
   Google Scholar
• Ganzer D, Giese K, Völker L, Pietzner U, Follak N, Merk H. Two-year results after lumbar microdiscectomy with and without prophylaxis of a peridural fibrosis using Adcon-L. Arch Orthop Trauma Surg 2003; 123: 17–21.
   PubMed Web of Science ®Google Scholar
• Gasiriski P, Radek M, Jriiwiak J, Lyczak P. Peridural fibrosis in lumbar disc surgery - pathogenesis, clinical problems and prophylactic attempts. Neurol Neurochir Pol 2000; 34: 983–93.
   PubMedGoogle Scholar
• Gerszten PC, Moossy JJ, Flickinger JC, Welch WC. Low-dose radiotherapy for the inhibition of peridural fibrosis after reexploratory nerve root decompression for postlaminectomy syndrome. J Neurosurg 2003;99(3 Suppl 1):271-77.
   Google Scholar
• Hadani M, Ram Z, Horowitz A, Shacked I. Silicon prevents post laminectomy epidural root adhesions. An experimental study in rats. Acta Neurochir (Wien) 1993; 123: 153–56.
   PubMed Web of Science ®Google Scholar
• He Y, Revel M, Loty B. A quantitative model of post-laminectomy scar formation. Effects of a nonsteroidal anti-inflammatory drug. Spine (Phila Pa 1976) 1995; 20: 557–63; discussion 579-80.
   PubMed Web of Science ®Google Scholar
• Kitano T, Zerwekh JE, Edwards ML, Usui Y, Allen MD. Viscous carboxymethylcellulose in the prevention of epidural scar formation. Spine (Phila Pa 1976) 1991; 16: 820–23.
   Google Scholar
• Lladó A, Sologaistua E, Guimerri J, Mann M. Expanded polytetrafluoroethylene membrane for the prevention of peridural fibrosis after spinal surgery: a clinical study. Eur Spine J 1999; 8: 144–50.
   PubMed Web of Science ®Google Scholar
• Manchikanti L, Singh V, Cash KA, Pampati V, Datta S. Preliminary results of a randomized, equivalence trial of fluoroscopic caudal epidural injections in managing chronic low back pain: part 3 - post surgery syndrome. Pain Phys 2008; 11: 817–31.
   PubMed Web of Science ®Google Scholar
• Mavrocordatos P, Cahana A. Minimally invasive procedures for the treatment of failed back surgery syndrome. Adv Tech Stand Neurosurg 2006; 31: 221–52.
   PubMedGoogle Scholar
• Nussbaum CE, McDonald JV, Baggs RB. Use of Vicryl (polyglactin 910) mesh to limit epidural scar formation after laminectomy. Neurosurgery 1990; 26: 649–54.
   PubMed Web of Science ®Google Scholar
• Sabuncuoglu H, Bavbek M, Sabuncuoglu B, Gadelha E, Köse K, Preul M. Attenuation of postlaminectomy epidural fibrosis with monoclonal antibodies against intercellular adhesion molecule-1 and CD-18. Spine J 2007; 7: 459–65.
   PubMed Web of Science ®Google Scholar
• Schofferman J, Reynolds J, Herzog R, Covington E, Dreyfuss P, O'Neill C. Failed back surgery: etiology and diagnostic evaluation. Spine J 2003; 3: 400–03.
   PubMedGoogle Scholar
• Sypert GW, Arpin-Sypert EJ. Evaluation and management of the failed back syndrome. In: Winn HR, Youmans JR, editors. Youmans neurological surgery. 5th ed. Philadelphia: W.B. Saunders; 2004. Vol. 4, p. 4327-47.
   Google Scholar
• Shinkai M, Henke MO, Rubin BK. Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action. Pharmacol Ther 2008; 117: 393–405.
   PubMed Web of Science ®Google Scholar
• Spector SL. Alternative treatments in the patient with intractable asthma. Curr Opin Pulm Med 1997; 3: 23–29.
   PubMedGoogle Scholar
• Abdelghaffar H, Vazifeh D, Labro MT. Erythromycin A-derived macrolides modify the functional activities of human neutrophils by altering the phospholipase D-phosphatidate phosphohydrolase transduction pathway: L-cladinose is involved both in alterations of neutrophil functions and modulation of this transductional pathway. J Immunol 1997; 159: 3995–4005.
