Post-stroke fatigue: a review on prevalence, correlates, measurement, and management

References

• Swain MG. Fatigue in chronic disease. Clin Sci. 2000;99(1):1–8.
   PubMed Web of Science ®Google Scholar
• de Groot MH, Phillips SJ, Eskes GA. Fatigue associated with stroke and other neurologic conditions: Implications for stroke rehabilitation. Arch Phys Med Rehabil. 2003;84(11):1714–1720.
   PubMed Web of Science ®Google Scholar
• Glader EL, Stegmayr B, Asplund K. Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden. Stroke. 2002;33(5):1327–1333.
   PubMed Web of Science ®Google Scholar
• Ingles JL, Eskes GA, Phillips SJ. Fatigue after stroke. Arch Phys Med Rehabil. 1999;80(2):173–178.
   PubMed Web of Science ®Google Scholar
• Crosby GA, Munshi S, Karat AS, Worthington E, Lincoln NB. Fatigue after stroke: frequency and effect on daily life. Disabil Rehabil. 2012;34(8):633–637.
   PubMed Web of Science ®Google Scholar
• Annoni JM, Staub F, Bogousslavsky J, Brioschi A. Frequency, characterisation and therapies of fatigue after stroke. Neurol Sci. 2008;29(Suppl 2):S244–S246.
   PubMed Web of Science ®Google Scholar
• Choi-Kwon S, Kim JS. Poststroke fatigue: an emerging, critical issue in stroke medicine. Int J Stroke. 2011;6(4):328–336.
   PubMed Web of Science ®Google Scholar
• van de Port IG, Kwakkel G, Schepers VP, Heinemans CT, Lindeman E. Is fatigue an independent factor associated with activities of daily living, instrumental activities of daily living and health-related quality of life in chronic stroke? Cerebrovasc Dis (Basel, Switzerland). 2007;23(1):40–45.
   PubMed Web of Science ®Google Scholar
• Naess H, Lunde L, Brogger J. The effects of fatigue, pain, and depression on quality of life in ischemic stroke patients: the Bergen Stroke Study. Vasc Health Risk Manage. 2012;8:407–413.
   PubMedGoogle Scholar
• Staub F, Bogousslavsky J. Fatigue after stroke: a major but neglected issue. Cerebrovasc Dis (Basel, Switzerland). 2001;12(2):75–81.
   PubMed Web of Science ®Google Scholar
• O'Connell C, Stokes EK. Fatigue — concepts for physiotherapy management and measurement. Phys Ther Rev. 2007;12(4):314–323.
   Google Scholar
• Staub F, Bogousslavsky J. Post-stroke depression or fatigue. Eur Neurol. 2001;45(1):3–5.
   PubMed Web of Science ®Google Scholar
• Zedlitz AM, Rietveld TC, Geurts AC, Fasotti L. Cognitive and graded activity training can alleviate persistent fatigue after stroke: a randomized, controlled trial. Stroke. 2012;43(4):1046–1051.
   PubMed Web of Science ®Google Scholar
• Kirkevold M, Christensen D, Andersen G, Johansen SP, Harder I. Fatigue after stroke: manifestations and strategies. Disabil Rehabil. 2012;34(8):665–670.
   PubMed Web of Science ®Google Scholar
• Tseng BY, Billinger SA, Gajewski BJ, Kluding PM. Exertion fatigue and chronic fatigue are two distinct constructs in people post-stroke. Stroke. 2010;41(12):2908–2912.
   PubMed Web of Science ®Google Scholar
• Johansson B, Ronnback L. Mental fatigue and cognitive impairment after an almost neurological recovered stroke. ISRN Psychiatry. 2012;2012, 686425.
   Google Scholar
• Zwarts MJ, Bleijenberg G, van Engelen BG. Clinical neurophysiology of fatigue. Clin Neurophysiol. 2008;119(1):2–10.
