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Redox Report
Communications in Free Radical Research
Volume 7, 2002 - Issue 2
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Review

Xanthine oxidase is a peroxynitrite synthase: newlyidentified roles for a very old enzyme

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Pages 65-70 | Published online: 19 Jul 2013

  • Schardinger F. Z Unters Nahr Genussm 1902; 5: 1113–1121.
  • Millar TM, Stevens CR, Blake DR. Xanthine oxidase can generate nitric oxide from nitrate in ischaemia. Biochem Soc Trans 1997;25: 528S.
  • Blake D, Stevens CR, Sahinoglu T et al. Xanthine oxidase: four roles for the enzyme in rheumatoid pathology. Biochem Soc Trans 1997;25: 812–816.
  • Millar TM, Stevens CR, Benjamin N et al. Xanthine oxido-reductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. FEBS Lett 1998; 427: 225–258.
  • Morgan E, Stewart CP, Hopkins FG. On the conversion of hypoxanthine and xanthine by bovine milk. Proc R Soc London (Ser. B) 1922; 94: 109–131.
  • Dixon M. XCIII. Studies on xanthine oxidase. VII. The specificity of the system. Biochem J 1926; 20: 703–718.
  • Horecker B, Heppel LA. The reduction of cytochrome c by xanthine oxidase. J Biol Chem 1949; 178: 683–690.
  • Fridovich I, Handler P. Xanthine oxidase: V. Differential inhibition of the reduction of various electron acceptors. J Biol Chem 1962; 237: 916–921.
  • Bach A. Reduktion der Nitrate durch das system perhydridase-aldehyd-wasser. Biochem Z 1911; 33: 282–288.
  • Sergeev N, Ananiadi LI, L'vov NP, Kretovich WL. The nitrate reductase activity of milk xanthine oxidase. J Appl Biochem 1985;7: 86–92.
  • Richert D, Westerfeld WW. A bioassay procedure for the dietary factor related to xanthine oxidase. J Biol Chem 1951; 192: 49–56.
  • Richert D, Westerfeld WW. Isolation and identification of the xanthine oxidase factor as molybdenum. J Biol Chem 1953; 203: 915–923.
  • Bray R, Meriwether LS. Electron spin resonance of xanthine oxidase substituted with molybdenum-95. Nature 1966; 212: 467–469.
  • Hille R. The mononuclear molybdenum enzymes. Chem Rev 1996; 96: 2757–2816.
  • Enroth C, Eger BT, Okamoto K, Nishino T, Nishino T, Pai EF. Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc Natl Acad Sci USA 2000; 97: 10723–10728.
  • Pateman J, Cove DJ, Rever BM, Roberts DB. A common co-factor for nitrate reductase and xanthine dehtdrogenase which also regulates the synthesis of nitrate reductase. Nature 1964; 201: 58–60.
  • Johnson J, Indermaur LW, Rajagopalan KV. Molybdenum cofactor biosynthesis in Escherichia coli. Requirement of the chlB gene product for the formation of molybdopterin guanine dinucleotide. J Biol Chem 1991; 266: 12140–12145.
  • Hille R, Nishino T. Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J 1995; 9: 995–1003.
  • Nishino T, Okamoto K. The role of the [2Fe-2S] cluster centers in xanthine oxidoreductase. J Inorg Biochem 2000; 82: 43–49.
  • Kay C, Solomonson LP, Barber MJ. Oxidation-reduction potentials of flavin and Mo-pterin centers in assimilatory nitrate reductase: variation with pH. Biochemistry 1990; 29: 10823–10828.
  • Ye R, Averill BA, Tiedje JIM. Denitrification: production and consumption of nitric oxide. Appl Environ Microbiol 1994; 60: 1053–1058.
  • Douglas P, Moorhead G, Hong Y, Morrice N, MacKintosh C. Purification of a nitrate reductase kinase from Spinacea oleracea leaves, and its identification as a calmodulin-domain protein kinase. Planta 1998;206: 435–442.
