Basic aspects of musculoskeletal pain: from acute to chronic pain

References

• Carli G, Suman AL, Biasi G, Marcolongo R. Reactivity to superficial and deep stimuli in patients with chronic musculoskeletal pain. Pain 2002;100:259–69.
   PubMed Web of Science ®Google Scholar
• Herren-Gerber R, Weiss S, Arendt-Nielsen L, Petersen-Felix S, Di SG, Radanov BP, et al. Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. Pain Med 2004;5:366–76.
   PubMed Web of Science ®Google Scholar
• Fernandez-de-Las-Penas C, Ge HY, Arendt-Nielsen L, Cuadrado ML, Pareja JA. The local and referred pain from myofascial trigger points in the temporalis muscle contributes to pain profile in chronic tension-type headache. Clin J Pain 2007;23:786–92.
   PubMed Web of Science ®Google Scholar
• Simons DG, Travell JG, Simons L. Myofascial pain and dysfunction. The trigger point manual. Philadelphia, PA: Lippincott, Williams & Wilkins; 1999.
   Google Scholar
• Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain 1993;54:241–89.
   PubMed Web of Science ®Google Scholar
• Neugebauer V, Schaible HG. Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat’s knee. J Neurophysiol 1990;64:299–311.
   PubMed Web of Science ®Google Scholar
• Sessle BJ, Hu JW, Yu X-M. Brainstem mechanisms of referred pain and hyperalgesia in the orofacial and temporomandibular region. In: , Vecchiet L, Albe-Fessard D, Lindblom U, editors. New trends in referred pain and hyperalgesia. Amsterdam: Elsevier Science Publishers B.V.; 1993. p. 59–71.
   Google Scholar
• Marchettini P, Simone DA, Caputi G, Ochoa JL. Pain from excitation of identified muscle nociceptors in humans. Brain Res 1996;740:109–16.
   PubMed Web of Science ®Google Scholar
• Simone DA, Marchettini P, Caputi G, Ochoa JL. Identification of muscle afferents subserving sensation of deep pain in humans. J Neurophysiol 1994;72:883–9.
   PubMed Web of Science ®Google Scholar
• Alfredson H, Lorentzon R. Chronic tendon pain: no signs of chemical inflammation but high concentrations of the neurotransmitter glutamate. Implications for treatment? Curr Drug Targets 2002;3:43–54.
   PubMed Web of Science ®Google Scholar
• Mense S, Meyer H. Different types of slowly conducting afferent units in cat skeletal muscle and tendon. J Physiol 1985;363:403–17.
   PubMed Web of Science ®Google Scholar
• Mense S, Simons DG. Muscle pain. Understanding its nature, diagnosis, and treatment. Philadelphia, PA: Lippincott Williams & Wilkins; 2001.
   Google Scholar
• Bjur D, Alfredson H, Forsgren S. The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation. Cell Tissue Res 2005;320:201–6.
   PubMed Web of Science ®Google Scholar
• Danielson P, Alfredson H, Forsgren S. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc Res Tech 2006;69:808–19.
   PubMed Web of Science ®Google Scholar
• Gibson W, Arendt-Nielsen L, Graven-Nielsen T. Referred pain and hyperalgesia in human tendon and muscle belly tissue. Pain 2006;120:113–23.
   PubMed Web of Science ®Google Scholar
• Gibson W, Arendt-Nielsen L, Sessle BJ, Graven-Nielsen T. Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue. Exp Brain Res 2009;194:173–82.
   PubMed Web of Science ®Google Scholar
• Delaney A, Fleetwood-Walker SM, Colvin LA, Fallon M. Translational medicine: cancer pain mechanisms and management. Br J Anaesth 2008;101:87–94.
   PubMed Web of Science ®Google Scholar
• Downey PA, Siegel MI. Bone biology and the clinical implications for osteoporosis. Phys Ther 2006;86:77–91.