   PubMed Web of Science ®Google Scholar
• Stokes EK, O'Connell C, Murphy B. An investigation into fatigue post-stroke and its multidimensional nature. Adv Physiother. 2011;13(1):2–10.
   Google Scholar
• Colle F, Bonan I, Gellez Leman MC, Bradai N, Yelnik A. Fatigue after stroke. Ann Readapt Med Phys. 2006;49(6):272–276, 361–274.
   PubMedGoogle Scholar
• Vuletic V, Lezaic Z, Morovic S. Post-stroke fatigue. Acta Clin Croat. 2011;50(3):341–344.
   PubMed Web of Science ®Google Scholar
• Zedlitz AMEE, van Eijk M, Kessels RPC, Geurts ACH, Fasotti L. Poststroke fatigue is still a neglected issue: findings from an internet-based study on the need for information and treatment in the Netherlands. ISRN Stroke. 2012;2012:1–5.
   Google Scholar
• Feigin VL, Barker-Collo S, Parag V, et al. Prevalence and predictors of 6-month fatigue in patients with ischemic stroke: a population-based stroke incidence study in Auckland, New Zealand, 2002–2003. Stroke. 2012;43(10):2604–2609.
   PubMed Web of Science ®Google Scholar
• van der Werf SP, van den Broek HL, Anten HW, Bleijenberg G. Experience of severe fatigue long after stroke and its relation to depressive symptoms and disease characteristics. Eur Neurol. 2001;45(1):28–33.
   PubMed Web of Science ®Google Scholar
• Schepers VP, Visser-Meily AM, Ketelaar M, Lindeman E. Poststroke fatigue: course and its relation to personal and stroke-related factors. Arch Phys Med Rehabil. 2006;87(2):184–188.
   PubMed Web of Science ®Google Scholar
• Mead GE, Graham C, Dorman P, et al. Fatigue after stroke: baseline predictors and influence on survival. Analysis of data from UK patients recruited in the International Stroke Trial. PLoS One. 2011;6(3):e16988.
   PubMed Web of Science ®Google Scholar
• Duncan F, Wu S, Mead GE. Frequency and natural history of fatigue after stroke: a systematic review of longitudinal studies. J Psychosom Res. 2012;73(1):18–27.
   PubMed Web of Science ®Google Scholar
• Christensen D, Johnsen SP, Watt T, Harder I, Kirkevold M, Andersen G. Dimensions of post-stroke fatigue: a two-year follow-up study. Cerebrovasc Dis (Basel, Switzerland). 2008;26(2):134–141.
   PubMed Web of Science ®Google Scholar
• Lerdal A, Lee KA, Bakken LN, Finset A, Kim HS. The course of fatigue during the first 18 months after first-ever stroke: a longitudinal study. Stroke Res Treat. 2012;2012:126275.
   PubMedGoogle Scholar
• Parks NE, Eskes GA, Gubitz GJ, Reidy Y, Christian C, Phillips SJ. Fatigue impact scale demonstrates greater fatigue in younger stroke survivors. Can J Neurol Sci. 2012;39(5):619–625.
   PubMed Web of Science ®Google Scholar
• Lerdal A. Curvilinear relationship between age and post-stroke fatigue among patients in the acute phase following first-ever stroke. Int J Phys Med Rehabil. 2013;01(05)
   Google Scholar
• Tang WK, Chen YK, Mok V, et al. Acute basal ganglia infarcts in poststroke fatigue: an MRI study. J Neurol. 2010;257(2):178–182.
   PubMed Web of Science ®Google Scholar
• Lerdal A, Bakken LN, Rasmussen EF. Physical impairment, depressive symptoms and pre-stroke fatigue are related to fatigue in the acute phase after stroke. Disabil Rehabil. 2011;33(4):334–342.
   PubMed Web of Science ®Google Scholar
• Choi-Kwon S, Han SW, Kwon SU, Kim JS. Poststroke fatigue: characteristics and related factors. Cerebrovasc Dis (Basel, Switzerland). 2005;19(2):84–90.
