Impact of prohepcidin levels and iron parameters on early post-transplantation toxicities

References

• Majhail NS, Lazarus HM, Burns LJ. Iron overload in hematopoietic cell transplantation. Bone Marrow Transplant 2008;41:997–1003.
   PubMed Web of Science ®Google Scholar
• Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev 2009;23:95–104.
   PubMed Web of Science ®Google Scholar
• Lucarelli G, Gaziev J. Advances in the allogeneic transplantation for thalassemia. Blood Rev 2008;22:53–63.
   PubMed Web of Science ®Google Scholar
• Gaziev J, Sodani P, Polchi P, Andreani M, Lucarelli G. Bone marrow transplantation in adults with thalassemia: treatment and long-term follow-up. Ann NY Acad Sci 2005;1054:196–205.
   PubMed Web of Science ®Google Scholar
• Armand P, Kim HT, Cutler CS, Ho VT, Koreth J, Alyea EP, et al.. Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation. Blood 2007;109:4586–8.
   PubMed Web of Science ®Google Scholar
• Altes A, Remacha AF, Sureda A, Martino R, Briones J, Canals C, et al.. Iron overload might increase transplant-related mortality in hematopoietic stem cell transplantation. Bone Marrow Transplant 2002;29:987–9.
   PubMed Web of Science ®Google Scholar
• Altes A, Remacha AF, Sarda P, Baiget M, Sureda A, Martino R, et al.. Early clinical impact of iron overload in stem cell transplantation. A prospective study. Ann Hematol 2007;86:443–7.
   PubMed Web of Science ®Google Scholar
• Morado M, Ojeda E, Garcia-Bustos J, Aguado MJ, Arrieta R, Quevedo E, et al.. Serum ferritin as a risk factor for veno-occlusive disease of the liver. Prospective cohort study. Hematology 2000;6:505–12.
   Google Scholar
• Ganz T. Hepcidin — a regulator of intestinal iron absorbtion and iron recycling by macrophages. Best Pract Res Clin Haematol 2005;18:171–82.
   PubMed Web of Science ®Google Scholar
• Kemna EHJM, Tjalsma H, Willems HL, Swinkels DW. Hepcidin: from discovery to differential diagnosis. Haematologica 2008;93:90–7.
   PubMed Web of Science ®Google Scholar
• Ganz T. Hepcidin in iron metabolism. Curr Opin Hematol 2004;11:251–4.
   PubMed Web of Science ®Google Scholar
• Vyoral D, Petrak J. Hepcidin: a direct link between iron metabolism and immunity. Int J Biochem Cell Biol 2005;37:1768–73.
   PubMed Web of Science ®Google Scholar
• McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, et al.. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med 1993;118:255–67.
   PubMed Web of Science ®Google Scholar
• Koreth J, Antin JH. Iron overload in hematologic malignancies and outcome of allogeneic hematopoietic stem cell transplantation. Haematologica 2010;95:364–6.
   PubMed Web of Science ®Google Scholar
• Kanda J, Mizumoto C, Kawabata H, Ichinohe T, Tsuchida H, Tomosugi N, et al.. Clinical significance of serum hepcidin levels on early infectious complications in allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2009;15:956–62.
   PubMed Web of Science ®Google Scholar
• Means RT. Hepcidin and anemia. Blood Rev 2004;18:219–25.
   PubMed Web of Science ®Google Scholar
• Mena NP, Esparza AL, Nunez MC. Regulation of transepithelial transport of iron by hepcidin. Biol Res 2006;39:191–3.
   PubMed Web of Science ®Google Scholar
• Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, et al.. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007;13:1096–101.
   PubMed Web of Science ®Google Scholar
• Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006;26:323–42.
   PubMed Web of Science ®Google Scholar
• Porter JB. Pathophysiology of transfusional iron overload: contrasting patterns in thalassemia major and sickle cell disease. Hemoglobin 2009;33(Suppl 1):S37–45.
   PubMedGoogle Scholar
• Evens AM, Mehta J, Gordon LI. Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress. Bone Marrow Transplant 2004;34:561–71.
   PubMed Web of Science ®Google Scholar
• McCord JM. Iron: free radicals, and oxidative injury. Semin Hematol 1998;35:5–12.
   PubMed Web of Science ®Google Scholar
• Ganz T. Iron in innate immunity: starve the invaders. Curr Opin Immunol 2009;21:63–7.
   PubMed Web of Science ®Google Scholar
• Özyılmaz E, Aydoğdu M, Sucak G, Akı SZ, Özkurt ZN, Yegin ZA, et al.. Risk factors for fungal pulmonary infections in hematopoietic stem cell transplantation recipients: the role of iron overload. Bone Marrow Transplant 2010;45:1528–33.