   PubMed Web of Science ®Google Scholar
• Luger NM, Mach DB, Sevcik MA, Mantyh PW. Bone cancer pain: from model to mechanism to therapy. J Pain Symptom Manage 2005;29:S32–S46.
   PubMed Web of Science ®Google Scholar
• Kellgren JH. On the distribution of pain arising from deep somatic structures with charts of segmental pain areas. Clin Sci 1939;4:35–46.
   Google Scholar
• Gronblad M, Liesi P, Korkala O, Karaharju E, Polak J. Innervation of human bone periosteum by peptidergic nerves. Anat Rec 1984;209:297–9.
   PubMedGoogle Scholar
• Brainin-Mattos J, Smith ND, Malkmus S, Rew Y, Goodman M, Taulane J, et al. Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist. Pain 2006;122:174–81.
   PubMed Web of Science ®Google Scholar
• Graven-Nielsen T, Arendt-Nielsen L, Svensson P, Jensen TS. Experimental muscle pain: a quantitative study of local and referred pain in humans following injection of hypertonic saline. J Musculoskel Pain 1997;5:49–69.
   Web of Science ®Google Scholar
• Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 2006;10:287–333.
   PubMed Web of Science ®Google Scholar
• Bennell K, Hodges P, Mellor R, Bexander C, Souvlis T. The nature of anterior knee pain following injection of hypertonic saline into the infrapatellar fat pad. J Orthop Res 2004;22:116–21.
   PubMed Web of Science ®Google Scholar
• Martindale JC, Wilson AW, Reeve AJ, Chessell IP, Headley PM. Chronic secondary hypersensitivity of dorsal horn neurones following inflammation of the knee joint. Pain 2007;133:79–86.
   PubMed Web of Science ®Google Scholar
• Schaible HG. Spinal mechanisms contributing to joint pain. Novartis Found Symp 2004;260:4–22.
   PubMedGoogle Scholar
• Felson DT. The sources of pain in knee osteoarthritis. Curr Opin Rheumatol 2005;17:624–8.
   PubMed Web of Science ®Google Scholar
• Schaible HG, Richter F, Ebersberger A, Boettger MK, Vanegas H, Natura G, et al. Joint pain. Exp Brain Res 2009;196:153–62.
   PubMed Web of Science ®Google Scholar
• Schaible HG, Schmidt RF. Activation of groups III and IV sensory units in medial articular nerve by local mechanical stimulation of knee joint. J Neurophysiol 1983;49:35–44.
   PubMed Web of Science ®Google Scholar
• Sluka KA. Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway. J Neurosci 2002;22:5687–93.
   PubMed Web of Science ®Google Scholar
• Dye SF, Vaupel GL, Dye CC. Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia. Am J Sports Med 1998;26:773–7.
   PubMed Web of Science ®Google Scholar
• Kellgren JH, Samuel EP. The sensitivity and innervation of the articular capsule. J Bone Joint Surg 1950;4:193–205.
   Google Scholar
• Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. Pain 2010;149:573–81.
   PubMed Web of Science ®Google Scholar
• Graven-Nielsen T. Fundamentals of muscle pain, referred pain, and deep tissue hyperalgesia. Scand J Rheumatol Suppl 2006;1–43.
   PubMedGoogle Scholar
• Graven-Nielsen T, Arendt-Nielsen L. Assessment of mechanisms in localized and widespread musculoskeletal pain. Nat Rev Rheumatol 2010;6:599–606.
   PubMed Web of Science ®Google Scholar
• Hoheisel U, Mense S, Simons DG, Yu X-M. Appearance of new receptive fields in rat dorsal horn neurons following noxious stimulation of skeletal muscle: a model for referral of muscle pain? Neurosci Lett 1993;153:9–12.
   PubMed Web of Science ®Google Scholar
• Mense S. Referral of muscle pain. New aspects. APS J 1994;3:1–9.
   Google Scholar
• Schulte H, Graven-Nielsen T, Sollevi A, Jansson Y, Arendt-Nielsen L, Segerdahl M. Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers. Acta Anaesthesiol Scand 2003;47:1020–30.
