- Guengerich FP. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res 1988; 48: 2946–2954.
- Conney AH. Induction of microsomal cytochrome P450 enzymes: the first Bernard Brodie lecture at Pennsylvania State University. Life Sci 1986; 39: 2493–2518.
- Moorthy B. Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues. J Phannacol Exp Ther 2000; 294: 313–322.
- Moorthy B, Chen S, Li D, Randerath K. 3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: possible link between P450 turnover and formation of DNA adducts and I-compounds. Carcinogenesis 1983; 14: 879–886.
- Harvey RG. Polycyclic aromatic hydrocarbons and cancer. Am Sci 1982;70: 386–393.
- Rasmussen RE, Anderson ER, MacEwen JD, Bruner RH. Carcinogenesis, benzo[a]pyrene metabolism, and sister chromatid exchanges in lungs of rats after intratracheal 3-methylcholanthrene. J Natl Cancer Inst 1984; 73: 257–264.
- Huggins C, Grand LC, Brillantes FP. Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression. Nature 1961; 189: 204-207.
- Thomas PE, Reik LM, Ryan DE, Levin W. Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochrome P450c and cytochrome P-450d by structurally diverse xenobiotics. J Biol Chem 1983;258: 4590–4598.
- Whitlock Jr JP. The regulation of gene expression by 2,3,7,8-tetrachlorodibenzop-dioxin. Pharmacol Rev 1987; 39: 147-161.
- Safe SH. Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzop-dioxin and related compounds. Pharmacol Ther 1995; 67: 247–281.
- Denison MS, Phelan D. The Ah receptor signal transduction pathway. In: Denison MS, Helferich WG. (eds) Toxicant-Receptor Interactions. New York: Taylor and Francis, 1998;3–33.
- Gasiewicz TA, Rucci G, Henry EC, Baggs RB. Changes in hamster hepatic cytochrome P-450, ethoxycoumarin O-deethylase, and reduced NAD(P):menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzop-dioxin. Partial dissociation with temporal and dose-response relationships from elicited toxicity. Biochem Pharmacol 1986; 35: 2737–2742.
- Chaturvedi S, Lakshman MK. Site-specific modification of the human N-ras proto-oncogene with each diol epoxide metabolite of benzo[a]pyrene and thermal denaturation studies of the adducted duplexes. Carcinogenesis 1996; 17: 2747–2752.
- Wei D, Maher VM, McCormick JM. Effect of nuclear environment on the distribution of benzo[a]pyrene diol epoxide-induced adducts in the HPRT gene of human fibroblasts. Carcinogenesis 1996; 17: 2695–2701.
- Puisieux A, Lim S, Groopman J, Ozturk M. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res 1991; 51: 6185–6189.
- Yakes FM, Chen Y, Houten By. PCR-based assays for the detection and quantitation of DNA damage and repair. In: Pfeifer GP. (ed) Technologies for Detection of DNA Damage and Mutations. New York: Plenum, 1996; 171–184.
- Arlt VM, Schmeiser HI-I, Pfeifer GP. Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR. Carcinogenesis 2001; 22: 133–140.
- Dennisenko MF, Pao Tang MS, Pfeifer GP. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hot spots in p53. Science 1996; 274: 430–432.
- Gupta RC. Non-random binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo. Proc Natl Acad Sci USA 1994; 81: 6943-6947.
- Kawajiri K, Nakachi K, Imai K, Hayashi S, Watanabe J. Individual differences in lung cancer susceptibility in relation to polymorphisms of P-4501A1 gene and cigarette dose. In: Ernstner L, Gelboin I-1V, Sugimura T. (eds) Xenobiotics and Cancer. Tokyo: Japan Society, and London: Taylor and Francis, 1991; 55-61.
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3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene
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