Sickle cell disease serum induces NADPH enzyme subunit expression and oxidant production in leukocytes

References

• Steinberg MH. Pathophysiology of sickle cell disease. Bailhere's Clin Haematol 1998; 11: 163–184.
   PubMedGoogle Scholar
• Conran N, Costa FF. Hemoglobin disorders and endothelial cell interactions. Clin Biochem 2009; 42: 1824–1838.
   PubMed Web of Science ®Google Scholar
• Chiang EY, Frenette PS. Sickle cell vaso-occlusion. Hematol OncolClin N Am 2005; 19: 771–784.
   PubMed Web of Science ®Google Scholar
• Stuart MJ, Nagel RL. Sickle-cell disease. Lancet 2004; 364: 1343–1360.
   PubMed Web of Science ®Google Scholar
• Wood KC, Granger DN. Sickle cell disease: role of reactive oxygenand nitrogen metabolites. Clin Exp Pharmacol Physiol 2007; 34: 926–932.
   PubMed Web of Science ®Google Scholar
• Natta CL, Chen LC, Chow CK. Selenium and glutathione peroxidase levels in sickle cell anemia. Acta Haematol 1990; 83: 130–132.
   PubMed Web of Science ®Google Scholar
• Amer J, Ghoti H, Rachmilewitz E, Koren A, Levin C, Fibach E. Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants. Br J Haematol 2006; 132: 108–113.
   PubMed Web of Science ®Google Scholar
• Aslan M, Freeman BA. Redox-dependent impairment of vascularfunction in sickle cell disease. Free Radic Biol Med 2007; 43: 1469–1483.
   PubMed Web of Science ®Google Scholar
• Iyamu EW, Perdew H, Woods GM. Cysteine-iron promotes arginase activity by driving the Fenton reaction. Biochem Biophys Res Commun 2008; 376: 116–120.
   PubMed Web of Science ®Google Scholar
• Kuypers FA, Scott MD, Schott MA, Lubin B, Chiu DT. Use of ektacytometry to determine red cell susceptibility to oxidative stress. J Lab Clin Med 1990; 116: 535–545.
   PubMed Web of Science ®Google Scholar
• Sultana C, Shen Y, Rattan V, Johnson C, Kalra VK. Interaction ofsickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes. Blood 1998; 92: 3924–3935.
   PubMed Web of Science ®Google Scholar
• English D, Andersen BR. Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque. J Immunol Methods 1974; 5: 249–252.
   PubMed Web of Science ®Google Scholar
• McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049–6055.
   PubMed Web of Science ®Google Scholar
• Vandesompele J, De Preter K, Pattyn F et al. Accurate normal-ization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034.1-RESEARCH.11.
   PubMed Web of Science ®Google Scholar
• Selemidis S, Sobey CG, Wingler K, Schmidt HH, Drummond GR. NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition. Pharmacol Ther 2008; 120: 254–291.
   PubMed Web of Science ®Google Scholar
• Boueiz A, Hassoun PM. Regulation of endothelial barrier function by reactive oxygen and nitrogen species. Microvasc Res 2009; 77: 26–34.
   PubMed Web of Science ®Google Scholar
• Hebbel RP, Eaton JW, Balasingam M, Steinberg MH. Spontaneous oxygen radical generation by sickle erythrocytes. J Clin Invest 1982; 70: 1253–1259.
   PubMed Web of Science ®Google Scholar
• Fibach E, Rachmilewitz E. The role of oxidative stress in hemolyticanemia. Curr Mol Med 2008; 8: 609–619.
   PubMed Web of Science ®Google Scholar
• Yasui K, Baba A. Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation. Inflamm Res 2006; 55: 359–363.
   PubMed Web of Science ®Google Scholar
• El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, Braut-Boucher F. p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases. Exp Mol Med 2009; 41: 217–225.
   PubMed Web of Science ®Google Scholar
• Raad H, Paclet MH, Boussetta T et al. Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp9lphox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox. Faseb J2009; 23: 1011–1022.
   PubMed Web of Science ®Google Scholar
• El-Benna J, Dang PM, Gougerot-Pocidalo MA. Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphor-ylation and NOX2 mobilization to the plasma membrane. Sem Immunopathol 2008; 30: 279–289.
   PubMed Web of Science ®Google Scholar
• El Benna J, Faust LP, Babior BM. The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. J Biol Chem 1994; 269: 23431–23436.
   PubMed Web of Science ®Google Scholar
• Clark RA, Volpp BD, Leidal KG, Nauseef WM. Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation. J Clin Invest 1990; 85:714–721.
   PubMed Web of Science ®Google Scholar
• Bouin AP, Grandvaux N, Vignais PV, Fuchs A. p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. J Biol Chem 1998; 273: 30097–30103.
   PubMed Web of Science ®Google Scholar
• Jacobsen FW, Veiby OP, Stokke T, Jacobsen SE. TNF-alpha bidirectionally modulates the viability of primitive murine hema-topoietic progenitor cells in vitro. J Immunol 1996; 157: 1193–1199.
   PubMed Web of Science ®Google Scholar
• Fadeel B, Ahlin A, Henter JJ, Orrenius S, Hampton MB. Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species. Blood 1998; 92: 4808–4818.
   PubMed Web of Science ®Google Scholar
• Purcell PL, Crary SE, Adix LM, Alder AC, Buchanan GR. Postsplenectomy vascular complications: Feasibility of studying patients with splenectomy following trauma. Am J Hematol 2009; 84: 316–317.
   PubMed Web of Science ®Google Scholar
• Ren H, Ghebremeskel K, Okpala I, Lee A, Ibegbulam O, Crawford M. Patients with sickle cell disease have reduced blood antioxidant protection. Int J Vitam Nutr Res 2008; 78: 139–147.
   PubMed Web of Science ®Google Scholar
• Hallett JM, Leitch AE, Riley NA, Duffin R, Haslett C, Rossi AG. Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation. Trends Pharmacol Sci 2008; 29: 250–257.
   PubMed Web of Science ®Google Scholar
• Conran N, Almeida CB, Lanaro C et al. Inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patients. Br J Haematol 2007; 139: 148–158.
   PubMed Web of Science ®Google Scholar
• Gbenebitse S, Jaja SI, Kehinde MO. Effect of changes in plasma vitamin E level of vascular responses and lipid peroxidation in sickle cell anaemia subjects. Niger Postgrad Med J2005; 12: 81–84.
   PubMedGoogle Scholar
• Hasanato RM. Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia. Ann Saudi Med 2006; 26: 17–21.
   PubMed Web of Science ®Google Scholar
• Bao B, Prasad AS, Beck FW et al. Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Trans/ Res 2008; 152: 67–80.
   PubMed Web of Science ®Google Scholar
• Kato GJ, Taylor JG, VI. Pleiotropic effects of intravascular haemolysis on vascular homeostasis. Br J Haematol 2010; 148: 690–701.
   PubMed Web of Science ®Google Scholar
• Pace BS, Shartava A, Pack-Mabien A, Mulekar M, Ardia A, Goodman SR. Effects of N-acetylcysteine on dense cell formation in sickle cell disease. Am J Hematol 2003; 73: 26–32.
   PubMed Web of Science ®Google Scholar
• Amer J, Fibach E. Chronic oxidative stress reduces the respiratory burst response of neutrophils from beta-thalassaemia patients. Br J Haematol 2005; 129: 435–441.
   PubMed Web of Science ®Google Scholar