  • Jones R, Lamont A, Garland PB. The mechanism of proton translocation driven by the respiratory nitrate reductase complex of Escherichia coli. Biochem J1980; 190: 79-94.
  • Mapp P. Klocke R, Walsh DA et al. Localization of 3-nitrotyrosine to rheumatoid and normal synovium. Arthritis Rheum 2001;44: 1534–1539.
  • Stevens C, Blake DR, Merry P, Revell PA, Levick JR. A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium. Arthritis Rheum 1991; 34: 1508–1513.
  • Abu-Soud H, Rousseau DL, Stuehr DJ. Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension. J Biol Chem 1996; 271: 32515–32518.
  • Krenitsky T. Aldehyde oxidase and xanthine oxidase - functional and evolutionary relationships. Biochem Pharmacol 1978; 27: 2763–2764.
  • Dudley R. Atmospheric oxygen, giant paleozoic insects and the evolution of anal locomotor performance. J Exp Biol 1998; 201: 1043–1050.
  • Millar TM. Novel Aspects of the Activity and Function of Xanthine Oxidase. University of Bath, UK: PhD Thesis, 1999.
  • Smith S, Rajagopalan KV, Handler P. Purification and properties of xanthine dehydrogenase from Micrococcus lactilyticus. J Biol Chem 1967;242: 4108–4117.
  • Hotz H, Uzzell T, Berger L. Linkage groups of protein-coding genes in Western palearctic water frogs reveal extensive evolutionary conservation. Genetics 1997; 147: 255–270.
  • Bodamyali T, Stevens CR, Billingham ME, Ohta S, Blake DR. Influence of hypoxia in inflammatory synovitis. Ann Rheum Dis 1998;57: 703–710.
  • Kissner R, Nauser T, Bugnon P, Lye PG, Koppenol WH. Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis. Chem Res Toxicol 1997; 10: 1285–1292.
  • MacMillan-Crow LA, Kerby JD, Beckman JS, Thompson JA. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proc Natl Acad Sci USA 1996; 93: 11853–11858.
  • Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A. Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med 2001; 30: 463–488.
  • Stevens C, Millar TM, Clinch JG, Kanczler JM, Bodamyali T, Blake DR. Antibacterial properties of xanthine oxidase in human milk. Lancet 2000; 356: 829–830.
  • Briley M, Eisenthal R. Association of xanthine oxidase with the bovine milk-fat-globule membrane. Nature of the enzyme-membrane association. Biochem J 1975; 147:417–423.
  • Terao M, Kurosaki M, Zanotta S, Garattini E. The xanthine oxidoreductase gene: structure and regulation. Biochem Soc Trans 1997;25: 791–796.
  • May J. Microbial contaminants and anti-microbial properties of human milk. Microbiol Sci 1988; 5: 42–46.
  • May J. Anti-microbial factors and microbial contaminants in human milk. J Paediatr Child Health 1994; 30: 470–475.
  • Newburg D. Human milk glycoconjugates that inhibit pathogens. Curr Med Chem 1999;6: 117–127.
  • Grulee E, Sanford HN, Schwarz H. Breast and artificial fed infants. JAMA 1934; 103: 735–739.
  • Stevenson S. The adequacy of artificial feeding in infancy. J Pediatr 1947; 31: 616–630.
  • Welsh J, May JT. Anti-infective properties of breast milk. J Pediatr 1979; 94: 1–9.
  • Martinez G, Dodd DA, Samartgedes JA. Milk feeding patterns in the United States during the first 12 months of life. Pediatrics 1981; 68: 863–868.
  • Beaudry M, Dufour R, Marcoux S. Relation between infant feeding and infections during the first six months of life. J Pediatr 1995; 126: 191–197.
  • Ruiz-Palacios G, Calva JJ, Pickering LK et al. Protection of breast-fed infants against Campylobacter diarrhoea by antibodies in human milk. J Pediatr 1990; 116: 707–713.

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