1,697
Views
47
CrossRef citations to date
0
Altmetric
OriginalArticle

A novel hemostasis assay for the simultaneous measurement of coagulation and fibrinolysis

, , , , , , , & show all
Pages 327-336 | Published online: 12 Nov 2013

References

  • Hemker HC, Wielders S, Kessels H, Beguin S. Continuous registration of thrombin generationin plasma, its use for the determination of the thrombin potential. ThrombHaemost 1993;70:617–24.
  • Sorensen B, Johansen P, Christiansen K, Woelke M, Ingerslev J. Whole blood coagulation thrombelastographicprofiles employing minimal tissue factor activation. JThromb Haemost 2003;1:551–8.
  • Hron G, Kollars M, Binder BR, Eichinger S, Kyrle PA. Identification of patients at low risk forrecurrent venous thromboembolism by measuring thrombin generation. JAMA 2006;296:397–402.
  • van Hylckama Vlieg A, Christiansen SC, Luddington R, Cannegieter SC, Rosendaal FR, Baglin TP. Elevated endogenous thrombin potential isassociated with an increased risk of a first deep venous thrombosis but notwith the risk of recurrence. Br J Haematol 2007;138:769–74.
  • Dargaud Y, Beguin S, Lienhart A, Al DR, Trzeciak C, Bordet JC, et al.. Evaluation of thrombin generating capacityin plasma from patients with haemophilia A and B. ThrombHaemost 2005;93:475–80.
  • Beguin S, Lindhout T, Hemker HC. The effect of trace amounts of tissue factoron thrombin generation in platelet rich plasma, its inhibition by heparin. ThrombHaemost 1989;61:25–9.
  • Hemker HC, Giesen PL, Ramjee M, Wagenvoord R, Beguin S. The thrombogram: monitoring thrombin generationin platelet-rich plasma. Thromb Haemost 2000;83:589–91.
  • Wagenvoord RJ, Hendrix HH, Kai H, Hemker HC. A chromogenic test to determine the procoagulantphospholipids in platelet-rich plasma and whole blood. ThrombHaemost 1994;72:582–7.
  • Tappenden KA, Gallimore MJ, Evans G, Mackie IJ, Jones DW. Thrombin generation: a comparison of assaysusing platelet-poor and -rich plasma and whole blood samples from healthycontrols and patients with a history of venous thromboembolism. BrJ Haematol 2007;139:106–12.
  • Spiess BD, Gillies BS, Chandler W, Verrier E. Changes in transfusion therapy and reexplorationrate after institution of a blood management program in cardiac surgical patients. JCardiothorac Vasc Anesth 1995;9:168–73.
  • Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA. Thromboelastography-guided transfusion algorithmreduces transfusions in complex cardiac surgery. AnesthAnalg 1999;88:312–9.
  • Kang YG, Martin DJ, Marquez J, Lewis JH, Bontempo FA, Shaw BW, et al.. Intraoperative changes in blood coagulationand thrombelastographic monitoring in liver transplantation. AnesthAnalg 1985;64:888–96.
  • Kakkar T, Boxenbaum H, Mayersohn M. Estimation of Ki in a competitive enzyme-inhibitionmodel: comparisons among three methods of data analysis. DrugMetab Dispos 1999;27:756–62.
  • Sorensen B, Asvaldsdottir HS, Gudmundsdottir BR, Onundarson PT. The combination of recombinant factor VIIaand fibrinogen correct clotting ex vivo in patient samples obtained followingcardiopulmonary bypass surgery. Thromb Res 2009;124:695–700.
  • Viuff D, Andersen S, Sorensen BB, Lethagen S. Optimizing thrombelastography (TEG) assayconditions to monitor rFVIIa (NovoSeven) therapy in haemophilia A patients. ThrombRes 2010;126:144–9.
  • Szlam F, Levy JH, Tanaka KA. Tissue plasminogen activator and thrombingeneration measurements using the Thrombinoscope. BloodCoagul Fibrinolysis 2006;17:603–4.
  • Leurs J, Nerme V, Sim Y, Hendriks D. Carboxypeptidase U (TAFIa) prevents lysisfrom proceeding into the propagation phase through a threshold-dependent mechanism. JThromb Haemost 2004;2:416–23.
  • van Zonneveld AJ, Veerman H, Pannekoek H. On the interaction of the finger and the kringle-2domain of tissue-type plasminogen activator with fibrin. Inhibition of kringle-2binding to fibrin by epsilon-amino caproic acid. JBiol Chem 1986;261:14214–8.