   PubMed Web of Science ®Google Scholar
• Jaracz K, Mielcarek L, Kozubski W. Clinical and psychological correlates of poststroke fatigue: preliminary results. Neurol Neurochirurg Pol. 2007;41(1):36–43.
   PubMed Web of Science ®Google Scholar
• Falconer M, Walsh S, Harbison JA. Estimated prevalence of fatigue following stroke and transient ischemic attack is dependent on terminology used and patient gender. J Stroke Cerebrovasc Dis. 2010;19(6):431–434.
   PubMed Web of Science ®Google Scholar
• Chestnut TJ. Fatigue in stroke rehabilitation patients: a pilot study. Physiother Res Int. 2011;16:151–158.
   PubMedGoogle Scholar
• Winward C, Sackley C, Metha Z, Rothwell PM. A population-based study of the prevalence of fatigue after transient ischemic attack and minor stroke. Stroke. 2009;40(3):757–761.
   PubMed Web of Science ®Google Scholar
• Sisson RA. Life after a stroke: coping with change. Rehabil Nurs. 1998;23(4):198–203.
   PubMedGoogle Scholar
• Sisson RA. Cognitive status as a predictor of right hemisphere stroke outcomes. J Neurosci Nurs. 1995;27(3):152–156.
   PubMedGoogle Scholar
• Kutlubaev MA, Duncan FH, Mead GE. Biological correlates of post-stroke fatigue: a systematic review. Acta Neurol Scand. 2012;125(4):219–227.
   PubMed Web of Science ®Google Scholar
• Sutcliffe K, Gray J, Tan MP, et al. Home orthostatic training in chronic fatigue syndrome — a randomized, placebo-controlled feasibility study. Eur J Clin Invest. 2010;40(1):18–24.
   PubMed Web of Science ®Google Scholar
• Harbison JA, Walsh S, Kenny RA. Hypertension and daytime hypotension found on ambulatory blood pressure is associated with fatigue following stroke and TIA. QJM. 2009;102(2):109–115.
   PubMed Web of Science ®Google Scholar
• McKechnie F, Lewis S, Mead G. A pilot observational study of the association between fatigue after stroke and C-reactive protein. J R Coll Phys Edinb. 2010;40(1):9–12.
   PubMedGoogle Scholar
• Ormstad H, Aass HC, Amthor KF, Lund-Sorensen N, Sandvik L. Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients. J Neurol. 2011;258(4):670–676.
   PubMed Web of Science ®Google Scholar
• Brandt L, Saveland H, Valdemarsson S, Sjoholm H, Reinstrup P. Fatigue after aneurysmal subarachnoid hemorrhage evaluated by pituitary function and 3D-CBF. Acta Neurol Scand. 2004;109(2):91–96.
   PubMed Web of Science ®Google Scholar
• Huijts M, Duits A, Staals J, van Oostenbrugge RJ. Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. PLoS One. 2012;7(1):e30519.
   PubMedGoogle Scholar
• Duncan F, Kutlubaev MA, Dennis MS, Greig C, Mead GE. Fatigue after stroke: a systematic review of associations with impaired physical fitness. Int J Stroke. 2012;7(2):157–162.
   PubMed Web of Science ®Google Scholar
• Lewis SJ, Barugh AJ, Greig CA, et al. Is fatigue after stroke associated with physical deconditioning? A cross-sectional study in ambulatory stroke survivors. Arch Phys Med Rehabil. 2011;92(2):295–298.
   PubMed Web of Science ®Google Scholar
• Mead G, Bernhardt J, Kwakkel G. Stroke: physical fitness, exercise, and fatigue. Stroke Res Treat. 2012;2012:632531.
   PubMedGoogle Scholar
• Zedlitz AM, Fasotti L, Geurts AC. Post-stroke fatigue: a treatment protocol that is being evaluated. Clin Rehabil. 2011;25(6):487–500.