   PubMed Web of Science ®Google Scholar
• Arendt-Nielsen L, Graven-Nielsen T. Muscle pain: sensory implications and interaction with motor control. Clin J Pain 2008;24:291–8.
   PubMed Web of Science ®Google Scholar
• Bogduk N. The neck and headaches. Neurol Clin 2004;22:151–71.
   PubMed Web of Science ®Google Scholar
• Arendt-Nielsen L, Graven-Nielsen T. translational aspects of musculoskeletal pain: from animals to patients. In: , Graven-Nielsen T, Arendt-Nielsen L, Mense S, editors. Fundamentals of Musculoskeletal Pain. Seattle, WA: IASP Press; 2008. p. 347–66.
   Google Scholar
• Nie H, Arendt-Nielsen L, Andersen H, Graven-Nielsen T. Temporal summation of pain evoked by mechanical stimulation in deep and superficial tissue. J Pain 2005;6:348–55.
   PubMed Web of Science ®Google Scholar
• Staud R, Cannon RC, Mauderli AP, Robinson ME, Price DD, Vierck CJ. Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain 2003;102:87–95.
   PubMed Web of Science ®Google Scholar
• Staud R, Craggs JG, Perlstein WM, Robinson ME, Price DD. Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls. Eur J Pain 2008;12:1078–89.
   PubMed Web of Science ®Google Scholar
• Sorensen J, Graven-Nielsen T, Henriksson KG, Bengtsson M, Arendt-Nielsen L. Hyperexcitability in fibromyalgia. J Rheumatol 1998;25:152–5.
   PubMed Web of Science ®Google Scholar
• Banic B, Petersen-Felix S, Andersen OK, Radanov BP, Villiger PM, Arendt-Nielsen L, et al. Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain 2004;107:7–15.
   PubMed Web of Science ®Google Scholar
• Arendt-Nielsen L, Yarnitsky D. Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera. J Pain 2009; 10:556–72.
   PubMed Web of Science ®Google Scholar
• Jensen KB, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, et al. Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain. Pain 2009;144:95–100.
   PubMed Web of Science ®Google Scholar
• Binderup AT, Arendt-Nielsen L, Madeleine P. Cluster analysis of pressure pain threshold maps from the trapezius muscle. Comput Methods Biomech Biomed Engin 2010;13:677–83.
   PubMed Web of Science ®Google Scholar
• Koelbaek JM, Graven-Nielsen T, Schou OA, Arendt-Nielsen L. Generalised muscular hyperalgesia in chronic whiplash syndrome. Pain 1999;83:229–34.
   PubMed Web of Science ®Google Scholar
• Sandkuhler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev 2009;89:707–58.
   PubMed Web of Science ®Google Scholar
• Slater H, Arendt-Nielsen L, Wright A, Graven-Nielsen T. Effects of a manual therapy technique in experimental lateral epicondylalgia. Man Ther 2006;11:107–17.
   PubMed Web of Science ®Google Scholar
• Holst H, Arendt-Nielsen L, Mosbech H, Serup J, Elberling J. Capsaicin-induced neurogenic inflammation in the skin in patients with symptoms induced by odorous chemicals. Skin Res Technol 2011;17:82–90.
   PubMed Web of Science ®Google Scholar
• Lemming D, Sorensen J, Graven-Nielsen T, Arendt-Nielsen L, Gerdle B. The responses to pharmacological challenges and experimental pain in patients with chronic whiplash-associated pain. Clin J Pain 2005;21:412–21.
   PubMed Web of Science ®Google Scholar
• Gibson W, Arendt-Nielsen L, Graven-Nielsen T. Delayed onset muscle soreness at tendon-bone junction and muscle tissue is associated with facilitated referred pain. Exp Brain Res 2006;174:351–60.
   PubMed Web of Science ®Google Scholar
• Babenko VV, Graven-Nielsen T, Svensson P, Drewes AM, Jensen TS, Arendt-Nielsen L. Experimental human muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P. Eur J Pain 1999;3:93–102.
