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Redox Report
Communications in Free Radical Research
Volume 5, 2000 - Issue 2-3
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Miscellany

Dichloroacetate (DCA) reduces brain lactate but increases brain glutamine in experimental cerebral malaria: a 1H-NMR study

C. RaeDepartment of Biochemistry University of Sydney , New South Wales, Australia
,
A. MaitlandDepartment of Pathology University of Sydney , New South Wales, Australia
,
W.A. BubbDepartment of Biochemistry University of Sydney , New South Wales, Australia
&
N.H. HuntDepartment of Pathology University of Sydney , New South Wales, Australia
Pages 141-143 | Published online: 19 Jul 2013

REFERENCES

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  • Warell DA, Veal N, Chanthavanich P et al. Cerebral anaerobic glycolysis and reduced cerebral oxygen transport in human cerebral malaria. Lancet 1988; 534–537.
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  • Thumwood CM, Hunt NH, Clark IA, Cowden WB. Breakdown of the blood-brain barrier in murine cerebral malaria. Parasitology 1988; 96: 579–589.
  • Sanni L, Rae C, Maitland A, Stocker R, Hunt NH. Is ischaemia involved in the pathogenesis of murine cerebral malaria? Manuscript in preparation.
  • Stacpoole PW. The pharmacology of dichloroacetate. Metab Clin Exp 1989; 38: 1124–1144.
  • Griffin JL, Rae C, Dixon RM, Radda GK, Matthews PM. Excitatory amino acid synthesis in hypoxic brain slices: does alanine act as a substrate for glutamate production in hypoxia?J Neurochem 1998; 71: 2477-2486.
  • Chang LH, Shimizu H, Abiko H et al. Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. J Cereb Blood Flow Metab 1992; 12: 1030–1038.
  • Krishna S, Supanaranond W, Pukrittayakamee S et al. Dichloro-acetate for lactic acidosis in severe malaria: a pharmacokinetic and pharmacodynamic assessment. Metab Clin Exp 1994; 43: 974–981.

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