   PubMed Web of Science ®Google Scholar
• Tunccan O, Yegin ZA, Ozkurt ZN, Erbas G, Akı SZ, Senol E, et al.. High ferritin levels are associated with hepatosplenic candidiasis in hematopoietic stem cell transplant candidates. Int J Infect Dis 2010;14(Suppl 3):e104–7.
   PubMed Web of Science ®Google Scholar
• Marx JJM. Iron and infection: competition between host and microbes for a precious element. Best Pract Res Clin Haematol 2002;15:411–26.
   PubMed Web of Science ®Google Scholar
• Maertens J, Demuynck H, Verbeken EK, Zachée P, Verhoef GE, Vandenberghe P, et al.. Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplant 1999;24:307–12.
   PubMed Web of Science ®Google Scholar
• Altes A, Remacha AF, Sadra P, Sancho FJ, Sureda A, Martino R, et al.. Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis. Bone Marrow Transplant 2004;34:505–9.
   PubMed Web of Science ®Google Scholar
• Dürken M, Nielsen P, Knobel S, Finckh B, Herrnring C, Dresow B, et al.. Nontransferrin bound iron in serum of patients receiving bone marrow transplantation. Free Radical Biol Med 1997;22:1159–63.
   PubMed Web of Science ®Google Scholar
• Sahlstedt L, Ebeling F, Bonsdorff L, Parkkinen J, Ruutu T. Non-transferin bound iron during allogeneic stem cell transplantation. Br J Haematol 2001;113:836–8.
   PubMed Web of Science ®Google Scholar
• Dürken M, Herrnring C, Finckh B, Nagel S, Nielsen P, Fischer R, et al.. Impaired plasma antioxidative defense and increased nontransferrin-bound iron during high-dose chemotherapy and radiochemotherapy preceding bone marrow transplantation. Free Radical Biol Med 2000;28:887–94.
   PubMed Web of Science ®Google Scholar
• Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother 2001;55:333–9.
   PubMed Web of Science ®Google Scholar
• Gordon LI, Brown SG, Tallman MS, Rademaker AW, Weitzman SA, Lazarus HM, et al.. Sequential changes in serum iron and ferritin in patients undergoing high- dose chemotherapy and radiation with autologous bone marrow transplantation: possible implications for treatment related toxicity. Free Radical Biol Med 1995;18:383–9.
   PubMed Web of Science ®Google Scholar
• Maradei SC, Maiolino A, Azevedo AM, Colares M, Bouzas LF, Nucci M. Serum ferritin as a risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation. Blood 2009;114:1270–5.
   PubMed Web of Science ®Google Scholar
• Sucak GT, Yeğin ZA, Özkurt ZN, Akı ŞZ, Karakan T, Akyol G. The role of liver biopsy in the work- up of liver dysfunction late after SCT: is the role of iron overload underestimated? Bone Marrow Transplant 2008;42:461–7.
   PubMed Web of Science ®Google Scholar
• Strasser SI, Kowdley KV, Sale GE, McDonald GB. Iron overload in bone marrow transplant recipients. Bone Marrow Transplant 1998;22:167–73.
   PubMed Web of Science ®Google Scholar
• Kamble RT, Selby GB, Mims M, Kharjan-Dabaja MA, Ozer H, George JN. Iron overload manifesting as apparent exacerbation of hepatic graft versus host disease after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006;12:506–10.
   PubMed Web of Science ®Google Scholar
• Ho GT, Parker A, MacKenzie JF, Morris JA, Stanley AJ. Abnormal liver function tests following bone marrow transplantation: aetiology and role of liver biopsy. Eur J Gastroenterol Hepatol 2004;16:157–62.
   PubMed Web of Science ®Google Scholar
• Mahindra A, Bolwell B, Sobecks R, Rybicki L, Pohlman B, Dean R, et al.. Elevated ferritin is associated with relapse after autologous hematopoietic stem cell transplantation for lymphoma. Biol Blood Marrow Transplant 2008;14:1239–44.
   PubMed Web of Science ®Google Scholar
• Hershko C. Mechanism of iron toxicity. Food Nutr Bull 2007;28(4 Suppl):S500–9.
   PubMed Web of Science ®Google Scholar
• Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, et al.. Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol 2006;135:254–63.
   PubMed Web of Science ®Google Scholar
• Kemma EHJM, Kartikasari AER, van Tits LJH, Pickkers P, Tjalsma H, Swinkels DW. Regulation of hepcidin: insights from biochemical analyses on human serum samples. Blood Cells Mol Dis 2008;40:339–46.
   PubMed Web of Science ®Google Scholar