   PubMed Web of Science ®Google Scholar
• Barbour VL, Mead GE. Fatigue after stroke: the patient's perspective. Stroke Res Treat. 2012;2012:863031.
   PubMedGoogle Scholar
• Hermann DM, Bassetti CL. Sleep-related breathing and sleep–wake disturbances in ischemic stroke. Neurology. 2009;73(16):1313–1322.
   PubMed Web of Science ®Google Scholar
• Sandberg O, Franklin KA, Bucht G, Gustafson Y. Sleep apnea, delirium, depressed mood, cognition, and ADL ability after stroke. J Am Geriatr Soc. 2001;49(4):391–397.
   PubMed Web of Science ®Google Scholar
• Leppavuori A, Pohjasvaara T, Vataja R, Kaste M, Erkinjuntti T. Insomnia in ischemic stroke patients. Cerebrovasc Dis. 2002;14(2):90–97.
   PubMed Web of Science ®Google Scholar
• Appelros P. Prevalence and predictors of pain and fatigue after stroke: a population-based study. Int J Rehabil Res. 2006;29(4):329–333.
   PubMed Web of Science ®Google Scholar
• Naess H, Lunde L, Brogger J, Waje-Andreassen U. Post-stroke pain on long-term follow-up: the Bergen stroke study. J Neurol. 2010;257(9):1446–1452.
   PubMed Web of Science ®Google Scholar
• Snaphaan L, van der Werf S, de Leeuw FE. Time course and risk factors of post-stroke fatigue: a prospective cohort study. Eur J Neurol. 2011;18(4):611–617.
   PubMed Web of Science ®Google Scholar
• Radman N, Staub F, Aboulafia-Brakha T, Berney A, Bogousslavsky J, Annoni JM. Poststroke fatigue following minor infarcts: a prospective study. Neurology. 2012;79(14):1422–1427.
   PubMed Web of Science ®Google Scholar
• Park JY, Chun MH, Kang SH, Lee JA, Kim BR, Shin MJ. Functional outcome in poststroke patients with or without fatigue. Am J Phys Med Rehabil. 2009;88(7):554–558.
   PubMed Web of Science ®Google Scholar
• van de Port IG, Kwakkel G, Bruin M. Lindeman E. Determinants of depression in chronic stroke: a prospective cohort study. Disabil Rehabil. 2007;29(5):353–358.
   PubMed Web of Science ®Google Scholar
• Barker-Collo S, Feigin VL, Dudley M. Post stroke fatigue–where is the evidence to guide practice? NZ Med J. 2007;120(1264):U2780.
   PubMedGoogle Scholar
• Carlsson GE, Moller A, Blomstrand C. Consequences of mild stroke in persons < 75 years — a 1-year follow-up. Cerebrovasc Dis. 2003;16(4):383–388.
   PubMed Web of Science ®Google Scholar
• Tang WK, Lu JY, Chen YK, Mok VC, Ungvari GS, Wong KS. Is fatigue associated with short-term health-related quality of life in stroke? Arch Phys Med Rehabil. 2010;91(10):1511–1515.
   PubMed Web of Science ®Google Scholar
• Naess H, Waje-Andreassen U, Thomassen L, Nyland H, Myhr KM. Health-related quality of life among young adults with ischemic stroke on long-term follow-up. Stroke. 2006;37(5):1232–1236.
   PubMed Web of Science ®Google Scholar
• Naess H, Nyland H. Poststroke fatigue and depression are related to mortality in young adults: a cohort study. BMJ Open. 2013;3(3)
   Google Scholar
• Michael K. Fatigue and stroke. Rehabil Nurs. 2002;27(3), 89–94, 103.
   PubMedGoogle Scholar
• Morley W, Jackson K, Mead GE. Post-stroke fatigue: an important yet neglected symptom. Age Ageing. 2005;34(3):313.