   PubMed Web of Science ®Google Scholar
• Shinkai M, Foster GH, Rubin BK. Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2006; 290: L75–85.
   PubMed Web of Science ®Google Scholar
• Shinkai M, Lopez-Boado YS, Rubin BK. Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellin. J Antimicrob Chemother 2007; 59: 1096–101.
   PubMed Web of Science ®Google Scholar
• He Y, Revel M, Loty B. A quantitative model of post-laminectomy scar formation. Effects of a nonsteroidal anti-inflammatory drug. Spine 1995; 20: 557–63.
   Google Scholar
• Ward PA, Hunninghake GW. Lung inflammation and fibrosis. Am J Respir Crit Care Med 1998; 157: 5123–29.
   Google Scholar
• Duncan MR, Berman B. Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J Exp Med 1985; 162: 516–27.
   PubMed Web of Science ®Google Scholar
• Gillery P, Serpier H, Polette M, Bellon G, Clavel C, Wegrowski Y, et al. Gamma-interferon inhibits extracellular matrix synthesis and remodeling in collagen lattice cultures of normal and scleroderma skin fibroblasts. Eur J Cell Biol 1992; 57: 244–53.
   PubMed Web of Science ®Google Scholar
• Goldring MB, Sandell LJ, Stephenson ML, Krane SM. Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes. J Biol Chem 1986; 261: 9049–55.
   PubMed Web of Science ®Google Scholar
• Granstein RD, Flotte TJ, Amento EP. Interferons and collagen production. J Invest Dermatol 1990; 95: 755–805.
   Google Scholar
• Emmez H, Kardes O, Dogulu F, Kurt G, Memis L, Baykaner MK. Role of antifibrotic cytokine interferon-gamma in the prevention of postlaminectomy peridural fibrosis in rats. Neurosurgery 2008; 62: 1351–57; discussion 1357-58.
   PubMed Web of Science ®Google Scholar
• Sime PJ, O'Reilly KM. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol 2001; 99: 308–19.
   PubMed Web of Science ®Google Scholar
• Tredget EE, Wang R, Shen Q, Scott PG, Ghahary A. Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: antagonism by IFN-alpha and IFN-gamma in vitro and in vivo. J Interferon Cytokine Res 2000; 20: 143–51.
   PubMed Web of Science ®Google Scholar
• Labro MT, Abdelghaffar H. Immunomodulation by macrolide antibiotics. J Chemother 2001; 13: 3–8.
   PubMed Web of Science ®Google Scholar
• Tamaoki J. The effects of macrolides on inflammatory cells. Chest 2004; 125: 415–50S; quiz 51S.
   Web of Science ®Google Scholar
• Shinkai M, Rubin BK. Macrolides and airway inflammation in children. Paediatr Respir Rev 2005; 6: 227–35.
   PubMedGoogle Scholar
• Shinkai M, Tamaoki J, Kobayashi H, Kanoh S, Motoyoshi K, Kute T, et al. Clarithromycin delays progression of bronchial epithelial cells from G1 phase to S phase and delays cell growth via extracellular signal-regulated protein kinase suppression. Antimicrob Agents Chemother 2006; 50: 1738-44.
   Google Scholar
• Kurt G, Aytar MH, Dogulu F, Cemil B, Erdem O, Baykaner MK, etal. A comparison of the local effectiveness of mitomycin C, aprotinin, and Adcon-L in experimental peridural fibrosis. Surg Neurol 2008; 70: 608–13; discussion 613.
   PubMedGoogle Scholar
• Lee JY, Stenzel W, Löhr M, Stritzer H, Ernestus RI, Klug N. The role of mitomycin C in reducing recurrence of epidural fibrosis after repeated operation in a laminectomy model in rats. J Neurosurg Spine 2006; 4: 329–33.
   PubMed Web of Science ®Google Scholar
• Sun Y, Wang LX, Wang L, Sun SX, Cao XJ, Wang P, et al. A comparison of the effectiveness of mitomycin C and 5-fluorouracil in the prevention of peridural adhesion after laminectomy. J Neurosurg Spine 2007; 7: 423–28.
   PubMed Web of Science ®Google Scholar
• Gilman AG, Rall TW, Nies AS, Taylor P, editors. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: McGraw Hill; 1992. Vol. 2, p. 1247-48.
   Google Scholar