   PubMed Web of Science ®Google Scholar
• Gerber RK, Nie H, Arendt-Nielsen L, Curatolo M, Graven-Nielsen T. Local pain and spreading hyperalgesia induced by intramuscular injection of nerve growth factor are not reduced by local anesthesia of the muscle. Clin J Pain 2011;27:240–7.
   PubMed Web of Science ®Google Scholar
• Andersen H, Arendt-Nielsen L, Svensson P, Danneskiold-Samsoe B, Graven-Nielsen T. Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humans. Exp Brain Res 2008;191:371–82.
   PubMed Web of Science ®Google Scholar
• Graven-Nielsen T, Arendt-Nielsen L, Svensson P, Jensen TS. Quantification of local and referred muscle pain in humans after sequential i.m. injections of hypertonic saline. Pain 1997;69:111–7.
   PubMed Web of Science ®Google Scholar
• Cairns BE, Svensson P, Wang K, Castrillon E, Hupfeld S, Sessle BJ, et al. Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Exp Brain Res 2006;169:467–72.
   PubMed Web of Science ®Google Scholar
• Witting N, Svensson P, Gottrup H, Arendt-Nielsen L, Jensen TS. Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain. Pain 2000;84:407–12.
   PubMed Web of Science ®Google Scholar
• Sluka KA, Price MP, Breese NM, Stucky CL, Wemmie JA, Welsh MJ. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain 2003;106:229–39.
   PubMed Web of Science ®Google Scholar
• Frey Law LA, Sluka KA, McMullen T, Lee J, Arendt-Nielsen L, Graven-Nielsen T. Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans. Pain 2008;140:254–64.
   PubMed Web of Science ®Google Scholar
• Issberner U, Reeh PW, Steen KH. Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia? Neurosci Lett 1996;208:191–4.
   PubMed Web of Science ®Google Scholar
• Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Zbinden AM. Epidural epinephrine and clonidine: segmental analgesia and effects on different pain modalities. Anesthesiol 1997;87:785–94.
   PubMed Web of Science ®Google Scholar
• Staahl C, Christrup LL, Andersen SD, Arendt-Nielsen L, Drewes AM. A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model. Pain 2006;123:28–36.
   PubMed Web of Science ®Google Scholar
• Adriaensen H, Gybels J, Handwerker HO, Van Hees J. Nociceptor discharges and sensations due to prolonged noxious mechanical stimulation-a paradox. Hum Neurobiol 1984;3:53–8.
   PubMedGoogle Scholar
• Neziri AY, Scaramozzino P, Andersen OK, Dickenson AH, Arendt-Nielsen L, Curatolo M. Reference values of mechanical and thermal pain tests in a pain-free population. Eur J Pain 2011;15:376–83.
   PubMed Web of Science ®Google Scholar
• Andersen H, Arendt-Nielsen L, Danneskiold-Samsoe B, Graven-Nielsen T. Pressure pain sensitivity and hardness along human normal and sensitized muscle. Somatosens Mot Res 2006;23:97–109.
   PubMed Web of Science ®Google Scholar
• Woolf CJ, Bennett GJ, Doherty M, Dubner R, Kidd B, Koltzenburg M, et al. Towards a mechanism-based classification of pain? Pain 1998;77:227–9.
   PubMed Web of Science ®Google Scholar
• Polianskis R, Graven-Nielsen T, Arendt-Nielsen L. Computer-controlled pneumatic pressure algometry–a new technique for quantitative sensory testing. Eur J Pain 2001;5:267–77.
   PubMed Web of Science ®Google Scholar
• Jespersen A, Dreyer L, Kendall S, Graven-Nielsen T, Arendt-Nielsen L, Bliddal H, et al. Computerized cuff pressure algometry: a new method to assess deep-tissue hypersensitivity in fibromyalgia. Pain 2007;131:57–62.
   PubMed Web of Science ®Google Scholar