   PubMed Web of Science ®Google Scholar
• Lerdal A, Gay CL. Fatigue in the acute phase after first stroke predicts poorer physical health 18 months later. Neurology. 2013;81(18):1581–1587.
   PubMed Web of Science ®Google Scholar
• Miller KK, Combs SA, van Puymbroeck M, et al. Fatigue and pain: relationships with physical performance and patient beliefs after stroke. Top Stroke Rehabil. 2013;20(4):347–355.
   PubMed Web of Science ®Google Scholar
• Flinn NA, Stube JE. Post-stroke fatigue: qualitative study of three focus groups. Occup Ther Int. 2010;17(2):81–91.
   PubMed Web of Science ®Google Scholar
• Andersen G, Christensen D, Kirkevold M, Johnsen SP. Post-stroke fatigue and return to work: a 2-year follow-up. Acta Neurol Scand. 2012;125(4):248–253.
   PubMed Web of Science ®Google Scholar
• Badaru UM, Ogwumike OO, Adeniyi AF, Olowe OO. Variation in functional independence among stroke survivors having fatigue and depression. Neurol Res Int. 2013;2013:842980.
   PubMedGoogle Scholar
• Tseng BY, Kluding P. The relationship between fatigue, aerobic fitness, and motor control in people with chronic stroke: a pilot study. J Geriatr Phys Ther. 2009;32(3):97–102.
   PubMedGoogle Scholar
• Michael KM, Allen JK, Macko RF. Fatigue after stroke: relationship to mobility, fitness, ambulatory activity, social support, and falls efficacy. Rehabil Nurs. 2006;31(5):210–217.
   PubMed Web of Science ®Google Scholar
• Hoang CL, Salle JY, Mandigout S, Hamonet J, Macian-Montoro F, Daviet JC. Physical factors associated with fatigue after stroke: an exploratory study. Top Stroke Rehabil. 2012;19(5):369–376.
   PubMed Web of Science ®Google Scholar
• Neuberger GB. Measures of fatigue. Arthritis Care Res. 2003;49(5S):S175–S183.
   Google Scholar
• Elbers RG, Rietberg MB, van Wegen EE, et al. Self-report fatigue questionnaires in multiple sclerosis, Parkinson's disease and stroke: a systematic review of measurement properties. Qual Life Res. 2012;21(6):925–944.
   PubMed Web of Science ®Google Scholar
• Mead G, Lynch J, Greig C, Young A, Lewis S, Sharpe M. Evaluation of fatigue scales in stroke patients. Stroke. 2007;38(7):2090–2095.
   PubMed Web of Science ®Google Scholar
• Dittner AJ, Wessely SC, Brown RG. The assessment of fatigue. J Psychosom Res. 2004;56(2):157–170.
   PubMed Web of Science ®Google Scholar
• Tyson SF, Brown P. How to measure fatigue in neurological conditions? A systematic review of psychometric properties and clinical utility of measures used so far. Clin Rehabil. 2014;28(8):804–816.
   PubMed Web of Science ®Google Scholar
• McGeough E, Pollock A, Smith LN, et al. Interventions for post-stroke fatigue. Cochrane Database Syst Rev. 2009; (3):CD007030.
   Google Scholar
• Ogden JA, Mee EW, Utley T. Too little, too late: does tirilazad mesylate reduce fatigue after subarachnoid hemorrhage? Neurosurgery. 1998;43(4):782–787.
   PubMed Web of Science ®Google Scholar
• Choi-Kwon S, Choi J, Kwon SU, Kang DW, Kim JS. Fluoxetine is not effective in the treatment of post-stroke fatigue: a double-blind, placebo-controlled study. Cerebrovasc Dis (Basel, Switzerland). 2007;23(2–3):103–108.
   PubMed Web of Science ®Google Scholar
• Karaiskos D, Tzavellas E, Spengos K, Vassilopoulou S, Paparrigopoulos T. Duloxetine versus citalopram and sertraline in the treatment of poststroke depression, anxiety, and fatigue. J Neuropsychiatry Clin Neurosci. 2012;24(3):349–353.
