MTBE: recent carcinogenicity studies

References

• Bird MG, Burleigh-Flayer HD, Chun JS, Douglas JF, Kneiss JJ, Andrews LS. Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. J Appl Toxicol 1997;17:S45–55.
   PubMed Web of Science ®Google Scholar
• Belpoggi F, Soffritti M, Maltoni C. Pathological characterization of testicular tumors and lymphomas–leukaemias, and of their precursors observed in Sprague–Dawley rats exposed to methyl-tertiary-butyl-ether (MTBE). Eur J Oncol 1998;3:201–6.
   Google Scholar
• Dodd DE, Layko DK, Bermudez E. Methyl tertiary-butyl ether (MTBE): two-year combined chronic toxicity/carcinogenicity drinking water study in Wistar rats. Protocol Number 07001. Research Triangle Park, NC: Hamner Institute for Health Sciences; 2010. Available from the following: http://hero.epa.gov/index.cfm?action=search.view&reference_id=835572 http://hero.epa.gov/index.cfm?action=search.view&reference_id=835686 http://hero.epa.gov/index.cfm?action=search.view&reference_id=835697 http://hero.epa.gov/index.cfm?action=search.view&reference_id=835726 http://hero.epa.gov/index.cfm?action=search.view&reference_id=835761
   Google Scholar
• Benson JM, Gigliotti AP, March TH, Barr EB, Tibbetts BM, Skipper BJ, et al.. Chronic carcinogenicity study of gasoline vapor condensate (GVC) and GVC containing methyl tertiary-butyl ether in F344 rats. J Toxicol Environ Health A2011;74:638–57
   PubMed Web of Science ®Google Scholar
• US Environmental Protection Agency. Methyl tertiary butyl ether (MTBE) overview; 2008. [cited 2011] Available from: http://www.epa.gov/mtbe/faq.htm
   Google Scholar
• Haseman JK, Huff J, Boorman GA. Use of historical control data in carcinogenicity studies in rodents. Toxicol Pathol 1984;12:126–35.
   PubMedGoogle Scholar
• Haseman JK, Boorman GA, Huff J. Value of historical control data and other issues related to the evaluation of long-term rodent carcinogenicity studies. Toxicol Pathol 1997;25:524–7.
   PubMed Web of Science ®Google Scholar
• Keenan C, Elmore S, Francke-Carroll S, Kemp R, Kerlin R, Peddada S, et al.. Best practices for use of historical control data of proliferative rodent lesions. Toxicol Pathol 2009;37:679–3
   PubMed Web of Science ®Google Scholar
• Walsh KM, Poteracki J. Spontaneous neoplasms in control Wistar rats. Fundam Appl Toxicol 1994;22:65–72.
   PubMedGoogle Scholar
• Poteracki J, Walsh KM. Spontaneous neoplasms in control Wistar rats: a comparison of reviews. Toxicol Sci 1998;45:1–8.
   PubMed Web of Science ®Google Scholar
• Weber K, Garman RH, Germann PG, Hardisty JF, Krinke G, Millar P, et al.. Classification of neural tumors in laboratory rodents, emphasizing the rat. Toxicol Pathol 2011;39:129–51.
   PubMed Web of Science ®Google Scholar
• Boorman GA, Montgomery CA, Eustis SL, Wolfe MJ, McConnell EE, Hardisty JF. Quality assurance in pathology for rodent carcinogenicity studies. In: , Milman H A, Weisburger E K, editors. Handbook of carcinogen testing. Park Ridge, NJ: Noyes Publications; 1985. p. 345–67.
   Google Scholar
• Prescott-Mathews JS, Poet TS, Borghoff SJ. Evaluation of the in vivo interaction of methyl tert-butyl ether with alpha2u-globulin nephropathy in male F-344 rats. Toxicol Appl Pharmacol 1999;157:60–7.
   PubMed Web of Science ®Google Scholar
• Prescott-Mathews JS, Wolf DC, Wong BA, Borghoff SJ. Methyl tert-butyl ether causes alpha2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats. Toxicol Appl Pharmacol 1997;143:301–14.
   PubMed Web of Science ®Google Scholar
• Capen C C, Dybing E, Rice J M, Wilbourn J D, editors. Species differences in thyroid, kidney and urinary bladder carcinogenesis. IARC Scientific Publication No. 147. Lyon: International Agency for Research on Cancer; 1999.
   Google Scholar
• US Environmental Protection Agency (US EPA). Alpha 2u-globulin association with chemically induced renal toxicity and neoplasia in the male rat. Risk Assessment Forum. EPA/625/3-91/019F. Washington, DC: US Environmental Protection Agency; 1991.
   Google Scholar
• Swenberg JA, Dietrich DR. Immunohistochemical localization of α2u-globulin in kidneys of treated and control rats of a 13-week vapor inhalation study undertaken with methyl tertiary butyl ether (MTBE). Report to the MTBE Health Effects Testing Task Force. 1991.
   Google Scholar
• Melnick RL, Kohn MC. Possible mechanisms of induction of renal tubular cell neoplasms in rats associated with α2u-globulin: role of protein accumulation versus ligand delivery to the kidney. In: , Capen C C, Dybing E, Rice J M, Wilbourn J D, editors. Species differences in thyroid, kidney and urinary bladder carcinogenesis. IARC Scientific Publication No. 147. Lyon: International Agency for Research on Cancer; 1999. p. 119–37.
   Google Scholar
• Melnick RL, White MC, Davis JM, Hartle RW, Ghanayem B, Ashley DL, et al.. Potential health effects of oxygenated gasoline. In: Interagency assessment of oxygenated fuels. Washington, DC: National Science and Technology Council; 1997. p. 4·1–4·38
   Google Scholar
• Brady JF, Xiao F, Ning SM, Yang CS. Metabolism of methyl tertiary-butyl ether by rat hepatic microsomes. Arch Toxicol 1990;64:157–60.
   PubMed Web of Science ®Google Scholar
• International Agency for Research on Cancer (IARC). Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. Vol. 88. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon: IARC; 2006.
   Google Scholar
• Baan R, Grosse Y, Straif K, Secretan B, El Ghissassi F, Bouvard V, et al.. A review of human carcinogens — Part F: Chemical agents and related occupations. Lancet Oncol 2009;10:1143–4.
   PubMed Web of Science ®Google Scholar
• International Agency for Research on Cancer (IARC). [cited 2011] Available from: http://monographs.iarc.fr/ENG/Preamble/index.php
   Google Scholar
• National Toxicology Program. [cited 2011] Available from: http://ntp.niehs.nih.gov/?objectid=47B37760-F1F6-975E-7C15022B9C93B5A6
   Google Scholar
• US Environmental Protection Agency. Guidelines for carcinogen risk assessment. EPA/630/P-03/001F. Washington, DC: US Environmental Protection Agency; 2005.
   Google Scholar