  • Gallistl S, Muntean W, Zenz W. Gly-pro-arg-pro (GPRP) enhances free thrombin. ThrombRes 1995;78:547–50.
  • Berntorp E, Salvagno GL. Standardization and clinical utility of thrombin-generationassays. Semin Thromb Hemost 2008;34:670–82.
  • He S, Zhu K, Skeppholm M, Vedin J, Svensson J, Egberg N, et al.. A global assay of haemostasis whichuses recombinant tissue factor and tissue-type plasminogen activator to measurethe rate of fibrin formation and fibrin degradation in plasma. ThrombHaemost 2007;98:871–82.
  • Goldenberg NA, Hathaway WE, Jacobson L, Manco-Johnson MJ. A new global assay of coagulation and fibrinolysis. ThrombRes 2005;116:345–56.
  • Spiess BD, Logas WG, Tuman KJ, Hughes T, Jagmin J, Ivankovich AD. Thromboelastography used for detection ofperioperative fibrinolysis: a report of four cases. JCardiothorac Anesth 1988;2:666–72.
  • Yamakage M, Tsujiguchi N, Kohro S, Tsuchida H, Namiki A. The usefulness of celite-activated thromboelastographyfor evaluation of fibrinolysis. Can J Anaesth 1998;45:993–6.
  • Butenas S, van’t VC, Mann KG. ‘Normal’ thrombin generation. Blood 1999;94:2169–78.
  • Hemker HC, Beguin S. Thrombin generation in plasma: its assessmentvia the endogenous thrombin potential. Thromb Haemost 1995;74:134–8.
  • Hemker HC, Beguin S. Phenotyping the clotting system. ThrombHaemost 2000;84:747–51.
  • Rijken DC, Hoegee-de NE, Jie AF, Atsma DE, Schalij MJ, Nieuwenhuizen W. Development of a new test for the global fibrinolyticcapacity in whole blood. J Thromb Haemost 2008;6:151–7.
  • Simpson ML, Goldenberg NA, Jacobson LJ, Bombardier CG, Hathaway WE, Manco-Johnson MJ. Simultaneous thrombin and plasmin generationcapacities in normal and abnormal states of coagulation and fibrinolysis inchildren and adults. Thromb Res 2011;127:317–23.
  • Schmaier AH, McCrae KR. The plasma kallikrein-kinin system: its evolutionfrom contact activation. J Thromb Haemost 2007;5:2323–9.
  • Seligsohn U. Factor XI deficiency in humans. JThromb Haemost 2009;7(Suppl 1):84–7.
  • Renne T, Pozgajova M, Gruner S, Schuh K, Pauer HU, Burfeind P, et al.. Defective thrombus formation in micelacking coagulation factor XII. J Exp Med 2005;202:271–81.
  • Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, et al.. A role for factor XIIa-mediated factorXI activation in thrombus formation in vivo. Blood 2010;116:3981–9.
  • Ogiwara K, Nogami K, Nishiya K, Shima M. Plasmin-induced procoagulant effects in theblood coagulation: a crucial role of coagulation factors V and VIII. BloodCoagul. Fibrinolysis 2010;21:568–76.
  • Gulba DC, Barthels M, Westhoff-Bleck M, Jost S, Rafflenbeul W, Daniel WG, et al.. Increased thrombin levels during thrombolytictherapy in acute myocardial infarction. Relevance for the success of therapy. Circulation 1991;83:937–44.
  • Walker JB, Bajzar L. The intrinsic threshold of the fibrinolyticsystem is modulated by basic carboxypeptidases, but the magnitude of the antifibrinolyticeffect of activated thrombin-activable fibrinolysis inhibitor is masked byits instability. J Biol Chem 2004;279:27896–904.
  • Broze GJ, Higuchi DA. Coagulation-dependent inhibition of fibrinolysis:role of carboxypeptidase-U and the premature lysis of clots from hemophilicplasma. Blood 1996;88:3815–23.
  • Wagenvoord RJ, Deinum J, Elg M, Hemker HC. The paradoxical stimulation by a reversiblethrombin inhibitor of thrombin generation in plasma measured with thrombinographyis caused by alpha(2)-macroglobulin-thrombin. J ThrombHaemost 2010;8:1281–9.
  • Barrett AJ, Starkey PM. The interaction of alpha 2-macroglobulin withproteinases. Characteristics and specificity of the reaction, and a hypothesisconcerning its molecular mechanism. Biochem J 1973;133:709–24.
  • Salvesen GS, Barrett AJ. Covalent binding of proteinases in their reactionwith alpha 2-macroglobulin. Biochem J 1980;187:695–701.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.