   PubMed Web of Science ®Google Scholar
• Brioschi A, Gramigna S, Werth E, et al. Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients. Eur Neurol. 2009;62(4):243–249.
   PubMed Web of Science ®Google Scholar
• Clarke A, Barker-Collo SL, Feigin VL. Poststroke fatigue: does group education make a difference? A randomized pilot trial. Top Stroke Rehabil. Jan-Feb 2012;19(1):32–39.
   PubMed Web of Science ®Google Scholar
• Ward N, Winters S. Results of a fatigue management programme in multiple sclerosis. Br J Nurs. 2003;12(18):1075–1080.
   PubMedGoogle Scholar
• Lim A, Lubitz L. Chronic fatigue syndrome: successful outcome of an intensive inpatient programme. J Paediatr Child Health. 2002;38(3):295–299.
   PubMed Web of Science ®Google Scholar
• Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46(10):1121–1123.
   PubMed Web of Science ®Google Scholar
• Valko PO, Bassetti CL, Bloch KE, Held U, Baumann CR. Validation of the fatigue severity scale in a Swiss cohort. Sleep. 2008;31(11):1601–1607.
   PubMed Web of Science ®Google Scholar
• Fisk JD, Ritvo PG, Ross L, Haase DA, Marrie TJ, Schlech WF. Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18 Suppl 1:S79–S83.
   PubMed Web of Science ®Google Scholar
• de Vries J, Michielsen H, van Heck GL, Drent M. Measuring fatigue in sarcoidosis: the Fatigue Assessment Scale (FAS). Br J Health Psychol. 2004;9(Pt 3):279–291.
   PubMed Web of Science ®Google Scholar
• Belza BL, Henke CJ, Yelin EH, Epstein WV, Gilliss CL. Correlates of fatigue in older adults with rheumatoid arthritis. Nurs Res. 1993;42(2):93–99.
   PubMed Web of Science ®Google Scholar
• Muller-Nordhorn J, Nolte CH, Rossnagel K, et al. The use of the 12-item short-form health status instrument in a longitudinal study of patients with stroke and transient ischaemic attack. Neuroepidemiology. 2005;24(4):196–202.
   PubMed Web of Science ®Google Scholar
• Smets E, Garssen B, Bonke B, de Haes J. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39(3):315–325.
   PubMed Web of Science ®Google Scholar
• Mills RJ, Pallant JF, Koufali M, et al. Validation of the Neurological Fatigue Index for stroke (NFI-Stroke). Health Qual Life Outcomes. 2012;10:51.
   PubMed Web of Science ®Google Scholar
• Tseng BY, Gajewski BJ, Kluding PM. Reliability, responsiveness, and validity of the visual analog fatigue scale to measure exertion fatigue in people with chronic stroke: a preliminary study. Stroke Res Treat. 2010;2010:412964.
   PubMedGoogle Scholar
• Vercoulen JH, Swanink CM, Fennis JF, Galama JM, van der Meer JW, Bleijenberg G. Dimensional assessment of chronic fatigue syndrome. J Psychosom Res. 1994;38(5):383–392.
   PubMed Web of Science ®Google Scholar
• Stein KD, Martin SC, Hann DM, Jacobsen PB. A multidimensional measure of fatigue for use with cancer patients. Cancer Pract. 1998;6(3):143–152.
   PubMedGoogle Scholar
• McNair DM, Lorr M. An analysis of mood in neurotics. J Abnorm Psychol. 1964;69:620–627.
   PubMed Web of Science ®Google Scholar
• Lynch J, Mead G, Greig C, Young A, Lewis S, Sharpe M. Fatigue after stroke: the development and evaluation of a case definition. J Psychosom Res. 2007;63(5):539–544.
   PubMed Web of Science ®Google Scholar