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Redox Report
Communications in Free Radical Research
Volume 6, 2001 - Issue 3
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Miscellany

The ‘pivotal antioxidant’ hypothesis for the role of flavonoids in their reduction of HO· radical-induced damage on DNA

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Pages 197-199 | Published online: 19 Jul 2013

  • Ames BN, Gold LS. Endogenous mutagens and the causes of aging and cancer. Mutat Res 1991; 250:3–16.
  • Olinski R, Zastawny T, Budzbon J, Skokowski J, Zegarski W, Dizdaroglu M. DNA base modifications in chromatin of human cancerous tissues. FEBS Left 1992; 309: 193–198.
  • Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90: 7915–7922.
  • Cadenas E, Davies KJA. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000; 29: 222–230.
  • Cerruti PA. Mechanisms of action of oxidant carcinogens. Cancer Detect Prey 1989; 14: 281–284.
  • Namiki M. Antioxidants/antimutagens in foods. CRC Crit Rev Food Sci Nutr 1990; 29:273–300.
  • Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 1996; 20: 933–956.
  • Husain SR, Cillard J, Cillard P. Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 1987; 26: 2489–2491.
  • Bohrs W, Saran M. Radical scavenging by flavonoid antioxidants. Free Radic Res Commun 1987; 2: 289–294.
  • Lee MJ, Wang ZY, Li H et at. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prey 1995; 4: 393–399.
  • Paganga G, Rice-Evans CA. The identification of flavonoids as glycosides in human plasma. FEBS Lett 1997; 401: 78–82.
  • Anderson RF, Amarasinghe C, Fisher U, Mak WB, Packer JE. Reduction in free-radical-induced DNA strand breaks and base damage through fast chemical repair by flavonoids. Free Radic Res 2000; 33: 91–103.
  • Hodgkins PS, Fairman MP, O'Neill P. Rejoining of gamma-radiation-induced single-strand breaks in plasmid DNA by human cell extracts: dependence on the concentration of the hydroxyl radical scavenger, Tris. Radiat Res 1996; 145: 24–30.
  • Hicks M, Gebicki JM. Rate constants for reaction of hydroxyl radicals with Tris, Tricine and HEPES buffers. FEBS Left 1986; 199:92–94.
  • Redpath IL, Willson RU. Reducing compounds in radioprotection and radiosensitization: model experiments using ascorbic acid. Int J Radiat Biol 1973; 23: 51–65.
  • Davies MJ, Fomi LG, Willson RU. Vitamin E analogue Trolox C. ESR and pulse-radiolysis studies of free radical reactions. Biochem J 1988; 255:513–522.
  • Quintiliani M, Badiello R, Tamba M, Esfandi A, Gorin G. Radiolysis of glutathione in oxygen-containing solutions of pH 7. Int J Radiat Biol 1977; 32: 195–202.
  • Lux O, Naidoo D. Biological variation of ascorbic acid and a-tocopherol. Redox Report 1994; 1: 45–49.
  • Rice ME. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci 2000; 23: 209–216.
  • Williams NH, Yandell JK. Outer-sphere electron-transfer reactions of ascorbate anions. Aust J Chem 1982; 35: 1133–1144.
  • Steenken S, Neta P. One-electron redox potentials of phenols. Hydroxy- and aminophenols and related compounds of biological interest. J Phys Chem 1982; 86: 3661–3667.
  • Surdhar PS, Armstrong DA. Reduction potentials and exchange reactions of thiyl radicals and disulfide anion radicals. J Phys Chem 1987; 91: 6532–6537.
  • Jovanovic SV, Steenken S, Tosic M, Marjanovic B, Simic MG. Flavonoids as antioxidants. J Am Chem Soc 1994; 116:4846–4851.
  • Jovanovic SV, Hara Y, Steenken S, Simic MG. Antioxidant potential of gallocatechins. A pulse radiolysis study. J Am Chem Soc 1995; 117: 9881–9888.
  • Steenken S, Jovanovic SV. The trap depth (in DNA) of 8-oxo-7,8-dihydro-2'-deoxyguanosine as derived from electron-transfer equilibria in aqueous solution. J Am Chem Soc 2000; 122: 2373–2374.
  • Jovanovic SV, Jankovic I, Josimovic L. Electron-transfer reactions of alkyl peroxy radicals. J Am Chem Soc 1992; 114: 9018–9021.
  • Jovanovic SV, Steenken S, Hara Y, Simic MG. Reduction potentials of flavonoids and model phenoxyl radicals. Which ring in flavonoids is responsible for antioxidant activity? J Chem Soc Perkin Trans 2 1996; 2497-2504.

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