341
Views
28
CrossRef citations to date
0
Altmetric
Hematological Malignancy

ABCB1 and ABCG2 proteins, their functional activity and gene expression in concert with drug sensitivity of leukemia cells

, , , , &
Pages 204-212 | Published online: 18 Jul 2013

References

  • Bradley G, Ling V. P-glycoprotein, multidrug resistance and tumor progression. Cancer Metastasis Rev 1994; 13: 223–233.
  • Deeley RG, Westlake C, Cole SPC. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006; 86: 849–899.
  • Ross DD, Karp JE, Chen TT, Doyle LA. Expression of breast cancer resistance protein in blast cells from patients with acute leukemia. Blood 2000; 96: 365–368.
  • Quiney C, Billard C, Faussat AM et al. Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells. Leuk Lymphoma 2007; 48: 1587–1599.
  • van den Heuvel-Eibrink MM, van der Holt B, Burnett AK et al. CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age. Ann Hematol 2007; 86: 329–337.
  • Szakacs G, Annereau JP, Lababidi S et al. Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell 2004; 6: 129–137.
  • Ling V. Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother Pharmacol 1997; 40: 3–8.
  • Shi CJ, Fu LW. Advances in the study of expression and regulationof P-glycoprotein. Yao Xue Xue Bao 2007; 42: 911–916.
  • Cavalcanti GB, da Cunha Vasconcelos F, de Faria GP et al. Coexpression of p53 protein and MDR functional phenotype in leukemias: the predominant association in chronic myeloid leukemia. Cytometry 2004; 61B(1): 1–8.
  • Wang Y, Liu X, Zhang HT et al. NF-kappaB regulating expression of mdrl gene and P-gp to reverse drug-resistance in leukemic cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007; 15: 950–954.
  • Abbott BL. ABCG2 (BCRP) expression in normal and malignant hematopoietic cells. Henzatol Oncol 2003; 21: 115–130.
  • Doyle LA and Ross DD. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 2003; 22: 7340–7358.
  • Litman T, Brangi M, Hudson E et al. The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci 2000; 113: 2011–2021.
  • Ugglaag B, Stählb E, Wägsäterd D et al. BCRP mRNA expression v. clinical outcome in 40 adult AML patients. Leukemia Res 2005; 29: 141–146.
  • van der Pol MA, Broxterman Hi, Pater JM et al. Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia. Haematologica 2003; 88(2): 134–147.
  • Benderra Z, Faussat AM, Sayada L et al. MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia. Clin Cancer Res 2005; 11: 7764–7772.
  • Shman TV, Savitskii VP, Potapnev MP et al. Study of expression and functional activity of P-GP membrane glycoprotein in children with acute leukemia. Bull Exp Biol Med 2006; 141(6): 727–730.
  • Leith CP, Kopecky KJ, Chen I-M et al. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia. A Southwest Oncology Group Study. Blood 1999; 94: 1086–1099.
  • Dhooge C, De Moerloose B, Laureys G et al. Expression of the multidrug transporter P-glycoprotein is highly correlated with clinical outcome in childhood acute lymphoblastic leukemia: results of a long-term prospective study. Leuk Lymphoma 2002; 43(2): 309–314.
  • Oselin K, Nowakowski-Gashaw I, Mrozikiewicz PM et al. Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic poly-morphisms in the MDR1 gene. Eur J Clin Investig 2003; 33: 261–267.
  • Plasschaert SL, Vellenga E, de Bont ES et al. High functional P-glycoprotein activity is more often present in T-cell acute lymphoblastic leukaemic cells in adults than in children. Leuk Lymphoma 2003; 44(1): 85–95.
  • Galimbertia S, Guerrinia F, Palumbob GA et al. Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients. Leukemia Res 2004; 28(4): 367–372.
  • van der Kolk DM, Vellenga E, Scheffer GL et al. Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia. Blood 2002; 99(10): 3763–3770.
  • Allen JD, Brinkhuis R.F., van Deemter L et al. Extensive contribution of the multidrug transporters P-glycoprotein and Mrpl to basal drug resistance. Cancer Res 2000; 60: 5761–5766.
  • Svirnovski A, Pasiukov V. Attempts to influence the drug resistance of tumor cells in experimental system. Exp Oncol 2005; 27(1): 43–46.
  • den Boer ML, Pieters R, Kazemier KM et al. Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. Blood 1998; 91: 2092–2098.
  • Sargent JM, Williamson CJ, Maliepaard M et al. Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia. Br J Haematol 2001; 115: 257–262.
  • Jamroziak K, Smolewski P, Cebula B et al. Relation of P-glycoprotein expression with spontaneous in vitro apoptosis in B-cell chronic lymphocytic leukemia. Neoplasma 2004; 51(3): 181–187.
  • De Moerloose B, Swerts K, Benoit Y et al. The combined analysis of P-glycoprotein expression and activity predicts outcome in childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 2003; 20(5): 381–391.
  • Sauerbrey A, Sell W, Steinbach D et al. Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia. Br J Haematol 2002; 118: 147–150.
  • Steinbach D, Sell W, Voigt A et al. BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Leukemia 2002; 16(8): 1443–1447.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.